| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Bradbury, A Brossi, B Costall, A M Domeney, W Gessner, R J Naylo. Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase. Neuropharmacology. vol 25. issue 6. 1986-10-16. PMID:3489197. |
the compound mpp+ was most effective to reduce motor responding and to decrease levels of dopamine, dopac and hva (50-56%) in the striatum in addition to reducing levels of dopamine, dopac, noradrenaline, serotonin and 5-hiaa (42-86%) in the substantia nigra, yet mpp+ has been shown to have very weak ability to inhibit dhpr. |
1986-10-16 |
2023-08-11 |
rat |
| N J Barnes, A J Bradbury, B Costall, A M Domeney, M E Kelly, R J Naylo. Neuropharmacological manipulations with MPTP. Journal of neural transmission. Supplementum. vol 20. 1986-10-03. PMID:3091761. |
the mao-b inhibitor deprenyl was shown to antagonize the actions of mptp, and its metabolite formed via oxidation through mao, mpp+, was shown to disrupt striatal dopamine function as determined behaviorally (as motor impairment) or biochemically (as loss of dopamine and its metabolites) when injected into the cerebral ventricles of mouse or infused into the substantia nigra of rat brain. |
1986-10-03 |
2023-08-11 |
mouse |
| M L Porceddu, O Giorgi, E Ongini, S Mele, G Biggi. 3H-SCH 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. Life sciences. vol 39. issue 4. 1986-09-17. PMID:3526066. |
3h-sch 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. |
1986-09-17 |
2023-08-11 |
rat |
| M L Porceddu, O Giorgi, E Ongini, S Mele, G Biggi. 3H-SCH 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. Life sciences. vol 39. issue 4. 1986-09-17. PMID:3526066. |
the results show that in the rat substantia nigra most of the 3h-sch 23390 binding sites have a presynaptic localization on the striato-nigral gabaergic afferent terminals and suggest that dopamine released from nigral dendrites exerts a tonic influence on these presynaptic d-1 dopamine receptors. |
1986-09-17 |
2023-08-11 |
rat |
| I Mintz, C Hammond, B Guibert, V Levie. Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. Brain research. vol 376. issue 2. 1986-09-16. PMID:3730844. |
stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. |
1986-09-16 |
2023-08-11 |
rat |
| I Mintz, C Hammond, B Guibert, V Levie. Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. Brain research. vol 376. issue 2. 1986-09-16. PMID:3730844. |
the release of dopamine in the substantia nigra and striatum was investigated in halothane anaesthetized rats by means of the push-pull cannula method. |
1986-09-16 |
2023-08-11 |
rat |
| I Mintz, C Hammond, B Guibert, V Levie. Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra. Brain research. vol 376. issue 2. 1986-09-16. PMID:3730844. |
electrical stimulation of the subthalamic nucleus produced a marked enhancement of dopamine release in the ipsilateral substantia nigra. |
1986-09-16 |
2023-08-11 |
rat |
| P Apicella, E Legallet, A Nieoullon, E Trouch. Differential time-course of reaction time recovery depending on variations in the amplitude of a goal-directed movement after nigrostriatal lesion in monkeys. Neuroscience letters. vol 68. issue 1. 1986-08-21. PMID:2873541. |
unilateral striatal dopamine depletion induced by 6-hydroxydopamine injections into the substantia nigra of behaving monkeys was found to increase the latency of a visually guided pointing movement performed by the contralateral forelimb. |
1986-08-21 |
2023-08-11 |
monkey |
| V W Yong, T L Perry, W J Godolphin, K A Jones, R M Clavier, M Ito, J G Foulk. Chronic organic manganese administration in the rat does not damage dopaminergic nigrostriatal neurons. Neurotoxicology. vol 7. issue 1. 1986-07-14. PMID:2872639. |
this was assessed by measurements of tyrosine hydroxylase activity and contents of dopamine and its metabolites in the striatum, and by histological examination of the substantia nigra. |
1986-07-14 |
2023-08-11 |
mouse |
| B Fornstedt, E Rosengren, A Carlsso. Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species. Neuropharmacology. vol 25. issue 4. 1986-07-10. PMID:3086766. |
the regional distribution of the metabolites was similar to that of dopamine; the metabolite concentrations ranged from less than 0.1 percent to more than 1 percent of the dopamine level, the highest ratios generally being found in substantia nigra. |
