| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Foote, R Maure. Opioid binding sites in the nigrostriatal system of the guinea pig are not located on nigral dopaminergic neurons. Neuroscience letters. vol 65. issue 3. 1986-06-30. PMID:3012421. |
unilateral 6-hydroxydopamine injection into the compact zone of the guinea pig substantia nigra was used to destroy nigral dopamine neurons. |
1986-06-30 |
2023-08-11 |
Not clear |
| R J Care. Relationship of changes in spontaneous motor activity to spontaneous circling in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. Experimental neurology. vol 92. issue 3. 1986-06-30. PMID:3086112. |
two unilateral injections of 6-hydroxydopamine into the substantia nigra and ventral tegmental area of adult rats pretreated with desmethylimipramine produced severe unilateral depletions of limbic and striatal dopamine. |
1986-06-30 |
2023-08-11 |
rat |
| S Nakamura, S R Vincen. Histochemistry of MPTP oxidation in the rat brain: sites of synthesis of the parkinsonism-inducing toxin MPP+. Neuroscience letters. vol 65. issue 3. 1986-06-30. PMID:3487052. |
it is proposed that the conversion of mptp to mpp+ occurs via mao-b within serotonin and histamine neurons which may innervate the substantia nigra where the toxin mpp+ could be released and then taken up into the dopamine neurons. |
1986-06-30 |
2023-08-11 |
rat |
| J H Carlson, D A Bergstrom, J R Walter. Neurophysiological evidence that D-1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor-mediated effects of dopamine agonists. European journal of pharmacology. vol 123. issue 2. 1986-06-27. PMID:2940101. |
sch 23390 (1 mg/kg) had no significant effect on the tonic activity of substantia nigra dopamine neurons in 47% of the 19 cells studied, while the firing rates of 53% of the cells were increased. |
1986-06-27 |
2023-08-11 |
Not clear |
| Y Ohno, M Sasa, S Takaor. Excitation by dopamine D-2 receptor agonists, bromocriptine and LY 171555, in caudate nucleus neurons activated by nigral stimulation. Life sciences. vol 38. issue 20. 1986-06-25. PMID:2939313. |
electrophysiological studies using cats anesthetized with alpha-chloralose were carried out to determine whether or not the dopamine d-2 receptor mediates the excitation of the caudate nucleus (cn) neurons activated by stimulation of the substantia nigra (sn). |
1986-06-25 |
2023-08-11 |
Not clear |
| M Parenti, C Flauto, E Parati, A Vescovi, A Groppett. Manganese neurotoxicity: effects of L-DOPA and pargyline treatments. Brain research. vol 367. issue 1-2. 1986-06-09. PMID:2421838. |
single, monolateral injection into rat substantia nigra of manganese chloride produced within two weeks from its administration a loss of dopamine in the striatum ipsilateral to the injected side. |
1986-06-09 |
2023-08-11 |
rat |
| W R Gibb, A J Lees, P Jenner, C D Marsde. The dopamine neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces histological lesions in the hypothalamus of the common marmoset. Neuroscience letters. vol 65. issue 1. 1986-06-09. PMID:3486388. |
these findings suggest that mptp may be toxic to dopamine neurons of the hypothalamus as well as to the substantia nigra. |
1986-06-09 |
2023-08-11 |
marmoset |
| J P Bennett, G F Woote. Dopamine denervation does not alter in vivo 3H-spiperone binding in rat striatum: implications for external imaging of dopamine receptors in Parkinson's disease. Annals of neurology. vol 19. issue 4. 1986-06-09. PMID:3707090. |
in addition, striatal binding of in vivo-administered 3h-sp is not affected by prior lesion of the substantia nigra, which results in profound ipsilateral striatal dopamine depletion. |
1986-06-09 |
2023-08-11 |
rat |
| F Vives, G J Mogenso. Electrophysiological study of the effects of D1 and D2 dopamine antagonists on the interaction of converging inputs from the sensory-motor cortex and substantia nigra neurons in the rat. Neuroscience. vol 17. issue 2. 1986-05-30. PMID:3517688. |
electrophysiological study of the effects of d1 and d2 dopamine antagonists on the interaction of converging inputs from the sensory-motor cortex and substantia nigra neurons in the rat. |
1986-05-30 |
2023-08-11 |
rat |
| O Magnusson, C J Fowler, C Köhler, S O Ogre. Dopamine D2 receptors and dopamine metabolism. Relationship between biochemical and behavioural effects of substituted benzamide drugs. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:2939362. |
remoxipride and haloperidol had little or no effect on the turnover of dopamine in either the hypothalamus or substantia nigra at the ed50 doses of these compounds for antagonism of apomorphine-induced stereotypy. |
1986-05-23 |
2023-08-11 |
rat |
