| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jill M Weimer, Jared W Benedict, Yasser M Elshatory, Douglas W Short, Denia Ramirez-Montealegre, Deborah A Ryan, Noreen A Alexander, Howard J Federoff, Jonathan D Cooper, David A Pearc. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain research. vol 1162. 2007-10-19. PMID:17617387. |
alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. |
2007-10-19 |
2023-08-12 |
mouse |
| A K Wright, G W Arbuthnot. The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats. The European journal of neuroscience. vol 26. issue 3. 2007-10-17. PMID:17634067. |
an ibotenic acid injection into the gp in rats removes the cells of the gp and, over the following 6 weeks, a progressive loss of dopamine cells (counted stereologically in sections stained for tyrosine hydroxylase) develops in substantia nigra (sn). |
2007-10-17 |
2023-08-12 |
rat |
| Jessika Urbanavicius, Margot Ferreira, Gustavo Costa, Juan Andrés Abin-Carriquiry, Susan Wonnacott, Federico Daja. Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17437548. |
it has been shown that nicotine prevents the loss of dopamine (da) in the corpus striatum (cs) after 6-hydroxydopamine injection in the substantia nigra. |
2007-10-15 |
2023-08-12 |
Not clear |
| Yan-Na Wu, Steven W Johnso. Rotenone potentiates NMDA currents in substantia nigra dopamine neurons. Neuroscience letters. vol 421. issue 2. 2007-09-28. PMID:17560718. |
rotenone potentiates nmda currents in substantia nigra dopamine neurons. |
2007-09-28 |
2023-08-12 |
rat |
| Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, Helen Chapman, Menelas N Pangalos, Neil Upton, David J Virle. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498809. |
in addition, mptp-treated mice were detected to have a marked depletion in striatal dopamine levels and a concomitant reduction in substantia nigra (sn) tyrosine hydroxylase (th) immunoreactivity, at 7 days post-mptp administration, indicative of dopaminergic neuronal loss. |
2007-09-27 |
2023-08-12 |
mouse |
| Alice Guyon, Jean-Louis Naho. Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity. Journal of molecular endocrinology. vol 38. issue 3. 2007-09-18. PMID:17339399. |
in various neuronal populations (ca1 neurons of the hippocampus, granular and purkinje cells of the cerebellum, melanin-concentrating hormone neurons of the lateral hypothalamus, vasopressinergic neurons of the supraoptic and the paraventricular nucleus of the hypothalamus, and dopaminergic neurons of the substantia nigra), sdf-1alpha can modulate the activity of neurons by multiple regulatory pathways including and often combining: (i) modulation of voltage-dependent channels (sodium, potassium, and calcium), (ii) activation of the g-protein-activated inward rectifier potassium current, and (iii) increase in neurotransmitter release (gamma-amino butyric acid (gaba), glutamate, and dopamine), often through ca-dependent mechanisms. |
2007-09-18 |
2023-08-12 |
Not clear |
| Heather A Boger, Lawrence D Middaugh, Kennerly S Patrick, Sammanda Ramamoorthy, Emily D Denehy, Haojie Zhu, Alejandra M Pacchioni, Ann-Charlotte Granholm, Jacqueline F McGint. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699663. |
two weeks after a methamphetamine binge (4 x 10 mg/kg, i.p., at 2 h intervals), gdnf(+/-) mice had a significantly greater reduction of tyrosine hydroxylase immunoreactivity in the medial striatum, a proportionally greater depletion of dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels in the striatum, and a greater increase in activated microglia in the substantia nigra than wild-type mice. |
2007-09-14 |
2023-08-12 |
mouse |
| David Sulzer, Yvonne Schmit. Parkinson's disease: return of an old prime suspect. Neuron. vol 55. issue 1. 2007-09-12. PMID:17610813. |
pacemaking activity in adult substantia nigra (sn) dopamine neurons relies on l-type ca2+ channels, but a surprising study in nature by chan et al. |
2007-09-12 |
2023-08-12 |
Not clear |
| Anya M Y Lin, S F Fang, P L Chao, C H Yan. Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. Journal of pineal research. vol 43. issue 2. 2007-09-07. PMID:17645694. |
local infusion of arsenite elevated lipid peroxidation and depleted glutathione content in the infused substantia nigra (sn), as well as reduced striatal dopamine content. |
2007-09-07 |
2023-08-12 |
rat |
| Joseph Rogers, Diego Mastroeni, Brian Leonard, Jeffrey Joyce, Andrew Grove. Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? International review of neurobiology. vol 82. 2007-09-05. PMID:17678964. |
although investigations of microglia in parkinson's disease (pd) are more recent and therefore less extensive, demonstration of a pathogenic role for microglial activation may actually be much simpler in pd than ad because the root pathological event in pd, loss of dopamine (da)-secreting substantia nigra neurons, is already well established. |
