| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abesh Kumar Bhattacharjee, Lindsey M Meister, Lisa Chang, Richard P Bazinet, Laura White, Stanley I Rapopor. In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease. NeuroImage. vol 37. issue 4. 2007-11-20. PMID:17681816. |
parkinson's disease involves loss of dopamine (da)-producing neurons in the substantia nigra, associated with fewer pre-synaptic da transporters (dats) but more post-synaptic dopaminergic d2 receptors in terminal areas of these neurons. |
2007-11-20 |
2023-08-12 |
rat |
| Zhen Hong, Gang Wang, Jing Gu, Jing Pan, Li Bai, Shi Zhang, Sheng-Di Che. Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17714494. |
the treatment with tw397 also significantly improved the level of dopamine in the substantia nigra and striatum to 157 and 191%, respectively, of the mptp- plus vehicle-treated group. |
2007-11-20 |
2023-08-12 |
mouse |
| Michael J Beckstead, Christopher P Ford, Paul E M Phillips, John T William. Presynaptic regulation of dendrodendritic dopamine transmission. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17822435. |
in the present study dendritic dopamine release was examined in the substantia nigra and ventral tegmental area in mouse brain slices using whole-cell recording of a dopamine-mediated inhibitory postsynaptic current (ipsc). |
2007-11-20 |
2023-08-12 |
mouse |
| Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paol. Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity. Biochemical pharmacology. vol 74. issue 9. 2007-11-19. PMID:17825264. |
methamphetamine reduced striatal dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations, striatal and substantia nigra dopamine and vesicular monoamine transporter specific binding as well substantia nigra dopamine and vesicular monoamine transporter mrna levels and increased striatal preproenkephalin mrna levels. |
2007-11-19 |
2023-08-12 |
mouse |
| Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paol. Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity. Biochemical pharmacology. vol 74. issue 9. 2007-11-19. PMID:17825264. |
tamoxifen at 50 microg reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mrna levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mrna levels. |
2007-11-19 |
2023-08-12 |
mouse |
| Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Toshiharu Nagatsu, Makoto Sawad. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17469135. |
by mptp administration to neonatal mice, the number of dopamine neurons in the substantia nigra (sn) was decreased significantly, whereas that in the mice treated with lps and mptp was recovered to normal, along with significant microglial activation. |
2007-11-05 |
2023-08-12 |
mouse |
| Liang-Wei Chen, Yan-Qin Wang, Li-Chun Wei, Mei Shi, Ying-Shing Cha. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS & neurological disorders drug targets. vol 6. issue 4. 2007-10-29. PMID:17691984. |
parkinson's disease (pd) is a common and debilitating degenerative disease resulting from massive degenerative loss of dopamine neurons, particularly in the substantia nigra. |
2007-10-29 |
2023-08-12 |
human |
| Carrie E John, Sara R Jone. Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. vol 52. issue 8. 2007-10-25. PMID:17459426. |
voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. |
2007-10-25 |
2023-08-12 |
mouse |
| Jill M Weimer, Jared W Benedict, Yasser M Elshatory, Douglas W Short, Denia Ramirez-Montealegre, Deborah A Ryan, Noreen A Alexander, Howard J Federoff, Jonathan D Cooper, David A Pearc. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain research. vol 1162. 2007-10-19. PMID:17617387. |
alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. |
2007-10-19 |
2023-08-12 |
mouse |
| A K Wright, G W Arbuthnot. The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats. The European journal of neuroscience. vol 26. issue 3. 2007-10-17. PMID:17634067. |
an ibotenic acid injection into the gp in rats removes the cells of the gp and, over the following 6 weeks, a progressive loss of dopamine cells (counted stereologically in sections stained for tyrosine hydroxylase) develops in substantia nigra (sn). |
2007-10-17 |
2023-08-12 |
rat |
| Jessika Urbanavicius, Margot Ferreira, Gustavo Costa, Juan Andrés Abin-Carriquiry, Susan Wonnacott, Federico Daja. Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17437548. |
it has been shown that nicotine prevents the loss of dopamine (da) in the corpus striatum (cs) after 6-hydroxydopamine injection in the substantia nigra. |
2007-10-15 |
2023-08-12 |
Not clear |
| Yan-Na Wu, Steven W Johnso. Rotenone potentiates NMDA currents in substantia nigra dopamine neurons. Neuroscience letters. vol 421. issue 2. 2007-09-28. PMID:17560718. |
