| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kiri. Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22659302. |
dysregulation of the dopamine machinery in the substantia nigra, on the other hand, could act as a trigger for induction of increased toxicity in these neurons and could explain how these neurons become more vulnerable and die in the disease process. |
2012-11-29 |
2023-08-12 |
mouse |
| Aurelio Campos-Romo, Rafael Ojeda-Flores, Pablo Moreno-Briseño, Paula Vergara, José Segovia, José D Carrillo-Ruiz, Juan Fernandez-Rui. Behavioral improvement in MPTP-treated nonhuman primates in the HALLWAY task after transfer of TH cDNA to host astrocytes. Acta neurobiologiae experimentalis. vol 72. issue 2. 2012-11-27. PMID:22810218. |
parkinson's disease is a neurodegenerative disease, resulting from deterioration of the substantia nigra which in turn leads to a decrease of dopamine levels in the striatum. |
2012-11-27 |
2023-08-12 |
rat |
| Shuang-Yong Sun, Chun-Na An, Xiao-Ping P. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. Brain research bulletin. vol 88. issue 6. 2012-11-23. PMID:22664331. |
we found that dj-1 protein could reduce apomorphine-induced rotations, inhibit reduction of dopamine contents and tyrosine hydroxylase levels in the striatum, and decrease dopaminergic neuron death in the substantia nigra. |
2012-11-23 |
2023-08-12 |
rat |
| J Deignan, R Luján, C Bond, A Riegel, M Watanabe, J T Williams, J Maylie, J P Adelma. SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. vol 217. 2012-11-19. PMID:22554781. |
the firing properties of dopamine (da) neurons in the substantia nigra (sn) pars compacta are strongly influenced by the activity of apamin-sensitive small conductance ca(2+)-activated k(+) (sk) channels. |
2012-11-19 |
2023-08-12 |
mouse |
| Gaynor A Smith, Ole Isacson, Stephen B Dunnet. The search for genetic mouse models of prodromal Parkinson's disease. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22819262. |
parkinson's disease is characterized and diagnosed by bradykinetic motor symptoms caused by the loss of dopamine neurons in the substantia nigra. |
2012-11-13 |
2023-08-12 |
mouse |
| Xiqun Chen, Guanhui Wu, Michael A Schwarzschil. Urate in Parkinson's disease: more than a biomarker? Current neurology and neuroscience reports. vol 12. issue 4. 2012-11-08. PMID:22580741. |
although appreciation of pd as a multisystem disorder has grown, loss of dopaminergic neurons in the substantia nigra remains a pathological and neurochemical hallmark, accounting for the substantial symptomatic benefits of dopamine replacement therapies. |
2012-11-08 |
2023-08-12 |
Not clear |
| Katarzyna Kuter, Wacław Kolasiewicz, Krystyna Gołembiowska, Anna Dziubina, Gert Schulze, Klemencja Berghauzen, Jadwiga Wardas, Krystyna Ossowsk. Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats. Pharmacological reports : PR. vol 63. issue 6. 2012-11-07. PMID:22358086. |
levels of dopamine, dopac and hva were decreased in the nucleus accumbens (nac) 2 weeks after 6-ohda but were not changed in the cp, frontal cortex (fcx) and substantia nigra (sn). |
2012-11-07 |
2023-08-12 |
rat |
| Julia Schiemann, Falk Schlaudraff, Verena Klose, Markus Bingmer, Susumu Seino, Peter J Magill, Kareem A Zaghloul, Gaby Schneider, Birgit Liss, Jochen Roepe. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature neuroscience. vol 15. issue 9. 2012-11-05. PMID:22902720. |
k-atp channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. |
2012-11-05 |
2023-08-12 |
mouse |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. |
2012-11-02 |
2023-08-12 |
Not clear |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
here, a multi-step method is presented for the analyses of dopamine tissue content, the protein levels of th, dat, or vmat2, and th phosphorylation from the substantia nigra and vta from rodent midbrain. |
2012-11-02 |
2023-08-12 |
Not clear |
| Ke-Zhong Shen, Steven W Johnso. Regulation of polysynaptic subthalamonigral transmission by D2, D3 and D4 dopamine receptors in rat brain slices. The Journal of physiology. vol 590. issue 10. 2012-10-25. PMID:22371474. |
dopamine depletion in experimental models of parkinson's disease promotes burst firing of neurons in the subthalamic nucleus (stn) and substantia nigra zona reticulata (snr). |
2012-10-25 |
2023-08-12 |
rat |
| Patricia Muñoz, Irmgard Paris, Laurie H Sanders, J Timothy Greenamyre, Juan Segura-Aguila. Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. Biochimica et biophysica acta. vol 1822. issue 7. 2012-10-15. PMID:22483869. |
studies with synaptic vesicles from rat substantia nigra revealed that vmat-2 uptake of ³h-aminochrome 6.3 ± 0.4nmol/min/mg was similar to dopamine uptake 6.2 ± 0.3nmol/min/mg that which were dependent on atp. |
2012-10-15 |
2023-08-12 |
rat |
| Hideaki Matsui, Roberto Gavinio, Ryosuke Takahash. Medaka fish Parkinson's disease model. Experimental neurobiology. vol 21. issue 3. 2012-10-12. PMID:23055787. |
despite the ubiquitous distribution of the inclusion bodies, the middle diencephalic dopaminergic neurons were particularly vulnerable to these toxins, supporting the idea that this dopamine cluster is similar to the human substantia nigra. |
2012-10-12 |
2023-08-12 |
human |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| E C Wolters, C M Franco. Mental dysfunction in Parkinson's disease. Parkinsonism & related disorders. vol 4. issue 3. 2012-10-02. PMID:18591098. |
the pathological hallmark of parkinson's disease (pd) is a degeneration of the dopamine (da) producing cells in the substantia nigra and the ventral tegmentum, resulting in a dopamine deficiency in the dopaminergic projection areas with defective functioning of specific cortico-subcortical extrapyramidal circuits. |
2012-10-02 |
2023-08-12 |
Not clear |
| J Abarca, G Busto. Release of d-[(3)H]aspartic acid from the rat substantia nigra: effect of veratridine-evoked depolarization and cortical ablation. Neurochemistry international. vol 7. issue 2. 2012-10-02. PMID:20492918. |
in contrast, both the accumulation and veratridine-evoked release of [(3)h]dopamine, remained unchanged in the ipsilateral substantia nigra slices to the lesion. |
2012-10-02 |
2023-08-12 |
rat |
| S A Greenfiel. The significance of dendritic release of transmitter and protein in the substantia nigra. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493000. |
the transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. |
2012-10-02 |
2023-08-12 |
Not clear |
| S A Greenfiel. The significance of dendritic release of transmitter and protein in the substantia nigra. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493000. |
it is possible that both dopamine and acetylcholinesterase, released in the substantia nigra, are acting in a novel, perhaps synergistic, fashion as "neuromodulators". |
2012-10-02 |
2023-08-12 |
Not clear |
| I W Chubb, J C Bornstei. Dopamine and acetylcholinesterase released in the substantia nigra: Cooperative or coincindental? Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493002. |
dopamine and acetylcholinesterase released in the substantia nigra: cooperative or coincindental? |
2012-10-02 |
2023-08-12 |
Not clear |