| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olle Bergman, Anna Håkansson, Lars Westberg, Andrea Carmine Belin, Olof Sydow, Lars Olson, Björn Holmberg, Laura Fratiglioni, Lars Bäckman, Elias Eriksson, Hans Nissbrand. Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease? Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 3. 2009-07-01. PMID:19189040. |
the key symptoms of parkinson's disease (pd) are caused by degeneration of dopamine neurons originating in substantia nigra. |
2009-07-01 |
2023-08-12 |
human |
| Amjad Abuirmeileh, Alexander Harkavyi, Ann Kingsbury, Rebecca Lever, Peter S Whitto. The CRF-like peptide urocortin greatly attenuates loss of extracellular striatal dopamine in rat models of Parkinson's disease by activating CRF(1) receptors. European journal of pharmacology. vol 604. issue 1-3. 2009-06-24. PMID:19026631. |
in the substantia nigra tissue dopamine changes mirrored those seen in striatal extracellular dopamine. |
2009-06-24 |
2023-08-12 |
rat |
| Shun Wang, Xiu-jie Qi, Di Ha. [Effect of electroacupuncture scalp point-through-point therapy on the expression of tyrosine hydroxylase and dopamine transporter mRNAs in substantia nigra of Parkinson's disease model rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 29. issue 5. 2009-06-24. PMID:19489498. |
[effect of electroacupuncture scalp point-through-point therapy on the expression of tyrosine hydroxylase and dopamine transporter mrnas in substantia nigra of parkinson's disease model rats]. |
2009-06-24 |
2023-08-12 |
rat |
| Tomokazu Amano, Theodora Papanikolaou, Li-Ying Sung, Jessica Lennington, Joanne Conover, Xiangzhong Yan. Nuclear transfer embryonic stem cells provide an in vitro culture model for Parkinson's disease. Cloning and stem cells. vol 11. issue 1. 2009-05-26. PMID:19196042. |
aphakia mice contain deletions in the pitx3 gene and show selective loss of dopamine neurons of the substantia nigra, specifically the neuron population susceptible to degeneration in parkinson's disease. |
2009-05-26 |
2023-08-12 |
mouse |
| Eugene V Mosharov, Kristin E Larsen, Ellen Kanter, Kester A Phillips, Krystal Wilson, Yvonne Schmitz, David E Krantz, Kazuto Kobayashi, Robert H Edwards, David Sulze. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. vol 62. issue 2. 2009-05-20. PMID:19409267. |
interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. |
2009-05-20 |
2023-08-12 |
Not clear |
| Sabrina Wang, Jia-Ying Yan, Yu-Kang Lo, Paul M Carvey, Zaodung Lin. Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. Brain research. vol 1265. 2009-05-13. PMID:19236855. |
we have reported previously that prenatal bacterial lipopolysaccharide (lps) exposure at the gestation window of vulnerability could consistently lead to dopamine (da) neuron loss in the substantia nigra (sn). |
2009-05-13 |
2023-08-12 |
rat |
| Katsumasa Muneoka, Yukihiko Shirayama, Morikuni Takigawa, Seiji Shiod. Brain region-specific effects of short-term treatment with duloxetine, venlafaxine, milnacipran and sertraline on monoamine metabolism in rats. Neurochemical research. vol 34. issue 3. 2009-05-11. PMID:18751896. |
venlafaxine significantly increased dopamine (da) levels in the nucleus accumbens (nac) and the substantia nigra and decreased da turnover in the nac. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
in this study, oea-induced neuroprotection has been tested in vitro and in vivo models of 6-ohda-induced degeneration of substantia nigra dopamine neurons. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
first, ppar-alpha receptors were confirmed to be located in the nigrostriatal circuit, these receptors being expressed by dopamine neurons of the substantia nigra, and intrinsic neurons and fibers bundles of the dorsal striatum. |
2009-05-11 |
2023-08-12 |
rat |
| B Galan-Rodriguez, J Suarez, R Gonzalez-Aparicio, F J Bermudez-Silva, R Maldonado, P Robledo, F Rodriguez de Fonseca, E Fernandez-Espej. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19070629. |
in conclusion, oea shows u-shaped partial and dose-dependent neuroprotective properties both in vitro and in vivo models of substantia nigra dopamine neuron degeneration. |
