| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin produces a long-lasting recovery in rats made hemiparkinsonian by 6-hydroxydopamine or lipopolysaccharide. Journal of the neurological sciences. vol 271. issue 1-2. 2008-11-05. PMID:18508084. |
the following day rats were dialysed to estimate extracellular striatal dopamine (da) and then sacrificed for estimation of striatal tissue da and subsequent immunohistochemistry of th(+) cells in the substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
rat |
| Rania Shamekh, Samuel Saporta, Don F Cameron, Alison E Willing, Cindy D Sanberg, Karl Johe, P R Sanber. Effects of Sertoli cell-conditioned medium on ventral midbrain neural stem cells: a preliminary report. Neurotoxicity research. vol 13. issue 3-4. 2008-11-05. PMID:18522903. |
the 796rmb cell line is a multipotent stem cell line isolated from human fetal midbrain tissues, a region from which dopamine neurons of the substantia nigra develop. |
2008-11-05 |
2023-08-12 |
human |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| Xiaodan Jiang, Ruxiang Xu, Zhijun Yang, Peng Jin, Qiang Xu, Gang Li, Wei Wang, Keli Liao, Xiaoqiu Liu, Yiquan Ke, Shizhong Zhang, Mouxuan Du, Yuxi Zou, Yingqian Cai, Yanjun Zen. Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrow. Cellular and molecular neurobiology. vol 28. issue 5. 2008-10-14. PMID:17805959. |
the verified cd133/nestin-positive bmscs-d-nscs were then transplanted into nude mice to detect the oncogenicity, into the right lateral cerebral ventricle or right caudae putamen and substantia nigra to examine, whether the symptoms were improved in parkinson's disease (pd) models after transplantation, by both spect image assay of dopamine transporter (dat) in corpus striatum and its average standard uptake value (suvave) in corpus striatum and thalamus. |
2008-10-14 |
2023-08-12 |
mouse |
| Shyamal H Mehta, John C Morgan, Kapil D Seth. Neuroimaging and transcranial ultrasonography in Parkinson's disease. Current neurology and neuroscience reports. vol 8. issue 4. 2008-10-09. PMID:18590613. |
parkinson's disease is a progressive, widespread, neurodegenerative disease in which the involvement of the dopaminergic neurons of the substantia nigra results in significant dopamine depletion in the striatum. |
2008-10-09 |
2023-08-12 |
Not clear |
| N M Kanaan, J H Kordower, T J Collie. Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18598263. |
there is a preferential loss of dopamine (da) neurons in the ventral tier of the substantia nigra (vtsn) compared to the dorsal tier and ventral tegmental area (vta) in pd. |
2008-10-09 |
2023-08-12 |
monkey |
| G A Oganesian, I V Romanova, E A Aristakesian, V V Kuzik, D M Makina, T Iu Morina, A E Khramenkova, I V Artamokhina, V A Belov. [Diencephalo-telencephalic changes of tyrosine hydroxylase in rats and common frogs (Rana temporaria) after sleep deprivation]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 44. issue 3. 2008-10-07. PMID:18727412. |
based on sleep deprivation-produced changes of electrographic parameters of the wakefulness--sleep cycle (wsc) in rats and common frogs, dynamics of activity of tyrosine hydroxylase, the key enzyme of dopamine synthesis, was studied immunohistochemically in substantia nigra and nigrostriatal pathway in rats and in striatum, paraventricular organ, and extrahypothalamic pathways in frogs. |
2008-10-07 |
2023-08-12 |
rat |
| Hironori Yokoyama, Sho Takagi, Yu Watanabe, Hiroyuki Kato, Tsutomu Arak. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235988. |
our immunohistochemical study showed that th (tyrosine hydroxylase) and dat (dopamine transporter) immunoreactivity was decreased significantly in the striatum and substantia nigra 5 days after mptp treatment. |
2008-10-03 |
2023-08-12 |
mouse |
| F Bergquist, M Ludwi. Dendritic transmitter release: a comparison of two model systems. Journal of neuroendocrinology. vol 20. issue 6. 2008-09-29. PMID:18601689. |
due to their anatomical features, the magnocellular vasopressin and oxytocin containing neurones of the hypothalamic supraoptic and paraventricular nuclei and the dopamine neurones of the substantia nigra have revealed important aspects of dendritic function including mechanisms of dendritic transmitter release. |
2008-09-29 |
2023-08-12 |
Not clear |
