| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brigitte Spinnewyn, Christelle Charnet, Sylvie Cornet, Véronique Roubert, Pierre-Etienne Chabrier, Michel Augue. An improved model to investigate the efficacy of antidyskinetic agents in hemiparkinsonian rats. Fundamental & clinical pharmacology. vol 25. issue 5. 2012-03-08. PMID:21077938. |
this model led to 90-100% of rats with a marked contralateral circling behaviour, significant limb use asymmetry (20%), a decrease in ipsilateral striatal dopamine content (70%) and degeneration of dopamine neurons in the substantia nigra (70%). |
2012-03-08 |
2023-08-12 |
human |
| Alison Yarnall, Lynn Rochester, David J Bur. The interplay of cholinergic function, attention, and falls in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 14. 2012-02-28. PMID:21898597. |
dopamine loss in the substantia nigra causes several of the motor signs seen in parkinson's disease, but there is now increasing evidence highlighting the importance of cholinergic loss in the pathophysiology of nonmotor symptoms. |
2012-02-28 |
2023-08-12 |
human |
| Shen Li, Xiao-Ping P. Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. Biological & pharmaceutical bulletin. vol 34. issue 8. 2012-02-27. PMID:21804220. |
we confirmed that mptp led to behavioral deficits, depletion of dopamine and its metabolites, reduction in superoxide dismutase (sod) and glutathione peroxidase (gsh-px) activity, and the elevation of malondialdehyde (mda) levels in the substantia nigra. |
2012-02-27 |
2023-08-12 |
mouse |
| Alex Iranz. Sleep-wake changes in the premotor stage of Parkinson disease. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21880334. |
patients with the idiopathic form of rbd with decreased striatal dopamine transporters imaging, substantia nigra hyperechogenicity and hyposmia have an increased short-term risk for developing the classical motor, dysautonomic and cognitive symptoms of a synucleinopathy. |
2012-02-16 |
2023-08-12 |
human |
| Birgit Mertens, Mustafa Varcin, Yvette Michotte, Sophie Sarr. The neuroprotective action of candesartan is related to interference with the early stages of 6-hydroxydopamine-induced dopaminergic cell death. The European journal of neuroscience. vol 34. issue 7. 2012-02-10. PMID:21936877. |
in the present work, the effect of daily treatment of rats with the angiotensin ii (ang ii) type 1 (at(1) ) receptor antagonist candesartan (3 mg/kg per day, s.c.) initiated 7 days before the intrastriatal injection of 6-hydroxydopamine (6-ohda) was investigated by means of tyrosine hydroxylase-positive cell counts in the substantia nigra, and dopamine and 3,4-dihydroxyphenylacetic acid measurements in the striatum. |
2012-02-10 |
2023-08-12 |
rat |
| Alicia M Pickrell, Milena Pinto, Aline Hida, Carlos T Morae. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 48. 2012-02-09. PMID:22131425. |
these symptoms are associated with massive loss of tyrosine hydroxylase-positive neurons in the substantia nigra (sn) causing an estimated 70-80% depletion of dopamine (da) in the striatum, where their projections are located. |
2012-02-09 |
2023-08-12 |
mouse |
| Yin-Xiu Ding, Yi Xia, Xi-Ying Jiao, Li Duan, Jun Yu, Xi Wang, Liang-Wei Che. The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21562748. |
in present study, immunofluorescence, fluoro-jade staining and laser scanning confocal microscopy were applied to investigate distribution and changes of trkb and trkc in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model. |
2012-02-08 |
2023-08-12 |
mouse |
| Yin-Xiu Ding, Yi Xia, Xi-Ying Jiao, Li Duan, Jun Yu, Xi Wang, Liang-Wei Che. The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21562748. |
this study has indicated that trkb-containing dopamine neurons are less sensitive in the substantia nigra of mptp mouse model, suggesting that specific organization of trks may be involved in neuronal vulnerability to mptp insult, and bdnf-trkb signaling may play more important role in protecting dopamine neurons and exhibit therapeutic potential for parkinson's disease. |
2012-02-08 |
2023-08-12 |
mouse |
| Y-N Wu, S W Johnso. Dopamine oxidation facilitates rotenone-dependent potentiation of N-methyl-D-aspartate currents in rat substantia nigra dopamine neurons. Neuroscience. vol 195. 2012-02-06. PMID:21884756. |
dopamine oxidation facilitates rotenone-dependent potentiation of n-methyl-d-aspartate currents in rat substantia nigra dopamine neurons. |
2012-02-06 |
2023-08-12 |
rat |
| R Gonzalez-Aparicio, J A Flores, I Tasset, I Tunez, E Fernandez-Espej. Mice lacking the peroxisome proliferator-activated receptor α gene present reduced number of dopamine neurons in the substantia nigra without altering motor behavior or dopamine neuron decline over life. Neuroscience. vol 186. 2012-01-30. PMID:21463665. |
mice lacking the peroxisome proliferator-activated receptor α gene present reduced number of dopamine neurons in the substantia nigra without altering motor behavior or dopamine neuron decline over life. |
2012-01-30 |
2023-08-12 |
mouse |
