| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher D Herzog, Biplob Dass, Mehdi Gasmi, Roy Bakay, James E Stansell, Mark Tuszynski, Krystof Bankiewicz, Er-Yun Chen, Yaping Chu, Kathie Bishop, Jeffrey H Kordower, Raymond T Bartu. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 10. 2008-12-12. PMID:18728639. |
we report here, for the first time, a dose-related: increase in ntn protein expression within the striatum and substantia nigra (sn) pars compacta of nonhuman primates; increase in nigrostriatal tyrosine hydroxylase (th), (the rate-limited enzyme for dopamine); and activation of phosphorylated signal-regulated kinase (a common neurotrophic signaling event). |
2008-12-12 |
2023-08-12 |
human |
| G A Oganesyan, E A Aristakesyan, I V Romanova, V A Belova, I V Artamokhin. The dopaminergic nigrostriatal system in sleep deprivation in cats. Neuroscience and behavioral physiology. vol 38. issue 8. 2008-12-08. PMID:18802772. |
in conditions of sleep deprivation, the caudate nucleus showed increases in the quantities of dopamine d1 and d2 receptor material, while there was a simultaneous decrease in the amount of immunoreactive material in the substantia nigra. |
2008-12-08 |
2023-08-12 |
rat |
| Melissa K McCoy, Kelly A Ruhn, Terina N Martinez, Fiona E McAlpine, Armin Blesch, Malú G Tanse. Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 9. 2008-11-18. PMID:18628756. |
here we demonstrate that a single injection of lentivirus-expressing dn-tnf into rat substantia nigra, administered concomitant with a striatal 6-hydroxydopamine lesion, results in sufficiently high expression of inhibitor in vivo to attenuate both da neuron loss and behavioral deficits resulting from striatal dopamine depletion. |
2008-11-18 |
2023-08-12 |
rat |
| Kelly L Janis, Ryan T Brennan, Robert E Drolet, Bahareh Behrouz, Sarah K Kaufman, Keith J Lookingland, John L Goudrea. Effects of sildenafil on nigrostriatal dopamine neurons in a murine model of Parkinson's disease. Journal of Alzheimer's disease : JAD. vol 15. issue 1. 2008-11-18. PMID:18780970. |
end points of neurotoxicity included dopamine (da) and tyrosine hydroxylase (th) concentrations in nsda axon terminals in the striatum, and stereological cell counts of th immunoreactive neurons in the substantia nigra. |
2008-11-18 |
2023-08-12 |
mouse |
| Tianhong Pan, Wen Zhu, Hongru Zhao, Hao Deng, Wenjie Xie, Joseph Jankovic, Weidong L. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain research. vol 1222. 2008-11-12. PMID:18579122. |
at same time, we found that there was a severer loss of tyrosine hydroxylase (th)-positive neurons in substantia nigra (sn) and greater reduction of striatal dopamine (da) levels in nurr1 +/- mice as compared with that in nurr1 +/+ mice. |
2008-11-12 |
2023-08-12 |
mouse |
| Riccardo Viaro, Rosario Sanchez-Pernaute, Matteo Marti, Claudio Trapella, Ole Isacson, Michele Morar. Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism. Neurobiology of disease. vol 30. issue 3. 2008-11-07. PMID:18413287. |
endogenous nociceptin/orphanin fq (n/ofq) inhibits the activity of dopamine neurons in the substantia nigra and affects motor behavior. |
2008-11-07 |
2023-08-12 |
mouse |
| Yan-Qin Wang, Gan-Lan Bian, Ya Bai, Rong Cao, Liang-Wei Che. Identification and kainic acid-induced up-regulation of low-affinity p75 neurotrophin receptor (p75NTR) in the nigral dopamine neurons of adult rats. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18639597. |
parkinson's disease is a common and severe debilitating neurological disease that results from massive and progressive degenerative death of dopamine neurons in the substantia nigra, but the mechanisms of neuronal degeneration and disease progression remains largely obscure. |
2008-11-06 |
2023-08-12 |
human |
| Yan-Qin Wang, Gan-Lan Bian, Ya Bai, Rong Cao, Liang-Wei Che. Identification and kainic acid-induced up-regulation of low-affinity p75 neurotrophin receptor (p75NTR) in the nigral dopamine neurons of adult rats. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18639597. |
taken together with previous data on p75ntr functions in neuronal apoptosis, this study also suggests that p75ntr may play important roles in neuronal cell survival or excitotoxic degeneration of dopamine neurons in the substantia nigra in pathogenesis of parkinson's disease in human beings. |
2008-11-06 |
2023-08-12 |
human |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin produces a long-lasting recovery in rats made hemiparkinsonian by 6-hydroxydopamine or lipopolysaccharide. Journal of the neurological sciences. vol 271. issue 1-2. 2008-11-05. PMID:18508084. |
the following day rats were dialysed to estimate extracellular striatal dopamine (da) and then sacrificed for estimation of striatal tissue da and subsequent immunohistochemistry of th(+) cells in the substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
rat |
