| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Beckstea. Striatal substance P cell clusters coincide with the high density terminal zones of the discontinuous nigrostriatal dopaminergic projection system in the cat: a study by combined immunohistochemistry and autoradiographic axon-tracing. Neuroscience. vol 20. issue 2. 1987-06-26. PMID:2438592. |
these data suggest that the striatal substance p cells, which send their axons selectively to the entopeduncular nucleus and substantia nigra, but much less so the globus pallidus, are a major target of nigrostriatal dopamine transmission. |
1987-06-26 |
2023-08-11 |
cat |
| Y Ohno, M Sasa, S Takaor. Coexistence of inhibitory dopamine D-1 and excitatory D-2 receptors on the same caudate nucleus neurons. Life sciences. vol 40. issue 19. 1987-06-18. PMID:3553819. |
microiontophoretic studies using cats anesthetized with alpha-chloralose were performed to determine whether or not dopamine d-1 and d-2 receptors co-exist in the same caudate nucleus (cn) neurons that receive inputs from the substantia nigra (sn), and in which spikes elicited by sn stimulation were blocked by domperidone, a selective d-2 antagonist. |
1987-06-18 |
2023-08-11 |
Not clear |
| E P Lapin, H S Maker, H Sershen, Y Hurd, A Lajth. Dopamine-like action of nicotine: lack of tolerance and reverse tolerance. Brain research. vol 407. issue 2. 1987-06-17. PMID:3567650. |
however, 10 min after the acute injection of 0.8 mg/kg nicotine no change was found in the ratios of dopamine to its metabolites dopac and homovanillic acid in the substantia nigra, caudate-putamen, nucleus accumbens, olfactory tubercle, frontal cortex, or ventral tegmental area. |
1987-06-17 |
2023-08-11 |
rat |
| A A Letter, K Merchant, J W Gibb, G R Hanso. Effect of methamphetamine on neurotensin concentrations in rat brain regions. The Journal of pharmacology and experimental therapeutics. vol 241. issue 2. 1987-06-12. PMID:3572804. |
these meth-induced increases in ntli concentrations were attenuated by coadministration of haloperidol in the substantia nigra, hypothalamus and hippocampus, indicating a possible involvement of dopamine receptors in these tissues. |
1987-06-12 |
2023-08-11 |
rat |
| E Kelly, P Jenner, C D Marsde. Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats. The Journal of pharmacy and pharmacology. vol 39. issue 3. 1987-06-10. PMID:2883284. |
however, the changes in motor activity are not necessarily related to altered nigrostriatal activity, suggesting the involvement of dopamine receptors located at non-dopaminergic sites within the substantia nigra. |
1987-06-10 |
2023-08-11 |
rat |
| J Chivers, P Jenner, C D Marsde. Pharmacological characterization of binding sites identified in rat brain following in vivo administration of [3H]-spiperone. British journal of pharmacology. vol 90. issue 3. 1987-05-28. PMID:2882801. |
[3h]-spiperone in vivo mainly labels dopamine receptors in striatum, tuberculum olfactorium, hypothalamus, substantia nigra and olfactory lobes. |
1987-05-28 |
2023-08-11 |
rat |
| A Y Deutch, S Y Tam, A S Freeman, M B Bowers, R H Rot. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:3569414. |
since the firing rate of both a10 (ventral tegmental area) and a9 (substantia nigra) dopamine neurons has previously been shown to be increased by phencyclidine, these data suggest that phencyclidine results in a differential regulation of presynaptic release of dopamine in mesolimbic/cortical as opposed to nigrostriatal dopaminergic regions. |
1987-05-28 |
2023-08-11 |
rat |
| J M Walker, L A Thompson, J Frascella, M W Friederic. Opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat. European journal of pharmacology. vol 134. issue 1. 1987-05-18. PMID:3030781. |
opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat. |
1987-05-18 |
2023-08-11 |
rat |
| L Paturle, D Fage, O Fourrier, P Vernier, C Feuerstein, P Demenge, B Scatto. Cortical ablation fails to influence striatal dopamine target cell supersensitivity induced by nigrostriatal denervation in the rat. Brain research. vol 402. issue 2. 1987-05-15. PMID:3828803. |
the possible influence of the corticostriatal (glutamatergic) pathway on denervation-induced striatal dopamine target cell supersensitivity has been investigated in the rat by measuring the changes in striatal acetylcholine levels induced by the dopamine agonist pergolide and the basal dopamine d2-receptor density after combined 6-hydroxydopamine-induced lesion of the substantia nigra and cortical ablation. |
1987-05-15 |
2023-08-11 |
rat |
| M L Bouthenet, M P Martres, N Sales, J C Schwart. A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with [125I]iodosulpride. Neuroscience. vol 20. issue 1. 1987-05-11. PMID:2882443. |
