| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Leon Brown, Heather Palacorolla, Dana E Cobb-Lewis, Thomas C Jhou, Pat McMahon, Dana Bell, Greg I Elmer, Paul D Shepar. Substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. Neuroscience. 2024-04-18. PMID:38636897. |
substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. |
2024-04-18 |
2024-04-21 |
rat |
| P Leon Brown, Heather Palacorolla, Dana E Cobb-Lewis, Thomas C Jhou, Pat McMahon, Dana Bell, Greg I Elmer, Paul D Shepar. Substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. Neuroscience. 2024-04-18. PMID:38636897. |
dopamine (da) neurons of the substantia nigra (sn) and ventral tegmental area generally respond to aversive stimuli or the absence of expected rewards with transient inhibition of firing rates, which can be recapitulated with activation of the lateral habenula (lhb) and eliminated by lesioning the intermediating rostromedial tegmental nucleus (rmtg). |
2024-04-18 |
2024-04-21 |
rat |
| Rabia Anjum, Chand Raza, Mehwish Faheem, Arif Ullah, Maham Chaudhr. Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities. PloS one. vol 19. issue 4. 2024-04-16. PMID:38625964. |
neurodegeneration of the substantia nigra (sn) and diminished release of dopamine are prominent causes of this progressive disease. |
2024-04-16 |
2024-04-19 |
mouse |
| Liv Engel, Amy R Wolff, Madelyn Blake, Val L Collins, Sonal Sinha, Benjamin T Saunder. Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585717. |
dopamine neurons in the ventral tegmental area (vta) and substantia nigra (snc) are crucial for this process. |
2024-04-08 |
2024-04-10 |
Not clear |
| Hadeer O Abou-Hany, Mohamed El-Sherbiny, Sally Elshaer, Eman Said, Tarek Moustaf. Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway. Neuropharmacology. 2024-03-17. PMID:38494124. |
of note, felodipine increased dopamine levels in the substantia nigra and striatum as confirmed by the suppression of inflammation and the significant reduction in striatal nf-κb and tnf-α contents. |
2024-03-17 |
2024-03-20 |
Not clear |
| Marieke van der Pluijm, Kenneth Wengler, Pascalle N Reijers, Clifford M Cassidy, Kaithlyn Tjong Tjin Joe, Olav R de Peuter, Guillermo Horga, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giesse. Neuromelanin-Sensitive MRI as Candidate Marker for Treatment Resistance in First-Episode Schizophrenia. The American journal of psychiatry. 2024-03-13. PMID:38476044. |
neuromelanin-sensitive mri (nm-mri), which indirectly measures dopamine function in the substantia nigra, has potential as a noninvasive marker for nonresponders. |
2024-03-13 |
2024-03-15 |
Not clear |
| Seth R Batten, Dan Bang, Brian H Kopell, Arianna N Davis, Matthew Heflin, Qixiu Fu, Ofer Perl, Kimia Ziafat, Alice Hashemi, Ignacio Saez, Leonardo S Barbosa, Thomas Twomey, Terry Lohrenz, Jason P White, Peter Dayan, Alexander W Charney, Martijn Figee, Helen S Mayberg, Kenneth T Kishida, Xiaosi Gu, P Read Montagu. Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange. Nature human behaviour. 2024-02-27. PMID:38409356. |
dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange. |
2024-02-27 |
2024-03-02 |
human |
| Cheng Liu, Yang Su, Xiaolong Ma, Yao Wei, Rui Qia. How close are we to a breakthrough? The hunt for blood biomarkers in Parkinson's disease diagnosis. The European journal of neuroscience. 2024-02-21. PMID:38379501. |
by the time clinical diagnosis becomes possible, more than 60% of dopamine neurons in the substantia nigra (sn) of patients have already degenerated. |
2024-02-21 |
2024-02-23 |
Not clear |
| Hadeel Khamis, Ohad Cohe. Coupled action potential and calcium dynamics underlie robust spontaneous firing in dopaminergic neurons. Physical biology. 2024-02-21. PMID:38382117. |
dopaminergic neurons are specialized cells in the substantia nigra, tasked with dopamine secretion. |
2024-02-21 |
2024-02-24 |
Not clear |
| Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, Sukriti Vishwas, Narendra Kumar Pandey, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia Zacconi, Terezinha de Jesus Andreoli Pinto, Muralikrishnan Dhanasekaran, Monica Gulati, Kamal Dua, Sachin Kumar Sing. Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation. Ageing research reviews. 2024-02-18. PMID:38369026. |
