| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia Muñoz, Irmgard Paris, Laurie H Sanders, J Timothy Greenamyre, Juan Segura-Aguila. Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. Biochimica et biophysica acta. vol 1822. issue 7. 2012-10-15. PMID:22483869. |
studies with synaptic vesicles from rat substantia nigra revealed that vmat-2 uptake of ³h-aminochrome 6.3 ± 0.4nmol/min/mg was similar to dopamine uptake 6.2 ± 0.3nmol/min/mg that which were dependent on atp. |
2012-10-15 |
2023-08-12 |
rat |
| Hideaki Matsui, Roberto Gavinio, Ryosuke Takahash. Medaka fish Parkinson's disease model. Experimental neurobiology. vol 21. issue 3. 2012-10-12. PMID:23055787. |
despite the ubiquitous distribution of the inclusion bodies, the middle diencephalic dopaminergic neurons were particularly vulnerable to these toxins, supporting the idea that this dopamine cluster is similar to the human substantia nigra. |
2012-10-12 |
2023-08-12 |
human |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| E C Wolters, C M Franco. Mental dysfunction in Parkinson's disease. Parkinsonism & related disorders. vol 4. issue 3. 2012-10-02. PMID:18591098. |
the pathological hallmark of parkinson's disease (pd) is a degeneration of the dopamine (da) producing cells in the substantia nigra and the ventral tegmentum, resulting in a dopamine deficiency in the dopaminergic projection areas with defective functioning of specific cortico-subcortical extrapyramidal circuits. |
2012-10-02 |
2023-08-12 |
Not clear |
| J Abarca, G Busto. Release of d-[(3)H]aspartic acid from the rat substantia nigra: effect of veratridine-evoked depolarization and cortical ablation. Neurochemistry international. vol 7. issue 2. 2012-10-02. PMID:20492918. |
in contrast, both the accumulation and veratridine-evoked release of [(3)h]dopamine, remained unchanged in the ipsilateral substantia nigra slices to the lesion. |
2012-10-02 |
2023-08-12 |
rat |
| S A Greenfiel. The significance of dendritic release of transmitter and protein in the substantia nigra. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493000. |
the transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. |
2012-10-02 |
2023-08-12 |
Not clear |
| S A Greenfiel. The significance of dendritic release of transmitter and protein in the substantia nigra. Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493000. |
it is possible that both dopamine and acetylcholinesterase, released in the substantia nigra, are acting in a novel, perhaps synergistic, fashion as "neuromodulators". |
2012-10-02 |
2023-08-12 |
Not clear |
| I W Chubb, J C Bornstei. Dopamine and acetylcholinesterase released in the substantia nigra: Cooperative or coincindental? Neurochemistry international. vol 7. issue 6. 2012-10-02. PMID:20493002. |
dopamine and acetylcholinesterase released in the substantia nigra: cooperative or coincindental? |
2012-10-02 |
2023-08-12 |
Not clear |
| J A Hardy, P Wester, I Backstrom, J Gottfries, L Oreland, A Stenstrom, B Winbla. The regional distribution of dopamine and serotonin uptake and transmitter concentrations in the human brain. Neurochemistry international. vol 10. issue 4. 2012-10-02. PMID:20501116. |
dopamine and metabolite concentrations were highest in the caudate, putamen and substantia nigra. |
2012-10-02 |
2023-08-12 |
human |
| J Abarca, G Busto. Depolarization evoked release of d-[(3)H]aspartate from slices of substantia nigra: Effects of dopamine receptor ligands. Neurochemistry international. vol 16. issue 3. 2012-10-02. PMID:20504565. |
the results shown support the idea that activation of nigral dopamine receptors may facilitate the ca(2+)-dependent, depolarization induced-release of excitatory amino acid transmitters from neuronal structures in substantia nigra. |
2012-10-02 |
2023-08-12 |
rat |
| T Kuriyama, J Taguchi, K Kuriyam. Functional alterations in striatal cholinergic and striato-nigral gabaergic neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. Neurochemistry international. vol 16. issue 3. 2012-10-02. PMID:20504575. |
although the adminstration of mptp (50 mg/kg, once a day for 5 days) to male mice of dd strain did not induce the changes in choline and acethylcholine contents in the striatum, a decrement of gaba content in the midbrain, especially in the substantia nigra, was found in addition to a significant decrease of dopamine content in the striatum. |
2012-10-02 |
2023-08-12 |
mouse |
| Xin Zhao, Quan Li, Lei Zhao, Xiaoping P. Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson's disease. Proteomics. Clinical applications. vol 1. issue 12. 2012-10-02. PMID:21136655. |
