| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefanie Reyes, Yuhong Fu, Kay L Double, Veronica Cottam, Lachlan H Thompson, Deniz Kirik, George Paxinos, Charles Watson, Helen M Cooper, Glenda M Hallida. Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22926168. |
enhanced dcc gene expression occurred in the substantia nigra, and higher amounts of dcc protein characterized vulnerable ventral nigral dopamine neurons. |
2013-05-24 |
2023-08-12 |
mouse |
| Guangwei Du, Mechelle M Lewis, Suman Sen, Jianli Wang, Michele L Shaffer, Martin Styner, Qing X Yang, Xuemei Huan. Imaging nigral pathology and clinical progression in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 13. 2013-05-13. PMID:23008179. |
the pattern of dopamine cell loss in parkinson's disease (pd) is known to be prominent in the ventrolateral and caudal substantia nigra (sn), but less severe in the dorsal and rostral region. |
2013-05-13 |
2023-08-12 |
human |
| Stefan Kobza, Stefano Ferrea, Alfons Schnitzler, Bettina Pollok, Martin Südmeyer, Christian Bellebau. Dissociation between active and observational learning from positive and negative feedback in Parkinsonism. PloS one. vol 7. issue 11. 2013-05-13. PMID:23185586. |
positive feedback leads to increased activity of dopamine neurons in the substantia nigra, whereas dopamine neuron activity is decreased following negative feedback. |
2013-05-13 |
2023-08-12 |
Not clear |
| Maurizio F Facheris, Andrew A Hicks, Peter P Pramstaller, Irene Pichle. Update on the management of restless legs syndrome: existing and emerging treatment options. Nature and science of sleep. vol 2. 2013-04-26. PMID:23616710. |
the symptoms reflect a circadian fluctuation of dopamine in the substantia nigra. |
2013-04-26 |
2023-08-12 |
Not clear |
| Maurizio F Facheris, Andrew A Hicks, Peter P Pramstaller, Irene Pichle. Update on the management of restless legs syndrome: existing and emerging treatment options. Nature and science of sleep. vol 2. 2013-04-26. PMID:23616710. |
rls patients have lower dopamine and iron levels in the substantia nigra and respond to both dopaminergic therapy and iron administration. |
2013-04-26 |
2023-08-12 |
Not clear |
| Emanuela Esposito, Daniela Impellizzeri, Emanuela Mazzon, Irene Paterniti, Salvatore Cuzzocre. Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease. PloS one. vol 7. issue 8. 2013-04-23. PMID:22912680. |
treatment with pea reduced mptp-induced microglial activation, the number of gfap-positive astrocytes and s100β overexpression, and protected against the alterations of microtubule-associated protein 2a,b-, dopamine transporter-, nnos- positive cells in the substantia nigra. |
2013-04-23 |
2023-08-12 |
mouse |
| Stefanie Reyes, Yuhong Fu, Kay Double, Lachlan Thompson, Deniz Kirik, George Paxinos, Glenda M Hallida. GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. The Journal of comparative neurology. vol 520. issue 12. 2013-04-08. PMID:22252428. |
girk2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. |
2013-04-08 |
2023-08-12 |
mouse |
| Stefanie Reyes, Yuhong Fu, Kay Double, Lachlan Thompson, Deniz Kirik, George Paxinos, Glenda M Hallida. GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. The Journal of comparative neurology. vol 520. issue 12. 2013-04-08. PMID:22252428. |
g-protein-regulated inward-rectifier potassium channel 2 (girk2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (sn), although very limited data are available in humans. |
2013-04-08 |
2023-08-12 |
mouse |
| Maria Sierra, Pascual Sánchez-Juan, María Isabel Martínez-Rodríguez, Isabel González-Aramburu, Inés García-Gorostiaga, María Remedios Quirce, Enrique Palacio, José Manuel Carril, José Berciano, Onofre Combarros, Jon Infant. Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease. Neurology. vol 80. issue 7. 2013-04-08. PMID:23325906. |
to ascertain in a cross-sectional study whether substantia nigra (sn) echogenicity, olfaction, and dopamine transporter (dat)-spect are reliable premotor biomarkers in a cohort of asymptomatic carriers of the lrrk2 g2019s mutation (asg2019s+). |
2013-04-08 |
2023-08-12 |
Not clear |
| Rajeswara B Mythri, Gangadharappa Harish, M M Bharat. Therapeutic potential of natural products in Parkinson's disease. Recent patents on endocrine, metabolic & immune drug discovery. vol 6. issue 3. 2013-03-14. PMID:22827714. |
the central objective in treating patients with parkinson's disease (pd) is two-fold (i) to increase the striatal dopamine content and (ii) to prevent further degeneration of the surviving dopaminergic neurons in the substantia nigra region of the ventral midbrain. |
