| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hernán Cortés, Francisco Paz, David Erlij, Jorge Aceves, Benjamín Florá. GABA(B) receptors modulate depolarization-stimulated [³H]glutamate release in slices of the pars reticulata of the rat substantia nigra. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20863782. |
gaba(b) receptors decrease the release of gaba from the striatal terminals within the pars reticulata of the substantia nigra by opposing the increase in the release caused by dopamine d₁ receptors. |
2011-03-03 |
2023-08-12 |
rat |
| Anamitra Ghosh, Karunakaran Chandran, Shasi V Kalivendi, Joy Joseph, William E Antholine, Cecilia J Hillard, Arthi Kanthasamy, Anumantha Kanthasamy, Balaraman Kalyanarama. Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free radical biology & medicine. vol 49. issue 11. 2011-02-23. PMID:20828611. |
mptp treatment induced a loss of striatal dopamine and its metabolites, inactivation of mitochondrial aconitase in the substantia nigra, and a loss of locomotor activity in mice. |
2011-02-23 |
2023-08-12 |
mouse |
| Kerstin E Braunstein, Judith Eschbach, Krisztina Ròna-Vörös, Rana Soylu, Elli Mikrouli, Yves Larmet, Frédérique René, Jose-Luis Gonzalez De Aguilar, Jean-Philippe Loeffler, Hans-Peter Müller, Selina Bucher, Thomas Kaulisch, Heiko G Niessen, Julia Tillmanns, Kristina Fischer, Birgit Schwalenstöcker, Jan Kassubek, Bernd Pichler, Detlef Stiller, Asa Petersen, Albert C Ludolph, Luc Dupui. A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons. Human molecular genetics. vol 19. issue 22. 2011-02-17. PMID:20807776. |
in the striatum, altered dopamine signalling, decreased dopamine d1 and d2 receptor binding in positron emission tomography scan and prominent astrocytosis were observed, although there was no neuronal loss either in the striatum or substantia nigra. |
2011-02-17 |
2023-08-12 |
mouse |
| Yeong-Gon Choi, Sabina Li. N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model. Biochimie. vol 92. issue 10. 2011-02-16. PMID:20624443. |
results show that the immunoreactivities of the tyrosine hydroxylase and dopamine transporter significantly decreased in the striatum and the substantia nigra (sn) in the mptp model compared to the subjects in the control group. |
2011-02-16 |
2023-08-12 |
mouse |
| Antonio Bueno-Nava, Rigoberto Gonzalez-Pina, Alfonso Alfaro-Rodrigue. Iron-dextran injection into the substantia nigra in rats decreases striatal dopamine content ipsilateral to the injury site and impairs motor function. Metabolic brain disease. vol 25. issue 2. 2011-01-13. PMID:20424901. |
iron-dextran injection into the substantia nigra in rats decreases striatal dopamine content ipsilateral to the injury site and impairs motor function. |
2011-01-13 |
2023-08-12 |
rat |
| Keiko Nakamura, Kyoko Itoh, Kanji Yoshimoto, Tohru Sugimoto, Shinji Fushik. Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice. Neuroscience letters. vol 484. issue 1. 2010-12-28. PMID:20709143. |
the levels of dopamine and its metabolite significantly increased in the caudate/putamen and dorsal raphe nucleus, whereas serotonin and its metabolite increased in the caudate/putamen, dorsal raphe nucleus, thalamus and substantia nigra in the bpa-exposure group at both p3w and/or p14-15w. |
2010-12-28 |
2023-08-12 |
mouse |
| Andre Chevrier, Russell J Schacha. Error detection in the stop signal task. NeuroImage. vol 53. issue 2. 2010-12-16. PMID:20600968. |
error detection deactivated the midbrain in the vicinity of dorsal substantia nigra where dopamine neurons originate, and the primary targets of dopamine neurons: dorsal striatum and ventral anterior cingulate. |
2010-12-16 |
2023-08-12 |
human |
| Matteo Marti, Silvio Sarubbo, Francesco Latini, Michele Cavallo, Roberto Eleopra, Sara Biguzzi, Christian Lettieri, Carlo Conti, Michele Simonato, Silvia Zucchini, Rocco Quatrale, Mariachiara Sensi, Sanzio Candeletti, Patrizia Romualdi, Michele Morar. Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 11. 2010-12-10. PMID:20589874. |
in situ hybridization demonstrated that dopamine depletion was associated with increase of n/ofq expression in substantia nigra (compacta +160%, reticulata +105%) and subthalamic nucleus (+45%), as well as reduction in caudate putamen (-20%). |
2010-12-10 |
2023-08-12 |
rat |
| Brandon S Pruett, Michael F Salvator. GFR α-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20731758. |
we recently reported that age-related bradykinesia was associated with reduced dopamine (da) tissue content, ser31 tyrosine hydroxylase (th) phosphorylation, and total th levels in substantia nigra (sn) only. |
2010-12-02 |
2023-08-12 |
rat |
| Ethan S Bromberg-Martin, Masayuki Matsumoto, Simon Hong, Okihide Hikosak. A pallidus-habenula-dopamine pathway signals inferred stimulus values. Journal of neurophysiology. vol 104. issue 2. 2010-12-01. PMID:20538770. |
