| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ninh Pham, T David Wait. Cu(II)-catalyzed oxidation of dopamine in aqueous solutions: mechanism and kinetics. Journal of inorganic biochemistry. vol 137. 2015-02-12. PMID:24815905. |
spontaneous oxidation of dopamine (da) and the resultant formation of free radical species within dopamine neurons of the substantia nigra (sn) is thought to bestow a considerable oxidative load upon these neurons and may contribute to their vulnerability to degeneration in parkinson's disease (pd). |
2015-02-12 |
2023-08-13 |
Not clear |
| Han Sam Cho, Dae Jung Baek, Seung Soo Bae. Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats. Journal of exercise nutrition & biochemistry. vol 18. issue 4. 2015-02-11. PMID:25671205. |
effect of exercise on hyperactivity, impulsivity and dopamine d2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats. |
2015-02-11 |
2023-08-13 |
rat |
| Falk Schlaudraff, Jan Gründemann, Michael Fauler, Elena Dragicevic, John Hardy, Birgit Lis. Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease. Neurobiology of aging. vol 35. issue 10. 2015-02-09. PMID:24742361. |
progressive loss of substantia nigra dopamine neurons (sn da) is a hallmark of aging and of parkinson's disease (pd). |
2015-02-09 |
2023-08-13 |
human |
| Kauê M Cost. The effects of aging on substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 46. 2015-02-09. PMID:25392480. |
the effects of aging on substantia nigra dopamine neurons. |
2015-02-09 |
2023-08-13 |
Not clear |
| Kunio Doi, Koji Uetsuk. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. International journal of molecular sciences. vol 12. issue 8. 2015-01-29. PMID:21954354. |
ota causes acute depletion of striatal dopamine and its metabolites, accompanying evidence of neuronal cell apoptosis in the substantia nigra, striatum and hippocampus. |
2015-01-29 |
2023-08-12 |
Not clear |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. Environmental toxicology and pharmacology. vol 37. issue 3. 2015-01-29. PMID:24863964. |
the mrna and protein expression of orphan nuclear hormone (nurr1), tyrosine hydroxylase(th), vesicular monoaminetransporter 2 (vmat2), dopamine transporter (dat), monoamine (mao), and catechol-o-methyl transferase (comt) in the midbrain were examined by fluorescence pcr and western blot when the offspring reached six-month old or one year old .when measured 6 months post-treatment, the level of da and expression of nurr1, vmat2, dat and th were reduced in the striatum and substantia nigra, respectively. |
2015-01-29 |
2023-08-13 |
human |
| G Cruz, R Riquelme, P Espinosa, P Jara, A Dagnino-Subiabre, G M Renard, R Sotomayor-Zárat. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 5. 2015-01-26. PMID:24323410. |
in the brain, neonatal estradiol valerate administration led to a significant increase in dopamine content in striatum, substantia nigra and ventral tegmental area. |
2015-01-26 |
2023-08-12 |
rat |
| G Cruz, R Riquelme, P Espinosa, P Jara, A Dagnino-Subiabre, G M Renard, R Sotomayor-Zárat. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 5. 2015-01-26. PMID:24323410. |
with respect to the contents of dopamine metabolites, only 3-methoxytyramine content increased in substantia nigra and ventral tegmental area. |
2015-01-26 |
2023-08-12 |
rat |
| Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling M. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-22. PMID:25610480. |
the neuroprotective effect of dbyw and qzs on dopamine (da) neurons in substantia nigra (sn) in the mptp-induced pd mice was investigated by behavioral test (pole test) and immunohistochemistry. |
2015-01-22 |
2023-08-13 |
mouse |
| Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling M. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-22. PMID:25610480. |
it was observed that dbyw and/or qzs served to ameliorate mptp-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase atp level in the midbrain tissue and downregulate sur1 expression at mrna and protein levels with no marked influence on kir6.2. |
2015-01-22 |
2023-08-13 |
mouse |
| Y Tang, T Li, J Li, J Yang, H Liu, X J Zhang, W L. Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease. Cell death and differentiation. vol 21. issue 3. 2015-01-15. PMID:24212761. |
