| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tanuja Bordia, Sharon R Grady, J Michael McIntosh, Maryka Qui. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Molecular pharmacology. vol 72. issue 1. 2007-07-30. PMID:17409284. |
parkinson's disease is a neurodegenerative movement disorder characterized by a loss of substantia nigra dopamine neurons, and corresponding declines in molecular components present on striatal dopaminergic nerve terminals. |
2007-07-30 |
2023-08-12 |
mouse |
| Hiroo Yamaguchi, Jie She. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular neurodegeneration. vol 2. 2007-07-30. PMID:17535435. |
we found that dj-1-/- mice at the age of 24-27 months have normal numbers of dopaminergic neurons in the substantia nigra and normal levels of dopamine and its major metabolites in the striatum. |
2007-07-30 |
2023-08-12 |
mouse |
| A Wasik, I Romańska, L Antkiewicz-Michalu. The effect of an endogenous compound 1-methyl-1,2,3,4,-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 58. issue 2. 2007-07-26. PMID:17622694. |
in this study, we investigated the effect of 1metiq on morphine-induced analgesia, tolerance and abstinence syndrome as well as its effect on morphine-induced changes in dopamine metabolism in rat brain structures (nucleus accumbens, striatum, substantia nigra) using hplc methodology. |
2007-07-26 |
2023-08-12 |
rat |
| Gan-Lan Bian, Li-Chun Wei, Mei Shi, Yan-Qin Wang, Rong Cao, Liang-Wei Che. Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine-treated C57BL/6 mice. Brain research. vol 1150. 2007-07-24. PMID:17397812. |
the animal model was first prepared by intraperitoneal injection of neurotoxicant mptp that can specifically induce degeneration of dopamine neurons in the substantia nigra of c57bl/6 mice. |
2007-07-24 |
2023-08-12 |
mouse |
| Marko Schirmer, Alina Lessenich, Sven Lindemann, Wolfgang Lösche. Marked differences in response to dopamine receptor antagonism in two rat mutants, ci2 and ci3, with lateralized rotational behavior. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17442411. |
both mutants show abnormal lateralities in striatal dopamine and in the density of dopaminergic neurons in substantia nigra or ventral tegmental area, which may be involved in the behavioral phenotype of these rats. |
2007-07-24 |
2023-08-12 |
rat |
| David Sulze. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends in neurosciences. vol 30. issue 5. 2007-07-12. PMID:17418429. |
we discuss the properties of substantia nigra dopamine neurons that might make them particular targets of such multiple hits. |
2007-07-12 |
2023-08-12 |
Not clear |
| Sarah N Blythe, Jeremy F Atherton, Mark D Beva. Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. Journal of neurophysiology. vol 97. issue 4. 2007-07-10. PMID:17251363. |
synaptic activation of dendritic ampa and nmda receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. |
2007-07-10 |
2023-08-12 |
rat |
| Sarah N Blythe, Jeremy F Atherton, Mark D Beva. Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. Journal of neurophysiology. vol 97. issue 4. 2007-07-10. PMID:17251363. |
transient high-frequency activity of substantia nigra dopamine neurons is critical for striatal synaptic plasticity and associative learning. |
2007-07-10 |
2023-08-12 |
rat |
| Sarah N Blythe, Jeremy F Atherton, Mark D Beva. Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. Journal of neurophysiology. vol 97. issue 4. 2007-07-10. PMID:17251363. |
taken together, these data suggest that dendritic ampa and nmda receptor-mediated synaptic conductances are sufficient to generate transient high-frequency activity in substantia nigra dopamine neurons by rapidly but transiently overwhelming the conductances underlying action potential afterhyperpolarization and/or engaging postsynaptic voltage-dependent ion channels in a manner that overcomes the limiting effects of afterhyperpolarization. |
2007-07-10 |
2023-08-12 |
rat |
| Katarzyna A Trzaska, Pranela Rameshwa. Current advances in the treatment of Parkinson's disease with stem cells. Current neurovascular research. vol 4. issue 2. 2007-07-06. PMID:17504208. |
control of motor behavior is lost in pd due to the selective degeneration of mesencephalic dopamine neurons (da) in the substantia nigra. |
2007-07-06 |
2023-08-12 |
Not clear |
| Patricio Fuentes, Irmgard Paris, Melissa Nassif, Pablo Caviedes, Juan Segura-Aguila. Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies. Chemical research in toxicology. vol 20. issue 5. 2007-07-05. PMID:17425337. |
