| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Torsten Falk, Shiling Zhang, Scott J Sherma. Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease. Molecular neurodegeneration. vol 4. 2011-07-14. PMID:20003314. |
parkinson's disease (pd) results from the degeneration of dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine released in the striatum. |
2011-07-14 |
2023-08-12 |
rat |
| Markos Poulopoulos, Cheryl Water. Carbidopa/levodopa/entacapone: the evidence for its place in the treatment of Parkinson's disease. Core evidence. vol 5. 2011-07-14. PMID:20694135. |
in the 1960s, it was shown that the degeneration of dopamine producing neurons in the substantia nigra (sn) caused the motor features of pd. |
2011-07-14 |
2023-08-12 |
Not clear |
| Frederick P Bellinger, Miyoko T Bellinger, Lucia A Seale, Andrea S Takemoto, Arjun V Raman, Takanori Miki, Amy B Manning-Boğ, Marla J Berry, Lon R White, G Webster Ros. Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21255396. |
parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia nigra in the midbrain to the putamen and caudate nuclei, leading to the clinical features of bradykinesia, rigidity, and rest tremor. |
2011-07-14 |
2023-08-12 |
Not clear |
| Tahira Farooqui, Akhlaq A Farooqu. Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. Parkinson's disease. vol 2011. 2011-07-14. PMID:21403820. |
pd is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, depletion of dopamine in the striatum, abnormal mitochondrial and proteasomal functions, and accumulation of α-synuclein that may be closely associated with pathological and clinical abnormalities. |
2011-07-14 |
2023-08-12 |
Not clear |
| Penny A Macdonald, Oury Monch. Differential effects of dopaminergic therapies on dorsal and ventral striatum in Parkinson's disease: implications for cognitive function. Parkinson's disease. vol 2011. 2011-07-14. PMID:21437185. |
whereas dorsal striatum receives dopamine input from the substantia nigra (sn), ventral striatum is innervated by dopamine-producing cells in the ventral tegmental area (vta). |
2011-07-14 |
2023-08-12 |
Not clear |
| Dawn Béraud, Margaret Twomey, Benjamin Bloom, Andrew Mittereder, Vy Ton, Katherine Neitzke, Sergey Chasovskikh, Timothy R Mhyre, Kathleen A Maguire-Zeis. α-Synuclein Alters Toll-Like Receptor Expression. Frontiers in neuroscience. vol 5. 2011-07-14. PMID:21747756. |
parkinson's disease, an age-related neurodegenerative disorder, is characterized by the loss of dopamine neurons in the substantia nigra, the accumulation of α-synuclein in lewy bodies and neurites, and neuroinflammation. |
2011-07-14 |
2023-08-12 |
mouse |
| W Michael Panneton, V B Kumar, Qi Gan, William J Burke, James E Galvi. The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. PloS one. vol 5. issue 12. 2011-07-05. PMID:21179455. |
we examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (dopal), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior and neuronal survival. |
2011-07-05 |
2023-08-12 |
rat |
| James B Koprich, Tom H Johnston, Philippe Huot, M Gabriela Reyes, Maria Espinosa, Jonathan M Brotchi. Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein. PloS one. vol 6. issue 3. 2011-07-05. PMID:21408191. |
the pathological hallmarks of parkinson's disease (pd) are degeneration of dopamine (da) neurons of the substantia nigra (sn) and the presence of alpha-synuclein (α-syn)-rich lewy bodies in da cells that remain. |
2011-07-05 |
2023-08-12 |
rat |
| Z-W Zhou, Y Shu, M Li, X Guo, C Pac-Soo, M Maze, D M. The glutaminergic, GABAergic, dopaminergic but not cholinergic neurons are susceptible to anaesthesia-induced cell death in the rat developing brain. Neuroscience. vol 174. 2011-06-21. PMID:21056635. |
the brains were sectioned and the slices that contained the basal forebrain, substantia nigra, cornu ammonis area 1 (ca1) subarea of hippocampus or cingulate cortex were selected and subsequently subjected to double-labelled fluorescent immunohistochemistry for choline acetyltransferase, dopamine, vesicular glutamate transporter 1 (vglut1) or glutamic acid decarboxylase 67 (gad67) together with caspase 3, respectively. |
2011-06-21 |
2023-08-12 |
rat |
| Judith Joyce Balcita-Pedicino, Natalia Omelchenko, Roland Bell, Susan R Sesac. The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus. The Journal of comparative neurology. vol 519. issue 6. 2011-05-31. PMID:21344406. |
the lateral habenula (lhb) provides an important source of negative reinforcement signals to midbrain dopamine (da) cells in the substantia nigra and ventral tegmental area (vta). |
2011-05-31 |
2023-08-12 |
rat |
