| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Reza Noorian, Jennifer Rha, Dana M Annerino, Douglas Bernhard, Georgia M Taylor, James G Green. Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system. Neurobiology of disease. vol 48. issue 1. 2013-01-14. PMID:22722052. |
while parkinsonian motor symptoms are caused by degeneration of dopamine neurons in the midbrain substantia nigra, the neurological localization of non-motor symptoms in pd is not known. |
2013-01-14 |
2023-08-12 |
mouse |
| Hyo Geun Kim, Mi Sun Ju, Sang Keun Ha, Hyangsook Lee, Hyejung Lee, Sun Yeou Kim, Myung Sook O. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biological & pharmaceutical bulletin. vol 35. issue 8. 2012-12-21. PMID:22863927. |
in addition, the acacetin-treated group inhibited degeneration of da neurons and depletion of dopamine level induced by mptp toxicity in the substantia nigra and striatum of the brain. |
2012-12-21 |
2023-08-12 |
mouse |
| Q David Walker, Misha L Johnson, Amanda E D Van Swearingen, Andrew E Arrant, Joseph M Caster, Cynthia M Kuh. Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22342988. |
dopamine neuron number and density in substantia nigra (sn) and ventral tegmental area (vta) were determined in the same animals using tyrosine-hydroxylase immunohistochemistry and unbiased stereology. |
2012-12-20 |
2023-08-12 |
rat |
| Mélanie Bourque, Dean E Dluzen, Thérèse Di Paol. Sex and temporally-dependent effects of methamphetamine toxicity on dopamine markers and signaling pathways. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22369785. |
under the present experimental conditions, methamphetamine treatments had modest effects on dopamine markers measured in the substantia nigra. |
2012-12-20 |
2023-08-12 |
mouse |
| Yan-xia Zhang, Rui-zhen Yan, Wen-yan Li. [Effects of dopamine receptors inhibited rats caudate nucleus on the pressor effect of substantia nigra]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 18. issue 4. 2012-12-03. PMID:21174829. |
[effects of dopamine receptors inhibited rats caudate nucleus on the pressor effect of substantia nigra]. |
2012-12-03 |
2023-08-12 |
rat |
| Yanzhen Zhu, Jing Zhang, Yanjun Zen. Overview of tyrosine hydroxylase in Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483316. |
parkinson's disease (pd) is characterized by severe loss of dopaminergic neurons and depletion of dopamine in substantia nigra. |
2012-12-03 |
2023-08-12 |
Not clear |
| I V Romanova, A Iu Chesnokova, A L Mikhrin. [Immunohistochemical study of CART-peptide in striato-nigral projections at dopamine loss]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 8. 2012-11-30. PMID:23155622. |
at the same time after in vitro incubation of nigro-accumbal brain slice with ampt (alpha-methyl-paratirosine--dopamine inhibitor) for 4 h the reduction of tyrosine hydroxylase optical density (the enzyme limiting dopamine synthesis) in substantia nigr neurons was found and optical density of cart-peptide in nucleus accumbens and substantia nigra was also revealed. |
2012-11-30 |
2023-08-12 |
rat |
| Kazunori Adachi, Masayuki Kobayashi, Toshiyuki Kawasaki, Chihiro Yokoyama, John L Waddington, Hiroshi Sakagami, Hirotaka Onoe, Noriaki Koshikaw. Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22350537. |
in monkeys receiving mptp into the right carotid artery (n = 3), positron emission tomography indicated significant reduction in the binding of (e)-n-(3-iodoprop-2-enyl)-2β-carbo[(11)c]methoxy-3β-(4-methylphenyl)nortropane ([(11)c]pe2i) to the dopamine transporter in the right caudate, putamen, nucleus accumbens and substantia nigra relative to the contralateral hemisphere. |
2012-11-29 |
2023-08-12 |
monkey |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kiri. Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22659302. |
dysregulation of the dopamine machinery in the substantia nigra, on the other hand, could act as a trigger for induction of increased toxicity in these neurons and could explain how these neurons become more vulnerable and die in the disease process. |