2009-05-11 |
2023-08-12 |
rat |
| H Braak, K Del Tredic. [A new look at the corticostriatal-thalamocortical circuit in sporadic Parkinson's disease]. Der Nervenarzt. vol 79. issue 12. 2009-04-20. PMID:18726081. |
in the classic model, major emphasis is placed on the dopamine deficiency in the dorsal striatum that occurs as a result of neuronal loss in the substantia nigra of the midbrain. |
2009-04-20 |
2023-08-12 |
Not clear |
| Hong-Guo Jin, Hiroshi Yamashita, Takeshi Nakamura, Hiromasa Fukuba, Tetsuya Takahashi, Masanori Hiji, Tatsuo Kohriyama, Masayasu Matsumot. Synphilin-1 transgenic mice exhibit mild motor impairments. Neuroscience letters. vol 445. issue 1. 2009-04-14. PMID:18782602. |
synphilin-1 was widely expressed in neurons in the brain including the substantia nigra, where massive loss of dopamine neurons was not observed. |
2009-04-14 |
2023-08-12 |
mouse |
| Maria A Mena, Justo García de Yébene. Glial cells as players in parkinsonism: the "good," the "bad," and the "mysterious" glia. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 14. issue 6. 2009-04-14. PMID:19029058. |
the proportion of astrocytes surrounding dopamine (da) neurons in the substantia nigra, the target nucleus for neurodegeneration in pd, is the lowest for any brain area, suggesting that da neurons are more vulnerable in terms of glial support than any neuron in other brain areas. |
2009-04-14 |
2023-08-12 |
Not clear |
| Vincent Ries, Robert M Silva, Tinmarla F Oo, Hsiao-Chun Cheng, Margarita Rzhetskaya, Nikolai Kholodilov, Richard A Flavell, Chia-Yi Kuan, Pasko Rakic, Robert E Burk. JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. Journal of neurochemistry. vol 107. issue 6. 2009-04-09. PMID:19014392. |
jnk2 and jnk3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. |
2009-04-09 |
2023-08-12 |
Not clear |
| Vincent Ries, Robert M Silva, Tinmarla F Oo, Hsiao-Chun Cheng, Margarita Rzhetskaya, Nikolai Kholodilov, Richard A Flavell, Chia-Yi Kuan, Pasko Rakic, Robert E Burk. JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. Journal of neurochemistry. vol 107. issue 6. 2009-04-09. PMID:19014392. |
activation of c-jun n-terminal kinase (jnk) by the mitogen-activated protein kinase cascade has been shown to play an important role in the death of dopamine neurons of the substantia nigra, one of the principal neuronal populations affected in parkinson's disease. |
2009-04-09 |
2023-08-12 |
Not clear |
| Wakoto Matsuda, Takahiro Furuta, Kouichi C Nakamura, Hiroyuki Hioki, Fumino Fujiyama, Ryohachi Arai, Takeshi Kanek. Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 2. 2009-04-08. PMID:19144844. |
our findings demonstrate that individual dopaminergic neurons of the substantia nigra can broadcast a dopamine signal and exert strong influence over a large number of striatal neurons. |
2009-04-08 |
2023-08-12 |
rat |
| Ilva Putzier, Paul H M Kullmann, John P Horn, Edwin S Levita. Dopamine neuron responses depend exponentially on pacemaker interval. Journal of neurophysiology. vol 101. issue 2. 2009-03-26. PMID:19073798. |
here responses of substantia nigra dopamine neurons to defined dynamic-clamp stimuli were measured to quantify the impact of cell-to-cell variation in intrinsic pacemaker rate. |
2009-03-26 |
2023-08-12 |
human |
| Haolan Ruan, Yi Yang, Xiaonan Zhu, Xuelan Wang, Ruzhu Che. Neuroprotective effects of (+/-)-catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19070648. |
mptp caused the death of dopaminergic neurons in the substantia nigra and decreased the level of striatal dopamine. |
2009-03-24 |
2023-08-12 |
mouse |
| Haolan Ruan, Yi Yang, Xiaonan Zhu, Xuelan Wang, Ruzhu Che. Neuroprotective effects of (+/-)-catechin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mice. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19070648. |
however, pretreatment with (+/-)-catechin was found to protect dopaminergic neurons in the substantia nigra against mptp toxicity, and restore the depletion of striatal dopamine in mice. |
2009-03-24 |
2023-08-12 |
mouse |