| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margaret Chia-Ying Wey, Elizabeth Fernandez, Paul Anthony Martinez, Patricia Sullivan, David S Goldstein, Randy Stron. Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384032. |
to address this hypothesis, we generated mice null for aldh1a1 and aldh2, the two isoforms known to be expressed in substantia nigra dopamine neurons. |
2012-08-27 |
2023-08-12 |
mouse |
| Margaret Chia-Ying Wey, Elizabeth Fernandez, Paul Anthony Martinez, Patricia Sullivan, David S Goldstein, Randy Stron. Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384032. |
we observed a significant loss of neurons immunoreactive for tyrosine hydroxylase (th) in the substantia nigra and a reduction of dopamine and metabolites in the striatum of aldh1a1(-/-)×aldh2(-/-) mice. |
2012-08-27 |
2023-08-12 |
mouse |
| Yu Xiang, Qian Wu, Liang Liang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Xiaoping Pu, Qiang Zhan. Chlorotoxin-modified stealth liposomes encapsulating levodopa for the targeting delivery against Parkinson's disease in the MPTP-induced mice model. Journal of drug targeting. vol 20. issue 1. 2012-08-23. PMID:22149216. |
after intraperitoneal injection to mice, the active targeting system loaded with ld significantly increased the distribution of dopamine and dihydroxyphenyl acetic acid, the metabolites of ld, in the substantia nigra and striata. |
2012-08-23 |
2023-08-12 |
mouse |
| Jose L Labandeira-Garcia, Jannette Rodriguez-Pallares, Begoña Villar-Cheda, Ana I Rodríguez-Perez, Pablo Garrido-Gil, Maria J Guerr. Aging, Angiotensin system and dopaminergic degeneration in the substantia nigra. Aging and disease. vol 2. issue 3. 2012-08-23. PMID:22396877. |
recent evidence suggests that dopamine and aii systems directly counterregulate each other in renal cells as well as in the striatum and substantia nigra. |
2012-08-23 |
2023-08-12 |
mouse |
| Jun Wang, Hong Jiang, Jun-Xia Xi. [Correlation between iron levels and degeneration of dopaminergic neurons in rat nigrostriatal system during the early 6-OHDA lesions in medial forebrain bundle]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 4. 2012-08-16. PMID:12937822. |
the results showed that 1 d or 3 d after lesions in mfb, there was a 45% or 66% reduction, respectively, in the density of tyrosine hydroxylase (th) immunoreactive cells in the substantia nigra (sn) of the lesioned side accompanied by an increase in iron staining intensity and iron concentration; while there was no change in dopamine (da) release in the striatum (str) of the lesioned side compared with the unlesioned side and the normal rats. |
2012-08-16 |
2023-08-12 |
rat |
| C Venkateshappa, G Harish, Rajeswara Babu Mythri, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21971758. |
parkinson's disease (pd) is characterized by selective degeneration and loss of dopaminergic neurons in the substantia nigra (sn) of the ventral mid brain leading to dopamine depletion in the striatum. |
2012-08-13 |
2023-08-12 |
human |
| Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto, Teisuke Takahashi, Kazuhiro Takuma, Toshio Matsud. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21903118. |
sea0400 protected against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in mptp-treated mice. |
2012-08-01 |
2023-08-12 |
mouse |
| Yulin Deng, Yongqian Zhang, Yujuan Li, Shengyuan Xiao, Dewei Song, Hong Qing, Qin Li, Ali H Rajpu. Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in parkinsonian brains. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 4. 2012-07-30. PMID:22065205. |
adtiq and its precursors, dopamine and methylglyoxal, were detected in different regions of frozen human brains such as the substantia nigra, caudate nucleus, putamen, frontal cortex, and the cerebellum. |
2012-07-30 |
2023-08-12 |
human |
| Peternella S Verhave, Marjan J Jongsma, Roland M Van Den Berg, Raymond A P Vanwersch, August B Smit, Ingrid H C H M Philippen. Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22178201. |
at three weeks following the last mptp challenge, brains were dissected and dopamine levels in the striatum and the tyrosine hydroxylase (th) expressing dopamine (da) neurons in the substantia nigra (sn) were compared. |
2012-07-27 |
2023-08-12 |
monkey |
| James G Green. Current status and future directions of gene expression profiling in Parkinson's disease. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21056669. |
motor symptoms are primarily caused by selective degeneration of substantia nigra dopamine (snda) neurons in the midbrain; non-motor symptoms may be referable to well-described pathology at multiple levels of the neuraxis. |
2012-07-23 |
2023-08-12 |
Not clear |
| Sang Ryong Kim, Tatyana Kareva, Olga Yarygina, Nikolai Kholodilov, Robert E Burk. AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth. Molecular therapy : the journal of the American Society of Gene Therapy. vol 20. issue 2. 2012-07-10. PMID:22008911. |