| Iu F Pastukhov, A Iu Chesnokova, A A Iakimchuk, I V Ekimova, I V Romanova, K A Khudi. [Sleep changes during degeneration of neurons in the substantia nigra induced by inhibitor of proteasomes lactacystin in rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 96. issue 12. 2011-05-31. PMID:21473106. |
a decrease in activity of ubiquitin proteasome system results in accumulation of toxic forms of protein and cell degeneration, including dopamine (da)-ergic neurons in the substantia nigra; these neurons are remarkable for their low proteolytic activity of proteosomes that makes them more vulnerable, especially when subjected to the neurotoxin action or parkinson's disease (pd). |
2011-05-31 |
2023-08-12 |
rat |
| Adarsh M Kumar, Raymond L Ownby, Drenna Waldrop-Valverde, Benny Fernandez, Mahendra Kuma. Human immunodeficiency virus infection in the CNS and decreased dopamine availability: relationship with neuropsychological performance. Journal of neurovirology. vol 17. issue 1. 2011-05-12. PMID:21165787. |
the purpose of the present study was to investigate the relationship between the decreased availability of dopamine found in the postmortem brain regions (fronto-cortical regions, basal ganglia, caudate, putamen, globus pallidus, and substantia nigra) of individuals with hiv/aids and the antemortem level of performance (assessed as t scores) in different np functions. |
2011-05-12 |
2023-08-12 |
human |
| Matthew W Bishop, Subhojit Chakraborty, Gillian A C Matthews, Antonios Dougalis, Nicholas W Wood, Richard Festenstein, Mark A Ungles. Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. Journal of neurophysiology. vol 104. issue 6. 2011-05-09. PMID:20926611. |
hyperexcitable substantia nigra dopamine neurons in pink1- and htra2/omi-deficient mice. |
2011-05-09 |
2023-08-12 |
mouse |
| V G Khaindrava, E A Kozina, V G Kucherianu, G N Kryzhanovskiĭ, V S Kudrin, P D Klodt, E V Bocharov, K S Raevskiĭ, M V Ugriumo. [Modeling of preclinical and early clinical stages of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 110. issue 7. 2011-05-02. PMID:20639856. |
in the substantia nigra, the region of dopamine neuron localization, the content of dopamine did not change though the total number of neurons decreased by 28%. |
2011-05-02 |
2023-08-12 |
mouse |
| V G Khaindrava, E A Kozina, V G Kucherianu, G N Kryzhanovskiĭ, V S Kudrin, P D Klodt, E V Bocharov, K S Raevskiĭ, M V Ugriumo. [Modeling of preclinical and early clinical stages of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 110. issue 7. 2011-05-02. PMID:20639856. |
in the substantia nigra, there were no changes in dopamine content but the number of dopaminergic neurons decreased by 43%. |
2011-05-02 |
2023-08-12 |
mouse |
| Lingyun Li, Xiaoxia Wang, Xifeng Fei, Liping Xia, Zhenghong Qin, Zhongqin Lian. Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neuroscience letters. vol 489. issue 1. 2011-05-02. PMID:21134415. |
in this study, we examined postmortem parkinson's disease (pd) substantia nigra for evidence of cathepsin l by immunofluorescent staining, and found increased expression of cathepsin l in dopamine neurons of pd patients. |
2011-05-02 |
2023-08-12 |
rat |
| Jean Pierre Oses, Cristiane Batassini, Daniela Pochmann, Ana Elisa Böhmer, Fernanda Cenci Vuaden, Roberta Bristot Silvestrin, Alcyr Oliveira, Carla Denise Bonan, Maurício Reis Bogo, Diogo Onofre Souza, Luis Valmor Cruz Portela, João José de Freitas Sarkis, Tadeu Mello e Souz. The hydrolysis of striatal adenine- and guanine-based purines in a 6-hydroxydopamine rat model of Parkinson's disease. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:21046237. |
parkinson's disease (pd) is characterized by a progressive neurodegeneration in the substantia nigra and a striatal dopamine decrease. |
2011-04-29 |
2023-08-12 |
rat |
| Joo-Ho Shin, Han Seok Ko, Hochul Kang, Yunjong Lee, Yun-Il Lee, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawso. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell. vol 144. issue 5. 2011-04-20. PMID:21376232. |
a hallmark of parkinson's disease (pd) is the preferential loss of substantia nigra dopamine neurons. |
2011-04-20 |
2023-08-12 |
human |
| Andrea Carmine Belin, Marie Westerlund, Anna Anvret, Eva Lindqvist, Karin Pernold, Sven Ove Ogren, Gregg Duester, Dagmar Galte. Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice. Behavioural brain research. vol 217. issue 2. 2011-04-18. PMID:21075145. |
we measured levels of monoamines and their metabolites in striatum, frontal cortex and substantia nigra and found increased levels of dopamine and dopac in substantia nigra of adh4-/- mice. |
2011-04-18 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |