| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae-Yoon Park, Jeha Jeon, Young Cha, Kwang-Soo Ki. Past, present, and future of cell replacement therapy for parkinson's disease: a novel emphasis on host immune responses. Cell research. 2024-05-22. PMID:38777859. |
central to the pathophysiology of pd is the specific degeneration of midbrain dopamine neurons (mdans) in the substantia nigra. |
2024-05-22 |
2024-05-27 |
human |
| Zarghona Imtiaz, Ayaka Kato, Brian H Kopell, Salman E Qasim, Arianna Neal Davis, Lizbeth Nunez Martinez, Matt Heflin, Kaustubh Kulkarni, Amr Morsi, Xiaosi Gu, Ignacio Sae. Human Substantia Nigra Neurons Encode Reward Expectations. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766086. |
dopamine (da) signals originating from substantia nigra (sn) neurons are centrally involved in the regulation of motor and reward processing. |
2024-05-20 |
2024-05-27 |
human |
| Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S Hnasko, Thomas Steinkellne. Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746104. |
viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. |
2024-05-15 |
2024-05-27 |
mouse |
| Rong Yang, Dai-di Li, Xiao-Xian Li, Xin-Xing Yang, Hui-Ming Gao, Feng Zhan. Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation. International journal of biological macromolecules. vol 269. issue Pt 2. 2024-05-11. PMID:38723817. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder, marked by the degeneration of dopamine (da) neurons in the substantia nigra (sn). |
2024-05-11 |
2024-05-27 |
Not clear |
| Meina He, Xiangming Zhang, Xia Ran, Yan Zhang, Xiaoran Nie, Bo Xiao, Li Lei, Suzhen Zhai, JinMing Zhu, Jingjing Zhang, Rong Li, Zuoji Liu, Yuping Zhu, Zhijun Dai, Zhixu He, Jian Feng, Chunlin Zhan. Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α-syn and Clearing ROS in Parkinson's Disease. Advanced materials (Deerfield Beach, Fla.). 2024-05-02. PMID:38696266. |
although evidence indicates that the abnormal accumulation of α-synuclein (α-syn) in dopamine neurons of the substantia nigra is the main pathological feature of parkinson's disease (pd), no compounds that have both α-syn anti-aggregation and α-syn degradation functions have been successful in treating the disease in the clinic. |
2024-05-02 |
2024-05-05 |
mouse |
| Jessica Ahrens, Farida Zaher, Rachel A Rabin, Clifford M Cassidy, Lena Palaniyappa. Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 161. 2024-04-28. PMID:38678736. |
neuromelanin in the substantia nigra (sn) may reflect dopamine auto-oxidation, and can be quantified using neuromelaninsensitive magnetic resonance imaging (neuromelanin-mri) in a non-invasive manner.in this pre-registered systematic review, we assess the current body of evidence related to neuromelanin levels in substance use disorders, using both post-mortem and mri examinations. |
2024-04-28 |
2024-05-01 |
Not clear |
| Ratna Dini Haryuni, Takamasa Nukui, Jin-Lan Piao, Takashi Shirakura, Chieko Matsui, Tomoyuki Sugimoto, Kousuke Baba, Shunya Nakane, Yuji Nakatsuj. Elevated Serum Xanthine Oxidase and Its Correlation with Antioxidant Status in Patients with Parkinson's Disease. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672506. |
parkinson's disease (pd) is a neurodegenerative movement disorder associated with a loss of dopamine neurons in the substantia nigra. |
2024-04-27 |
2024-04-29 |
Not clear |
| Katerina Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose B Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda M Halliday, Alexandra B Nelson, Elyssa B Margolis, Ken Nakamur. Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645054. |
parkinson's disease (pd) is characterized by the death of substantia nigra (snc) dopamine (da) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. |
2024-04-22 |
2024-04-24 |
mouse |
| P Leon Brown, Heather Palacorolla, Dana E Cobb-Lewis, Thomas C Jhou, Pat McMahon, Dana Bell, Greg I Elmer, Paul D Shepar. Substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. Neuroscience. 2024-04-18. PMID:38636897. |
substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. |
2024-04-18 |
2024-04-21 |
rat |
| P Leon Brown, Heather Palacorolla, Dana E Cobb-Lewis, Thomas C Jhou, Pat McMahon, Dana Bell, Greg I Elmer, Paul D Shepar. Substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. Neuroscience. 2024-04-18. PMID:38636897. |