| Rania Shamekh, Samuel Saporta, Don F Cameron, Alison E Willing, Cindy D Sanberg, Karl Johe, P R Sanber. Effects of Sertoli cell-conditioned medium on ventral midbrain neural stem cells: a preliminary report. Neurotoxicity research. vol 13. issue 3-4. 2008-11-05. PMID:18522903. |
the 796rmb cell line is a multipotent stem cell line isolated from human fetal midbrain tissues, a region from which dopamine neurons of the substantia nigra develop. |
2008-11-05 |
2023-08-12 |
human |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| Xiaodan Jiang, Ruxiang Xu, Zhijun Yang, Peng Jin, Qiang Xu, Gang Li, Wei Wang, Keli Liao, Xiaoqiu Liu, Yiquan Ke, Shizhong Zhang, Mouxuan Du, Yuxi Zou, Yingqian Cai, Yanjun Zen. Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrow. Cellular and molecular neurobiology. vol 28. issue 5. 2008-10-14. PMID:17805959. |
the verified cd133/nestin-positive bmscs-d-nscs were then transplanted into nude mice to detect the oncogenicity, into the right lateral cerebral ventricle or right caudae putamen and substantia nigra to examine, whether the symptoms were improved in parkinson's disease (pd) models after transplantation, by both spect image assay of dopamine transporter (dat) in corpus striatum and its average standard uptake value (suvave) in corpus striatum and thalamus. |
2008-10-14 |
2023-08-12 |
mouse |
| Shyamal H Mehta, John C Morgan, Kapil D Seth. Neuroimaging and transcranial ultrasonography in Parkinson's disease. Current neurology and neuroscience reports. vol 8. issue 4. 2008-10-09. PMID:18590613. |
parkinson's disease is a progressive, widespread, neurodegenerative disease in which the involvement of the dopaminergic neurons of the substantia nigra results in significant dopamine depletion in the striatum. |
2008-10-09 |
2023-08-12 |
Not clear |
| N M Kanaan, J H Kordower, T J Collie. Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18598263. |
there is a preferential loss of dopamine (da) neurons in the ventral tier of the substantia nigra (vtsn) compared to the dorsal tier and ventral tegmental area (vta) in pd. |
2008-10-09 |
2023-08-12 |
monkey |
| G A Oganesian, I V Romanova, E A Aristakesian, V V Kuzik, D M Makina, T Iu Morina, A E Khramenkova, I V Artamokhina, V A Belov. [Diencephalo-telencephalic changes of tyrosine hydroxylase in rats and common frogs (Rana temporaria) after sleep deprivation]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 44. issue 3. 2008-10-07. PMID:18727412. |
based on sleep deprivation-produced changes of electrographic parameters of the wakefulness--sleep cycle (wsc) in rats and common frogs, dynamics of activity of tyrosine hydroxylase, the key enzyme of dopamine synthesis, was studied immunohistochemically in substantia nigra and nigrostriatal pathway in rats and in striatum, paraventricular organ, and extrahypothalamic pathways in frogs. |
2008-10-07 |
2023-08-12 |
rat |
| Hironori Yokoyama, Sho Takagi, Yu Watanabe, Hiroyuki Kato, Tsutomu Arak. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235988. |
our immunohistochemical study showed that th (tyrosine hydroxylase) and dat (dopamine transporter) immunoreactivity was decreased significantly in the striatum and substantia nigra 5 days after mptp treatment. |
2008-10-03 |
2023-08-12 |
mouse |
| F Bergquist, M Ludwi. Dendritic transmitter release: a comparison of two model systems. Journal of neuroendocrinology. vol 20. issue 6. 2008-09-29. PMID:18601689. |
due to their anatomical features, the magnocellular vasopressin and oxytocin containing neurones of the hypothalamic supraoptic and paraventricular nuclei and the dopamine neurones of the substantia nigra have revealed important aspects of dendritic function including mechanisms of dendritic transmitter release. |
2008-09-29 |
2023-08-12 |
Not clear |
| Daniel Kondziella, Ursula Sonnewald, Mats Tullberg, Carsten Wikkels. Brain metabolism in adult chronic hydrocephalus. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18419769. |
compromised periventricular blood flow, decreased dopamine levels in the substantia nigra and damaged striatal gabaergic interneurons may reflect basal ganglia symptoms. |
2008-09-12 |
2023-08-12 |
human |
| Luigi Zecca, Luigi Casella, Alberto Albertini, Chiara Bellei, Fabio A Zucca, Mireille Engelen, Andrzej Zadlo, Grzegorz Szewczyk, Mariusz Zareba, Tadeusz Sarn. Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18624918. |
here, we investigated the interaction of neuromelanin from human substantia nigra with iron in the presence of ascorbic acid, dopamine, and hydrogen peroxide. |
2008-09-12 |
2023-08-12 |
human |
| Okihide Hikosak. [Decision-making and learning by cortico-basal ganglia network]. Brain and nerve = Shinkei kenkyu no shinpo. vol 60. issue 7. 2008-09-11. PMID:18646620. |
such reward-dependent modulation may be caused by inputs from dopamine neurons located in the substantia nigra and surrounding areas. |
2008-09-11 |
2023-08-12 |
monkey |