| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason R Cannon, Victor Tapias, Hye Mee Na, Anthony S Honick, Robert E Drolet, J Timothy Greenamyr. A highly reproducible rotenone model of Parkinson's disease. Neurobiology of disease. vol 34. issue 2. 2009-08-04. PMID:19385059. |
rotenone treatment caused a 45% loss of tyrosine hydroxylase-positive substantia nigra neurons and a commensurate loss of striatal dopamine. |
2009-08-04 |
2023-08-12 |
human |
| Jason R Cannon, Victor Tapias, Hye Mee Na, Anthony S Honick, Robert E Drolet, J Timothy Greenamyr. A highly reproducible rotenone model of Parkinson's disease. Neurobiology of disease. vol 34. issue 2. 2009-08-04. PMID:19385059. |
additionally, in rotenone-treated animals, alpha-synuclein and poly-ubiquitin positive aggregates were observed in dopamine neurons of the substantia nigra. |
2009-08-04 |
2023-08-12 |
human |
| Randy L Hunter, Baohua Cheng, Dong-Young Choi, Mei Liu, Shuwei Liu, Wayne A Cass, Guoying Bin. Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice. Journal of neuroscience research. vol 87. issue 8. 2009-07-30. PMID:19224579. |
we showed progressive and specific dopaminergic neurodegeneration in the substantia nigra, which is accompanied by striatal dopamine depletion and progressive behavioral impairment, which was alleviated by the use of the pd drug l-dopa. |
2009-07-30 |
2023-08-12 |
mouse |
| Yu Shin Kim, Jung Hoon Shin, F Scott Hall, David J Linde. Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 26. 2009-07-20. PMID:19571144. |
previous work in other brain regions, such as the substantia nigra and ventral tegmental area, has shown that dopamine can be released from dendrites to produce paracrine and autocrine signaling. |
2009-07-20 |
2023-08-12 |
mouse |
| Arthur S Walters, William G Ondo, Wen Zhu, Weidong L. Does the endogenous opiate system play a role in the Restless Legs Syndrome? A pilot post-mortem study. Journal of the neurological sciences. vol 279. issue 1-2. 2009-07-17. PMID:19167016. |
there was no difference in leu-enkephalin in the thalamus or changes in beta endorphin, met-enkephalin, leu-enkephalin or tyrosine hydroxylase, the rate limiting step for dopamine synthesis, in the substantia nigra. |
2009-07-17 |
2023-08-12 |
Not clear |
| Min Jeong Kang, Suk Ju Gil, Hyun Chul Ko. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. Toxicology letters. vol 188. issue 2. 2009-07-13. PMID:19446248. |
paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. |
2009-07-13 |
2023-08-12 |
mouse |
| Min Jeong Kang, Suk Ju Gil, Hyun Chul Ko. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. Toxicology letters. vol 188. issue 2. 2009-07-13. PMID:19446248. |
in this study, we investigated the effect of pq on dopamine (da) and glutathione levels in the substantia nigra (sn) of mice. |
2009-07-13 |
2023-08-12 |
mouse |
| Mark T Harnett, Brian E Bernier, Kee-Chan Ahn, Hitoshi Morikaw. Burst-timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. Neuron. vol 62. issue 6. 2009-07-09. PMID:19555651. |
here we report ltp of nmdar-mediated excitatory transmission onto dopamine neurons in the substantia nigra. |
2009-07-09 |
2023-08-12 |
Not clear |
| Olle Bergman, Anna Håkansson, Lars Westberg, Andrea Carmine Belin, Olof Sydow, Lars Olson, Björn Holmberg, Laura Fratiglioni, Lars Bäckman, Elias Eriksson, Hans Nissbrand. Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease? Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 3. 2009-07-01. PMID:19189040. |
the key symptoms of parkinson's disease (pd) are caused by degeneration of dopamine neurons originating in substantia nigra. |
2009-07-01 |
2023-08-12 |
