| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y-N Wu, S W Johnso. Dopamine oxidation facilitates rotenone-dependent potentiation of N-methyl-D-aspartate currents in rat substantia nigra dopamine neurons. Neuroscience. vol 195. 2012-02-06. PMID:21884756. |
dopamine oxidation facilitates rotenone-dependent potentiation of n-methyl-d-aspartate currents in rat substantia nigra dopamine neurons. |
2012-02-06 |
2023-08-12 |
rat |
| R Gonzalez-Aparicio, J A Flores, I Tasset, I Tunez, E Fernandez-Espej. Mice lacking the peroxisome proliferator-activated receptor α gene present reduced number of dopamine neurons in the substantia nigra without altering motor behavior or dopamine neuron decline over life. Neuroscience. vol 186. 2012-01-30. PMID:21463665. |
mice lacking the peroxisome proliferator-activated receptor α gene present reduced number of dopamine neurons in the substantia nigra without altering motor behavior or dopamine neuron decline over life. |
2012-01-30 |
2023-08-12 |
mouse |
| Tatyana Verina, Samara F Kiihl, Jay S Schneider, Tomás R Guilart. Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21112353. |
in chronic mn exposure, dopamine neurons in the substantia nigra (sn) do not degenerate but they appear to be dysfunctional. |
2012-01-25 |
2023-08-12 |
Not clear |
| Yasuyuki Irie, Makio Saeki, Hidekazu Tanaka, Yonehiro Kanemura, Shinpei Otake, Yoshiyuki Ozono, Toshisaburou Nagai, Yukiko Kondo, Kenzo Kudo, Yoshinori Kamisaki, Naomasa Miki, Eiichi Tair. Methamphetamine induces endoplasmic reticulum stress related gene CHOP/Gadd153/ddit3 in dopaminergic cells. Cell and tissue research. vol 345. issue 2. 2012-01-24. PMID:21789578. |
treatment of cath.a cells with methamphetamine caused a re-distribution of dopamine inside the cells, which mimicked the presynaptic activity of neurons with cell bodies located in the ventral tegmental area or the substantia nigra. |
2012-01-24 |
2023-08-12 |
mouse |
| L W Chen, F Kuang, L C Wei, Y X Ding, K K L Yung, Y S Cha. Potential application of induced pluripotent stem cells in cell replacement therapy for Parkinson's disease. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495962. |
parkinson's disease (pd), a common degenerative disease in humans, is known to result from loss of dopamine neurons in the substantia nigra and is characterized by severe motor symptoms of tremor, rigidity, bradykinsia and postural instability. |
2012-01-12 |
2023-08-12 |
mouse |
| Waleed Ahmed El-Said, Jin-Ho Lee, Byung-Keun Oh, Jeong-Woo Cho. Electrochemical sensor to detect neurotransmitter using gold nano-island coated ITO electrode. Journal of nanoscience and nanotechnology. vol 11. issue 7. 2012-01-05. PMID:22121752. |
parkinson disease is a chronic neurodegenerative disorder characterized by the loss of dopamine, which is a neurotransmitter in the substantia nigra. |
2012-01-05 |
2023-08-12 |
cattle |
| Anand Kumar Singh, Manindra Nath Tiwari, Anubhuti Dixit, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. Toxicological sciences : an official journal of the Society of Toxicology. vol 122. issue 2. 2011-12-19. PMID:21561882. |
the expressions of α-internexin intermediate filament (α-iif), atp synthase d chain (atp-sd), heat shock protein (hsp)-70, truncated connexin-47, hsp-60, mitogen-activated protein kinase-activated kinase-5, nicotinamide adenine dinucleotide dehydrogenase 24k chain precursor, platelet-activating factor acetyl hydrolase 1b-α2 (paf-ah 1b-α2), and synaptosomal-associated protein-25 (snap-25) were altered in the substantia nigra and nicotinamide adenine dinucleotide- specific isocitrate dehydrogenase, phosphatidylethanolamine-binding protein-1, prohibitin, protein disulfide isomerase-endoplasmic reticulum 60 protease, stathmin, and ubiquitin-conjugating enzyme in the striatum along with motor impairment, decreased dopamine and th-ir, and increased microglial activation after cypermethrin exposure. |
2011-12-19 |
2023-08-12 |
Not clear |
| Stéphanie Vuillermot, Joram Feldon, Urs Meye. Relationship between sensorimotor gating deficits and dopaminergic neuroanatomy in Nurr1-deficient mice. Experimental neurology. vol 232. issue 1. 2011-12-07. PMID:21820432. |
we found that prepulse inhibition deficits in nurr1-deficient mice were paralleled by reduced numbers of substantia nigra dopamine cells expressing tyrosine hydroxylase, and by decreased tyrosine hydroxylase and dopamine transporter immunoreactivity in ventral parts of the striatum. |
2011-12-07 |
2023-08-12 |
mouse |
| Raquel Bajo-Grañeras, Maria D Ganfornina, Esperanza Martín-Tejedor, Diego Sanche. Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems. Glia. vol 59. issue 10. 2011-11-29. PMID:21688324. |
locomotor performance, dopamine concentration, and gene expression levels in the substantia nigra were assayed in mice treated with paraquat (pq). |