| Tatyana Verina, Samara F Kiihl, Jay S Schneider, Tomás R Guilart. Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21112353. |
in chronic mn exposure, dopamine neurons in the substantia nigra (sn) do not degenerate but they appear to be dysfunctional. |
2012-01-25 |
2023-08-12 |
Not clear |
| Yasuyuki Irie, Makio Saeki, Hidekazu Tanaka, Yonehiro Kanemura, Shinpei Otake, Yoshiyuki Ozono, Toshisaburou Nagai, Yukiko Kondo, Kenzo Kudo, Yoshinori Kamisaki, Naomasa Miki, Eiichi Tair. Methamphetamine induces endoplasmic reticulum stress related gene CHOP/Gadd153/ddit3 in dopaminergic cells. Cell and tissue research. vol 345. issue 2. 2012-01-24. PMID:21789578. |
treatment of cath.a cells with methamphetamine caused a re-distribution of dopamine inside the cells, which mimicked the presynaptic activity of neurons with cell bodies located in the ventral tegmental area or the substantia nigra. |
2012-01-24 |
2023-08-12 |
mouse |
| L W Chen, F Kuang, L C Wei, Y X Ding, K K L Yung, Y S Cha. Potential application of induced pluripotent stem cells in cell replacement therapy for Parkinson's disease. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495962. |
parkinson's disease (pd), a common degenerative disease in humans, is known to result from loss of dopamine neurons in the substantia nigra and is characterized by severe motor symptoms of tremor, rigidity, bradykinsia and postural instability. |
2012-01-12 |
2023-08-12 |
mouse |
| Waleed Ahmed El-Said, Jin-Ho Lee, Byung-Keun Oh, Jeong-Woo Cho. Electrochemical sensor to detect neurotransmitter using gold nano-island coated ITO electrode. Journal of nanoscience and nanotechnology. vol 11. issue 7. 2012-01-05. PMID:22121752. |
parkinson disease is a chronic neurodegenerative disorder characterized by the loss of dopamine, which is a neurotransmitter in the substantia nigra. |
2012-01-05 |
2023-08-12 |
cattle |
| Anand Kumar Singh, Manindra Nath Tiwari, Anubhuti Dixit, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. Toxicological sciences : an official journal of the Society of Toxicology. vol 122. issue 2. 2011-12-19. PMID:21561882. |
the expressions of α-internexin intermediate filament (α-iif), atp synthase d chain (atp-sd), heat shock protein (hsp)-70, truncated connexin-47, hsp-60, mitogen-activated protein kinase-activated kinase-5, nicotinamide adenine dinucleotide dehydrogenase 24k chain precursor, platelet-activating factor acetyl hydrolase 1b-α2 (paf-ah 1b-α2), and synaptosomal-associated protein-25 (snap-25) were altered in the substantia nigra and nicotinamide adenine dinucleotide- specific isocitrate dehydrogenase, phosphatidylethanolamine-binding protein-1, prohibitin, protein disulfide isomerase-endoplasmic reticulum 60 protease, stathmin, and ubiquitin-conjugating enzyme in the striatum along with motor impairment, decreased dopamine and th-ir, and increased microglial activation after cypermethrin exposure. |
2011-12-19 |
2023-08-12 |
Not clear |
| Stéphanie Vuillermot, Joram Feldon, Urs Meye. Relationship between sensorimotor gating deficits and dopaminergic neuroanatomy in Nurr1-deficient mice. Experimental neurology. vol 232. issue 1. 2011-12-07. PMID:21820432. |
we found that prepulse inhibition deficits in nurr1-deficient mice were paralleled by reduced numbers of substantia nigra dopamine cells expressing tyrosine hydroxylase, and by decreased tyrosine hydroxylase and dopamine transporter immunoreactivity in ventral parts of the striatum. |
2011-12-07 |
2023-08-12 |
mouse |
| Raquel Bajo-Grañeras, Maria D Ganfornina, Esperanza Martín-Tejedor, Diego Sanche. Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems. Glia. vol 59. issue 10. 2011-11-29. PMID:21688324. |
locomotor performance, dopamine concentration, and gene expression levels in the substantia nigra were assayed in mice treated with paraquat (pq). |
2011-11-29 |
2023-08-12 |
mouse |
| Ann D Cohen, Michael J Zigmond, Amanda D Smit. Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration. Brain research. vol 1370. 2011-11-23. PMID:21062624. |
6-ohda caused a loss of cells in the substantia nigra that expressed both fg and tyrosine hydroxylase (th) and striatal terminals expressing th, the high affinity dopamine transporter (dat), and the vesicular monoamine transporter 2 (vmat2) as assessed 2-8 weeks later. |
2011-11-23 |
2023-08-12 |
Not clear |
| J A Steiner, E Angot, P Brundi. A deadly spread: cellular mechanisms of α-synuclein transfer. Cell death and differentiation. vol 18. issue 9. 2011-11-15. PMID:21566660. |
the molecular mechanisms by which substantia nigra dopamine neurons die and whether the lewy pathology is directly involved in the cell death pathway are open questions. |
2011-11-15 |
2023-08-12 |
Not clear |
| Wacław Kolasiewicz, Katarzyna Kuter, Przemysław Nowak, Agnieszka Pastuszka, Krystyna Ossowsk. Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:21279489. |
the levels of dopamine, noradrenaline, serotonin, and their metabolites were measured by hplc in the cerebellum, substantia nigra, caudate-putamen, and frontal cortex. |
2011-11-10 |
2023-08-12 |
rat |