| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca E Colebrooke, Trevor Humby, Patrick J Lynch, Daniel P McGowan, Jing Xia, Piers C Emso. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. The European journal of neuroscience. vol 24. issue 9. 2007-01-19. PMID:17100850. |
we report that evidence for cytosolic accumulation of dopamine in substantia nigra neurons in these mice is two-fold: firstly, there is reduced phosphorylation of tyrosine hydroxylase at the residue associated with catechol feedback inhibition; and, secondly, there are increased rates of dopamine turnover at 6, 12 and 24 months of age. |
2007-01-19 |
2023-08-12 |
mouse |
| Zena De March, Carmela Giampà, Stefano Patassini, Giorgio Bernardi, Francesca R Fusc. Cellular localization of TRPC5 in the substantia nigra of rat. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16635549. |
we previously observed several subtypes of trpc to be expressed at an mrna level in the substantia nigra dopamine neurons. |
2007-01-16 |
2023-08-12 |
rat |
| Judy P Q Zhu, Wenjing Xu, Jesus A Angul. Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance p in the striatum of mice. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105911. |
in contrast, substance p may mediate damage of the dopamine terminals via an extrastriatal mechanism involving the substantia nigra and cortical glutamate release. |
2007-01-10 |
2023-08-12 |
mouse |
| James P Carson, Tao Ju, Hui-Chen Lu, Christina Thaller, Mei Xu, Sarah L Pallas, Michael C Crair, Joe Warren, Wah Chiu, Gregor Eichel. A digital atlas to characterize the mouse brain transcriptome. PLoS computational biology. vol 1. issue 4. 2007-01-09. PMID:16184189. |
as an illustration of utility, we identify candidate genes that may be related to parkinson disease by using the expression of a dopamine transporter in the substantia nigra as a search query pattern. |
2007-01-09 |
2023-08-12 |
mouse |
| Erwin Lauwers, Dirk Bequé, Koen Van Laere, Johan Nuyts, Guy Bormans, Luc Mortelmans, Cindy Casteels, Linda Vercammen, Olivier Bockstael, Bart Nuttin, Zeger Debyser, Veerle Baekeland. Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16423428. |
there was a strong correlation between the reduction of dopaminergic neurons in the substantia nigra and the reduction of dopamine transporter binding in the striatum. |
2007-01-09 |
2023-08-12 |
rat |
| Wayne A Cass, Richard Grondin, Anders H Andersen, Zhiming Zhang, Peter A Hardy, Lindsay K Hussey-Andersen, William S Rayens, Greg A Gerhardt, Don M Gas. Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16442671. |
these perturbations include alterations in dopamine (da) release, regulation and transport in the striatum and substantia nigra, striatal atrophy and elevated iron levels in the basal ganglia. |
2007-01-09 |
2023-08-12 |
monkey |
| Rui D S Prediger, Luciano C Batista, Rodrigo Medeiros, Pablo Pandolfo, Jorge C Florio, Reinaldo N Takahash. The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16908021. |
moreover, intranasal administration of mptp reduced the expression of the enzyme tyrosine hydroxylase in the olfactory bulb and substantia nigra of rats, resulting in a significant reduction of dopamine concentration in the olfactory bulb, prefrontal cortex and striatum, but not in the hippocampus. |
2007-01-03 |
2023-08-12 |
human |
| Ana I Rojo, Celia Montero, María Salazar, Ryan M Close, Javier Fernández-Ruiz, Miguel A Sánchez-González, María Rosa de Sagarra, Vernice Jackson-Lewis, Carmen Cavada, Antonio Cuadrad. Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. The European journal of neuroscience. vol 24. issue 7. 2006-12-21. PMID:17067291. |
c57bl/6 mice, submitted to daily intranasal inoculation with mptp for 30 days, developed motor deficits that correlated with a progressive and severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase and dopamine transporter staining in substantia nigra and striatum. |
2006-12-21 |
2023-08-12 |
mouse |
| C M Kotz, C Wang, J A Teske, A J Thorpe, C M Novak, K Kiwaki, J A Levin. Orexin A mediation of time spent moving in rats: neural mechanisms. Neuroscience. vol 142. issue 1. 2006-12-20. PMID:16809007. |
dopamine signaling is important to substantia nigra function and so we also co-injected a dopamine 1 receptor antagonist (sch 23390) in the substantia nigra pars compacta. |
2006-12-20 |
2023-08-12 |
human |
| Marjan Jahanshahi, Catherine R G Jones, Georg Dirnberger, Christopher D Frit. The substantia nigra pars compacta and temporal processing. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 47. 2006-12-15. PMID:17122052. |
the fundamental role of the substantia nigra in temporal processing is discussed in relation to previous animal lesion studies and evidence for the modulating influence of dopamine on temporal processing. |
2006-12-15 |
2023-08-12 |
human |
| Mathew E Brevard, Jerrold S Meyer, Josie A Harder, Craig F Ferri. Imaging brain activity in conscious monkeys following oral MDMA ("ecstasy"). Magnetic resonance imaging. vol 24. issue 6. 2006-12-07. PMID:16824965. |
following mdma administration, the midbrain raphe nuclei and substantia nigra, major sources of serotonin and dopamine, were activated as were the hippocampus, hypothalamus and amygdala. |
