| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia Navailles, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's disease. Neurobiology of disease. vol 38. issue 1. 2010-06-22. PMID:20096781. |
by using microdialysis in a rat model of parkinson's disease, we found that l-dopa (3-100 mg/kg) increased dopamine extracellular levels monitored simultaneously in four brain regions receiving serotonergic innervation: striatum, substantia nigra, hippocampus, prefrontal cortex. |
2010-06-22 |
2023-08-12 |
rat |
| Xiangming Wang, Xiaoyan Wang, Huili Gao, Danqiao Wan. [Study of molecular mechanism of anti-Parkinson's disease traditional Chinese medicine using model of Caenorhabditis elegans]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 35. issue 5. 2010-06-17. PMID:20506834. |
the brains of patients affected with pd are characterized by a loss of neurons in dopamine neurons in the substantia nigra, decreasing of dopamine secretion, and the deposition of lewy bodies (lbs) in the cytoplasm of remaining neurons. |
2010-06-17 |
2023-08-12 |
caenorhabditis_elegans |
| Mark R Cookso. DJ-1, PINK1, and their effects on mitochondrial pathways. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187230. |
second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. |
2010-06-14 |
2023-08-12 |
Not clear |
| C Savio Chan, Tracy S Gertler, D James Surmeie. A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187241. |
a molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and parkinson's disease. |
2010-06-14 |
2023-08-12 |
Not clear |
| Feng Zhang, Li Qian, Patrick M Flood, Jing-Shan Shi, Jau-Shyong Hong, Hui-Ming Ga. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 333. issue 3. 2010-06-11. PMID:20190013. |
parkinson's disease (pd) is a progressive neurological disorder characterized by a selective loss of dopamine (da) neurons in the substantia nigra (sn). |
2010-06-11 |
2023-08-12 |
Not clear |
| N N Inamdar, D K Arulmozhi, A Tandon, S L Bodhanka. Parkinson's disease: genetics and beyond. Current neuropharmacology. vol 5. issue 2. 2010-06-10. PMID:18615181. |
parkinson's disease (pd) is characterized clinically by resting tremor, rigidity, bradykinesia and postural instability due to progressive and selective loss of dopamine neurons in the ventral substantia nigra, with the presence of ubiquitinated protein deposits called lewy bodies in the neurons. |
2010-06-10 |
2023-08-12 |
Not clear |
| Nobuyuki Katagiri, Satomi Chida, Kenji Abe, Hiroshi Nojima, Michikazu Kitabatake, Keiko Hoshi, Yoshie Horiguchi, Kyoji Taguch. Preventative effects of 1,3-dimethyl- and 1,3-dimethyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on MPTP-induced Parkinson's disease-like symptoms in mice. Brain research. vol 1321. 2010-06-09. PMID:20114039. |
pretreatment with 1,3-dimetiq did not prevent the mptp-induced decrease in dopamine content in the striatum or the decrease in the number of tyrosine hydroxylase-positive cells in the substantia nigra. |
2010-06-09 |
2023-08-12 |
mouse |
| R Orme, R A Fricker-Gates, M A Gate. Ontogeny of substantia nigra dopamine neurons. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411764. |
ontogeny of substantia nigra dopamine neurons. |
2010-05-14 |
2023-08-12 |
Not clear |
| Wei-Xing Sh. Electrophysiological characteristics of dopamine neurons: a 35-year update. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411771. |
the first section provides a general description of the electrophysiological characteristics of dopamine (da) neurons in both the substantia nigra and ventral tegmental area. |
2010-05-14 |
2023-08-12 |
Not clear |
| Catherine R G Jones, Marjan Jahanshah. The substantia nigra, the basal ganglia, dopamine and temporal processing. Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411776. |
the substantia nigra, the basal ganglia, dopamine and temporal processing. |
2010-05-14 |
2023-08-12 |
Not clear |
| Giuseppe Di Giovann. A diet for dopaminergic neurons? Journal of neural transmission. Supplementum. issue 73. 2010-05-14. PMID:20411790. |
since the discovery of dopamine (da) neuronal cell loss within the substantia nigra in pd, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive rate. |
