| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshihisa Kitamura, Shotaro Watanabe, Masanobu Taguchi, Kentaro Takagi, Takuya Kawata, Kazuko Takahashi-Niki, Hiroyuki Yasui, Hiroshi Maita, Sanae Mm Iguchi-Ariga, Hiroyoshi Arig. Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats. Molecular neurodegeneration. vol 6. issue 1. 2011-11-10. PMID:21740546. |
pd is caused by decreased dopamine levels in the substantia nigra and striatum, and cerebral ischemia occurs as a result of local reduction or arrest of blood supply. |
2011-11-10 |
2023-08-12 |
rat |
| Wei Zhang, Kester Phillips, Albert R Wielgus, Jie Liu, Alberto Albertini, Fabio A Zucca, Rudolph Faust, Steven Y Qian, David S Miller, Colin F Chignell, Belinda Wilson, Vernice Jackson-Lewis, Serge Przedborski, Danielle Joset, John Loike, Jau-Shyong Hong, David Sulzer, Luigi Zecc. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:19957214. |
in parkinson's disease (pd), there is a progressive loss of neuromelanin (nm)-containing dopamine neurons in substantia nigra (sn) which is associated with microgliosis and presence of extracellular nm. |
2011-11-08 |
2023-08-12 |
mouse |
| Martyna Songin, Joanna B Strosznajder, Magdalena Fitał, Katarzyna Kuter, Wacław Kolasiewicz, Przemysław Nowak, Krystyna Ossowsk. Glycogen synthase kinase 3β and its phosphorylated form (Y216) in the paraquat-induced model of parkinsonism. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:20143200. |
parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. |
2011-11-08 |
2023-08-12 |
rat |
| Victoria S Dalton, Katerina Zavitsano. Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. Journal of chemical neuroanatomy. vol 40. issue 4. 2011-11-07. PMID:20673846. |
dopamine d1 receptor (d1r) or d2 receptor (d2r) density was measured in the medial and lateral (cpul) caudate putamen, nucleus accumbens, olfactory tubercle (tu) and substantia nigra (d1r only) using in vitro autoradiography. |
2011-11-07 |
2023-08-12 |
rat |
| Jacqueline A Gleave, Troy H Farncombe, Chantal Saab, Laurie C Doerin. Correlative single photon emission computed tomography imaging of [123I]altropane binding in the rat model of Parkinson's. Nuclear medicine and biology. vol 38. issue 5. 2011-10-31. PMID:21718949. |
we sought to assess if the right to left [(123)i]altropane striatal ratios correlated with dopamine content in the striatum and substantia nigra and with behavioural outcomes. |
2011-10-31 |
2023-08-12 |
rat |
| Stephanie C Gantz, Christopher P Ford, Kim A Neve, John T William. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880923. |
loss of mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. |
2011-10-21 |
2023-08-12 |
mouse |
| Stephanie C Gantz, Christopher P Ford, Kim A Neve, John T William. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880923. |
this study examined age-dependent changes in dopamine neurons of the substantia nigra (sn) from wild-type, presymptomatic, and symptomatic mecp2(+/-) mice. |
2011-10-21 |
2023-08-12 |
mouse |
| Thi-Lien Nguyen, Yu-Hua Tian, In-Jee You, Seok-Yong Lee, Choon-Gon Jan. Modafinil-induced conditioned place preference via dopaminergic system in mice. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21157933. |
in addition, there were widespread changes in receptor binding in the brains of modafinil-treated mice; dopamine d₁ binding was increased in the caudate putamen, the accumbens, and the substantia nigra, while dopamine d₂ binding was decreased in the caudate putamen and the accumbens. |
2011-10-18 |
2023-08-12 |
mouse |
| Taco R Werkman, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218451. |
in vitro midbrain slice preparations of both species were used to record (extracellularly) the firing rates of dopamine neurons located in the substantia nigra (sn) and ventral tegmental area (vta). |
2011-10-18 |
2023-08-12 |
rat |
| Ewa Bromek, Anna Haduch, Krystyna Gołembiowska, Władysława A Danie. Cytochrome P450 mediates dopamine formation in the brain in vivo. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21651557. |
in model a, quinine (a cyp2d inhibitor) given intraperitoneally caused a significant decrease in dopamine level in the striatum and nucleus accumbens and tended to fall in the substantia nigra and frontal cortex. |
2011-10-14 |
2023-08-12 |
rat |
| Aditiben Patel, Giuseppe V Toia, Kalea Colletta, Brinda Desai Bradaric, Paul M Carvey, Bill Hende. An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity. Experimental neurology. vol 231. issue 1. 2011-10-13. PMID:21703263. |