post-biotic is believed to mediate its neuroprotection by elevating the level of dopamine and reducing the level of α-synuclein in substantia nigra, protecting the loss of dopaminergic neurons, reducing the aggregation of nft, reducing the deposition of amyloid β peptide plagues and ameliorating motor deficits. |
2024-02-18 |
2024-02-21 |
human |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |
| David Zarate-Lopez, Andrea P Garzón-Partida, Oscar Gonzalez-Perez, Alma Y Gálvez-Contrera. Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. Developmental psychobiology. vol 66. issue 2. 2024-02-13. PMID:38351305. |
these abnormal patterns may be due to alterations in dopamine synthesis in the ventral tegmental area (vta) and substantia nigra (sn). |
2024-02-13 |
2024-02-16 |
mouse |
| Niklas Reich, Christian Hölsche. Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer's and Parkinson's disease. Frontiers in neuroendocrinology. 2024-02-12. PMID:38346453. |
by stimulating cck-1 receptors (cck-1rs), sulphated cck-8 elicits dopamine release in the substantia nigra and striatum. |
2024-02-12 |
2024-02-15 |
Not clear |
| Bart de Laat, Jocelyn Hoye, Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan, Dustin W Wooten, Xiaomeng Zhang, Thanh D Nguyen, Jose Key, Giulia Colonna, Yiyun Huang, Nabeel Nabulsi, Amar Patel, David Matuskey, Evan D Morris, Sule Tina. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease. NPJ Parkinson's disease. vol 10. issue 1. 2024-02-09. PMID:38336768. |
intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in parkinson's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Pol Andrés-Benito, Angelique di Domenico, Yvonne Richaud-Patin, Valentina Baruffi, Laura Marruecos, Lluís Espinosa, Alicia Garrido, Eduardo Tolosa, Michael J Edel, Manel Juan Otero, José Luis Mosquera, Isidre Ferrer, Angel Raya, Antonella Consigli. Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson's disease. JCI insight. vol 9. issue 3. 2024-02-08. PMID:38329129. |
parkinson's disease (pd) is a neurodegenerative disease associated with progressive death of midbrain dopamine (dan) neurons in the substantia nigra (sn). |
2024-02-08 |
2024-02-10 |
human |
| Himanshi Varshney, Yasir Hasan Siddiqu. Effect of Flavonoids against Parkinson's Disease. Central nervous system agents in medicinal chemistry. 2024-02-02. PMID:38305395. |
it is characterized by the depletion of striatal dopamine content and aggregation of alphasynuclein in the substantia nigra (sn). |
2024-02-02 |
2024-02-04 |
Not clear |
| Cerebellar projections to the substantia nigra modulate basal ganglia dopamine levels. Nature neuroscience. 2024-01-31. PMID:38297081. |
cerebellar projections to the substantia nigra modulate basal ganglia dopamine levels. |
2024-01-31 |
2024-02-03 |
Not clear |
| Ana Perez-Villalba, María Salomé Sirerol-Piquer, Raúl Soriano-Cantón, Virginia Folgado, Azucena Pérez-Cañamás, Martina Kirstein, Isabel Fariñas, Francisco Pérez-Sánche. Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging. Scientific reports. vol 14. issue 1. 2024-01-30. PMID:38291230. |
these motor disturbances correlate with reduced dopamine (da) levels, increased da turnover, synaptic terminal loss, and notably, the depletion of dopaminergic neurons in the substantia nigra and noradrenergic neurons in the locus coeruleus. |
2024-01-30 |
2024-02-02 |
mouse |
| Vasanthi Chinraj, Ramakkamma Aishwarya Reddy, Jubie Selvaraj, Raman Sureshkuma. Design, Synthesis and In Vitro Evaluation of Levodopa Stearic Acid Hydrazide Conjugate for the Management of Parkinson's DiseaseNovel Conjugate for Parkinson's Disease. Drug research. 2024-01-29. PMID:38286420. |
the pathological identification for parkinson's disease is loss of dopaminergic neurons in substantia nigra region of the brain that in turn leads to dopamine deficiency that affects the body's normal physiological and neurological disorder. |
2024-01-29 |
2024-02-01 |
Not clear |
| Brian Bicknell, Ann Liebert, Geoffrey Herke. Parkinson's Disease and Photobiomodulation: Potential for Treatment. Journal of personalized medicine. vol 14. issue 1. 2024-01-26. PMID:38276234. |
parkinson's disease is characterised by mitochondrial dysfunction and neuronal death in the substantia nigra, a reduction in dopamine, accumulation of α-synuclein aggregates and neuroinflammation. |
2024-01-26 |
2024-01-28 |
Not clear |