2010-05-14 |
2023-08-12 |
Not clear |
| Takashi Nakano, Tomokazu Doi, Junichiro Yoshimoto, Kenji Doy. A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. PLoS computational biology. vol 6. issue 2. 2010-05-10. PMID:20169176. |
corticostriatal synapse plasticity of medium spiny neurons is regulated by glutamate input from the cortex and dopamine input from the substantia nigra. |
2010-05-10 |
2023-08-12 |
Not clear |
| Xinxin Yang, Lu Song, Zhenguo Li. The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease. Neuroreport. vol 21. issue 4. 2010-05-05. PMID:20087233. |
furthermore, rtms decreased the levels of cyclooxygenase-2 and tumor necrosis factor-alpha in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with parkinson's disease. |
2010-05-05 |
2023-08-12 |
rat |
| Li Rebekah Feng, Kathleen A Maguire-Zeis. Gene therapy in Parkinson's disease: rationale and current status. CNS drugs. vol 24. issue 3. 2010-05-04. PMID:20155994. |
consequently, as the number of substantia nigra dopamine neurons and striatal projections decrease, these treatments become less efficacious. |
2010-05-04 |
2023-08-12 |
Not clear |
| A V Droblenkov, N P Karelina, P D Shabano. [Diagnostics of alcoholic intoxication from micromorphological changes in neurons and neuroglia of the mesoaccumbocingular dopaminergic system in experiment]. Sudebno-meditsinskaia ekspertiza. vol 52. issue 6. 2010-05-03. PMID:20088135. |
alcohol affects the mesoaccumbocingular system (ventral tegumental region, substantia nigra--nucleus accumbence--anterior cingular cortex) and other parts of the mesocorticolimbic dopaminergic system by altering patterns of dopamine release. |
2010-05-03 |
2023-08-12 |
Not clear |
| Hanna S Lindgren, Daniel R Andersson, Sören Lagerkvist, Hans Nissbrandt, M Angela Cenc. L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20050978. |
l-dopa-induced dopamine efflux in the striatum and the substantia nigra in a rat model of parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. |
2010-04-30 |
2023-08-12 |
rat |
| Fleur L Warton, Fleur M Howells, Vivienne A Russel. Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. Metabolic brain disease. vol 24. issue 4. 2010-04-29. PMID:19821016. |
increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. |
2010-04-29 |
2023-08-12 |
rat |
| Maryka Quik, Carla Campos, Neeraja Parameswaran, J William Langston, J Michael McIntosh, Michael Yeluashvil. Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19685015. |
nicotine treatment did not affect the dopamine transporter or the number of tyrosine hydroxylase positive cells in the substantia nigra of lesioned monkeys. |
2010-04-21 |
2023-08-12 |
monkey |
| Michael Rosemann, Alesia Ivashkevich, Jack Favor, Claudia Dalke, Sabine M Hölter, Lore Becker, Ildikó Rácz, Ines Bolle, Martina Klempt, Birgit Rathkolb, Svetoslav Kalaydjiev, Thure Adler, Antonio Aguilar, Wolfgang Hans, Marion Horsch, Jan Rozman, Julia Calzada-Wack, Sandra Kunder, Beatrix Naton, Valerie Gailus-Durner, Helmut Fuchs, Holger Schulz, Johannes Beckers, Dirk H Busch, J Peter H Burbach, Marten P Smidt, Leticia Quintanilla-Martinez, Irene Esposito, Thomas Klopstock, Martin Klingenspor, Markus Ollert, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Martin Hrabé de Angelis, Michael Atkinson, Ulrich Heinzmann, Jochen Gra. Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mammalian genome : official journal of the International Mammalian Genome Society. vol 21. issue 1-2. 2010-04-15. PMID:20033184. |
the novel pitx3 ( eyl/eyl ) mutants expressed ophthalmological and brain defects similar to pitx3 ( ak/ak ) mice: microphthalmia or anophthalmia and loss of dopamine neurons of the substantia nigra. |
2010-04-15 |
2023-08-12 |
mouse |
| Fei Xu, Jian-hong Luo, Jing-hua Ji. [Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 37. issue 5. 2010-04-02. PMID:18925724. |
parkinson's disease (pd) is characterized pathologically by the relatively preferential loss of dopaminergic neurons with resultant depletion of striatal dopamine and presence of lewy bodies mainly composed by alpha-synuclein (alpha-syn) in the remaining neurons in the substantia nigra. |
2010-04-02 |
2023-08-12 |
Not clear |