we previously demonstrated that several dopamine (da) neurotoxins produced punctate areas of fitc-labeled albumin (fitc-la) leakage in the substantia nigra and striatum suggesting blood brain barrier (bbb) dysfunction. |
2011-10-13 |
2023-08-12 |
mouse |
| Mickael Decressac, Ayse Ulusoy, Bengt Mattsson, Biljana Georgievska, Marina Romero-Ramos, Deniz Kirik, Anders Björklun. GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease. Brain : a journal of neurology. vol 134. issue Pt 8. 2011-10-13. PMID:21712347. |
we found that viral vector-mediated delivery of glial cell line-derived neurotrophic factor into substantia nigra and/or striatum, administered 2-3 weeks before α-synuclein, was inefficient in preventing the wild-type α-synuclein-induced loss of dopamine neurons and terminals. |
2011-10-13 |
2023-08-12 |
human |
| C V Fontanilla, Z Ma, X Wei, J Klotsche, L Zhao, P Wisniowski, R C Dodel, M R Farlow, W H Oertel, Y D. Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration. Neuroscience. vol 188. 2011-10-12. PMID:21571045. |
parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. |
2011-10-12 |
2023-08-12 |
mouse |
| Alix B W Norton, Yong Sang Jo, Emily W Clark, Cortney A Taylor, Sheri J Y Mizumor. Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats. The European journal of neuroscience. vol 33. issue 10. 2011-09-26. PMID:21395868. |
phasic firing of dopamine (da) neurons in the ventral tegmental area (vta) and substantia nigra (sn) is likely to be crucial for reward processing that guides learning. |
2011-09-26 |
2023-08-12 |
rat |
| M Flint Bea. Neuroprotective effects of creatine. Amino acids. vol 40. issue 5. 2011-09-15. PMID:21448659. |
creatine produced dose-dependent neuroprotective effects against mptp toxicity reducing the loss of dopamine within the striatum and the loss of dopaminergic neurons in the substantia nigra. |
2011-09-15 |
2023-08-12 |
mouse |
| Hui-Ming Gao, Jau-Shyong Hon. Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Progress in neurobiology. vol 94. issue 1. 2011-09-08. PMID:21439347. |
the gradual, irreversible loss of dopamine neurons in the substantia nigra is the signature lesion of pd. |
2011-09-08 |
2023-08-12 |
Not clear |
| Zhen-Hua Gui, Jian Liu, Yong Wang, Umar Ali, Tao Wang, Li Che. Effects of chronic, systemic treatment with the dopamine receptor agonist R-apomorphine in partially lesioned rat model of Parkinson's disease: an electrophysiological study of substantia nigra dopamine neurons. The Chinese journal of physiology. vol 54. issue 2. 2011-08-18. PMID:21789890. |
effects of chronic, systemic treatment with the dopamine receptor agonist r-apomorphine in partially lesioned rat model of parkinson's disease: an electrophysiological study of substantia nigra dopamine neurons. |
2011-08-18 |
2023-08-12 |
rat |
| Zhanyun Lv, Hong Jiang, Huamin Xu, Ning Song, Junxia Xi. Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 3. 2011-08-16. PMID:20556443. |
the staging of lewy-related pathology in sporadic parkinson's disease (pd) reveals that many brain nuclei are affected in pd during different stages, except the ventral tegmental area (vta), which is close related to the substantia nigra (sn) and enriched in dopamine (da) neurons. |
2011-08-16 |
2023-08-12 |
mouse |
| Thomas Carlsson, Friederike R Schindler, Matthias Höllerhage, Candan Depboylu, Oscar Arias-Carrión, Stefan Schnurrbusch, Thomas W Rösler, Wojciech Wozny, Gerhard P Schwall, Karlfried Groebe, Wolfgang H Oertel, Patrik Brundin, André Schrattenholz, Günter U Höglinge. Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's disease. Journal of neurochemistry. vol 117. issue 6. 2011-08-03. PMID:21517849. |
we observed that systemic injections of the extracellular domain of nrg1β(1) (nrg1β(1)-ecd) increased dopamine levels in the substantia nigra and striatum of adult mice. |
2011-08-03 |
2023-08-12 |
mouse |
| M Kathleen Borland, Patricia A Trimmer, Jeremy D Rubinstein, Paula M Keeney, Kp Mohanakumar, Lei Liu, James P Bennet. Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells. Molecular neurodegeneration. vol 3. 2011-07-14. PMID:19114014. |
rostral progression into substantia nigra with death of dopamine neurons produces the motor impairment phenotype that yields a clinical diagnosis. |
2011-07-14 |
2023-08-12 |
Not clear |