the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) replicates many of the pathological hallmarks of parkinson's disease (pd) in mice via selective destruction of dopamine neurons of the substantia nigra and striatum. |
2012-10-02 |
2023-08-12 |
mouse |
| T F Oo, R E Burk. Animal models of induced apoptotic death in the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318770. |
the purpose of the models we have developed of induced apoptosis in dopamine neurons of the substantia nigra (sn) is to try to translate what is being learned about the molecular mechanisms of apoptosis in simpler systems to these neurons. |
2012-10-02 |
2023-08-12 |
human |
| T F Oo, R E Burk. Apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318771. |
in the preceding chapter we described three paradigms by which we have studied programmed cell death in the substantia nigra (sn) of living animals: natural cell death and death induced either by developmental injury to the target striatum or by dopamine terminal destruction with the neurotoxin 6-hydroxydopamine (6-ohda). |
2012-10-02 |
2023-08-12 |
Not clear |
| M B Youdim, N Drigues, S Mande. Oxidative stress indices in Parkinson's disease : biochemical determination. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318773. |
table 1 biochemical alterations in substantia nigra of parkinson's disease indicating oxidative stress elevated decreased iron (in microglia, astrocytes, oligodendrocytes, and melanized dopamine neurons and mitochondria) gsh (gssg unchanged); gsh/gssg ratio decreased mitochondrial complex i ferritin calcium binding protein (calbindin 28) mitochondrial monoamine oxidase b transferrin and transferrin receptor lipofuscin vitamins e and c ubiquitin copper cu/zn-superoxide dismutase cytotoxic cytokines (tnf-a, il-1, il-6) inflammatory transcription factor nfkb heme oxygenase-1 ratio of oxidized to reduced glutathione (gssg/gsh) nitric oxide neuromelanin. |
2012-10-02 |
2023-08-12 |
Not clear |
| J D O. Regulation of Striatal N-Methyl-D-Aspartate Receptor (NMDAR) Function by Phosphorylation of its Subunits in Parkinsonian Rats. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318780. |
the cardinal signs of parkinson's disease (pd) reflect striatal dopamine depletion due to the progressive degeneration of neurons arising from the substantia nigra. |
2012-10-02 |
2023-08-12 |
rat |
| J L Mendoza-Ramírez, R Aguilar-Roblero, A Zainos-Rosales, R Drucker-Colí. Fetal substantia nigra and adrenal medullary grafts placed contralateral to the nigrostriatal lesion side induce a decrease in turning behavior but not in dopamine receptor density. Restorative neurology and neuroscience. vol 3. issue 4. 2012-10-02. PMID:21551635. |
motor asymmetries as well as changes in the density of postsynaptic dopamine receptors produced by unilateral denervation of the striatum have been reduced by both substantia nigra (sn) and adrenal medullary (am) grafts. |
2012-10-02 |
2023-08-12 |
rat |
| J B Becker, M A Arian. Behavioral effects of fetal substantia nigra tissue grafted into the dopamine-denervated striatum: responses to selective D1 and D2 dopamine receptor agonists. Restorative neurology and neuroscience. vol 3. issue 4. 2012-10-02. PMID:21551636. |
in this report, the behavioral response to amphetamine, apomorphine, the d1 receptor agonist skf82958, and the d2 receptor agonist ly171555 were tested before and after intrastriatal grafts of fetal substantia nigra, of fetal striatum or no implantation procedure in animals with unilateral dopamine denervation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Stacey E Seidl, Judith A Potashki. The promise of neuroprotective agents in Parkinson's disease. Frontiers in neurology. vol 2. 2012-10-02. PMID:22125548. |
parkinson's disease (pd) is characterized by loss of dopamine neurons in the substantia nigra of the brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| Magen M Johnson, Sharon K Michelhaugh, Mohamad Bouhamdan, Carl J Schmidt, Michael J Banno. The Transcription Factor NURR1 Exerts Concentration-Dependent Effects on Target Genes Mediating Distinct Biological Processes. Frontiers in neuroscience. vol 5. 2012-10-02. PMID:22194714. |
in order to better understand the nature of nurr1-responsive genes and their potential roles in dopamine neuron differentiation and survival, we used a human neural cellular background (sk-n-as cells) in which to generate a number of stable clonal lines with graded nurr1 gene expression that approximated that seen in da cell-rich human substantia nigra. |
2012-10-02 |
2023-08-12 |
human |