2006-12-07 |
2023-08-12 |
monkey |
| Giuseppe Di Giovanni, Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Ennio Esposit. Serotonin involvement in the basal ganglia pathophysiology: could the 5-HT2C receptor be a new target for therapeutic strategies? Current medicinal chemistry. vol 13. issue 25. 2006-12-05. PMID:17073648. |
in fact, serotonergic terminals have been reported to make synaptic contacts with dopamine (da)-containing neurons and gamma-aminobutyric acid (gaba)-containing neurons in the striatum, globus pallidus, subthalamus and substantia nigra. |
2006-12-05 |
2023-08-12 |
human |
| Paola Sgadò, Lavinia Albéri, Daniel Gherbassi, Sherri L Galasso, Geert M J Ramakers, Kambiz N Alavian, Marten P Smidt, Richard H Dyck, Horst H Simo. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 41. 2006-11-28. PMID:17015829. |
specifically, postnatal mutant mice exhibit a progressive degeneration of dopaminergic neurons in the substantia nigra during the first 3 mo of their lives, leading to diminished storage and release of dopamine in the caudate putamen, motor deficits similar to akinesia and bradykinesia, and a lower body weight. |
2006-11-28 |
2023-08-12 |
mouse |
| Veljko Puskovic, Darren Wolfe, James Wechuck, David Krisky, Jeff Collins, Joseph C Glorioso, David J Fink, Marina Mat. HSV-mediated delivery of erythropoietin restores dopaminergic function in MPTP-treated mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 14. issue 5. 2006-11-22. PMID:16949343. |
inoculation with dhepo prior to mptp intoxication preserved behavioral function measured by pellet retrieval and the histological markers of tyrosine hydroxylase-immunoreactive (th-ir) neuronal cell bodies in the substantia nigra (sn) and th-ir and dopamine transporter-immunoreactive (dat-ir) terminals in striatum. |
2006-11-22 |
2023-08-12 |
mouse |
| Zhiming Zhang, Anders H Andersen, Yi Ai, Aaron Loveland, Peter A Hardy, Greg A Gerhardt, Don M Gas. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. NeuroImage. vol 33. issue 2. 2006-11-21. PMID:16949305. |
the primary findings were (1) the putamen and substantia nigra (sn) but not the caudate nucleus displayed significant bold responses to these dopaminergic drugs; (2) a significant relationship was found between amphetamine-evoked activation and the number of surviving dopamine neurons in the sn, which was also correlated with bradykinesia; and (3) inverse relationships were seen in response to apomorphine and amphetamine stimulation between the mptp-lesioned and unlesioned putamen and sn. |
2006-11-21 |
2023-08-12 |
monkey |
| Masatoshi Inden, Takahiro Taira, Yoshihisa Kitamura, Takashi Yanagida, Daiju Tsuchiya, Kazuyuki Takata, Daijiro Yanagisawa, Kaneyasu Nishimura, Takashi Taniguchi, Yoshiaki Kiso, Kanji Yoshimoto, Tomohiro Agatsuma, Shizuyo Koide-Yoshida, Sanae M M Iguchi-Ariga, Shun Shimohama, Hiroyoshi Arig. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiology of disease. vol 24. issue 1. 2006-11-07. PMID:16860563. |
pd phenotypes, including dopaminergic neuron death in the substantia nigra, decrease in dopamine, and dopamine transporter levels in the striatum, and motor abnormality, were dramatically improved by wild-type dj-1 but not l166p dj-1, a mutant form of dj-1 found in pd patients. |
2006-11-07 |
2023-08-12 |
rat |
| Alessandro Martorana, Carmela Giampà, Zena DeMarch, Maria Teresa Viscomi, Stefano Patassini, Giuseppe Sancesario, Giorgio Bernardi, Francesca R Fusc. Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930403. |
single-label immunohistochemistry and double-label immunofluorescence were used to study the expression of trpc1 among substantia nigra dopamine neurons and cellular processes using antibodies against tyrosine hydroxylase (th), substance p (sp), enkephalin, synaptophysin, vesicular glutamate transporter-2 (vglut-2), microtubule associated protein-2 and metabotropic glutamate receptor 1 (mglur1). |
2006-11-01 |
2023-08-12 |
rat |
| James G Green. Gene expression profiles of brain dopamine neurons and relevance to neuropsychiatric disease. The Journal of physiology. vol 575. issue Pt 2. 2006-10-26. PMID:16740610. |
specifically, dopamine neurons in the substantia nigra (sn), which are prone to degenerate in parkinson's disease, express high levels of transcripts related to energy metabolism, mitochondria and phosphate signalling pathways. |
2006-10-26 |
2023-08-12 |
Not clear |
| R E Burk. GDNF as a candidate striatal target-derived neurotrophic factor for the development of substantia nigra dopamine neurons. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017507. |
gdnf as a candidate striatal target-derived neurotrophic factor for the development of substantia nigra dopamine neurons. |
2006-10-24 |
2023-08-12 |
mouse |
| R E Burk. GDNF as a candidate striatal target-derived neurotrophic factor for the development of substantia nigra dopamine neurons. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017507. |
glial cell line-derived neurotrophic factor (gdnf) has been known for many years to protect and restore dopamine neurons of the substantia nigra (sn) in lesion models of parkinsonism, but much less has been known of its normal physiologic role. |
2006-10-24 |
2023-08-12 |
mouse |