| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Päivi Lindholm, Merja H Voutilainen, Juha Laurén, Johan Peränen, Veli-Matti Leppänen, Jaan-Olle Andressoo, Maria Lindahl, Sanna Janhunen, Nisse Kalkkinen, Tõnis Timmusk, Raimo K Tuominen, Mart Saarm. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. vol 448. issue 7149. 2007-08-27. PMID:17611540. |
in parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. |
2007-08-27 |
2023-08-12 |
mouse |
| Lyn R Patric. Restless legs syndrome: pathophysiology and the role of iron and folate. Alternative medicine review : a journal of clinical therapeutic. vol 12. issue 2. 2007-08-14. PMID:17604457. |
these symptoms reflect a circadian fluctuation of dopamine in the substantia nigra. |
2007-08-14 |
2023-08-12 |
Not clear |
| Lyn R Patric. Restless legs syndrome: pathophysiology and the role of iron and folate. Alternative medicine review : a journal of clinical therapeutic. vol 12. issue 2. 2007-08-14. PMID:17604457. |
patients with rls have lower levels of dopamine in the substantia nigra and respond to iron administration. |
2007-08-14 |
2023-08-12 |
Not clear |
| Katarzyna Kuter, Maria Smiałowska, Joanna Wierońska, Barbara Zieba, Jadwiga Wardas, Małgorzata Pietraszek, Przemysław Nowak, Izabela Biedka, Wojciech Roczniak, Jolanta Konieczny, Stanisław Wolfarth, Krystyna Ossowsk. Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats. Brain research. vol 1155. 2007-08-13. PMID:17493592. |
two days after withdrawal the levels of the dopamine metabolites and dopamine turnover in the caudate-putamen, substantia nigra and prefrontal cortex were reduced by ca. |
2007-08-13 |
2023-08-12 |
rat |
| Katarzyna Kuter, Maria Smiałowska, Joanna Wierońska, Barbara Zieba, Jadwiga Wardas, Małgorzata Pietraszek, Przemysław Nowak, Izabela Biedka, Wojciech Roczniak, Jolanta Konieczny, Stanisław Wolfarth, Krystyna Ossowsk. Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats. Brain research. vol 1155. 2007-08-13. PMID:17493592. |
three days after paraquat withdrawal, the level of dopamine in the caudate-putamen was significantly increased, and earlier decreases in dopac and hva in the substantia nigra, as well as [(3)h]gbr 12,935 binding in the caudate-putamen were reversed. |
2007-08-13 |
2023-08-12 |
rat |
| Gloria Lazzeri, Paola Lenzi, Carla L Busceti, Michela Ferrucci, Alessandra Falleni, Valeria Bruno, Antonio Paparelli, Francesco Forna. Mechanisms involved in the formation of dopamine-induced intracellular bodies within striatal neurons. Journal of neurochemistry. vol 101. issue 5. 2007-08-06. PMID:17286589. |
in vivo studies demonstrate the occurrence of these morphological alterations both in the dopamine (da) neurons of the substantia nigra and striatal cells. |
2007-08-06 |
2023-08-12 |
Not clear |
| Huifang Ji, Paul D Shepar. Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 26. 2007-08-01. PMID:17596440. |
single-pulse stimulation of the lhb (0.5 ma, 100 micros) transiently suppressed the activity of 97% of the dopamine neurons recorded in the substantia nigra and ventral tegmental area. |
2007-08-01 |
2023-08-12 |
rat |
| Ronald L Klein, Robert D Dayton, Nancy J Leidenheimer, Karen Jansen, Todd E Golde, Richard M Zwei. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Molecular therapy : the journal of the American Society of Gene Therapy. vol 13. issue 3. 2007-07-31. PMID:16325474. |
in the substantia nigra, the gfp expression conferred by aav8 was toxic to dopamine neurons, although toxicity could be avoided with dose titration. |
2007-07-31 |
2023-08-12 |
rat |
| Tanuja Bordia, Sharon R Grady, J Michael McIntosh, Maryka Qui. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Molecular pharmacology. vol 72. issue 1. 2007-07-30. PMID:17409284. |
parkinson's disease is a neurodegenerative movement disorder characterized by a loss of substantia nigra dopamine neurons, and corresponding declines in molecular components present on striatal dopaminergic nerve terminals. |
2007-07-30 |
2023-08-12 |
mouse |
| Hiroo Yamaguchi, Jie She. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular neurodegeneration. vol 2. 2007-07-30. PMID:17535435. |
we found that dj-1-/- mice at the age of 24-27 months have normal numbers of dopaminergic neurons in the substantia nigra and normal levels of dopamine and its major metabolites in the striatum. |
2007-07-30 |
2023-08-12 |
mouse |