d-2 receptors in substantia nigra (pars compacta or reticulata) and ventral tegmental area were strongly reduced after injections of the neurotoxin 6-hydroxydopamine into the medial forebrain bundle, suggesting their major localization on dendrites and perikarya of dopamine neurons. |
1987-05-11 |
2023-08-11 |
rat |
| J F Plantjé, H W Steinbusch, J Schipper, F A Dijcks, P F Verheijden, J C Stoo. D-2 dopamine-receptors regulate the release of [3H]dopamine in rat cortical regions showing dopamine immunoreactive fibers. Neuroscience. vol 20. issue 1. 1987-05-11. PMID:2951613. |
therefore it is our conclusion that d-2 receptors regulate the release of dopamine from dopaminergic neurons originating in the ventral tegmental area as well as in the substantia nigra. |
1987-05-11 |
2023-08-11 |
rat |
| E H Lee, S L Huang, C Y Cha. Association between the behavioral and neurochemical effects of amphetamine: hemispheric asymmetry study. Life sciences. vol 40. issue 14. 1987-05-04. PMID:2882400. |
behaviorally, amphetamine also decreased l-r asymmetry of the spontaneous turning behavior in rats and this latter effect is most closely associated with the reductions of dopamine and norepinephrine asymmetries in the substantia nigra and reduction of norepinephrine asymmetry in the locus coeruleus. |
1987-05-04 |
2023-08-11 |
rat |
| M J Perlo. Brain grafting as a treatment for Parkinson's disease. Neurosurgery. vol 20. issue 2. 1987-04-30. PMID:3550516. |
some clinical manifestations of this illness are correlated with pathological changes in the substantia nigra and with a loss of dopamine in the nigra and striatum. |
1987-04-30 |
2023-08-11 |
human |
| D J Sirinathsinghji, P E Whittington, A R Audsle. Neurochemical changes in the substantiae nigrae and caudate nuclei following acute unilateral intranigral infusions of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Brain research. vol 399. issue 2. 1987-04-27. PMID:2435361. |
there were pronounced increases in the levels of dopamine (da), dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the ipsilateral substantia nigra and a significant decrease in the levels of da in the ipsilateral caudate nucleus while opposite changes occurred in the contralateral substantia nigra and caudate nucleus. |
1987-04-27 |
2023-08-11 |
rat |
| M Shibuya, N Arita, Y L Yamamot. Regional differences in local cerebral blood flow (LCBF) and glucose utilization (LCGU) in the basal ganglia after occlusion of the middle cerebral artery in rats. Journal of neural transmission. vol 68. issue 3-4. 1987-04-27. PMID:3559540. |
in contrast to the unanimous decrease of lcbf in the ipsilateral cortices and the lateral striatum, complexed changes in lcgu were found in not only the cortex and striatum but also in many other subcortical regions which were closely related to the distribution of the mesencephalic dopamine neurons, such as globus pallidus, substantia nigra, subthalamic nucleus, nucleus accumbens, olfactory tubercle and lateral habenular nucleus. |
1987-04-27 |
2023-08-11 |
rat |
| R Hargraves, W J Free. Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra. Life sciences. vol 40. issue 10. 1987-04-21. PMID:3821366. |
chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra. |
1987-04-21 |
2023-08-11 |
rat |
| E Pileblad, G Engber. GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies. Naunyn-Schmiedeberg's archives of pharmacology. vol 334. issue 4. 1987-04-20. PMID:2950328. |
did not alter the spontaneous firing rate of dopamine neurons in the substantia nigra zona compacta. |
1987-04-20 |
2023-08-11 |
rat |
| E Pileblad, G Engber. GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies. Naunyn-Schmiedeberg's archives of pharmacology. vol 334. issue 4. 1987-04-20. PMID:2950328. |
however, pretreatment with the drug (20 mg/kg, i.p., 10-30 min) enhanced the inhibitory response of microiontophoretically applied dopamine onto the dopamine neurons of substantia nigra. |
1987-04-20 |
2023-08-11 |
rat |
| E Pileblad, G Engber. GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies. Naunyn-Schmiedeberg's archives of pharmacology. vol 334. issue 4. 1987-04-20. PMID:2950328. |
present electrophysiological data are in line with the existence of a somatic or dendritic uptake system of dopamine within the substantia nigra but do not support the notion that the impulse activity of nigral dopamine neurons is regulated via a striatonigral feedback pathway. |
1987-04-20 |
2023-08-11 |
rat |
| C A Altar, R E Heikkila, L Manzino, M R Marie. 1-Methyl-4-phenylpyridine (MPP+): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation. European journal of pharmacology. vol 131. issue 2-3. 1987-04-07. PMID:3493157. |
[3h]mpp+ was transported by the high-affinity dopamine uptake system equally in the caudate-putamen (cp), nucleus accumbens (na) and olfactory tubercle (ot), and to a lesser extent in the substantia nigra. |
1987-04-07 |
2023-08-11 |
rat |