| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Xing Sh. Electrophysiological characteristics of dopamine neurons: a 35-year update. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411771. |
the first section provides a general description of the electrophysiological characteristics of dopamine (da) neurons in both the substantia nigra and ventral tegmental area. |
2010-05-14 |
2023-08-12 |
Not clear |
| Catherine R G Jones, Marjan Jahanshah. The substantia nigra, the basal ganglia, dopamine and temporal processing. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411776. |
the substantia nigra, the basal ganglia, dopamine and temporal processing. |
2010-05-14 |
2023-08-12 |
Not clear |
| Giuseppe Di Giovann. A diet for dopaminergic neurons? Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411790. |
since the discovery of dopamine (da) neuronal cell loss within the substantia nigra in pd, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive rate. |
2010-05-14 |
2023-08-12 |
Not clear |
| Takashi Nakano, Tomokazu Doi, Junichiro Yoshimoto, Kenji Doy. A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. PLoS computational biology. vol 6. issue 2. 2010-05-10. PMID:20169176. |
corticostriatal synapse plasticity of medium spiny neurons is regulated by glutamate input from the cortex and dopamine input from the substantia nigra. |
2010-05-10 |
2023-08-12 |
Not clear |
| Xinxin Yang, Lu Song, Zhenguo Li. The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease. Neuroreport. vol 21. issue 4. 2010-05-05. PMID:20087233. |
furthermore, rtms decreased the levels of cyclooxygenase-2 and tumor necrosis factor-alpha in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with parkinson's disease. |
2010-05-05 |
2023-08-12 |
rat |
| Li Rebekah Feng, Kathleen A Maguire-Zeis. Gene therapy in Parkinson's disease: rationale and current status. CNS drugs. vol 24. issue 3. 2010-05-04. PMID:20155994. |
consequently, as the number of substantia nigra dopamine neurons and striatal projections decrease, these treatments become less efficacious. |
2010-05-04 |
2023-08-12 |
Not clear |
| A V Droblenkov, N P Karelina, P D Shabano. [Diagnostics of alcoholic intoxication from micromorphological changes in neurons and neuroglia of the mesoaccumbocingular dopaminergic system in experiment]. Sudebno-meditsinskaia ekspertiza. vol 52. issue 6. 2010-05-03. PMID:20088135. |
alcohol affects the mesoaccumbocingular system (ventral tegumental region, substantia nigra--nucleus accumbence--anterior cingular cortex) and other parts of the mesocorticolimbic dopaminergic system by altering patterns of dopamine release. |
2010-05-03 |
2023-08-12 |
Not clear |
| Hanna S Lindgren, Daniel R Andersson, Sören Lagerkvist, Hans Nissbrandt, M Angela Cenc. L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20050978. |
l-dopa-induced dopamine efflux in the striatum and the substantia nigra in a rat model of parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. |
2010-04-30 |
2023-08-12 |
rat |
| Fleur L Warton, Fleur M Howells, Vivienne A Russel. Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. Metabolic brain disease. vol 24. issue 4. 2010-04-29. PMID:19821016. |
increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. |
2010-04-29 |
2023-08-12 |
rat |
| Maryka Quik, Carla Campos, Neeraja Parameswaran, J William Langston, J Michael McIntosh, Michael Yeluashvil. Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19685015. |
nicotine treatment did not affect the dopamine transporter or the number of tyrosine hydroxylase positive cells in the substantia nigra of lesioned monkeys. |
2010-04-21 |
2023-08-12 |
monkey |
| Michael Rosemann, Alesia Ivashkevich, Jack Favor, Claudia Dalke, Sabine M Hölter, Lore Becker, Ildikó Rácz, Ines Bolle, Martina Klempt, Birgit Rathkolb, Svetoslav Kalaydjiev, Thure Adler, Antonio Aguilar, Wolfgang Hans, Marion Horsch, Jan Rozman, Julia Calzada-Wack, Sandra Kunder, Beatrix Naton, Valerie Gailus-Durner, Helmut Fuchs, Holger Schulz, Johannes Beckers, Dirk H Busch, J Peter H Burbach, Marten P Smidt, Leticia Quintanilla-Martinez, Irene Esposito, Thomas Klopstock, Martin Klingenspor, Markus Ollert, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Martin Hrabé de Angelis, Michael Atkinson, Ulrich Heinzmann, Jochen Gra. Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mammalian genome : official journal of the International Mammalian Genome Society. vol 21. issue 1-2. 2010-04-15. PMID:20033184. |