| T C Napier, D A Gay, K L Hulebak, G R Brees. Behavioral and biochemical assessment of time-related changes in globus pallidus and striatal dopamine induced by intranigrally administered neurotensin. Peptides. vol 6. issue 6. 1986-05-23. PMID:3938838. |
microinjection of neurotensin (nt; 2 and 5 micrograms) into the substantia nigra zona compacta caused an increase in dopamine (da) and da metabolites in the rodent globus pallidus and striatum which persisted for at least 20 hours after peptide administration. |
1986-05-23 |
2023-08-11 |
rat |
| T C Napier, D A Gay, K L Hulebak, G R Brees. Behavioral and biochemical assessment of time-related changes in globus pallidus and striatal dopamine induced by intranigrally administered neurotensin. Peptides. vol 6. issue 6. 1986-05-23. PMID:3938838. |
these studies indicated that: dopaminergic functions of the globus pallidus are influenced, like the striatum, by manipulations of the substantia nigra: nt and ghb likely act via different mechanisms to effect nigral dopamine-containing cells; and nt was capable of inducing changes in dopamine neurons which had long term consequences. |
1986-05-23 |
2023-08-11 |
rat |
| M van den Buuse, D H Versteeg, W de Jon. Brain dopamine depletion by lesions in the substantia nigra attenuates the development of hypertension in the spontaneously hypertensive rat. Brain research. vol 368. issue 1. 1986-05-22. PMID:3006867. |
brain dopamine depletion by lesions in the substantia nigra attenuates the development of hypertension in the spontaneously hypertensive rat. |
1986-05-22 |
2023-08-11 |
rat |
| M van den Buuse, D H Versteeg, W de Jon. Brain dopamine depletion by lesions in the substantia nigra attenuates the development of hypertension in the spontaneously hypertensive rat. Brain research. vol 368. issue 1. 1986-05-22. PMID:3006867. |
after substantia nigra lesions depletion of dopamine was found especially in the nucleus caudatus posterior and the dorsomedial nucleus. |
1986-05-22 |
2023-08-11 |
rat |
| M C McNamara, J L Gingras-Leatherman, E E Lawso. Effect of hypoxia on brainstem concentration of biogenic amines in postnatal rabbits. Brain research. vol 390. issue 2. 1986-04-28. PMID:3955374. |
radioenzymatic assays were used to determine the concentration of dopamine, norepinephrine and serotonin in the following brainstem nuclei: substantia nigra, locus coeruleus, dorsal raphe and the nucleus reticularis pontis oralis. |
1986-04-28 |
2023-08-11 |
rabbit |
| J A Joseph, G S Roth, A S Lipp. Reduction of motor behavioral deficits in senescent animals via chronic prolactin administration. I. Rotational behavior. Neurobiology of aging. vol 7. issue 1. 1986-04-22. PMID:3081822. |
the effects of chronic prolactin administration on amphetamine or dopamine (da) induced rotational behavior was examined in mature (6 month) and senescent (24 month) wistar rats which were unilaterally lesioned in the left substantia nigra with 6-hydroxydopamine. |
1986-04-22 |
2023-08-11 |
rat |
| T C Napier, B S Givens, D W Schulz, B S Bunney, G R Breese, R B Mailma. SCH23390 effects on apomorphine-induced responses of nigral dopaminergic neurons. The Journal of pharmacology and experimental therapeutics. vol 236. issue 3. 1986-04-18. PMID:3512819. |
collectively, these results agree with previous studies which suggest that dopamine receptors located on dopamine-containing neurons of the substantia nigra zona compacta are likely not of the d1-type. |
1986-04-18 |
2023-08-11 |
Not clear |
| R T Matthews, D C Germa. Evidence for a functional role of dopamine type-1 (D-1) receptors in the substantia nigra of rats. European journal of pharmacology. vol 120. issue 1. 1986-04-10. PMID:2868905. |
evidence for a functional role of dopamine type-1 (d-1) receptors in the substantia nigra of rats. |
1986-04-10 |
2023-08-11 |
rat |
| R T Matthews, D C Germa. Evidence for a functional role of dopamine type-1 (D-1) receptors in the substantia nigra of rats. European journal of pharmacology. vol 120. issue 1. 1986-04-10. PMID:2868905. |
the microiontophoretic application of dopamine onto neurons in the substantia nigra of rats increased the spontaneous activity of zona reticulata (zr) neurons but decreased the activity of zone compacta (zc) neurons. |
1986-04-10 |
2023-08-11 |
rat |
| A J Bradbury, B Costall, M E Kelly, R J Naylor, J A Smit. Biochemical correlates of motor changes caused by the manipulation of dopamine function in the substantia nigra of the mouse. Neuropharmacology. vol 24. issue 12. 1986-04-07. PMID:4094652. |
biochemical correlates of motor changes caused by the manipulation of dopamine function in the substantia nigra of the mouse. |
1986-04-07 |
2023-08-11 |
mouse |