| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia Cechova, B Jill Vento. Transient adenosine efflux in the rat caudate-putamen. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18194431. |
in this study, we measured the subsecond time course of adenosine efflux in the caudate-putamen of anesthetized rats after a 1 s, high-frequency stimulation of dopamine neurons in the substantia nigra. |
2008-06-06 |
2023-08-12 |
rat |
| Mügen Terzioglu, Dagmar Galte. Parkinson's disease: genetic versus toxin-induced rodent models. The FEBS journal. vol 275. issue 7. 2008-06-03. PMID:18279376. |
parkinson's disease (pd), a common progressive neurodegenerative disorder, is characterized by degeneration of dopamine neurons in the substantia nigra and neuronal proteinaceous aggregates called lewy bodies (lbs). |
2008-06-03 |
2023-08-12 |
mouse |
| M Shamoto-Nagai, W Maruyama, Y Hashizume, M Yoshida, T Osawa, P Riederer, M Nao. In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 12. 2008-05-28. PMID:17690948. |
in parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. |
2008-05-28 |
2023-08-12 |
Not clear |
| M Shamoto-Nagai, W Maruyama, Y Hashizume, M Yoshida, T Osawa, P Riederer, M Nao. In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 12. 2008-05-28. PMID:17690948. |
this paper reports that in the dopamine neurons of the substantia nigra containing neuromelanin from pd patients, alphasyn was modified with acrolein (acr), an aldehyde product of lipid peroxidation. |
2008-05-28 |
2023-08-12 |
Not clear |
| Antonio J Herrera, Rocío M de Pablos, Eloisa Carreño-Müller, Ruth F Villarán, José L Venero, Mayka Tomás-Camardiel, Josefina Cano, Alberto Machad. The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18179476. |
when we studied the effects on substantia nigra, we found the disappearance of dopaminergic neurons, shown by loss of th immunoreactivity, loss of expression of th and dopamine transporter mrnas, and disappearance of fluorogold-labelled nigral neurons. |
2008-05-22 |
2023-08-12 |
rat |
| William J Burke, Vijaya B Kumar, Neeraj Pandey, W Michael Panneton, Qi Gan, Mark W Franko, Mark O'Dell, Shu Wen Li, Yi Pan, Hyung D Chung, James E Galvi. Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine. Acta neuropathologica. vol 115. issue 2. 2008-05-21. PMID:17965867. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopamine (da) neurons and the presence of alpha-synuclein (as) aggregates as lewy bodies (lbs) in the remaining substantia nigra (sn) neurons. |
2008-05-21 |
2023-08-12 |
rat |
| M Bousquet, M Saint-Pierre, C Julien, N Salem, F Cicchetti, F Calo. Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:18032633. |
high n-3 pufa dietary consumption completely prevented the mptp-induced decrease of tyrosine hydroxylase (th)-labeled nigral cells (p<0.01 vs. mptp mice on control diet), nurr1 mrna (p<0.01 vs. mptp mice on control diet), and dopamine transporter mrna levels (p<0.05 vs. mptp mice on control diet) in the substantia nigra. |
2008-05-16 |
2023-08-12 |
mouse |
| Göran Bertilsson, Cesare Patrone, Olof Zachrisson, Annica Andersson, Karin Dannaeus, Jessica Heidrich, Jarkko Kortesmaa, Alex Mercer, Elisabet Nielsen, Harriet Rönnholm, Lilian Wikströ. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17803225. |
in conclusion, our results show that exendin-4 is able to promote adult neurogenesis in vitro and in vivo, normalize dopamine imbalance, and increase the number of cells positive for markers of dopaminergic neurons in the substantia nigra in a model of parkinson's disease. |
2008-05-13 |
2023-08-12 |
rat |
| Florian Doepp, Michail Plotkin, Lara Siegel, Anatol Kivi, Doreen Gruber, Elmar Lobsien, Andreas Kupsch, Stephan J Schreibe. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 3. 2008-05-08. PMID:18067184. |
the echogenicity of the substantia nigra (sn) and the striatal binding of dopamine transporters (dat) were evaluated by tcs and fp-cit spect, respectively. |
2008-05-08 |
2023-08-12 |
Not clear |
| Chun-Hung Lin, Jui-Yen Huang, Cheng-Hsin Ching, Jih-Ing Chuan. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Journal of pineal research. vol 44. issue 2. 2008-05-05. PMID:18289173. |
rotenone subcutaneously infused for 14 days induced pd symptoms in rats, as indicated by reduced spontaneous locomotor activity (hypokinesis), loss of tyrosine hydroxylase (th, a marker enzyme for dopamine neurons) immunoreactivity in the substantia nigra and striatum, obvious alpha-synuclein accumulation, downregulated dat protein expression, and upregulated d2r expression. |
2008-05-05 |
2023-08-12 |
rat |