we then recorded from three populations of reward-coding neurons: substantia nigra dopamine neurons; a major input to dopamine neurons, the lateral habenula; and neurons that project to the lateral habenula, located in the globus pallidus. |
2010-12-01 |
2023-08-12 |
monkey |
| Li Qian, Patrick M Flood, Jau-Shyong Hon. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20571837. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2010-11-30 |
2023-08-12 |
Not clear |
| Alex Iranzo, Francisco Lomeña, Heike Stockner, Francesc Valldeoriola, Isabel Vilaseca, Manel Salamero, Jose Luis Molinuevo, Monica Serradell, Joan Duch, Javier Pavía, Judith Gallego, Klaus Seppi, Birgit Högl, Eduard Tolosa, Werner Poewe, Joan Santamari. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. The Lancet. Neurology. vol 9. issue 11. 2010-11-16. PMID:20846908. |
decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. |
2010-11-16 |
2023-08-12 |
Not clear |
| Alex Iranzo, Francisco Lomeña, Heike Stockner, Francesc Valldeoriola, Isabel Vilaseca, Manel Salamero, Jose Luis Molinuevo, Monica Serradell, Joan Duch, Javier Pavía, Judith Gallego, Klaus Seppi, Birgit Högl, Eduard Tolosa, Werner Poewe, Joan Santamari. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. The Lancet. Neurology. vol 9. issue 11. 2010-11-16. PMID:20846908. |
in patients with parkinson's disease, ¹²³i-2β-carbomethoxy-3β-(4-iodophenyl)-n-(3-fluoropropyl)-nortropane (¹²³i-fp-cit) spect detects striatal dopamine dysfunction resulting from nigral pathology whereas transcranial sonography (tcs) shows increased substantia nigra echogenic size, even before parkinsonism is clinically evident. |
2010-11-16 |
2023-08-12 |
Not clear |
| Emma Thornton, Tuyet T B Tran, Robert Vin. A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death. Neuroscience letters. vol 481. issue 1. 2010-11-08. PMID:20599590. |
dopamine induces release of the neuropeptide substance p (sp) within the substantia nigra, whereas sp is able to potentiate striatal dopamine release, thus creating a positive feedback mechanism. |
2010-11-08 |
2023-08-12 |
Not clear |
| Heli Tuppurainen, Jyrki T Kuikka, Heimo Viinamäki, Minna Husso, Jari Tiihone. Extrapyramidal side-effects and dopamine D(2/3) receptor binding in substantia nigra. Nordic journal of psychiatry. vol 64. issue 4. 2010-10-26. PMID:20629610. |
extrapyramidal side-effects and dopamine d(2/3) receptor binding in substantia nigra. |
2010-10-26 |
2023-08-12 |
Not clear |
| Chao Li, S Biswas, Xingang Li, A K Dutta, Weidong L. Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin. Journal of neuroscience research. vol 88. issue 11. 2010-10-20. PMID:20623619. |
parkinson's disease (pd), a progressive neurodegenerative movement disorder, is known to be caused by diverse pathological conditions resulting from dysfunction of the ubiquitin-proteasome system (ups), mitochondria, and oxidative stress leading to preferential nigral dopamine (da) neuron degeneration in the substantia nigra. |
2010-10-20 |
2023-08-12 |
mouse |
| Heather A O'Malley, Yanghae Park, Lori L Isom, Margaret E Gneg. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20641161. |
using immunofluorescence and confocal microscopy, we demonstrated co-localization of dat and pkcbeta in primary cultures of mesencephalic neurons and in dopamine neurons in rat substantia nigra and ventral tegmental area. |
2010-09-24 |
2023-08-12 |
rat |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
in close coordination with glutamatergic and gabaergic activity, these excitatory cholinergic projections activate nicotinic and muscarinic acetylcholine receptors within the substantia nigra and ventral tegmental area to modulate dopamine transmission in the dorsal/ventral striatum and prefrontal cortex. |
2010-09-22 |
2023-08-12 |
Not clear |
| Feng Zhang, Jing-Shan Shi, Hui Zhou, Belinda Wilson, Jau-Shyong Hong, Hui-Ming Ga. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Molecular pharmacology. vol 78. issue 3. 2010-09-21. PMID:20554604. |
parkinson's disease (pd) is the second most common neurodegenerative disease characterized by a progressive loss of dopamine (da) neurons in the substantia nigra. |
2010-09-21 |
2023-08-12 |
mouse |
| Mohamed R Ahmed, Amandine Berthet, Evgeny Bychkov, Gregory Porras, Qin Li, Bernard H Bioulac, Yonatan T Carl, Bertrand Bloch, Seunghyi Kook, Incarnation Aubert, Sandra Dovero, Evelyne Doudnikoff, Vsevolod V Gurevich, Eugenia V Gurevich, Erwan Bezar. Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Science translational medicine. vol 2. issue 28. 2010-09-20. PMID:20410529. |
parkinson's disease is caused primarily by degeneration of brain dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine in the striatum. |
2010-09-20 |
2023-08-12 |
rat |