| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling M. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-22. PMID:25610480. |
the neuroprotective effect of dbyw and qzs on dopamine (da) neurons in substantia nigra (sn) in the mptp-induced pd mice was investigated by behavioral test (pole test) and immunohistochemistry. |
2015-01-22 |
2023-08-13 |
mouse |
| Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling M. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-22. PMID:25610480. |
it was observed that dbyw and/or qzs served to ameliorate mptp-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase atp level in the midbrain tissue and downregulate sur1 expression at mrna and protein levels with no marked influence on kir6.2. |
2015-01-22 |
2023-08-13 |
mouse |
| Y Tang, T Li, J Li, J Yang, H Liu, X J Zhang, W L. Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease. Cell death and differentiation. vol 21. issue 3. 2015-01-15. PMID:24212761. |
we also observed that the suppression of jmjd3 in the substantia nigra (sn) in vivo dramatically caused microglial overactivation and exacerbated dopamine (da) neuron death in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-intoxicated mouse model of pd. |
2015-01-15 |
2023-08-12 |
mouse |
| L-F Zheng, J Song, R-F Fan, C-L Chen, Q-Z Ren, X-L Zhang, X-Y Feng, Y Zhang, L-S Li, J-X Zh. The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. Acta physiologica (Oxford, England). vol 211. issue 2. 2015-01-09. PMID:24410908. |
the role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. |
2015-01-09 |
2023-08-12 |
rat |
| Edson Bor-Seng-Shu, Jose Luiz Pedroso, Andre C Felicio, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Pedro Braga-Neto, Ilza Rosa Batista, Orlando Graziani Povoas Barsottini, Vanderci Borges, Henrique Ballalai Ferraz, Ming Chi Shih, Rodrigo A Bressan, Luiz Augusto Franco de Andrade, Uwe Walte. Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: a cross-sectional study. Parkinsonism & related disorders. vol 20. issue 5. 2015-01-07. PMID:24629800. |
substantia nigra echogenicity and imaging of striatal dopamine transporters in parkinson's disease: a cross-sectional study. |
2015-01-07 |
2023-08-12 |
human |
| Edson Bor-Seng-Shu, Jose Luiz Pedroso, Andre C Felicio, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Pedro Braga-Neto, Ilza Rosa Batista, Orlando Graziani Povoas Barsottini, Vanderci Borges, Henrique Ballalai Ferraz, Ming Chi Shih, Rodrigo A Bressan, Luiz Augusto Franco de Andrade, Uwe Walte. Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: a cross-sectional study. Parkinsonism & related disorders. vol 20. issue 5. 2015-01-07. PMID:24629800. |
the current study addresses the use of transcranial sonography and single-photon emission computed tomography (spect) using (99m)tc-trodat-1 to evaluate the echogenicity of the substantia nigra (sn) and the density of striatal presynaptic dopamine transporters, respectively, in a sample of 20 pd patients (13 males and 7 females) and 9 healthy subjects. |
2015-01-07 |
2023-08-12 |
human |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. |
2015-01-05 |
2023-08-12 |
Not clear |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is implicated in schizophrenia as dopamine has been heavily implicated in the dopamine hypothesis of schizophrenia and the prevalent psychotic symptoms and the monoamine theory of depression, and is a target for the development of new therapies. |
2015-01-05 |
2023-08-12 |
Not clear |
| Mary V Burke, Christine Nocjar, Alex J Sonneborn, Andrew C McCreary, Elizabeth A Pehe. Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra. Journal of neurochemistry. vol 131. issue 4. 2015-01-05. PMID:25073477. |
striatal serotonin 2c receptors decrease nigrostriatal dopamine release by increasing gaba-a receptor tone in the substantia nigra. |
2015-01-05 |
2023-08-13 |
rat |
| Qingwei Zhou, Jiajun Chen, Shihong Yi, Yongwei Lou, Weimin Tang, Yongmao Liu, Pengguo Zhan. Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats. Neural regeneration research. vol 7. issue 27. 2015-01-05. PMID:25558223. |
our experimental findings indicate that zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase b and tyrosine hydroxylase in the substantia nigra of parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. |
2015-01-05 |
2023-08-13 |
rat |