| A Wasik, I Romańska, L Antkiewicz-Michalu. The effect of an endogenous compound 1-methyl-1,2,3,4,-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 2. 2007-07-26. PMID:17622694. |
in this study, we investigated the effect of 1metiq on morphine-induced analgesia, tolerance and abstinence syndrome as well as its effect on morphine-induced changes in dopamine metabolism in rat brain structures (nucleus accumbens, striatum, substantia nigra) using hplc methodology. |
2007-07-26 |
2023-08-12 |
rat |
| Gan-Lan Bian, Li-Chun Wei, Mei Shi, Yan-Qin Wang, Rong Cao, Liang-Wei Che. Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine-treated C57BL/6 mice. Brain research. vol 1150. 2007-07-24. PMID:17397812. |
the animal model was first prepared by intraperitoneal injection of neurotoxicant mptp that can specifically induce degeneration of dopamine neurons in the substantia nigra of c57bl/6 mice. |
2007-07-24 |
2023-08-12 |
mouse |
| Marko Schirmer, Alina Lessenich, Sven Lindemann, Wolfgang Lösche. Marked differences in response to dopamine receptor antagonism in two rat mutants, ci2 and ci3, with lateralized rotational behavior. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17442411. |
both mutants show abnormal lateralities in striatal dopamine and in the density of dopaminergic neurons in substantia nigra or ventral tegmental area, which may be involved in the behavioral phenotype of these rats. |
2007-07-24 |
2023-08-12 |
rat |
| David Sulze. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends in neurosciences. vol 30. issue 5. 2007-07-12. PMID:17418429. |
we discuss the properties of substantia nigra dopamine neurons that might make them particular targets of such multiple hits. |
2007-07-12 |
2023-08-12 |
Not clear |
| Sarah N Blythe, Jeremy F Atherton, Mark D Beva. Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. Journal of neurophysiology. vol 97. issue 4. 2007-07-10. PMID:17251363. |
synaptic activation of dendritic ampa and nmda receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. |
2007-07-10 |
2023-08-12 |
rat |
| Sarah N Blythe, Jeremy F Atherton, Mark D Beva. Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. Journal of neurophysiology. vol 97. issue 4. 2007-07-10. PMID:17251363. |
transient high-frequency activity of substantia nigra dopamine neurons is critical for striatal synaptic plasticity and associative learning. |
2007-07-10 |
2023-08-12 |
rat |
| Sarah N Blythe, Jeremy F Atherton, Mark D Beva. Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. Journal of neurophysiology. vol 97. issue 4. 2007-07-10. PMID:17251363. |
taken together, these data suggest that dendritic ampa and nmda receptor-mediated synaptic conductances are sufficient to generate transient high-frequency activity in substantia nigra dopamine neurons by rapidly but transiently overwhelming the conductances underlying action potential afterhyperpolarization and/or engaging postsynaptic voltage-dependent ion channels in a manner that overcomes the limiting effects of afterhyperpolarization. |
2007-07-10 |
2023-08-12 |
rat |
| Katarzyna A Trzaska, Pranela Rameshwa. Current advances in the treatment of Parkinson's disease with stem cells. Current neurovascular research. vol 4. issue 2. 2007-07-06. PMID:17504208. |
control of motor behavior is lost in pd due to the selective degeneration of mesencephalic dopamine neurons (da) in the substantia nigra. |
2007-07-06 |
2023-08-12 |
Not clear |
| Patricio Fuentes, Irmgard Paris, Melissa Nassif, Pablo Caviedes, Juan Segura-Aguila. Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies. Chemical research in toxicology. vol 20. issue 5. 2007-07-05. PMID:17425337. |
we have induced intracellular dopamine oxidation to aminochrome in rcsn-3 cells derived from rat substantia nigra by inhibiting vmat-2 with reserpine to increase free cytosolic dopamine concentration, to study aminochrome-dependent neurotoxicity in the absence of exogenous oxidizing agents such as metals, which may potentiate an aminochrome cytotoxic effect. |
2007-07-05 |
2023-08-12 |
rat |
| H Wang, J Katz, P Dagostino, J-J Soghomonia. Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. Neuroscience. vol 145. issue 2. 2007-06-26. PMID:17218060. |
unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic l-dopa administration in the adult rat alters the expression of the vesicular gaba transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. |
2007-06-26 |
2023-08-12 |
rat |