we also observed that the suppression of jmjd3 in the substantia nigra (sn) in vivo dramatically caused microglial overactivation and exacerbated dopamine (da) neuron death in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-intoxicated mouse model of pd. |
2015-01-15 |
2023-08-12 |
mouse |
| L-F Zheng, J Song, R-F Fan, C-L Chen, Q-Z Ren, X-L Zhang, X-Y Feng, Y Zhang, L-S Li, J-X Zh. The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. Acta physiologica (Oxford, England). vol 211. issue 2. 2015-01-09. PMID:24410908. |
the role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. |
2015-01-09 |
2023-08-12 |
rat |
| Edson Bor-Seng-Shu, Jose Luiz Pedroso, Andre C Felicio, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Pedro Braga-Neto, Ilza Rosa Batista, Orlando Graziani Povoas Barsottini, Vanderci Borges, Henrique Ballalai Ferraz, Ming Chi Shih, Rodrigo A Bressan, Luiz Augusto Franco de Andrade, Uwe Walte. Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: a cross-sectional study. Parkinsonism & related disorders. vol 20. issue 5. 2015-01-07. PMID:24629800. |
substantia nigra echogenicity and imaging of striatal dopamine transporters in parkinson's disease: a cross-sectional study. |
2015-01-07 |
2023-08-12 |
human |
| Edson Bor-Seng-Shu, Jose Luiz Pedroso, Andre C Felicio, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Pedro Braga-Neto, Ilza Rosa Batista, Orlando Graziani Povoas Barsottini, Vanderci Borges, Henrique Ballalai Ferraz, Ming Chi Shih, Rodrigo A Bressan, Luiz Augusto Franco de Andrade, Uwe Walte. Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: a cross-sectional study. Parkinsonism & related disorders. vol 20. issue 5. 2015-01-07. PMID:24629800. |
the current study addresses the use of transcranial sonography and single-photon emission computed tomography (spect) using (99m)tc-trodat-1 to evaluate the echogenicity of the substantia nigra (sn) and the density of striatal presynaptic dopamine transporters, respectively, in a sample of 20 pd patients (13 males and 7 females) and 9 healthy subjects. |
2015-01-07 |
2023-08-12 |
human |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. |
2015-01-05 |
2023-08-12 |
Not clear |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is implicated in schizophrenia as dopamine has been heavily implicated in the dopamine hypothesis of schizophrenia and the prevalent psychotic symptoms and the monoamine theory of depression, and is a target for the development of new therapies. |
2015-01-05 |
2023-08-12 |
Not clear |
| Mary V Burke, Christine Nocjar, Alex J Sonneborn, Andrew C McCreary, Elizabeth A Pehe. Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra. Journal of neurochemistry. vol 131. issue 4. 2015-01-05. PMID:25073477. |
striatal serotonin 2c receptors decrease nigrostriatal dopamine release by increasing gaba-a receptor tone in the substantia nigra. |
2015-01-05 |
2023-08-13 |
rat |
| Qingwei Zhou, Jiajun Chen, Shihong Yi, Yongwei Lou, Weimin Tang, Yongmao Liu, Pengguo Zhan. Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats. Neural regeneration research. vol 7. issue 27. 2015-01-05. PMID:25558223. |
our experimental findings indicate that zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase b and tyrosine hydroxylase in the substantia nigra of parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. |
2015-01-05 |
2023-08-13 |
rat |
| Xijin Wang, Meihua Wang, Liu Yang, Jie Bai, Zhiqiang Yan, Yuhong Zhang, Zhenguo Li. Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. Neural regeneration research. vol 9. issue 21. 2015-01-05. PMID:25558243. |
furthermore, after ak-7 (a selective sirtuin 2 inhibitor) was injected into the substantia nigra at postnatal 540 days and 570 days (5 μg/side per day), striatal dopamine depletion was significantly diminished and behavior abnormality was improved in aging rats with neonatal iron intake. |
2015-01-05 |
2023-08-13 |
rat |
| Erica L Unger, Laura E Bianco, Byron C Jones, Richard P Allen, Christopher J Earle. Low brain iron effects and reversibility on striatal dopamine dynamics. Experimental neurology. vol 261. 2014-12-17. PMID:24999026. |
iron deficiency (id) in rodents leads to decreased ventral midbrain (vmb) iron concentrations and to changes in the dopamine (da) system that mimic many of the dopaminergic changes seen in rls patient where low substantia nigra iron is a known pathology of the disease. |
2014-12-17 |
2023-08-13 |
rat |