| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z-W Zhou, Y Shu, M Li, X Guo, C Pac-Soo, M Maze, D M. The glutaminergic, GABAergic, dopaminergic but not cholinergic neurons are susceptible to anaesthesia-induced cell death in the rat developing brain. Neuroscience. vol 174. 2011-06-21. PMID:21056635. |
the brains were sectioned and the slices that contained the basal forebrain, substantia nigra, cornu ammonis area 1 (ca1) subarea of hippocampus or cingulate cortex were selected and subsequently subjected to double-labelled fluorescent immunohistochemistry for choline acetyltransferase, dopamine, vesicular glutamate transporter 1 (vglut1) or glutamic acid decarboxylase 67 (gad67) together with caspase 3, respectively. |
2011-06-21 |
2023-08-12 |
rat |
| Judith Joyce Balcita-Pedicino, Natalia Omelchenko, Roland Bell, Susan R Sesac. The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus. The Journal of comparative neurology. vol 519. issue 6. 2011-05-31. PMID:21344406. |
the lateral habenula (lhb) provides an important source of negative reinforcement signals to midbrain dopamine (da) cells in the substantia nigra and ventral tegmental area (vta). |
2011-05-31 |
2023-08-12 |
rat |
| Iu F Pastukhov, A Iu Chesnokova, A A Iakimchuk, I V Ekimova, I V Romanova, K A Khudi. [Sleep changes during degeneration of neurons in the substantia nigra induced by inhibitor of proteasomes lactacystin in rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 96. issue 12. 2011-05-31. PMID:21473106. |
a decrease in activity of ubiquitin proteasome system results in accumulation of toxic forms of protein and cell degeneration, including dopamine (da)-ergic neurons in the substantia nigra; these neurons are remarkable for their low proteolytic activity of proteosomes that makes them more vulnerable, especially when subjected to the neurotoxin action or parkinson's disease (pd). |
2011-05-31 |
2023-08-12 |
rat |
| Adarsh M Kumar, Raymond L Ownby, Drenna Waldrop-Valverde, Benny Fernandez, Mahendra Kuma. Human immunodeficiency virus infection in the CNS and decreased dopamine availability: relationship with neuropsychological performance. Journal of neurovirology. vol 17. issue 1. 2011-05-12. PMID:21165787. |
the purpose of the present study was to investigate the relationship between the decreased availability of dopamine found in the postmortem brain regions (fronto-cortical regions, basal ganglia, caudate, putamen, globus pallidus, and substantia nigra) of individuals with hiv/aids and the antemortem level of performance (assessed as t scores) in different np functions. |
2011-05-12 |
2023-08-12 |
human |
| Matthew W Bishop, Subhojit Chakraborty, Gillian A C Matthews, Antonios Dougalis, Nicholas W Wood, Richard Festenstein, Mark A Ungles. Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. Journal of neurophysiology. vol 104. issue 6. 2011-05-09. PMID:20926611. |
hyperexcitable substantia nigra dopamine neurons in pink1- and htra2/omi-deficient mice. |
2011-05-09 |
2023-08-12 |
mouse |
| V G Khaindrava, E A Kozina, V G Kucherianu, G N Kryzhanovskiĭ, V S Kudrin, P D Klodt, E V Bocharov, K S Raevskiĭ, M V Ugriumo. [Modeling of preclinical and early clinical stages of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 110. issue 7. 2011-05-02. PMID:20639856. |
in the substantia nigra, the region of dopamine neuron localization, the content of dopamine did not change though the total number of neurons decreased by 28%. |
2011-05-02 |
2023-08-12 |
mouse |
| V G Khaindrava, E A Kozina, V G Kucherianu, G N Kryzhanovskiĭ, V S Kudrin, P D Klodt, E V Bocharov, K S Raevskiĭ, M V Ugriumo. [Modeling of preclinical and early clinical stages of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 110. issue 7. 2011-05-02. PMID:20639856. |
in the substantia nigra, there were no changes in dopamine content but the number of dopaminergic neurons decreased by 43%. |
2011-05-02 |
2023-08-12 |
mouse |
| Lingyun Li, Xiaoxia Wang, Xifeng Fei, Liping Xia, Zhenghong Qin, Zhongqin Lian. Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neuroscience letters. vol 489. issue 1. 2011-05-02. PMID:21134415. |
in this study, we examined postmortem parkinson's disease (pd) substantia nigra for evidence of cathepsin l by immunofluorescent staining, and found increased expression of cathepsin l in dopamine neurons of pd patients. |
2011-05-02 |
2023-08-12 |
rat |
