| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang-Lin Liang, Tom T Wang, Kate Luby-Phelps, Dwight C Germa. Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17010972. |
mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for parkinson's disease. |
2007-03-20 |
2023-08-12 |
mouse |
| Eva de Lago, Silvia Ortega-Gutiérrez, José A Ramos, Maria L López Rodríguez, Javier Fernández-Rui. Neurochemical effects of the endocannabinoid uptake inhibitor UCM707 in various rat brain regions. Life sciences. vol 80. issue 10. 2007-03-20. PMID:17173937. |
so, changes in gaba transmission (decrease) were restricted to the substantia nigra, but did not appear in other regions, whereas dopamine transmission was also altered in the caudate-putamen and the nucleus accumbens. |
2007-03-20 |
2023-08-12 |
rat |
| Hidetaka Yamada, Toshihide Kuroki, Tatsuo Nakahara, Kijiro Hashimoto, Tetsuyuki Tsutsumi, Makoto Hirano, Hisao Maed. The dopamine D1 receptor agonist, but not the D2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens. Brain research. vol 1131. issue 1. 2007-03-09. PMID:17169339. |
in contrast, combination of both dopamine agonists produced a greater increase than skf38393 did in the mrna levels of c-fos in the nucleus accumbens, striatum and substantia nigra. |
2007-03-09 |
2023-08-12 |
rat |
| Jon F Davis, John-Andrews M McQuade, Deborah L Drazen, Stephen C Woods, Randy J Seeley, Stephen C Benoi. Role for dopamine-3 receptor in the hyperphagia of an unanticipated high-fat meal in rats. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16978686. |
behavioral studies have indicated that midbrain dopamine projections arising in the ventral tegmental area and substantia nigra play a central role in integrating violations of expectancy in reward-related paradigms. |
2007-02-23 |
2023-08-12 |
rat |
| Andrew C McCreary, Jeffrey C Glennon, Charles R Ashby, Herbert Y Meltzer, Zhu Li, Jan-Hendrik Reinders, Mayke B Hesselink, Stephen K Long, Arnoud H Herremans, Herman van Stuivenberg, Rolf W Feenstra, Chris G Krus. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 1. 2007-02-09. PMID:16710314. |
the number of spontaneously active dopamine cells in the ventral tegmental area was reduced by slv313 and clozapine, while no such changes were seen in the substantia nigra zona compacta following chronic administration. |
2007-02-09 |
2023-08-12 |
human |
| Gloria E Meredith, Un Jung Kan. Behavioral models of Parkinson's disease in rodents: a new look at an old problem. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 10. 2007-02-02. PMID:16830310. |
the circuitry important for voluntary movement is influenced by dopamine from the substantia nigra and regulated by the nigrostriatal system. |
2007-02-02 |
2023-08-12 |
human |
| James E Galvi. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16791599. |
interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of parkinson's disease: a case for the selective vulnerability of the substantia nigra. |
2007-02-01 |
2023-08-12 |
mouse |
| Noriko Yamamoto, R Christopher Pierce, Jean-Jacques Soghomonia. Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata. Brain research. vol 1123. issue 1. 2007-02-01. PMID:17027936. |
subchronic administration of l-dopa to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced gaba release in the substantia nigra, pars reticulata. |
2007-02-01 |
2023-08-12 |
rat |
| Noriko Yamamoto, R Christopher Pierce, Jean-Jacques Soghomonia. Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata. Brain research. vol 1123. issue 1. 2007-02-01. PMID:17027936. |
the present study, using in vivo microdialysis, investigated the effects of a single or subchronic administration of l-dopa to adult rats with a unilateral 6-ohda lesion of dopamine neurons on gaba release in the substantia nigra, pars reticulata (snr). |
2007-02-01 |
2023-08-12 |
rat |
| Vincent Ries, Claire Henchcliffe, Tatyana Kareva, Margarita Rzhetskaya, Ross Bland, Matthew J During, Nikolai Kholodilov, Robert E Burk. Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 49. 2007-02-01. PMID:17116866. |
we have evaluated this approach in dopamine neurons of the substantia nigra, neurons affected in parkinson's disease, by adeno-associated virus 1 transduction with a gene encoding a myristoylated, constitutively active form of the oncoprotein akt/pkb. |
2007-02-01 |
2023-08-12 |
mouse |
| Elzbieta Lorenc-Koci, Hans Rommelspacher, Gert Schulze, Catrin Wernicke, Katarzyna Kuter, Maria Smiałowska, Joana Wierońska, Barbara Zieba, Krystyna Ossowsk. Parkinson's disease-like syndrome in rats induced by 2,9-dimethyl-beta-carbolinium ion, a beta-carboline occurring in the human brain. Behavioural pharmacology. vol 17. issue 5-6. 2007-01-29. PMID:16940767. |