| Daniel Alvarez-Fischer, Carmen Henze, Corinna Strenzke, Jan Westrich, Boris Ferger, Günter U Höglinger, Wolfgang H Oertel, Andreas Hartman. Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053987. |
the aim of the present study was to characterize the time course of intra-striatal 6-ohda lesions in mice with regard to i) dopaminergic cell loss, ii) dopamine concentrations in the substantia nigra and the striatum, iii) hydroxylation products in substantia nigra and striatum and iv) behavioural impairment. |
2008-05-02 |
2023-08-12 |
mouse |
| Anupom Borah, Kochupurackal P Mohanakuma. Long-term L-DOPA treatment causes indiscriminate increase in dopamine levels at the cost of serotonin synthesis in discrete brain regions of rats. Cellular and molecular neurobiology. vol 27. issue 8. 2008-05-01. PMID:17934805. |
l-dopa, norepinephrine, 5-ht, 5-hydroxyindoleacetic acid (5-hiaa), dopamine, homovanillic acid (hva), and 3,4-dihydroxyphenylacetic acid (dopac) were measured in striatum, nucleus raphe dorsalis (nrd), nucleus accumbens (nac), substantia nigra, cerebellum, and cortex employing hplc-electrochemical procedure. |
2008-05-01 |
2023-08-12 |
rat |
| Kaya Bork, Christoph Kannicht, Sabine Nöhring, Werner Reutter, Wenke Weidemann, Gerald W Hart, Rüdiger Horstkort. N-propanoylmannosamine interferes with O-GlcNAc modification of the tyrosine 3-monooxygenase and stimulates dopamine secretion. Journal of neuroscience research. vol 86. issue 3. 2008-04-28. PMID:17896794. |
the most consistent neurochemical abnormality in parkinson's disease is degeneration of dopaminergic neurons in the substantia nigra, leading to a reduction of striatal dopamine levels. |
2008-04-28 |
2023-08-12 |
Not clear |
| Jon Stoess. Potential therapeutic targets for Parkinson's disease. Expert opinion on therapeutic targets. vol 12. issue 4. 2008-04-17. PMID:18348679. |
the cardinal features are related to dopamine deficiency, arising from loss of neurons projecting from the substantia nigra in the midbrain to the striatum. |
2008-04-17 |
2023-08-12 |
human |
| R Laguna Goya, P Tyers, R A Barke. The search for a curative cell therapy in Parkinson's disease. Journal of the neurological sciences. vol 265. issue 1-2. 2008-04-11. PMID:17936303. |
parkinson's disease (pd) is a neurodegenerative disorder, characterised by the progressive loss of dopaminergic neurons in the substantia nigra, and typically treated by dopamine replacement. |
2008-04-11 |
2023-08-12 |
human |
| Die Zhang, Shen Yang, Guo-Zhang Jin, Benjamin S Bunney, Wei-Xing Sh. Oscillatory firing of dopamine neurons: differences between cells in the substantia nigra and ventral tegmental area. Synapse (New York, N.Y.). vol 62. issue 3. 2008-04-11. PMID:18081182. |
oscillatory firing of dopamine neurons: differences between cells in the substantia nigra and ventral tegmental area. |
2008-04-11 |
2023-08-12 |
rat |
| Kimberlee D'Ardenne, Samuel M McClure, Leigh E Nystrom, Jonathan D Cohe. BOLD responses reflecting dopaminergic signals in the human ventral tegmental area. Science (New York, N.Y.). vol 319. issue 5867. 2008-03-13. PMID:18309087. |
although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fmri) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (vstr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (vta) and substantia nigra]. |
2008-03-13 |
2023-08-12 |
human |
| J Russel Keath, Michael P Iacoviello, Lindy E Barrett, Huibert D Mansvelder, Daniel S McGehe. Differential modulation by nicotine of substantia nigra versus ventral tegmental area dopamine neurons. Journal of neurophysiology. vol 98. issue 6. 2008-03-05. PMID:17942622. |
differential modulation by nicotine of substantia nigra versus ventral tegmental area dopamine neurons. |
2008-03-05 |
2023-08-12 |
Not clear |
| Haoyu Mao, Xi Fang, Katon M Floyd, Jeanette E Polcz, Ping Zhang, Bin Li. Induction of microglial reactive oxygen species production by the organochlorinated pesticide dieldrin. Brain research. vol 1186. 2008-03-04. PMID:17999924. |
dieldrin, a highly persistent organochlorinated pesticide found enriched in the substantia nigra of some postmortem pd brains, has been shown to be toxic to dopamine neurons. |
2008-03-04 |
2023-08-12 |
Not clear |
| I Rite, S Argüelles, J L Venero, S García-Rodriguez, A Ayala, J Cano, A Machad. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. Journal of neuroscience research. vol 85. issue 16. 2008-02-19. PMID:17705290. |
in this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss of more than 80% dopamine terminals in the striatum, with a similar diminution of dopamine levels in both structures. |
2008-02-19 |
2023-08-12 |
rat |