| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui D S Prediger, Argelia E Rojas-Mayorquin, Aderbal S Aguiar, Caroline Chevarin, Raymond Mongeau, Michel Hamon, Laurence Lanfumey, Elaine Del Bel, Hisako Muramatsu, José Courty, Rita Raisman-Vozar. Mice with genetic deletion of the heparin-binding growth factor midkine exhibit early preclinical features of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 8. 2012-05-29. PMID:21301897. |
moreover, the genetic deletion of midkine decreased the expression of the enzyme tyrosine hydroxylase in the substantia nigra reducing partially the levels of dopamine and its metabolites in the olfactory bulb and striatum of mice. |
2012-05-29 |
2023-08-12 |
mouse |
| Stephan Steidl, Anthony D Miller, Charles D Blaha, John S Yeoman. M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. PloS one. vol 6. issue 11. 2012-05-08. PMID:22102904. |
however, cholinergic inputs from the laterodorsal (ldt) and pedunculopontine (ppt) tegmental nucleus to the vta and substantia nigra (sn) importantly contribute, as either ldt or ppt lesions strongly attenuate morphine-induced forebrain dopamine elevations. |
2012-05-08 |
2023-08-12 |
mouse |
| Martin Lundblad, Mickael Decressac, Bengt Mattsson, Anders Björklun. Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 9. 2012-05-08. PMID:22315428. |
we used in vivo amperometry to monitor changes in synaptic dopamine (da) release in the striatum induced by overexpression of human wild-type α-synuclein in nigral da neurons, induced by injection of an adeno-associated virus type 6 (aav6)-α-synuclein vector unilaterally into the substantia nigra in adult rats. |
2012-05-08 |
2023-08-12 |
human |
| Chang-Liang Xu, Qi-Zhi Wang, Ling-Mei Sun, Xiu-Min Li, Ji-Min Deng, Lu-Fan Li, Jin Zhang, Rong Xu, Shi-Ping M. Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:22001429. |
on 14th day, the rats were sacrificed, substantia nigra (sn) and striatum were dissected, and then dopamine (da) and its metabolites in striatum and malonyldialdehyde (mda) contents, reduced glutathione (gsh) level and gene expression level in sn were estimated. |
2012-05-04 |
2023-08-12 |
rat |
| Ahrom Ham, Sung-Jin Lee, Jongheon Shin, Kyung-Ho Kim, Woongchon Ma. Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells. Neuroscience letters. vol 507. issue 2. 2012-04-26. PMID:22040670. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic (daergic) neurons in the substantia nigra and the subsequent depletion of dopamine (da). |
2012-04-26 |
2023-08-12 |
human |
| John S Yeoman. Muscarinic receptors in brain stem and mesopontine cholinergic arousal functions. Handbook of experimental pharmacology. issue 208. 2012-04-25. PMID:22222702. |
ch5,6 activation of dopamine neurons of the ventral tegmental area and substantia nigra (via m₅ receptors) increases reward-seeking and energizes motor functions. |
2012-04-25 |
2023-08-12 |
Not clear |
| Anand Kumar Singh, Manindra Nath Tiwari, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20371137. |
levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum, and tyrosine hydroxylase (th) immunoreactivity and 4',6-diamidino-2-phenylindole (dapi)/fluoro-jade b staining in the substantia nigra were measured to assess dopaminergic neurodegeneration. |
2012-04-19 |
2023-08-12 |
rat |
| Yan-Na Wu, Adam C Munhall, Steven W Johnso. Mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons. Brain research. vol 1395. 2012-04-19. PMID:21550595. |
mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons. |
2012-04-19 |
2023-08-12 |
rat |
| Yan-Na Wu, Adam C Munhall, Steven W Johnso. Mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons. Brain research. vol 1395. 2012-04-19. PMID:21550595. |
we used patch pipettes to record whole-cell currents under voltage-clamp (-60 mv) in substantia nigra dopamine neurons in slices of rat brain. |
2012-04-19 |
2023-08-12 |
rat |
| Shengyuan Ding, Wei Wei, Fu-Ming Zho. Molecular and functional differences in voltage-activated sodium currents between GABA projection neurons and dopamine neurons in the substantia nigra. Journal of neurophysiology. vol 106. issue 6. 2012-04-16. PMID:21880943. |
molecular and functional differences in voltage-activated sodium currents between gaba projection neurons and dopamine neurons in the substantia nigra. |
2012-04-16 |
2023-08-12 |
Not clear |
| Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyungjin Bae, Younbyoung Chae, Insop Shim, Hyangsook Lee, Woongjoon Moon, Hyejung Lee, Hi-Joon Par. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132113. |