1986-07-10 |
2023-08-11 |
Not clear |
| K Kamata, A Sugimoto, T Kameyam. In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata. Japanese journal of pharmacology. vol 40. issue 3. 1986-07-07. PMID:3712872. |
in vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata. |
1986-07-07 |
2023-08-11 |
Not clear |
| K Kamata, A Sugimoto, T Kameyam. In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata. Japanese journal of pharmacology. vol 40. issue 3. 1986-07-07. PMID:3712872. |
effect of microinjection of apomorphine into the substantia nigra zona reticulata (snr) on the dopamine (da) release in the ipsilateral striatum was examined in the present study. |
1986-07-07 |
2023-08-11 |
Not clear |
| R W Foote, R Maure. Opioid binding sites in the nigrostriatal system of the guinea pig are not located on nigral dopaminergic neurons. Neuroscience letters. vol 65. issue 3. 1986-06-30. PMID:3012421. |
unilateral 6-hydroxydopamine injection into the compact zone of the guinea pig substantia nigra was used to destroy nigral dopamine neurons. |
1986-06-30 |
2023-08-11 |
Not clear |
| R J Care. Relationship of changes in spontaneous motor activity to spontaneous circling in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. Experimental neurology. vol 92. issue 3. 1986-06-30. PMID:3086112. |
two unilateral injections of 6-hydroxydopamine into the substantia nigra and ventral tegmental area of adult rats pretreated with desmethylimipramine produced severe unilateral depletions of limbic and striatal dopamine. |
1986-06-30 |
2023-08-11 |
rat |
| S Nakamura, S R Vincen. Histochemistry of MPTP oxidation in the rat brain: sites of synthesis of the parkinsonism-inducing toxin MPP+. Neuroscience letters. vol 65. issue 3. 1986-06-30. PMID:3487052. |
it is proposed that the conversion of mptp to mpp+ occurs via mao-b within serotonin and histamine neurons which may innervate the substantia nigra where the toxin mpp+ could be released and then taken up into the dopamine neurons. |
1986-06-30 |
2023-08-11 |
rat |
| J H Carlson, D A Bergstrom, J R Walter. Neurophysiological evidence that D-1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor-mediated effects of dopamine agonists. European journal of pharmacology. vol 123. issue 2. 1986-06-27. PMID:2940101. |
sch 23390 (1 mg/kg) had no significant effect on the tonic activity of substantia nigra dopamine neurons in 47% of the 19 cells studied, while the firing rates of 53% of the cells were increased. |
1986-06-27 |
2023-08-11 |
Not clear |
| Y Ohno, M Sasa, S Takaor. Excitation by dopamine D-2 receptor agonists, bromocriptine and LY 171555, in caudate nucleus neurons activated by nigral stimulation. Life sciences. vol 38. issue 20. 1986-06-25. PMID:2939313. |
electrophysiological studies using cats anesthetized with alpha-chloralose were carried out to determine whether or not the dopamine d-2 receptor mediates the excitation of the caudate nucleus (cn) neurons activated by stimulation of the substantia nigra (sn). |
1986-06-25 |
2023-08-11 |
Not clear |
| M Parenti, C Flauto, E Parati, A Vescovi, A Groppett. Manganese neurotoxicity: effects of L-DOPA and pargyline treatments. Brain research. vol 367. issue 1-2. 1986-06-09. PMID:2421838. |
single, monolateral injection into rat substantia nigra of manganese chloride produced within two weeks from its administration a loss of dopamine in the striatum ipsilateral to the injected side. |
1986-06-09 |
2023-08-11 |
rat |
| W R Gibb, A J Lees, P Jenner, C D Marsde. The dopamine neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces histological lesions in the hypothalamus of the common marmoset. Neuroscience letters. vol 65. issue 1. 1986-06-09. PMID:3486388. |
these findings suggest that mptp may be toxic to dopamine neurons of the hypothalamus as well as to the substantia nigra. |
1986-06-09 |
2023-08-11 |
marmoset |
| J P Bennett, G F Woote. Dopamine denervation does not alter in vivo 3H-spiperone binding in rat striatum: implications for external imaging of dopamine receptors in Parkinson's disease. Annals of neurology. vol 19. issue 4. 1986-06-09. PMID:3707090. |
in addition, striatal binding of in vivo-administered 3h-sp is not affected by prior lesion of the substantia nigra, which results in profound ipsilateral striatal dopamine depletion. |
1986-06-09 |
2023-08-11 |
rat |