2013-03-14 |
2023-08-12 |
Not clear |
| Noelia Granado, Sara Ares-Santos, Rosario Moratall. Methamphetamine and Parkinson's disease. Parkinson's disease. vol 2013. 2013-03-12. PMID:23476887. |
the molecular basis of parkinson's disease is the loss of dopamine in the basal ganglia (caudate/putamen) due to the degeneration of dopaminergic neurons in the substantia nigra, which leads to the motor impairment characteristic of the disease. |
2013-03-12 |
2023-08-12 |
human |
| Noelia Granado, Sara Ares-Santos, Rosario Moratall. Methamphetamine and Parkinson's disease. Parkinson's disease. vol 2013. 2013-03-12. PMID:23476887. |
in rodents, methamphetamine exposure damages dopaminergic neurons in the substantia nigra, resulting in a significant loss of dopamine in the striatum. |
2013-03-12 |
2023-08-12 |
human |
| Tertia D Purves-Tyson, David J Handelsman, Kay L Double, Samantha J Owens, Sonia Bustamante, Cynthia Shannon Weicker. Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC neuroscience. vol 13. 2013-03-08. PMID:22867132. |
we investigated whether gonadectomy and sex steroid replacement could influence dopamine levels by changing tyrosine hydroxylase (th) protein and mrna and/or dopamine breakdown enzyme mrna levels [catechol-o-methyl transferase (comt) and monoamine oxygenase (mao) a and b] in the adolescent male rat substantia nigra. |
2013-03-08 |
2023-08-12 |
rat |
| Philipp Klaissle, Anne Lesemann, Petra Huehnchen, Andreas Hermann, Alexander Storch, Barbara Steine. Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner. BMC neuroscience. vol 13. 2013-03-08. PMID:23110504. |
parkinson's disease is characterized by a continuous loss of neurons within the substantia nigra (sn) leading to a depletion of dopamine. |
2013-03-08 |
2023-08-12 |
mouse |
| ZeGang Ma, Yu Zhou, JunXia Xi. Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22259026. |
nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. |
2013-02-27 |
2023-08-12 |
rat |
| Keun-Sung Lee, Jin-Koo Lee, Hyung-Gun Kim, Hak Rim Ki. Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 1. 2013-02-27. PMID:23440908. |
in addition to behavioral analysis, endogenous levels of dopamine and tetrahydrobiopterin in mice brain regions, such as striatum, substantia nigra, and hippocampus were directly quantified by liquid chromatography-tandem mass spectrometry. |
2013-02-27 |
2023-08-12 |
mouse |
| Perumal Gurusamy, Kaliappan Muthukumar, Seenivasan Rajesh, Gurusamy Muneeswaran, Subbu Perumal, Chandran Karunakara. Theoretical investigation of quinone metabolites of dopamine interaction with DNA--insights into toxicological effects. Journal of structural biology. vol 180. issue 1. 2013-02-21. PMID:22634727. |
dopamine (3,4-dihydroxyphenylethylamine, da), an important neurotransmitter, exists in the cell bodies of the dopaminergic neurons of the substantia nigra. |
2013-02-21 |
2023-08-12 |
Not clear |
| Jose L Labandeira-Garcia, Jannette Rodriguez-Pallares, Ana I Rodríguez-Perez, Pablo Garrido-Gil, Begoña Villar-Cheda, Rita Valenzuela, Maria J Guerr. Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease. American journal of neurodegenerative disease. vol 1. issue 3. 2013-02-06. PMID:23383395. |
it is particularly interesting for pd the important interaction observed between angiotensin and dopamine, which counterregulate each other in renal cells and also in the striatum and substantia nigra. |
2013-02-06 |
2023-08-12 |
human |
| Jose L Labandeira-Garcia, Jannette Rodriguez-Pallares, Ana I Rodríguez-Perez, Pablo Garrido-Gil, Begoña Villar-Cheda, Rita Valenzuela, Maria J Guerr. Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease. American journal of neurodegenerative disease. vol 1. issue 3. 2013-02-06. PMID:23383395. |
in recent studies, we have observed both a local and an intracellular ras in the rodent, monkey and human substantia nigra, and that dopamine depletion induced ras upregulation possibly as a compensatory mechanism. |
2013-02-06 |
2023-08-12 |
human |
| Ali Reza Noorian, Jennifer Rha, Dana M Annerino, Douglas Bernhard, Georgia M Taylor, James G Green. Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system. Neurobiology of disease. vol 48. issue 1. 2013-01-14. PMID:22722052. |
while parkinsonian motor symptoms are caused by degeneration of dopamine neurons in the midbrain substantia nigra, the neurological localization of non-motor symptoms in pd is not known. |
2013-01-14 |
2023-08-12 |
mouse |