parkinson's disease (pd) is caused by the selective loss of dopaminergic neurons in the substantia nigra (sn) and the depletion of striatal dopamine (da). |
2012-04-02 |
2023-08-12 |
mouse |
| David E Vaillancourt, Matthew B Spraker, Janey Prodoehl, Xiaohong Joe Zhou, Deborah M Littl. Effects of aging on the ventral and dorsal substantia nigra using diffusion tensor imaging. Neurobiology of aging. vol 33. issue 1. 2012-03-13. PMID:20359780. |
dopaminergic neurons in the substantia nigra produce dopamine for the nigrostriatal pathway that facilitates motor function. |
2012-03-13 |
2023-08-12 |
Not clear |
| Brigitte Spinnewyn, Christelle Charnet, Sylvie Cornet, Véronique Roubert, Pierre-Etienne Chabrier, Michel Augue. An improved model to investigate the efficacy of antidyskinetic agents in hemiparkinsonian rats. Fundamental & clinical pharmacology. vol 25. issue 5. 2012-03-08. PMID:21077938. |
this model led to 90-100% of rats with a marked contralateral circling behaviour, significant limb use asymmetry (20%), a decrease in ipsilateral striatal dopamine content (70%) and degeneration of dopamine neurons in the substantia nigra (70%). |
2012-03-08 |
2023-08-12 |
human |
| Alison Yarnall, Lynn Rochester, David J Bur. The interplay of cholinergic function, attention, and falls in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 14. 2012-02-28. PMID:21898597. |
dopamine loss in the substantia nigra causes several of the motor signs seen in parkinson's disease, but there is now increasing evidence highlighting the importance of cholinergic loss in the pathophysiology of nonmotor symptoms. |
2012-02-28 |
2023-08-12 |
human |
| Shen Li, Xiao-Ping P. Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. Biological & pharmaceutical bulletin. vol 34. issue 8. 2012-02-27. PMID:21804220. |
we confirmed that mptp led to behavioral deficits, depletion of dopamine and its metabolites, reduction in superoxide dismutase (sod) and glutathione peroxidase (gsh-px) activity, and the elevation of malondialdehyde (mda) levels in the substantia nigra. |
2012-02-27 |
2023-08-12 |
mouse |
| Alex Iranz. Sleep-wake changes in the premotor stage of Parkinson disease. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21880334. |
patients with the idiopathic form of rbd with decreased striatal dopamine transporters imaging, substantia nigra hyperechogenicity and hyposmia have an increased short-term risk for developing the classical motor, dysautonomic and cognitive symptoms of a synucleinopathy. |
2012-02-16 |
2023-08-12 |
human |
| Birgit Mertens, Mustafa Varcin, Yvette Michotte, Sophie Sarr. The neuroprotective action of candesartan is related to interference with the early stages of 6-hydroxydopamine-induced dopaminergic cell death. The European journal of neuroscience. vol 34. issue 7. 2012-02-10. PMID:21936877. |
in the present work, the effect of daily treatment of rats with the angiotensin ii (ang ii) type 1 (at(1) ) receptor antagonist candesartan (3 mg/kg per day, s.c.) initiated 7 days before the intrastriatal injection of 6-hydroxydopamine (6-ohda) was investigated by means of tyrosine hydroxylase-positive cell counts in the substantia nigra, and dopamine and 3,4-dihydroxyphenylacetic acid measurements in the striatum. |
2012-02-10 |
2023-08-12 |
rat |
| Alicia M Pickrell, Milena Pinto, Aline Hida, Carlos T Morae. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 48. 2012-02-09. PMID:22131425. |
these symptoms are associated with massive loss of tyrosine hydroxylase-positive neurons in the substantia nigra (sn) causing an estimated 70-80% depletion of dopamine (da) in the striatum, where their projections are located. |
2012-02-09 |
2023-08-12 |
mouse |
| Yin-Xiu Ding, Yi Xia, Xi-Ying Jiao, Li Duan, Jun Yu, Xi Wang, Liang-Wei Che. The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21562748. |
in present study, immunofluorescence, fluoro-jade staining and laser scanning confocal microscopy were applied to investigate distribution and changes of trkb and trkc in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model. |
2012-02-08 |
2023-08-12 |
mouse |
| Yin-Xiu Ding, Yi Xia, Xi-Ying Jiao, Li Duan, Jun Yu, Xi Wang, Liang-Wei Che. The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21562748. |
this study has indicated that trkb-containing dopamine neurons are less sensitive in the substantia nigra of mptp mouse model, suggesting that specific organization of trks may be involved in neuronal vulnerability to mptp insult, and bdnf-trkb signaling may play more important role in protecting dopamine neurons and exhibit therapeutic potential for parkinson's disease. |
2012-02-08 |
2023-08-12 |
mouse |