| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Gugliandolo, P Bramanti, E Mazzo. Mesenchymal stem cell therapy in Parkinson's disease animal models. Current research in translational medicine. vol 65. issue 2. 2019-11-20. PMID:28466824. |
parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, and as a consequence, by decreased dopamine levels in the striatum. |
2019-11-20 |
2023-08-13 |
Not clear |
| Panchanan Maiti, Jayeeta Manna, Gary L Dunba. Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments. Translational neurodegeneration. vol 6. 2019-11-20. PMID:29090092. |
gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |
| Bing Hu, Qianqian Shi, Yu Guo, Xiyezi Diao, Heng Guo, Jinsong Zhang, Liang Yu, Hao Dai, Luonan Che. The oscillatory boundary conditions of different frequency bands in Parkinson's disease. Journal of theoretical biology. vol 451. 2019-11-18. PMID:29727632. |
the most important pathological change in pd is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which results in a decrease in the dopamine (da) content of the striatum. |
2019-11-18 |
2023-08-13 |
Not clear |
| Courtney K Walker, Joy K Roche, Vidushi Sinha, Rosalinda C Robert. Substantia nigra ultrastructural pathology in schizophrenia. Schizophrenia research. vol 197. 2019-11-08. PMID:29274737. |
dopamine is thought to play a role in schizophrenia pathology, yet the substantia nigra (sn), the origin of dopaminergic pathways, has not been studied extensively in schizophrenia. |
2019-11-08 |
2023-08-13 |
human |
| Kevin A White, Geoffrey Mulberry, Kiminobu Sugaya, Brian N Ki. On-chip Detection of Single Vesicle Release from Neuroblastoma Cells using Monolithic CMOS Bioelectronics. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2018. 2019-10-29. PMID:30441479. |
neuroblastoma cells are often used as a cell model to study parkinson's disease, which causes reduced dopamine release in substantia nigra, the midbrain that controls movements. |
2019-10-29 |
2023-08-13 |
Not clear |
| Mengke Qu, Qing Lin, Luyi Huang, Yao Fu, Luyao Wang, Shanshan He, Yu Fu, Shengyong Yang, Zhirong Zhang, Ling Zhang, Xun Su. Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society. vol 287. 2019-10-21. PMID:30165139. |
further in vitro and in vivo studies demonstrates these exosomes successfully delivered dopamine to brain, including the striatum and substantia nigra. |
2019-10-21 |
2023-08-13 |
mouse |
| Roberto Di Maio, Eric K Hoffman, Emily M Rocha, Matthew T Keeney, Laurie H Sanders, Briana R De Miranda, Alevtina Zharikov, Amber Van Laar, Antonia F Stepan, Thomas A Lanz, Julia K Kofler, Edward A Burton, Dario R Alessi, Teresa G Hastings, J Timothy Greenamyr. LRRK2 activation in idiopathic Parkinson's disease. Science translational medicine. vol 10. issue 451. 2019-10-04. PMID:30045977. |
using these proximity ligation assays, we show that wild-type lrrk2 kinase activity was selectively enhanced in substantia nigra dopamine neurons in postmortem brain tissue from patients with ipd and in two different rat models of the disease. |
2019-10-04 |
2023-08-13 |
rat |
| Willemieke M Kouwenhoven, Hendrikus J van Heesbee. BMP/SMAD Pathway and the Development of Dopamine Substantia Nigra Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 28. 2019-09-30. PMID:29997164. |
bmp/smad pathway and the development of dopamine substantia nigra neurons. |
2019-09-30 |
2023-08-13 |
Not clear |
| Rania M Salama, Mariane G Tadros, Mona F Schaalan, Nevine Bahaa, Ahmed M Abdel-Tawab, Amani E Khalif. Potential neuroprotective effect of androst-5-ene-3β, 17β-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model. Journal of cellular physiology. vol 233. issue 8. 2019-09-23. PMID:29266208. |
amelioration in striatal dopamine (da), nuclear factor-kappa b (nf-κb), and the expression of down-stream inflammatory mediators, as well as apoptotic markers were observed in the striatum and substantia nigra (sn) upon pre-treatment with the three doses of adiol. |
2019-09-23 |
2023-08-13 |
rat |
| Claire McDonald, Gavin Gordon, Annette Hand, Richard W Walker, James M Fishe. 200 Years of Parkinson's disease: what have we learnt from James Parkinson? Age and ageing. vol 47. issue 2. 2019-09-23. PMID:29315364. |
key observation over the next 2 centuries, included the recognition of the link between the substantia nigra and pd and the discoveries of dopamine deficiency in patients with pd. |
2019-09-23 |
2023-08-13 |
Not clear |