2012-11-29 |
2023-08-12 |
mouse |
| Aurelio Campos-Romo, Rafael Ojeda-Flores, Pablo Moreno-Briseño, Paula Vergara, José Segovia, José D Carrillo-Ruiz, Juan Fernandez-Rui. Behavioral improvement in MPTP-treated nonhuman primates in the HALLWAY task after transfer of TH cDNA to host astrocytes. Acta neurobiologiae experimentalis. vol 72. issue 2. 2012-11-27. PMID:22810218. |
parkinson's disease is a neurodegenerative disease, resulting from deterioration of the substantia nigra which in turn leads to a decrease of dopamine levels in the striatum. |
2012-11-27 |
2023-08-12 |
rat |
| Shuang-Yong Sun, Chun-Na An, Xiao-Ping P. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. Brain research bulletin. vol 88. issue 6. 2012-11-23. PMID:22664331. |
we found that dj-1 protein could reduce apomorphine-induced rotations, inhibit reduction of dopamine contents and tyrosine hydroxylase levels in the striatum, and decrease dopaminergic neuron death in the substantia nigra. |
2012-11-23 |
2023-08-12 |
rat |
| J Deignan, R Luján, C Bond, A Riegel, M Watanabe, J T Williams, J Maylie, J P Adelma. SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. vol 217. 2012-11-19. PMID:22554781. |
the firing properties of dopamine (da) neurons in the substantia nigra (sn) pars compacta are strongly influenced by the activity of apamin-sensitive small conductance ca(2+)-activated k(+) (sk) channels. |
2012-11-19 |
2023-08-12 |
mouse |
| Gaynor A Smith, Ole Isacson, Stephen B Dunnet. The search for genetic mouse models of prodromal Parkinson's disease. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22819262. |
parkinson's disease is characterized and diagnosed by bradykinetic motor symptoms caused by the loss of dopamine neurons in the substantia nigra. |
2012-11-13 |
2023-08-12 |
mouse |
| Xiqun Chen, Guanhui Wu, Michael A Schwarzschil. Urate in Parkinson's disease: more than a biomarker? Current neurology and neuroscience reports. vol 12. issue 4. 2012-11-08. PMID:22580741. |
although appreciation of pd as a multisystem disorder has grown, loss of dopaminergic neurons in the substantia nigra remains a pathological and neurochemical hallmark, accounting for the substantial symptomatic benefits of dopamine replacement therapies. |
2012-11-08 |
2023-08-12 |
Not clear |
| Katarzyna Kuter, Wacław Kolasiewicz, Krystyna Gołembiowska, Anna Dziubina, Gert Schulze, Klemencja Berghauzen, Jadwiga Wardas, Krystyna Ossowsk. Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats. Pharmacological reports : PR. vol 63. issue 6. 2012-11-07. PMID:22358086. |
levels of dopamine, dopac and hva were decreased in the nucleus accumbens (nac) 2 weeks after 6-ohda but were not changed in the cp, frontal cortex (fcx) and substantia nigra (sn). |
2012-11-07 |
2023-08-12 |
rat |
| Julia Schiemann, Falk Schlaudraff, Verena Klose, Markus Bingmer, Susumu Seino, Peter J Magill, Kareem A Zaghloul, Gaby Schneider, Birgit Liss, Jochen Roepe. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature neuroscience. vol 15. issue 9. 2012-11-05. PMID:22902720. |
k-atp channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. |
2012-11-05 |
2023-08-12 |
mouse |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. |
2012-11-02 |
2023-08-12 |
Not clear |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
here, a multi-step method is presented for the analyses of dopamine tissue content, the protein levels of th, dat, or vmat2, and th phosphorylation from the substantia nigra and vta from rodent midbrain. |
2012-11-02 |
2023-08-12 |
Not clear |
| Ke-Zhong Shen, Steven W Johnso. Regulation of polysynaptic subthalamonigral transmission by D2, D3 and D4 dopamine receptors in rat brain slices. The Journal of physiology. vol 590. issue 10. 2012-10-25. PMID:22371474. |
dopamine depletion in experimental models of parkinson's disease promotes burst firing of neurons in the subthalamic nucleus (stn) and substantia nigra zona reticulata (snr). |
2012-10-25 |
2023-08-12 |
rat |