| Jean Pierre Oses, Cristiane Batassini, Daniela Pochmann, Ana Elisa Böhmer, Fernanda Cenci Vuaden, Roberta Bristot Silvestrin, Alcyr Oliveira, Carla Denise Bonan, Maurício Reis Bogo, Diogo Onofre Souza, Luis Valmor Cruz Portela, João José de Freitas Sarkis, Tadeu Mello e Souz. The hydrolysis of striatal adenine- and guanine-based purines in a 6-hydroxydopamine rat model of Parkinson's disease. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:21046237. |
parkinson's disease (pd) is characterized by a progressive neurodegeneration in the substantia nigra and a striatal dopamine decrease. |
2011-04-29 |
2023-08-12 |
rat |
| Joo-Ho Shin, Han Seok Ko, Hochul Kang, Yunjong Lee, Yun-Il Lee, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawso. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell. vol 144. issue 5. 2011-04-20. PMID:21376232. |
a hallmark of parkinson's disease (pd) is the preferential loss of substantia nigra dopamine neurons. |
2011-04-20 |
2023-08-12 |
human |
| Andrea Carmine Belin, Marie Westerlund, Anna Anvret, Eva Lindqvist, Karin Pernold, Sven Ove Ogren, Gregg Duester, Dagmar Galte. Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice. Behavioural brain research. vol 217. issue 2. 2011-04-18. PMID:21075145. |
we measured levels of monoamines and their metabolites in striatum, frontal cortex and substantia nigra and found increased levels of dopamine and dopac in substantia nigra of adh4-/- mice. |
2011-04-18 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |
| Ricardo Pellón, Ana Ruíz, Margarita Moreno, Francisco Claro, Emilio Ambrosio, Pilar Flore. Individual differences in schedule-induced polydipsia: neuroanatomical dopamine divergences. Behavioural brain research. vol 217. issue 1. 2011-04-01. PMID:20974181. |
ld and hd rats showed opposite patterns of binding in dopamine d1 and d2 receptors in the nucleus accumbens, medial prefrontal cortex, amygdala, ventral tegmental area and substantia nigra. |
2011-04-01 |
2023-08-12 |
rat |
| Nao Chuhma, Kenji F Tanaka, René Hen, Stephen Raypor. Functional connectome of the striatal medium spiny neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 4. 2011-03-30. PMID:21273403. |
in the substantia nigra, medium spiny neurons connected strongly with gaba, but not with dopamine neurons. |
2011-03-30 |
2023-08-12 |
mouse |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. |
2011-03-22 |
2023-08-12 |
mouse |
| G R Khakimova, E A Kozina, A Ya Sapronova, M V Ugryumo. Dopamine uptake in the substantia nigra and striatum in the presymptomatic and early symptomatic stages in parkinsonian mice. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. vol 435. 2011-03-17. PMID:21221887. |
dopamine uptake in the substantia nigra and striatum in the presymptomatic and early symptomatic stages in parkinsonian mice. |
2011-03-17 |
2023-08-12 |
mouse |
| S Cechova, A M Elsobky, B J Vento. A1 receptors self-regulate adenosine release in the striatum: evidence of autoreceptor characteristics. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20933584. |
short electrical stimulation trains delivered to the substantia nigra (60 pulses, 60 hz) were used to evoke dopamine and adenosine release in the striatum. |
2011-03-10 |
2023-08-12 |
Not clear |
| Hasna Erazi, Samir Ahboucha, Halima Gamran. Chronic exposure to aluminum reduces tyrosine hydroxylase expression in the substantia nigra and locomotor performance in rats. Neuroscience letters. vol 487. issue 1. 2011-03-09. PMID:20884324. |
the present study was designed to evaluate by means of immunohistochemistry using antibodies against tyrosine hydroxylase (th; the rate-limiting enzyme of dopamine synthesis) the effects of chronic al exposure (0, 3%) in drinking water during 4 months in adulthood or since intra-uterine age in the substantia nigra. |
2011-03-09 |
2023-08-12 |
rat |
| S Gouty, J M Brown, J Rosenberger, B M Co. MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20417255. |
we have evaluated the temporal relationship of dopamine cell loss to increased ppn/ofq mrna expression in the substantia nigra after mptp treatment, and characterized the cellular locations in which increased ppn/ofq mrna expression was observed after mptp treatment. |
2011-03-04 |
2023-08-12 |
mouse |
| S Gouty, J M Brown, J Rosenberger, B M Co. MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20417255. |
this period coincided with the timing of the loss of dopamine neurons from the pars compacta of substantia nigra (snc) after mptp. |
2011-03-04 |
2023-08-12 |
mouse |