rotenone potentiates nmda currents in substantia nigra dopamine neurons. |
2007-09-28 |
2023-08-12 |
rat |
| Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, Helen Chapman, Menelas N Pangalos, Neil Upton, David J Virle. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498809. |
in addition, mptp-treated mice were detected to have a marked depletion in striatal dopamine levels and a concomitant reduction in substantia nigra (sn) tyrosine hydroxylase (th) immunoreactivity, at 7 days post-mptp administration, indicative of dopaminergic neuronal loss. |
2007-09-27 |
2023-08-12 |
mouse |
| Alice Guyon, Jean-Louis Naho. Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity. Journal of molecular endocrinology. vol 38. issue 3. 2007-09-18. PMID:17339399. |
in various neuronal populations (ca1 neurons of the hippocampus, granular and purkinje cells of the cerebellum, melanin-concentrating hormone neurons of the lateral hypothalamus, vasopressinergic neurons of the supraoptic and the paraventricular nucleus of the hypothalamus, and dopaminergic neurons of the substantia nigra), sdf-1alpha can modulate the activity of neurons by multiple regulatory pathways including and often combining: (i) modulation of voltage-dependent channels (sodium, potassium, and calcium), (ii) activation of the g-protein-activated inward rectifier potassium current, and (iii) increase in neurotransmitter release (gamma-amino butyric acid (gaba), glutamate, and dopamine), often through ca-dependent mechanisms. |
2007-09-18 |
2023-08-12 |
Not clear |
| Heather A Boger, Lawrence D Middaugh, Kennerly S Patrick, Sammanda Ramamoorthy, Emily D Denehy, Haojie Zhu, Alejandra M Pacchioni, Ann-Charlotte Granholm, Jacqueline F McGint. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699663. |
two weeks after a methamphetamine binge (4 x 10 mg/kg, i.p., at 2 h intervals), gdnf(+/-) mice had a significantly greater reduction of tyrosine hydroxylase immunoreactivity in the medial striatum, a proportionally greater depletion of dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels in the striatum, and a greater increase in activated microglia in the substantia nigra than wild-type mice. |
2007-09-14 |
2023-08-12 |
mouse |
| David Sulzer, Yvonne Schmit. Parkinson's disease: return of an old prime suspect. Neuron. vol 55. issue 1. 2007-09-12. PMID:17610813. |
pacemaking activity in adult substantia nigra (sn) dopamine neurons relies on l-type ca2+ channels, but a surprising study in nature by chan et al. |
2007-09-12 |
2023-08-12 |
Not clear |
| Anya M Y Lin, S F Fang, P L Chao, C H Yan. Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. Journal of pineal research. vol 43. issue 2. 2007-09-07. PMID:17645694. |
local infusion of arsenite elevated lipid peroxidation and depleted glutathione content in the infused substantia nigra (sn), as well as reduced striatal dopamine content. |
2007-09-07 |
2023-08-12 |
rat |
| Joseph Rogers, Diego Mastroeni, Brian Leonard, Jeffrey Joyce, Andrew Grove. Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? International review of neurobiology. vol 82. 2007-09-05. PMID:17678964. |
although investigations of microglia in parkinson's disease (pd) are more recent and therefore less extensive, demonstration of a pathogenic role for microglial activation may actually be much simpler in pd than ad because the root pathological event in pd, loss of dopamine (da)-secreting substantia nigra neurons, is already well established. |
2007-09-05 |
2023-08-12 |
human |
| D Eugene Redmond, Kimberly B Bjugstad, Yang D Teng, Vaclav Ourednik, Jitka Ourednik, Dustin R Wakeman, Xuejun H Parsons, Rodolfo Gonzalez, Barbara C Blanchard, Seung U Kim, Zezong Gu, Stuart A Lipton, Eleni A Markakis, Robert H Roth, John D Elsworth, John R Sladek, Richard L Sidman, Evan Y Snyde. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 29. 2007-08-30. PMID:17586681. |
stem cells have been widely assumed to be capable of replacing lost or damaged cells in a number of diseases, including parkinson's disease (pd), in which neurons of the substantia nigra (sn) die and fail to provide the neurotransmitter, dopamine (da), to the striatum. |
2007-08-30 |
2023-08-12 |
human |
| Tomoya Kitayama, Yuri Onitsuka, Liqiu Song, Norimitsu Morioka, Katsuya Morita, Toshihiro Doh. Assessing an eating disorder induced by 6-OHDA and the possibility of nerve regeneration therapy by transplantation of neural progenitor cells in rats. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 27. issue 3. 2007-08-28. PMID:17633522. |
parkinson's disease is a neurodegenerative disorder of the substantia nigra accompanied by the depletion of dopamine levels. |
2007-08-28 |
2023-08-12 |
rat |