to this end we have investigated the ability of a constitutively active form of the gtpase rheb, an important activator of mammalian target of rapamycin (mtor) signaling, to mediate neurotrophic effects in dopamine neurons of the substantia nigra (sn), a population of neurons affected in pd. |
2012-07-10 |
2023-08-12 |
mouse |
| Saif Ahmad, M Badruzzaman Khan, M Nasrul Hoda, Kanchan Bhatia, Rizwanul Haque, Inayat Saleem Fazili, Arshad Jamal, Jafar Salamt Khan, Deepshikha Pande Katar. Neuroprotective effect of sesame seed oil in 6-hydroxydopamine induced neurotoxicity in mice model: cellular, biochemical and neurochemical evidence. Neurochemical research. vol 37. issue 3. 2012-06-29. PMID:22089932. |
increased tyrosine hydroxylase (th) expression in substantia nigra as well as dopamine and its metabolite dopac level in l+so group also support our findings that so may inhibit activation of nadph oxidase dependent inflammatory mechanism due to 6-ohda induced neurotoxicity in mice. |
2012-06-29 |
2023-08-12 |
mouse |
| S K Kidd, J S Schneide. Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience. vol 194. 2012-06-25. PMID:21846494. |
vpa was able to partially prevent striatal dopamine depletion and almost completely protect against substantia nigra daergic cell loss. |
2012-06-25 |
2023-08-12 |
mouse |
| Ferry S P Sagala, Daniel Harnack, Evgeny Bobrov, Reinhard Sohr, Christoph Gertler, D James Surmeier, Andreas Kupsc. Neurochemical characterization of the striatum and the nucleus accumbens in L-type Ca(v)1.3 channels knockout mice. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22202668. |
l-type ca(v)1.3 channels control the autonomous pacemaking of the substantia nigra (sn) dopamine (da) neurons, which maintains the sustained release of da in the striatum, its target structure. |
2012-06-25 |
2023-08-12 |
mouse |
| Marcos Roberto de Oliveira, Ricardo Fagundes da Rocha, Matheus Augusto de Bittencourt Pasquali, José Cláudio Fonseca Moreir. The effects of vitamin A supplementation for 3 months on adult rat nigrostriatal axis: increased monoamine oxidase enzyme activity, mitochondrial redox dysfunction, increased β-amyloid(1-40) peptide and TNF-α contents, and susceptibility of mitochondria to an in vitro H2O2 challenge. Brain research bulletin. vol 87. issue 4-5. 2012-06-22. PMID:22274401. |
in this regard, we investigated here the consequences of vitamin a supplementation at 500, 1000, or 2500 iu/kg day(-1) for 3 months on adult rat substantia nigra and striatum total and mitochondrial redox state (both oxidative and nitrosative stress markers), electron transfer chain activity, monoamine oxidase (mao) enzyme activity, endoplasmic reticulum stress marker (bip), α- and β-synucleins, β-amyloid peptide (1-40), dopamine d2 receptor (d2r), receptor for advanced glycation end products (rage), caspase-3 and caspase-8 enzyme activity and tumor necrosis factor-α (tnf-α) levels. |
2012-06-22 |
2023-08-12 |
human |
| Richard Kone. Mitochondrial therapy for Parkinson's disease: neuroprotective pharmaconutrition may be disease-modifying. Clinical pharmacology : advances and applications. vol 2. 2012-06-19. PMID:22291504. |
progressive destruction of neurons that produce dopamine in the basal ganglia of the brain, particularly the substantia nigra, is a hallmark of parkinson's disease. |
2012-06-19 |
2023-08-12 |
Not clear |
| Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F Oo, W Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E Burk. Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21782946. |
therefore, to explore the possible role of endogenous akt signaling in maintaining the viability and functionality of substantia nigra (sn) dopamine neurons, one of the principal systems affected in pd, we have used an adeno-associated viral vector to transduce them with a dominant negative (dn) form of akt, the pleckstrin homology (ph) domain alone (dn(ph)-akt). |
2012-06-11 |
2023-08-12 |
mouse |
| S Walsh, D P Finn, E Dow. Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat. Neuroscience. vol 175. 2012-06-01. PMID:21145947. |
dopamine neuron loss from the substantia nigra did not occur until 2 weeks after terminal lesion, and this was preceded by microglial, but not astroglial, activation. |
2012-06-01 |
2023-08-12 |
human |
| R B Mythri, M M Srinivas Bharat. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22211691. |
the motor symptoms in pd arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Tim Aumann, Mal Horn. Activity-dependent regulation of the dopamine phenotype in substantia nigra neurons. Journal of neurochemistry. vol 121. issue 4. 2012-05-30. PMID:22356203. |
activity-dependent regulation of the dopamine phenotype in substantia nigra neurons. |
2012-05-30 |
2023-08-12 |
Not clear |