| Daniel Kondziella, Ursula Sonnewald, Mats Tullberg, Carsten Wikkels. Brain metabolism in adult chronic hydrocephalus. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18419769. |
compromised periventricular blood flow, decreased dopamine levels in the substantia nigra and damaged striatal gabaergic interneurons may reflect basal ganglia symptoms. |
2008-09-12 |
2023-08-12 |
human |
| Luigi Zecca, Luigi Casella, Alberto Albertini, Chiara Bellei, Fabio A Zucca, Mireille Engelen, Andrzej Zadlo, Grzegorz Szewczyk, Mariusz Zareba, Tadeusz Sarn. Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18624918. |
here, we investigated the interaction of neuromelanin from human substantia nigra with iron in the presence of ascorbic acid, dopamine, and hydrogen peroxide. |
2008-09-12 |
2023-08-12 |
human |
| Okihide Hikosak. [Decision-making and learning by cortico-basal ganglia network]. Brain and nerve = Shinkei kenkyu no shinpo. vol 60. issue 7. 2008-09-11. PMID:18646620. |
such reward-dependent modulation may be caused by inputs from dopamine neurons located in the substantia nigra and surrounding areas. |
2008-09-11 |
2023-08-12 |
monkey |
| Jun-Ping Cao, Jing-Kao Yu, Chong Li, Yu Sun, Hong-Hua Yuan, Hong-Jun Wang, Dian-Shuai Ga. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. The Journal of comparative neurology. vol 509. issue 2. 2008-09-10. PMID:18465789. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor for the substantia nigra (sn) dopamine (da) neurons. |
2008-09-10 |
2023-08-12 |
Not clear |
| Ayse Ulusoy, Deniz Kiri. Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease? Experimental neurology. vol 212. issue 2. 2008-09-02. PMID:18538324. |
parkinson's disease (pd) is a progressive neurodegenerative disorder caused by selective degeneration of the dopamine producing neurons in the substantia nigra. |
2008-09-02 |
2023-08-12 |
Not clear |
| N Yamamoto, J-J Soghomonia. Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. Neuroscience. vol 154. issue 3. 2008-08-29. PMID:18495353. |
in the present study, the effects of a single or subchronic systemic administration of the dopamine d1/d5-preferring receptor agonist skf-81297 on gad65, gad67, ppd and vgat mrna levels in the striatum and gaba(a) receptor alpha1 subunit mrna levels in the substantia nigra, pars reticulata, were measured in rats with a unilateral 6-hydroxydopamine (6-ohda) lesion. |
2008-08-29 |
2023-08-12 |
rat |
| Ferogh A Ahmadi, Tom N Grammatopoulos, Andy M Poczobutt, Susan M Jones, Laurence D Snell, Mita Das, W Michael Zawad. Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17992568. |
among various types of neurons affected in parkinson's disease, dopamine (da) neurons of the substantia nigra undergo the most pronounced degeneration. |
2008-08-11 |
2023-08-12 |
rat |
| Mathieu Marella, Byoung Boo Seo, Eiko Nakamaru-Ogiso, J Timothy Greenamyre, Akemi Matsuno-Yagi, Takao Yag. Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease. PloS one. vol 3. issue 1. 2008-08-08. PMID:18197244. |
it was clear that the introduction of the ndi1 protein in the substantia nigra rendered resistance to the deleterious effects caused by rotenone exposure as assessed by the levels of tyrosine hydroxylase and dopamine. |
2008-08-08 |
2023-08-12 |
mouse |
| R G Nair-Roberts, S D Chatelain-Badie, E Benson, H White-Cooper, J P Bolam, M A Ungles. Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18355970. |
midbrain dopamine neurons in the ventral tegmental area, substantia nigra and retrorubral field play key roles in reward processing, learning and memory, and movement. |
2008-08-07 |
2023-08-12 |
rat |
| Lichuan Yang, Noel Y Calingasan, Beverly J Lorenzo, M Flint Bea. Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV. Experimental neurology. vol 211. issue 1. 2008-07-30. PMID:18328479. |
we found that rolipram administered at 1.25 mg/kg or 2.5 mg/kg doses significantly attenuated mptp-induced dopamine depletion in the striatum, and reduced the loss of tyrosine hydroxylase-positive neurons in the substantia nigra. |
2008-07-30 |
2023-08-12 |
mouse |
| Jeffrey H Kordower, Yaping Chu, Robert A Hauser, Thomas B Freeman, C Warren Olano. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nature medicine. vol 14. issue 5. 2008-07-17. PMID:18391962. |
these pathological changes suggest that parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. |
2008-07-17 |
2023-08-12 |
Not clear |