| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiqun Chen, Margarita Rzhetskaya, Tatyana Kareva, Ross Bland, Matthew J During, A William Tank, Nikolai Kholodilov, Robert E Burk. Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 3. 2008-02-08. PMID:18199767. |
antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. |
2008-02-08 |
2023-08-12 |
Not clear |
| Ana I Rojo, Carmen Cavada, María Rosa de Sagarra, Antonio Cuadrad. Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Experimental neurology. vol 208. issue 1. 2008-01-17. PMID:17880941. |
mptp-treated mice developed motor deficits that correlated with a severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase staining in substantia nigra and striatum. |
2008-01-17 |
2023-08-12 |
mouse |
| C Vadasz, J F Smiley, K Figarsky, M Saito, R Toth, B M Gyetvai, M Oros, K K Kovacs, P Mohan, R Wan. Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes. Neuroscience. vol 149. issue 3. 2008-01-16. PMID:17920205. |
immunocytochemical studies demonstrated that the number of th-positive cells in substantia nigra was 31.3% higher in balb/cj than that in c57bl/6byj (p<0.01), while the average dopamine neuron volume was not significantly different. |
2008-01-16 |
2023-08-12 |
mouse |
| C Vadasz, J F Smiley, K Figarsky, M Saito, R Toth, B M Gyetvai, M Oros, K K Kovacs, P Mohan, R Wan. Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes. Neuroscience. vol 149. issue 3. 2008-01-16. PMID:17920205. |
we found significantly higher mesencephalic th protein content in c4a6/b in comparison to c4a6/n (p=0.01), and a tendency for higher number of dopamine neurons in the substantia nigra in c4a6/b in comparison to c4a6/n, which, however, did not reach statistical significance. |
2008-01-16 |
2023-08-12 |
mouse |
| César Nava-Asbell, Francisco Paz-Bermudez, David Erlij, Jorge Aceves, Benjamín Florá. GABA(B) receptor activation inhibits dopamine D1 receptor-mediated facilitation of [(3)H]GABA release in substantia nigra pars reticulata. Neuropharmacology. vol 53. issue 5. 2008-01-14. PMID:17868750. |
gaba(b) receptors inhibit and dopamine d1 receptors stimulate the release of gaba from striatal terminals in the pars reticulata of the substantia nigra. |
2008-01-14 |
2023-08-12 |
rat |
| Yan-Na Wu, Giuseppina Martella, Steven W Johnso. Rotenone enhances N-methyl-D-aspartate currents by activating a tyrosine kinase in rat dopamine neurons. Neuroreport. vol 18. issue 17. 2008-01-11. PMID:18090317. |
our previous work showed that the pesticide rotenone increases the amplitude of inward currents evoked by n-methyl-d-aspartate (nmda) in substantia nigra dopamine neurons. |
2008-01-11 |
2023-08-12 |
rat |
| Vural Ozdemir, M Mazen Jamal, Klara Osapay, Martin R Jadus, Zsuzsanna Sandor, Mehrtash Hashemzadeh, Sandor Szab. Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 55. issue 6. 2008-01-10. PMID:17963681. |
the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,36-tetrahydropyridine (mptp) depletes central dopamine and induces lesions in the substantia nigra, and, if given in high doses, mptp induces a parkinson disease-like syndrome and gastric ulcers. |
2008-01-10 |
2023-08-12 |
Not clear |
| Gilmor I Keshet, Ravi J Tolwani, Angelica Trejo, Peggy Kraft, Regis Doyonnas, Carol Clayberger, James M Weimann, Helen M Bla. Increased host neuronal survival and motor function in BMT Parkinsonian mice: involvement of immunosuppression. The Journal of comparative neurology. vol 504. issue 6. 2008-01-04. PMID:17722033. |
post-bmt, mice exposed to mptp had substantially greater numbers of endogenous tyrosine hydroxylase-positive neuronal cell bodies in the substantia nigra and increased dopamine transporter-positive projections into the striatum compared to controls. |
2008-01-04 |
2023-08-12 |
mouse |
| O P Soldin, M Aschne. Effects of manganese on thyroid hormone homeostasis: potential links. Neurotoxicology. vol 28. issue 5. 2007-12-26. PMID:17576015. |
manganism and parkinson's disease are both characterized by motor deficits and damage to nuclei of the basal ganglia, particularly the substantia nigra, with altered dopamine (and its metabolites) contributing to these disorders. |
2007-12-26 |
2023-08-12 |
Not clear |
| Ben Ampe, Ann Massie, Jean D'Haens, Guy Ebinger, Yvette Michotte, Sophie Sarr. NMDA-mediated release of glutamate and GABA in the subthalamic nucleus is mediated by dopamine: an in vivo microdialysis study in rats. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17727638. |
the observed effects in intact animals depend on the nigral dopaminergic innervation, as dopamine denervation, by means of 6-hydroxydopamine lesioning of the substantia nigra, clearly abolished the effects of nmda on neurotransmitter release at the level of the stn. |