human |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin greatly attenuates loss of extracellular striatal dopamine in rat models of Parkinson's disease by activating CRF(1) receptors. European journal of pharmacology. vol 604. issue 1-3. 2009-06-24. PMID:19026631. |
in the substantia nigra tissue dopamine changes mirrored those seen in striatal extracellular dopamine. |
2009-06-24 |
2023-08-12 |
rat |
| Shun Wang, Xiu-jie Qi, Di Ha. [Effect of electroacupuncture scalp point-through-point therapy on the expression of tyrosine hydroxylase and dopamine transporter mRNAs in substantia nigra of Parkinson's disease model rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 29. issue 5. 2009-06-24. PMID:19489498. |
[effect of electroacupuncture scalp point-through-point therapy on the expression of tyrosine hydroxylase and dopamine transporter mrnas in substantia nigra of parkinson's disease model rats]. |
2009-06-24 |
2023-08-12 |
rat |
| Tomokazu Amano, Theodora Papanikolaou, Li-Ying Sung, Jessica Lennington, Joanne Conover, Xiangzhong Yan. Nuclear transfer embryonic stem cells provide an in vitro culture model for Parkinson's disease. Cloning and stem cells. vol 11. issue 1. 2009-05-26. PMID:19196042. |
aphakia mice contain deletions in the pitx3 gene and show selective loss of dopamine neurons of the substantia nigra, specifically the neuron population susceptible to degeneration in parkinson's disease. |
2009-05-26 |
2023-08-12 |
mouse |
| Eugene V Mosharov, Kristin E Larsen, Ellen Kanter, Kester A Phillips, Krystal Wilson, Yvonne Schmitz, David E Krantz, Kazuto Kobayashi, Robert H Edwards, David Sulze. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. vol 62. issue 2. 2009-05-20. PMID:19409267. |
interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. |
2009-05-20 |
2023-08-12 |
Not clear |
| Sabrina Wang, Jia-Ying Yan, Yu-Kang Lo, Paul M Carvey, Zaodung Lin. Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. Brain research. vol 1265. 2009-05-13. PMID:19236855. |
we have reported previously that prenatal bacterial lipopolysaccharide (lps) exposure at the gestation window of vulnerability could consistently lead to dopamine (da) neuron loss in the substantia nigra (sn). |
2009-05-13 |
2023-08-12 |
rat |
| Katsumasa Muneoka, Yukihiko Shirayama, Morikuni Takigawa, Seiji Shiod. Brain region-specific effects of short-term treatment with duloxetine, venlafaxine, milnacipran and sertraline on monoamine metabolism in rats. Neurochemical research. vol 34. issue 3. 2009-05-11. PMID:18751896. |
venlafaxine significantly increased dopamine (da) levels in the nucleus accumbens (nac) and the substantia nigra and decreased da turnover in the nac. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
in this study, oea-induced neuroprotection has been tested in vitro and in vivo models of 6-ohda-induced degeneration of substantia nigra dopamine neurons. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
first, ppar-alpha receptors were confirmed to be located in the nigrostriatal circuit, these receptors being expressed by dopamine neurons of the substantia nigra, and intrinsic neurons and fibers bundles of the dorsal striatum. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
in conclusion, oea shows u-shaped partial and dose-dependent neuroprotective properties both in vitro and in vivo models of substantia nigra dopamine neuron degeneration. |
2009-05-11 |
2023-08-12 |
rat |
| H Braak, K Del Tredic. [A new look at the corticostriatal-thalamocortical circuit in sporadic Parkinson's disease]. Der Nervenarzt. vol 79. issue 12. 2009-04-20. PMID:18726081. |
in the classic model, major emphasis is placed on the dopamine deficiency in the dorsal striatum that occurs as a result of neuronal loss in the substantia nigra of the midbrain. |
2009-04-20 |
2023-08-12 |
Not clear |