| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T N Ferraro, G T Golden, M DeMattei, T A Hare, R G Fariell. Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse. Neuropharmacology. vol 25. issue 9. 1986-12-12. PMID:2430229. |
depletion of striatal dopamine and metabolites in mptp-treated mice is accompanied by depletion of glutathione (gsh) in the substantia nigra (sn). |
1986-12-12 |
2023-08-11 |
mouse |
| S N Habe. Neurotransmitters in the human and nonhuman primate basal ganglia. Human neurobiology. vol 5. issue 3. 1986-12-09. PMID:2876974. |
these include: the well-described terminal fields in the striatum which originate from the brain stem and contain the monoamines, dopamine and serotonin; amino acid containing axons projecting from the cortex and thalamus; striatal cholinergic and peptide-positive interneurons; and amino acid and peptide containing projection neurons to the globus pallidus and substantia nigra. |
1986-12-09 |
2023-08-11 |
human |
| G Jonsson, E Nwanze, J Luthman, E Sundströ. Effect of MPTP and its pyridinium metabolites on monoamine uptake and on central catecholamine neurons in mice. Acta physiologica Scandinavica. vol 128. issue 2. 1986-12-05. PMID:3535380. |
intracerebral injection of mpp+ into substantia nigra produced an almost complete disappearance of dopamine in striatum and noradrenaline in cerebral cortex, while injection of mptp or mpdp+ had no or only moderate catecholamine-depleting effects. |
1986-12-05 |
2023-08-11 |
mouse |
| M Van den Buuse, H D Veldhuis, D H Versteeg, W De Jon. Substantia nigra lesions attenuate the development of hypertension and behavioural hyperreactivity in spontaneously hypertensive rats. Pharmacology, biochemistry, and behavior. vol 25. issue 2. 1986-11-21. PMID:3763656. |
depletion of striatal dopamine by lesions in the substantia nigra of spontaneously hypertensive rats (shr) was associated with an inhibition of the development of hypertension. |
1986-11-21 |
2023-08-11 |
rat |
| K Kamata, A Sugimoto, T Kameyam. Effect of chronic haloperidol on dopamine release following microinjection of GABA into the substantia nigra zona reticulata in the rat. Brain research. vol 380. issue 1. 1986-11-13. PMID:3756464. |
effect of chronic haloperidol on dopamine release following microinjection of gaba into the substantia nigra zona reticulata in the rat. |
1986-11-13 |
2023-08-11 |
rat |
| K Kamata, A Sugimoto, T Kameyam. Effect of chronic haloperidol on dopamine release following microinjection of GABA into the substantia nigra zona reticulata in the rat. Brain research. vol 380. issue 1. 1986-11-13. PMID:3756464. |
to investigate the influence of the striatonigral gamma-aminobutyric acid (gaba) system on the nigrostriatal dopamine (da) system, the release of da and/or 3,4-dihydroxyphenylacetic acid in the striatum ipsilateral to the injection side was examined by in vivo voltammetry following microinjection of gaba into the substantia nigra zona reticulata (snr). |
1986-11-13 |
2023-08-11 |
rat |
| W G Erwin, T F Turc. Current concepts in clinical therapeutics: Parkinson's disease. Clinical pharmacy. vol 5. issue 9. 1986-11-03. PMID:3530616. |
the clinical features of parkinsonism result from a depletion in dopaminergic transmission in the corpus striatum; the dopamine deficiency is caused by a loss of melanin-containing nerve cells within the substantia nigra and locus ceruleus. |
1986-11-03 |
2023-08-11 |
Not clear |
| A A Grace, B S Bunne. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. The Journal of pharmacology and experimental therapeutics. vol 238. issue 3. 1986-10-23. PMID:3746660. |
acute administration of the antipsychotic drug haloperidol causes an increase in the firing rate and in the proportion of spontaneously active dopamine neurons in the substantia nigra. |
1986-10-23 |
2023-08-11 |
rat |
| A J Bradbury, A Brossi, B Costall, A M Domeney, W Gessner, R J Naylo. Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase. Neuropharmacology. vol 25. issue 6. 1986-10-16. PMID:3489197. |
the compound mpp+ was most effective to reduce motor responding and to decrease levels of dopamine, dopac and hva (50-56%) in the striatum in addition to reducing levels of dopamine, dopac, noradrenaline, serotonin and 5-hiaa (42-86%) in the substantia nigra, yet mpp+ has been shown to have very weak ability to inhibit dhpr. |
1986-10-16 |
2023-08-11 |
rat |