| Xijin Wang, Meihua Wang, Liu Yang, Jie Bai, Zhiqiang Yan, Yuhong Zhang, Zhenguo Li. Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. Neural regeneration research. vol 9. issue 21. 2015-01-05. PMID:25558243. |
furthermore, after ak-7 (a selective sirtuin 2 inhibitor) was injected into the substantia nigra at postnatal 540 days and 570 days (5 μg/side per day), striatal dopamine depletion was significantly diminished and behavior abnormality was improved in aging rats with neonatal iron intake. |
2015-01-05 |
2023-08-13 |
rat |
| Erica L Unger, Laura E Bianco, Byron C Jones, Richard P Allen, Christopher J Earle. Low brain iron effects and reversibility on striatal dopamine dynamics. Experimental neurology. vol 261. 2014-12-17. PMID:24999026. |
iron deficiency (id) in rodents leads to decreased ventral midbrain (vmb) iron concentrations and to changes in the dopamine (da) system that mimic many of the dopaminergic changes seen in rls patient where low substantia nigra iron is a known pathology of the disease. |
2014-12-17 |
2023-08-13 |
rat |
| Ping Liu, Liang Sun, Xu-Li Zhao, Peng Zhang, Xue-Mei Zhao, Jian Zhan. PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease. Brain research. vol 1565. 2014-12-15. PMID:24747612. |
parkinson׳s disease (pd) is a common neurodegenerative disorder characterized by the selective degeneration of projecting dopaminergic neurons in the substantia nigra and diminished dopamine levels in the striatum. |
2014-12-15 |
2023-08-13 |
rat |
| C H Carriere, N H Kang, L P Nile. Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience. vol 267. 2014-12-09. PMID:24613722. |
stereological cell counting indicated a significant (p<0.05) decrease in tyrosine hydroxylase-positive dopamine neurons in the substantia nigra of rotenone-lesioned animals, which was confirmed by nissl staining. |
2014-12-09 |
2023-08-12 |
rat |
| Kaela R S Reinert, Claudia D Umphlet, Ariana Quattlebaum, Heather A Boge. Short-term effects of an endotoxin on substantia nigra dopamine neurons. Brain research. vol 1557. 2014-12-03. PMID:24513404. |
short-term effects of an endotoxin on substantia nigra dopamine neurons. |
2014-12-03 |
2023-08-12 |
mouse |
| Kaela R S Reinert, Claudia D Umphlet, Ariana Quattlebaum, Heather A Boge. Short-term effects of an endotoxin on substantia nigra dopamine neurons. Brain research. vol 1557. 2014-12-03. PMID:24513404. |
studies using the endotoxin lipopolysaccharide (lps), a potent inflammogen, show that systemic insults can trigger prolonged microglial activation and pro-inflammatory cytokine production leading to degeneration of substantia nigra (sn) dopamine (da) neurons, mimicking idiopathic pd. |
2014-12-03 |
2023-08-12 |
mouse |
| Xinhong Xue, Hong Liu, Lifeng Qi, Xueli Li, Cunju Guo, Dianrong Gong, Huaiqian Q. Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease. Brain research bulletin. vol 103. 2014-12-03. PMID:24576689. |
parkinson's disease (pd) is a common neurodegenerative disorder, which is characterized by a loss of projecting dopaminergic neurons in the substantia nigra and diminished dopamine level in the striatum. |
2014-12-03 |
2023-08-12 |
mouse |
| Olivier Barret, Jonas Hannestad, David Alagille, Christine Vala, Adriana Tavares, Caroline Papin, Thomas Morley, Krista Fowles, Hsiaoju Lee, John Seibyl, Dominique Tytgat, Marc Laruelle, Gilles Tamagna. Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 55. issue 10. 2014-12-03. PMID:25082853. |
motor symptoms in parkinson disease (pd) are caused by a loss of dopamine input from the substantia nigra to the striatum. |
2014-12-03 |
2023-08-13 |
monkey |
| Daping Xu, Hongwei Duan, Zaijun Zhang, Wei Cui, Liang Wang, Yewei Sun, Ming Lang, Pui Man Hoi, Yifan Han, Yuqiang Wang, Simon MingYuen Le. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 2. 2014-11-24. PMID:24233519. |
tn-2 significantly reversed the loss of dopaminergic neurons in the substantia nigra and the decrease in dopamine level in the striatum induced by mptp in mice. |
2014-11-24 |
2023-08-12 |
mouse |
| N Shimokawa, B Yousefi, S Morioka, S Yamaguchi, A Ohsawa, H Hayashi, A Azuma, H Mizuno, M Kasagi, H Masuda, H Jingu, S-I Furudate, A Haijima, Y Takatsuru, T Iwasaki, M Umezu, N Koibuch. Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism. Journal of neuroendocrinology. vol 26. issue 3. 2014-11-24. PMID:24460919. |
interestingly, the rdw rats showed high levels of dopamine in the substantia nigra and low levels in the striatum, an important centre for the coordination of behaviour. |
2014-11-24 |
2023-08-12 |
rat |