2011-11-29 |
2023-08-12 |
mouse |
| Ann D Cohen, Michael J Zigmond, Amanda D Smit. Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration. Brain research. vol 1370. 2011-11-23. PMID:21062624. |
6-ohda caused a loss of cells in the substantia nigra that expressed both fg and tyrosine hydroxylase (th) and striatal terminals expressing th, the high affinity dopamine transporter (dat), and the vesicular monoamine transporter 2 (vmat2) as assessed 2-8 weeks later. |
2011-11-23 |
2023-08-12 |
Not clear |
| J A Steiner, E Angot, P Brundi. A deadly spread: cellular mechanisms of α-synuclein transfer. Cell death and differentiation. vol 18. issue 9. 2011-11-15. PMID:21566660. |
the molecular mechanisms by which substantia nigra dopamine neurons die and whether the lewy pathology is directly involved in the cell death pathway are open questions. |
2011-11-15 |
2023-08-12 |
Not clear |
| Wacław Kolasiewicz, Katarzyna Kuter, Przemysław Nowak, Agnieszka Pastuszka, Krystyna Ossowsk. Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:21279489. |
the levels of dopamine, noradrenaline, serotonin, and their metabolites were measured by hplc in the cerebellum, substantia nigra, caudate-putamen, and frontal cortex. |
2011-11-10 |
2023-08-12 |
rat |
| Yoshihisa Kitamura, Shotaro Watanabe, Masanobu Taguchi, Kentaro Takagi, Takuya Kawata, Kazuko Takahashi-Niki, Hiroyuki Yasui, Hiroshi Maita, Sanae Mm Iguchi-Ariga, Hiroyoshi Arig. Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats. Molecular neurodegeneration. vol 6. issue 1. 2011-11-10. PMID:21740546. |
pd is caused by decreased dopamine levels in the substantia nigra and striatum, and cerebral ischemia occurs as a result of local reduction or arrest of blood supply. |
2011-11-10 |
2023-08-12 |
rat |
| Wei Zhang, Kester Phillips, Albert R Wielgus, Jie Liu, Alberto Albertini, Fabio A Zucca, Rudolph Faust, Steven Y Qian, David S Miller, Colin F Chignell, Belinda Wilson, Vernice Jackson-Lewis, Serge Przedborski, Danielle Joset, John Loike, Jau-Shyong Hong, David Sulzer, Luigi Zecc. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:19957214. |
in parkinson's disease (pd), there is a progressive loss of neuromelanin (nm)-containing dopamine neurons in substantia nigra (sn) which is associated with microgliosis and presence of extracellular nm. |
2011-11-08 |
2023-08-12 |
mouse |
| Martyna Songin, Joanna B Strosznajder, Magdalena Fitał, Katarzyna Kuter, Wacław Kolasiewicz, Przemysław Nowak, Krystyna Ossowsk. Glycogen synthase kinase 3β and its phosphorylated form (Y216) in the paraquat-induced model of parkinsonism. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:20143200. |
parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. |
2011-11-08 |
2023-08-12 |
rat |
| Victoria S Dalton, Katerina Zavitsano. Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. Journal of chemical neuroanatomy. vol 40. issue 4. 2011-11-07. PMID:20673846. |
dopamine d1 receptor (d1r) or d2 receptor (d2r) density was measured in the medial and lateral (cpul) caudate putamen, nucleus accumbens, olfactory tubercle (tu) and substantia nigra (d1r only) using in vitro autoradiography. |
2011-11-07 |
2023-08-12 |
rat |
| Jacqueline A Gleave, Troy H Farncombe, Chantal Saab, Laurie C Doerin. Correlative single photon emission computed tomography imaging of [123I]altropane binding in the rat model of Parkinson's. Nuclear medicine and biology. vol 38. issue 5. 2011-10-31. PMID:21718949. |
we sought to assess if the right to left [(123)i]altropane striatal ratios correlated with dopamine content in the striatum and substantia nigra and with behavioural outcomes. |
2011-10-31 |
2023-08-12 |
rat |
| Stephanie C Gantz, Christopher P Ford, Kim A Neve, John T William. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880923. |
loss of mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. |
2011-10-21 |
2023-08-12 |
mouse |
| Stephanie C Gantz, Christopher P Ford, Kim A Neve, John T William. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880923. |
this study examined age-dependent changes in dopamine neurons of the substantia nigra (sn) from wild-type, presymptomatic, and symptomatic mecp2(+/-) mice. |
2011-10-21 |
2023-08-12 |
mouse |
| Thi-Lien Nguyen, Yu-Hua Tian, In-Jee You, Seok-Yong Lee, Choon-Gon Jan. Modafinil-induced conditioned place preference via dopaminergic system in mice. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21157933. |
in addition, there were widespread changes in receptor binding in the brains of modafinil-treated mice; dopamine d₁ binding was increased in the caudate putamen, the accumbens, and the substantia nigra, while dopamine d₂ binding was decreased in the caudate putamen and the accumbens. |
2011-10-18 |
2023-08-12 |
mouse |