2007-12-21 |
2023-08-12 |
rat |
| Camila L Zold, Celia Larramendy, Luis A Riquelme, M Gustavo Mure. Distinct changes in evoked and resting globus pallidus activity in early and late Parkinson's disease experimental models. The European journal of neuroscience. vol 26. issue 5. 2007-11-28. PMID:17767504. |
here we report a marked increase in the responsiveness of globus pallidus neurons to electrical motor cortex stimulation, in the absence of noticeable changes in resting activity, in anesthetized rats that had consistently shown a deficit in forelimb use during behavioral testing before the experiments, and had approximately 45% dopamine neurons spared in the substantia nigra. |
2007-11-28 |
2023-08-12 |
rat |
| D Alvarez-Fischer, G Blessmann, C Trosowski, M Béhé, T Schurrat, A Hartmann, T M Behr, W H Oertel, G U Höglinger, H Höffke. Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease. NeuroImage. vol 38. issue 1. 2007-11-26. PMID:17716921. |
it is unclear, however, if there is a stable relationship between the striatal [(123)i]fp-cit binding and other functionally important parameters of the nigrostriatal system, such as the striatal dopamine levels and the number of dopaminergic neurons in the substantia nigra. |
2007-11-26 |
2023-08-12 |
mouse |
| Abesh Kumar Bhattacharjee, Lindsey M Meister, Lisa Chang, Richard P Bazinet, Laura White, Stanley I Rapopor. In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease. NeuroImage. vol 37. issue 4. 2007-11-20. PMID:17681816. |
parkinson's disease involves loss of dopamine (da)-producing neurons in the substantia nigra, associated with fewer pre-synaptic da transporters (dats) but more post-synaptic dopaminergic d2 receptors in terminal areas of these neurons. |
2007-11-20 |
2023-08-12 |
rat |
| Zhen Hong, Gang Wang, Jing Gu, Jing Pan, Li Bai, Shi Zhang, Sheng-Di Che. Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17714494. |
the treatment with tw397 also significantly improved the level of dopamine in the substantia nigra and striatum to 157 and 191%, respectively, of the mptp- plus vehicle-treated group. |
2007-11-20 |
2023-08-12 |
mouse |
| Michael J Beckstead, Christopher P Ford, Paul E M Phillips, John T William. Presynaptic regulation of dendrodendritic dopamine transmission. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17822435. |
in the present study dendritic dopamine release was examined in the substantia nigra and ventral tegmental area in mouse brain slices using whole-cell recording of a dopamine-mediated inhibitory postsynaptic current (ipsc). |
2007-11-20 |
2023-08-12 |
mouse |
| Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paol. Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity. Biochemical pharmacology. vol 74. issue 9. 2007-11-19. PMID:17825264. |
methamphetamine reduced striatal dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations, striatal and substantia nigra dopamine and vesicular monoamine transporter specific binding as well substantia nigra dopamine and vesicular monoamine transporter mrna levels and increased striatal preproenkephalin mrna levels. |
2007-11-19 |
2023-08-12 |
mouse |
| Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paol. Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity. Biochemical pharmacology. vol 74. issue 9. 2007-11-19. PMID:17825264. |
tamoxifen at 50 microg reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mrna levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mrna levels. |
2007-11-19 |
2023-08-12 |
mouse |
| Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Toshiharu Nagatsu, Makoto Sawad. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17469135. |
by mptp administration to neonatal mice, the number of dopamine neurons in the substantia nigra (sn) was decreased significantly, whereas that in the mice treated with lps and mptp was recovered to normal, along with significant microglial activation. |
2007-11-05 |
2023-08-12 |
mouse |
| Liang-Wei Chen, Yan-Qin Wang, Li-Chun Wei, Mei Shi, Ying-Shing Cha. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS & neurological disorders drug targets. vol 6. issue 4. 2007-10-29. PMID:17691984. |
parkinson's disease (pd) is a common and debilitating degenerative disease resulting from massive degenerative loss of dopamine neurons, particularly in the substantia nigra. |
2007-10-29 |
2023-08-12 |
human |
| Carrie E John, Sara R Jone. Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. vol 52. issue 8. 2007-10-25. PMID:17459426. |
voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. |
2007-10-25 |
2023-08-12 |
mouse |