2007-09-05 |
2023-08-12 |
human |
| D Eugene Redmond, Kimberly B Bjugstad, Yang D Teng, Vaclav Ourednik, Jitka Ourednik, Dustin R Wakeman, Xuejun H Parsons, Rodolfo Gonzalez, Barbara C Blanchard, Seung U Kim, Zezong Gu, Stuart A Lipton, Eleni A Markakis, Robert H Roth, John D Elsworth, John R Sladek, Richard L Sidman, Evan Y Snyde. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 29. 2007-08-30. PMID:17586681. |
stem cells have been widely assumed to be capable of replacing lost or damaged cells in a number of diseases, including parkinson's disease (pd), in which neurons of the substantia nigra (sn) die and fail to provide the neurotransmitter, dopamine (da), to the striatum. |
2007-08-30 |
2023-08-12 |
human |
| Tomoya Kitayama, Yuri Onitsuka, Liqiu Song, Norimitsu Morioka, Katsuya Morita, Toshihiro Doh. Assessing an eating disorder induced by 6-OHDA and the possibility of nerve regeneration therapy by transplantation of neural progenitor cells in rats. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 27. issue 3. 2007-08-28. PMID:17633522. |
parkinson's disease is a neurodegenerative disorder of the substantia nigra accompanied by the depletion of dopamine levels. |
2007-08-28 |
2023-08-12 |
rat |
| Päivi Lindholm, Merja H Voutilainen, Juha Laurén, Johan Peränen, Veli-Matti Leppänen, Jaan-Olle Andressoo, Maria Lindahl, Sanna Janhunen, Nisse Kalkkinen, Tõnis Timmusk, Raimo K Tuominen, Mart Saarm. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. vol 448. issue 7149. 2007-08-27. PMID:17611540. |
in parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. |
2007-08-27 |
2023-08-12 |
mouse |
| Lyn R Patric. Restless legs syndrome: pathophysiology and the role of iron and folate. Alternative medicine review : a journal of clinical therapeutic. vol 12. issue 2. 2007-08-14. PMID:17604457. |
these symptoms reflect a circadian fluctuation of dopamine in the substantia nigra. |
2007-08-14 |
2023-08-12 |
Not clear |
| Lyn R Patric. Restless legs syndrome: pathophysiology and the role of iron and folate. Alternative medicine review : a journal of clinical therapeutic. vol 12. issue 2. 2007-08-14. PMID:17604457. |
patients with rls have lower levels of dopamine in the substantia nigra and respond to iron administration. |
2007-08-14 |
2023-08-12 |
Not clear |
| Katarzyna Kuter, Maria Smiałowska, Joanna Wierońska, Barbara Zieba, Jadwiga Wardas, Małgorzata Pietraszek, Przemysław Nowak, Izabela Biedka, Wojciech Roczniak, Jolanta Konieczny, Stanisław Wolfarth, Krystyna Ossowsk. Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats. Brain research. vol 1155. 2007-08-13. PMID:17493592. |
two days after withdrawal the levels of the dopamine metabolites and dopamine turnover in the caudate-putamen, substantia nigra and prefrontal cortex were reduced by ca. |
2007-08-13 |
2023-08-12 |
rat |
| Katarzyna Kuter, Maria Smiałowska, Joanna Wierońska, Barbara Zieba, Jadwiga Wardas, Małgorzata Pietraszek, Przemysław Nowak, Izabela Biedka, Wojciech Roczniak, Jolanta Konieczny, Stanisław Wolfarth, Krystyna Ossowsk. Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats. Brain research. vol 1155. 2007-08-13. PMID:17493592. |
three days after paraquat withdrawal, the level of dopamine in the caudate-putamen was significantly increased, and earlier decreases in dopac and hva in the substantia nigra, as well as [(3)h]gbr 12,935 binding in the caudate-putamen were reversed. |
2007-08-13 |
2023-08-12 |
rat |
| Gloria Lazzeri, Paola Lenzi, Carla L Busceti, Michela Ferrucci, Alessandra Falleni, Valeria Bruno, Antonio Paparelli, Francesco Forna. Mechanisms involved in the formation of dopamine-induced intracellular bodies within striatal neurons. Journal of neurochemistry. vol 101. issue 5. 2007-08-06. PMID:17286589. |
in vivo studies demonstrate the occurrence of these morphological alterations both in the dopamine (da) neurons of the substantia nigra and striatal cells. |
2007-08-06 |
2023-08-12 |
Not clear |
| Huifang Ji, Paul D Shepar. Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 26. 2007-08-01. PMID:17596440. |
single-pulse stimulation of the lhb (0.5 ma, 100 micros) transiently suppressed the activity of 97% of the dopamine neurons recorded in the substantia nigra and ventral tegmental area. |
2007-08-01 |
2023-08-12 |
rat |
| Ronald L Klein, Robert D Dayton, Nancy J Leidenheimer, Karen Jansen, Todd E Golde, Richard M Zwei. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Molecular therapy : the journal of the American Society of Gene Therapy. vol 13. issue 3. 2007-07-31. PMID:16325474. |
in the substantia nigra, the gfp expression conferred by aav8 was toxic to dopamine neurons, although toxicity could be avoided with dose titration. |
2007-07-31 |
2023-08-12 |
rat |