the novel pitx3 ( eyl/eyl ) mutants expressed ophthalmological and brain defects similar to pitx3 ( ak/ak ) mice: microphthalmia or anophthalmia and loss of dopamine neurons of the substantia nigra. |
2010-04-15 |
2023-08-12 |
mouse |
| Fei Xu, Jian-hong Luo, Jing-hua Ji. [Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 37. issue 5. 2010-04-02. PMID:18925724. |
parkinson's disease (pd) is characterized pathologically by the relatively preferential loss of dopaminergic neurons with resultant depletion of striatal dopamine and presence of lewy bodies mainly composed by alpha-synuclein (alpha-syn) in the remaining neurons in the substantia nigra. |
2010-04-02 |
2023-08-12 |
Not clear |
| Mats I Ekstrand, Dagmar Galte. The MitoPark Mouse - an animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082987. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by selective and progressive degeneration of dopamine neurons in the substantia nigra. |
2010-03-31 |
2023-08-12 |
mouse |
| Yasuomi Ouchi, Shunsuke Yagi, Masamichi Yokokura, Masanobu Sakamot. Neuroinflammation in the living brain of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082990. |
evidence shows that neuronal injury accompanies neuroinflammatory reactions in the brain, and well as in parkinson's disease (pd) animal models, in which the loss of dopamine neurons is associated with the activation of microglia in the substantia nigra. |
2010-03-31 |
2023-08-12 |
Not clear |
| M S Oh, S J Hong, Y Huh, K-S Ki. Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter. Gene therapy. vol 16. issue 3. 2010-03-26. PMID:18800154. |
the midbrain dopamine (da) neuron system consists of the retrorubral area (a8), the substantia nigra (sn; a9) and the ventral tegmental area (vta; a10). |
2010-03-26 |
2023-08-12 |
rat |
| Yaping Chu, Jeffrey H Kordowe. Lewy body pathology in fetal grafts. Annals of the New York Academy of Sciences. vol 1184. 2010-03-25. PMID:20146690. |
these pathological changes suggest that pd is an ongoing process that affects grafted cells in the striatum in a manner similar to how resident dopamine neurons are affected in the substantia nigra. |
2010-03-25 |
2023-08-12 |
Not clear |
| Shane Grealish, Marie E Jönsson, Meng Li, Deniz Kirik, Anders Björklund, Lachlan H Thompso. The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 2. 2010-03-16. PMID:20123725. |
grafts of foetal ventral mesencephalon, used in cell replacement therapy for parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the a9 neurons of the substantia nigra and the a10 neurons of the ventral tegmental area. |
2010-03-16 |
2023-08-12 |
rat |
| Kim A Caldwell, Michelle L Tucci, Jafa Armagost, Tyler W Hodges, Jue Chen, Shermeen B Memon, Jeana E Blalock, Susan M DeLeon, Robert H Findlay, Qingmin Ruan, Philip J Webber, David G Standaert, Julie B Olson, Guy A Caldwel. Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration. PloS one. vol 4. issue 10. 2010-03-12. PMID:19806188. |
parkinson disease (pd) involves progressive neurodegeneration, including loss of dopamine (da) neurons from the substantia nigra. |
2010-03-12 |
2023-08-12 |
human |
| Ke-Zhong Shen, Steven W Johnso. Ca2+ influx through NMDA-gated channels activates ATP-sensitive K+ currents through a nitric oxide-cGMP pathway in subthalamic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 5. 2010-03-05. PMID:20130197. |
using whole-cell recording techniques in rat brain slices, we report that inward currents evoked by nmda are greatly potentiated by atp-sensitive k(+) (k-atp) channel blocking agents in stn neurons but not in dopamine neurons in the substantia nigra. |
2010-03-05 |
2023-08-12 |
rat |
| Ciro Isidoro, Francesca Biagioni, Filippo Sean Giorgi, Federica Fulceri, Antonio Paparelli, Francesco Forna. The role of autophagy on the survival of dopamine neurons. Current topics in medicinal chemistry. vol 9. issue 10. 2010-03-04. PMID:19754403. |
this evidence is supported by neuropathological data showing at the ultrastructural level, the occurrence of an altered atg in the dopamine (da) neurons of the substantia nigra of patients affected by pd. |
2010-03-04 |
2023-08-12 |
Not clear |