dopamine (da) neurons of the substantia nigra (sn) and ventral tegmental area generally respond to aversive stimuli or the absence of expected rewards with transient inhibition of firing rates, which can be recapitulated with activation of the lateral habenula (lhb) and eliminated by lesioning the intermediating rostromedial tegmental nucleus (rmtg). |
2024-04-18 |
2024-04-21 |
rat |
| Rabia Anjum, Chand Raza, Mehwish Faheem, Arif Ullah, Maham Chaudhr. Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities. PloS one. vol 19. issue 4. 2024-04-16. PMID:38625964. |
neurodegeneration of the substantia nigra (sn) and diminished release of dopamine are prominent causes of this progressive disease. |
2024-04-16 |
2024-04-19 |
mouse |
| Liv Engel, Amy R Wolff, Madelyn Blake, Val L Collins, Sonal Sinha, Benjamin T Saunder. Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585717. |
dopamine neurons in the ventral tegmental area (vta) and substantia nigra (snc) are crucial for this process. |
2024-04-08 |
2024-04-10 |
Not clear |
| Hadeer O Abou-Hany, Mohamed El-Sherbiny, Sally Elshaer, Eman Said, Tarek Moustaf. Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway. Neuropharmacology. 2024-03-17. PMID:38494124. |
of note, felodipine increased dopamine levels in the substantia nigra and striatum as confirmed by the suppression of inflammation and the significant reduction in striatal nf-κb and tnf-α contents. |
2024-03-17 |
2024-03-20 |
Not clear |
| Marieke van der Pluijm, Kenneth Wengler, Pascalle N Reijers, Clifford M Cassidy, Kaithlyn Tjong Tjin Joe, Olav R de Peuter, Guillermo Horga, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giesse. Neuromelanin-Sensitive MRI as Candidate Marker for Treatment Resistance in First-Episode Schizophrenia. The American journal of psychiatry. 2024-03-13. PMID:38476044. |
neuromelanin-sensitive mri (nm-mri), which indirectly measures dopamine function in the substantia nigra, has potential as a noninvasive marker for nonresponders. |
2024-03-13 |
2024-03-15 |
Not clear |
| Seth R Batten, Dan Bang, Brian H Kopell, Arianna N Davis, Matthew Heflin, Qixiu Fu, Ofer Perl, Kimia Ziafat, Alice Hashemi, Ignacio Saez, Leonardo S Barbosa, Thomas Twomey, Terry Lohrenz, Jason P White, Peter Dayan, Alexander W Charney, Martijn Figee, Helen S Mayberg, Kenneth T Kishida, Xiaosi Gu, P Read Montagu. Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange. Nature human behaviour. 2024-02-27. PMID:38409356. |
dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange. |
2024-02-27 |
2024-03-02 |
human |
| Cheng Liu, Yang Su, Xiaolong Ma, Yao Wei, Rui Qia. How close are we to a breakthrough? The hunt for blood biomarkers in Parkinson's disease diagnosis. The European journal of neuroscience. 2024-02-21. PMID:38379501. |
by the time clinical diagnosis becomes possible, more than 60% of dopamine neurons in the substantia nigra (sn) of patients have already degenerated. |
2024-02-21 |
2024-02-23 |
Not clear |
| Hadeel Khamis, Ohad Cohe. Coupled action potential and calcium dynamics underlie robust spontaneous firing in dopaminergic neurons. Physical biology. 2024-02-21. PMID:38382117. |
dopaminergic neurons are specialized cells in the substantia nigra, tasked with dopamine secretion. |
2024-02-21 |
2024-02-24 |
Not clear |
| Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, Sukriti Vishwas, Narendra Kumar Pandey, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Muralikrishnan Dhanasekaran, Monica Gulati, Kamal Dua, Sachin Kumar Sing. Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation. Ageing research reviews. 2024-02-18. PMID:38369026. |
post-biotic is believed to mediate its neuroprotection by elevating the level of dopamine and reducing the level of α-synuclein in substantia nigra, protecting the loss of dopaminergic neurons, reducing the aggregation of nft, reducing the deposition of amyloid β peptide plagues and ameliorating motor deficits. |
2024-02-18 |
2024-02-21 |
human |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |
| David Zarate-Lopez, Andrea P Garzón-Partida, Oscar Gonzalez-Perez, Alma Y Gálvez-Contrera. Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. Developmental psychobiology. vol 66. issue 2. 2024-02-13. PMID:38351305. |
these abnormal patterns may be due to alterations in dopamine synthesis in the ventral tegmental area (vta) and substantia nigra (sn). |
2024-02-13 |
2024-02-16 |
mouse |