| N J Barnes, A J Bradbury, B Costall, A M Domeney, M E Kelly, R J Naylo. Neuropharmacological manipulations with MPTP. Journal of neural transmission. Supplementum. vol 20. 1986-10-03. PMID:3091761. |
the mao-b inhibitor deprenyl was shown to antagonize the actions of mptp, and its metabolite formed via oxidation through mao, mpp+, was shown to disrupt striatal dopamine function as determined behaviorally (as motor impairment) or biochemically (as loss of dopamine and its metabolites) when injected into the cerebral ventricles of mouse or infused into the substantia nigra of rat brain. |
1986-10-03 |
2023-08-11 |
mouse |
| M L Porceddu, O Giorgi, E Ongini, S Mele, G Biggi. 3H-SCH 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. Life sciences. vol 39. issue 4. 1986-09-17. PMID:3526066. |
3h-sch 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. |
1986-09-17 |
2023-08-11 |
rat |
| M L Porceddu, O Giorgi, E Ongini, S Mele, G Biggi. 3H-SCH 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. Life sciences. vol 39. issue 4. 1986-09-17. PMID:3526066. |
the results show that in the rat substantia nigra most of the 3h-sch 23390 binding sites have a presynaptic localization on the striato-nigral gabaergic afferent terminals and suggest that dopamine released from nigral dendrites exerts a tonic influence on these presynaptic d-1 dopamine receptors. |
1986-09-17 |
2023-08-11 |
rat |
| I Mintz, C Hammond, B Guibert, V Levie. Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. Brain research. vol 376. issue 2. 1986-09-16. PMID:3730844. |
stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. |
1986-09-16 |
2023-08-11 |
rat |
| I Mintz, C Hammond, B Guibert, V Levie. Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. Brain research. vol 376. issue 2. 1986-09-16. PMID:3730844. |
the release of dopamine in the substantia nigra and striatum was investigated in halothane anaesthetized rats by means of the push-pull cannula method. |
1986-09-16 |
2023-08-11 |
rat |
| I Mintz, C Hammond, B Guibert, V Levie. Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. Brain research. vol 376. issue 2. 1986-09-16. PMID:3730844. |
electrical stimulation of the subthalamic nucleus produced a marked enhancement of dopamine release in the ipsilateral substantia nigra. |
1986-09-16 |
2023-08-11 |
rat |
| P Apicella, E Legallet, A Nieoullon, E Trouch. Differential time-course of reaction time recovery depending on variations in the amplitude of a goal-directed movement after nigrostriatal lesion in monkeys. Neuroscience letters. vol 68. issue 1. 1986-08-21. PMID:2873541. |
unilateral striatal dopamine depletion induced by 6-hydroxydopamine injections into the substantia nigra of behaving monkeys was found to increase the latency of a visually guided pointing movement performed by the contralateral forelimb. |
1986-08-21 |
2023-08-11 |
monkey |
| V W Yong, T L Perry, W J Godolphin, K A Jones, R M Clavier, M Ito, J G Foulk. Chronic organic manganese administration in the rat does not damage dopaminergic nigrostriatal neurons. Neurotoxicology. vol 7. issue 1. 1986-07-14. PMID:2872639. |
this was assessed by measurements of tyrosine hydroxylase activity and contents of dopamine and its metabolites in the striatum, and by histological examination of the substantia nigra. |
1986-07-14 |
2023-08-11 |
mouse |
| B Fornstedt, E Rosengren, A Carlsso. Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species. Neuropharmacology. vol 25. issue 4. 1986-07-10. PMID:3086766. |
the regional distribution of the metabolites was similar to that of dopamine; the metabolite concentrations ranged from less than 0.1 percent to more than 1 percent of the dopamine level, the highest ratios generally being found in substantia nigra. |
1986-07-10 |
2023-08-11 |
Not clear |
| K Kamata, A Sugimoto, T Kameyam. In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata. Japanese journal of pharmacology. vol 40. issue 3. 1986-07-07. PMID:3712872. |
in vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata. |
1986-07-07 |
2023-08-11 |
Not clear |
| K Kamata, A Sugimoto, T Kameyam. In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata. Japanese journal of pharmacology. vol 40. issue 3. 1986-07-07. PMID:3712872. |
effect of microinjection of apomorphine into the substantia nigra zona reticulata (snr) on the dopamine (da) release in the ipsilateral striatum was examined in the present study. |
1986-07-07 |
2023-08-11 |
Not clear |