we have induced intracellular dopamine oxidation to aminochrome in rcsn-3 cells derived from rat substantia nigra by inhibiting vmat-2 with reserpine to increase free cytosolic dopamine concentration, to study aminochrome-dependent neurotoxicity in the absence of exogenous oxidizing agents such as metals, which may potentiate an aminochrome cytotoxic effect. |
2007-07-05 |
2023-08-12 |
rat |
| H Wang, J Katz, P Dagostino, J-J Soghomonia. Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. Neuroscience. vol 145. issue 2. 2007-06-26. PMID:17218060. |
unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic l-dopa administration in the adult rat alters the expression of the vesicular gaba transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. |
2007-06-26 |
2023-08-12 |
rat |
| H Wang, J Katz, P Dagostino, J-J Soghomonia. Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. Neuroscience. vol 145. issue 2. 2007-06-26. PMID:17218060. |
the loss of dopamine neurons combined or not with the subsequent administration of l-dopa in patients with parkinson's disease or in experimental models of the disease results in altered gabaergic signaling throughout the basal ganglia, including the striatum and the substantia nigra, pars reticulata. |
2007-06-26 |
2023-08-12 |
rat |
| L Antkiewicz-Michaluk, M Filip, J Michaluk, I Romańska, E Przegaliński, J Vetulan. An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 3. 2007-06-21. PMID:16897599. |
the priming cocaine dose inhibited dopamine metabolism in the structures containing nerve endings (frontal cortex, nucleus accumbens, and striatum) but not in the substantia nigra and ventral tegmental area. |
2007-06-21 |
2023-08-12 |
rat |
| L Antkiewicz-Michaluk, M Filip, J Michaluk, I Romańska, E Przegaliński, J Vetulan. An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 3. 2007-06-21. PMID:16897599. |
a behaviorally active dose of 1-methyl-1,2,3,4-tetrahydroisoquinoline administered 30 min before a priming dose of cocaine significantly increased the dopamine concentration in the limbic structures, and strongly inhibited dopamine metabolism in the substantia nigra and ventral tegmental area. |
2007-06-21 |
2023-08-12 |
rat |
| Agnes Vehovszky, Henriette Szabó, László Hiripi, Christopher J H Elliott, László Hernád. Behavioural and neural deficits induced by rotenone in the pond snail Lymnaea stagnalis. A possible model for Parkinson's disease in an invertebrate. The European journal of neuroscience. vol 25. issue 7. 2007-06-21. PMID:17439496. |
parkinson's disease is a neurodegenerative disorder, related to the loss of dopamine (da)-containing neurons in the substantia nigra. |
2007-06-21 |
2023-08-12 |
Not clear |
| Rebekah J Jakel, Jessica A Townsend, Andrew D Kraft, Jeffrey A Johnso. Nrf2-mediated protection against 6-hydroxydopamine. Brain research. vol 1144. 2007-06-13. PMID:17336276. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by cell loss in the substantia nigra resulting in striatal dopamine depletion. |
2007-06-13 |
2023-08-12 |
mouse |
| Marat V Avshalumov, Li Bao, Jyoti C Patel, Margaret E Ric. H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Antioxidants & redox signaling. vol 9. issue 2. 2007-06-12. PMID:17115944. |
in this review, data are summarized to show that h2o2 is a diffusible messenger in the striatum, generated downstream from glutamate receptor activation, and an intracellular signal in dopamine neurons of the substantia nigra, generated during normal pacemaker activity. |
2007-06-12 |
2023-08-12 |
Not clear |
| Jelena Mijatovic, Mikko Airavaara, Anu Planken, Petri Auvinen, Atso Raasmaja, T Petteri Piepponen, Frank Costantini, Liisa Ahtee, Mart Saarm. Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 18. 2007-06-06. PMID:17475787. |
constitutive ret activity in knock-in multiple endocrine neoplasia type b mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of th-positive cells in the substantia nigra. |
2007-06-06 |
2023-08-12 |
mouse |
| John L Beard, Erica L Unger, Laura E Bianco, Tessy Paul, Sarah E Rundle, Byron C Jone. Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats. The Journal of nutrition. vol 137. issue 5. 2007-05-31. PMID:17449578. |
dopamine transporter densities in caudate and substantia nigra were lower in id rats but were normalized with iron repletion. |
2007-05-31 |
2023-08-12 |
rat |