the present study examined the effect of bilateral, intranigral administration of 2,9-dimethyl-beta-carbolinium ion on muscle tone, electromyographic activity, dopamine metabolism in the striatum, and the number of tyrosine hydroxylase-immunoreactive neurons and volume of the substantia nigra in rats. |
2007-01-29 |
2023-08-12 |
human |
| Sung Jae Kim, Sung Yul Kim, Young-Soon Na, Hyun Jung Lee, Kwang Chul Chung, Ja-Hyun Bai. Alpha-synuclein enhances dopamine D2 receptor signaling. Brain research. vol 1124. issue 1. 2007-01-23. PMID:17087919. |
parkinson's disease (pd) is characterized by a selective loss of dopamine-producing neurons in the substantia nigra (sn), which in turn results in dopamine depletion in the striatum, and the presence of neuronal cytoplasmic inclusions known as lewy bodies (lbs). |
2007-01-23 |
2023-08-12 |
Not clear |
| Rebecca E Colebrooke, Trevor Humby, Patrick J Lynch, Daniel P McGowan, Jing Xia, Piers C Emso. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. The European journal of neuroscience. vol 24. issue 9. 2007-01-19. PMID:17100850. |
we report that evidence for cytosolic accumulation of dopamine in substantia nigra neurons in these mice is two-fold: firstly, there is reduced phosphorylation of tyrosine hydroxylase at the residue associated with catechol feedback inhibition; and, secondly, there are increased rates of dopamine turnover at 6, 12 and 24 months of age. |
2007-01-19 |
2023-08-12 |
mouse |
| Zena De March, Carmela Giampà, Stefano Patassini, Giorgio Bernardi, Francesca R Fusc. Cellular localization of TRPC5 in the substantia nigra of rat. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16635549. |
we previously observed several subtypes of trpc to be expressed at an mrna level in the substantia nigra dopamine neurons. |
2007-01-16 |
2023-08-12 |
rat |
| Judy P Q Zhu, Wenjing Xu, Jesus A Angul. Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance p in the striatum of mice. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105911. |
in contrast, substance p may mediate damage of the dopamine terminals via an extrastriatal mechanism involving the substantia nigra and cortical glutamate release. |
2007-01-10 |
2023-08-12 |
mouse |
| James P Carson, Tao Ju, Hui-Chen Lu, Christina Thaller, Mei Xu, Sarah L Pallas, Michael C Crair, Joe Warren, Wah Chiu, Gregor Eichel. A digital atlas to characterize the mouse brain transcriptome. PLoS computational biology. vol 1. issue 4. 2007-01-09. PMID:16184189. |
as an illustration of utility, we identify candidate genes that may be related to parkinson disease by using the expression of a dopamine transporter in the substantia nigra as a search query pattern. |
2007-01-09 |
2023-08-12 |
mouse |
| Erwin Lauwers, Dirk Bequé, Koen Van Laere, Johan Nuyts, Guy Bormans, Luc Mortelmans, Cindy Casteels, Linda Vercammen, Olivier Bockstael, Bart Nuttin, Zeger Debyser, Veerle Baekeland. Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16423428. |
there was a strong correlation between the reduction of dopaminergic neurons in the substantia nigra and the reduction of dopamine transporter binding in the striatum. |
2007-01-09 |
2023-08-12 |
rat |
| Wayne A Cass, Richard Grondin, Anders H Andersen, Zhiming Zhang, Peter A Hardy, Lindsay K Hussey-Andersen, William S Rayens, Greg A Gerhardt, Don M Gas. Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys. Neurobiology of aging. vol 28. issue 2. 2007-01-09. PMID:16442671. |
these perturbations include alterations in dopamine (da) release, regulation and transport in the striatum and substantia nigra, striatal atrophy and elevated iron levels in the basal ganglia. |
2007-01-09 |
2023-08-12 |
monkey |
| Rui D S Prediger, Luciano C Batista, Rodrigo Medeiros, Pablo Pandolfo, Jorge C Florio, Reinaldo N Takahash. The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16908021. |
moreover, intranasal administration of mptp reduced the expression of the enzyme tyrosine hydroxylase in the olfactory bulb and substantia nigra of rats, resulting in a significant reduction of dopamine concentration in the olfactory bulb, prefrontal cortex and striatum, but not in the hippocampus. |
2007-01-03 |
2023-08-12 |
human |
| Ana I Rojo, Celia Montero, María Salazar, Ryan M Close, Javier Fernández-Ruiz, Miguel A Sánchez-González, María Rosa de Sagarra, Vernice Jackson-Lewis, Carmen Cavada, Antonio Cuadrad. Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. The European journal of neuroscience. vol 24. issue 7. 2006-12-21. PMID:17067291. |
c57bl/6 mice, submitted to daily intranasal inoculation with mptp for 30 days, developed motor deficits that correlated with a progressive and severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase and dopamine transporter staining in substantia nigra and striatum. |
2006-12-21 |
2023-08-12 |
mouse |