| William B Lynch, Christopher W Tschumi, Amanda L Sharpe, Sarah Y Branch, Cang Chen, Guo Ge, Senlin Li, Michael J Beckstea. Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model. Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 12. 2019-09-10. PMID:30440089. |
parkinson's disease is characterized by the progressive loss of dopamine neurons in the substantia nigra, leading to severe motor deficits. |
2019-09-10 |
2023-08-13 |
mouse |
| Ye Zhao, Shikara Keshiya, Farzaneh Atashrazm, Jianqun Gao, Lars M Ittner, Dario R Alessi, Glenda M Halliday, Yuhong Fu, Nicolas Dzamk. Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice. Neurobiology of disease. vol 120. 2019-09-06. PMID:30194047. |
despite striatal pathology, there was no degeneration of dopamine neurons in the substantia nigra and no evidence of a pd motor phenotype in the knockin mice. |
2019-09-06 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Christopher W Tschumi, Michael J Beckstea. Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 3. 2019-08-26. PMID:30686631. |
acute and subchronic pcp attenuate d2 autoreceptor signaling in substantia nigra dopamine neurons. |
2019-08-26 |
2023-08-13 |
Not clear |
| Elisabeth Piccart, Christopher W Tschumi, Michael J Beckstea. Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 3. 2019-08-26. PMID:30686631. |
here we used whole-cell and cell-attached patch-clamp electrophysiology of substantia nigra dopamine neurons to determine the effects of acute and subchronic pcp exposure on both dopamine d2 autoreceptor-mediated currents and burst firing evoked by glutamate receptor activation. |
2019-08-26 |
2023-08-13 |
Not clear |
| Christopher J Rour. Indication of quantum mechanical electron transport in human substantia nigra tissue from conductive atomic force microscopy analysis. Bio Systems. vol 179. 2019-08-26. PMID:30826349. |
neuromelanin and ferritin in dopamine neurons of the substantia nigra have a distribution and density that is similar to disordered arrays of quantum dots in photovoltaic devices, which have been experimentally shown to conduct electric energy using quantum mechanical electron transport mechanisms. |
2019-08-26 |
2023-08-13 |
human |
| Mani Sugumar, Murugan Sevanan, Sathiya Seka. Neuroprotective effect of naringenin against MPTP-induced oxidative stress. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30433834. |
parkinson's disease is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to excitotoxicity, oxidative stress and many other factors may contribute to mptp- and pd-related neurodegeneration. |
2019-08-12 |
2023-08-13 |
mouse |
| Takaya Ogasawara, Masafumi Nejime, Masahiko Takada, Masayuki Matsumot. Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415993. |
subsets of dopamine neurons in the substantia nigra and striatal neurons receiving the dopaminergic input were activated when the monkey was required to cancel a planned saccadic eye movement. |
2019-08-08 |
2023-08-13 |
monkey |
| Wenfei Han, Luis A Tellez, Matthew H Perkins, Isaac O Perez, Taoran Qu, Jozelia Ferreira, Tatiana L Ferreira, Daniele Quinn, Zhong-Wu Liu, Xiao-Bing Gao, Melanie M Kaelberer, Diego V Bohórquez, Sara J Shammah-Lagnado, Guillaume de Lartigue, Ivan E de Arauj. A Neural Circuit for Gut-Induced Reward. Cell. vol 175. issue 3. 2019-07-29. PMID:30245012. |
specifically, right, but not left, vagal sensory ganglion activation sustained self-stimulation behavior, conditioned both flavor and place preferences, and induced dopamine release from substantia nigra. |
2019-07-29 |
2023-08-13 |
Not clear |
| Wenfei Han, Luis A Tellez, Matthew H Perkins, Isaac O Perez, Taoran Qu, Jozelia Ferreira, Tatiana L Ferreira, Daniele Quinn, Zhong-Wu Liu, Xiao-Bing Gao, Melanie M Kaelberer, Diego V Bohórquez, Sara J Shammah-Lagnado, Guillaume de Lartigue, Ivan E de Arauj. A Neural Circuit for Gut-Induced Reward. Cell. vol 175. issue 3. 2019-07-29. PMID:30245012. |
in particular, transneuronal labeling identified the glutamatergic neurons of the dorsolateral parabrachial region as the obligatory relay linking the right vagal sensory ganglion to dopamine cells in substantia nigra. |
2019-07-29 |
2023-08-13 |
Not clear |
| Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeid. miR-7 Replacement Therapy in Parkinson's Disease. Current gene therapy. vol 18. issue 3. 2019-07-12. PMID:29714132. |
depletion of mir-7 in the substantia nigra of clinical samples is related to α-syn accumulation, loss of dopaminergic cells, and reduction of dopamine in the striatum. |
2019-07-12 |
2023-08-13 |
Not clear |