| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Nissbrandt, A Carlsso. Turnover of dopamine and dopamine metabolites in rat brain: comparison between striatum and substantia nigra. Journal of neurochemistry. vol 49. issue 3. 1987-09-23. PMID:3612134. |
measurements of the turnover of dopamine (da) and da metabolites have been performed in the striatum and substantia nigra (sn) of the rat. |
1987-09-23 |
2023-08-11 |
rat |
| M L Porceddu, O Giorgi, G De Montis, S Mele, L Cocco, E Ongini, G Biggi. 6-Hydroxydopamine-induced degeneration of nigral dopamine neurons: differential effect on nigral and striatal D-1 dopamine receptors. Life sciences. vol 41. issue 6. 1987-09-21. PMID:2956472. |
the results indicate that: within the substantia nigra a fraction (30%) of d-1 dopamine receptors coupled to the adenylate cyclase is located on cell bodies and/or dendrites of dopaminergic neurons; striatal d-1 dopamine receptors are tonically innervated by nigrostriatal afferent fibers. |
1987-09-21 |
2023-08-11 |
rat |
| F S Archibald, C Tyre. Manganese poisoning and the attack of trivalent manganese upon catecholamines. Archives of biochemistry and biophysics. vol 256. issue 2. 1987-09-17. PMID:3039917. |
human manganese poisoning or manganism results in damage to the substantia nigra of the brain stem, a drop in the level of the inhibitory neurotransmitter dopamine, and symptoms resembling those of parkinson's disease. |
1987-09-17 |
2023-08-11 |
human |
| S Benkirane, S Arbilla, S Z Lange. A functional response to D1 dopamine receptor stimulation in the central nervous system: inhibition of the release of [3H]-serotonin from the rat substantia nigra. Naunyn-Schmiedeberg's archives of pharmacology. vol 335. issue 5. 1987-09-11. PMID:2956523. |
these results indicate that, in rat substantia nigra, exogenous as well as endogenous dopamine causes inhibition of serotonin release by activation of dopamine receptors of the d1-subtype. |
1987-09-11 |
2023-08-11 |
rat |
| G Fishell, D van der Koo. Pattern formation in the striatum: developmental changes in the distribution of striatonigral neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 7. 1987-08-31. PMID:2886562. |
early in development, dopamine fibers from the substantia nigra selectively innervate the patches. |
1987-08-31 |
2023-08-11 |
rat |
| G Fishell, D van der Koo. Pattern formation in the striatum: developmental changes in the distribution of striatonigral neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 7. 1987-08-31. PMID:2886562. |
in the perinatal striatum, we observed a close match between the distributions of striatal cell bodies with axonal projections to the substantia nigra and patches of afferent dopamine fibers. |
1987-08-31 |
2023-08-11 |
rat |
| M Chowdhury, L Steardo, M Fillen. Cholecystokinin stimulates dopamine synthesis in synaptosomes by a cyclic AMP-dependent mechanism. Journal of neurochemistry. vol 49. issue 2. 1987-08-12. PMID:3037032. |
the effects of different fragments of cholecystokinin (cck) on dopamine synthesis were studied in synaptosomal preparations from the striatum, substantia nigra, and frontal cortex. |
1987-08-12 |
2023-08-11 |
Not clear |
| E H Lee, F B Wang, Y P Tang, M A Geye. Gabaergic interneurons in the dorsal raphe mediate the effects of apomorphine on serotonergic system. Brain research bulletin. vol 18. issue 3. 1987-07-16. PMID:2438015. |
we have previously demonstrated that the serotonergic actions of apo were secondary to dopamine (da) autoreceptor stimulation in the substantia nigra. |
1987-07-16 |
2023-08-11 |
Not clear |
| T Suppes, R D Pinnoc. Sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metoclopramide and SCH 23390. Neuropharmacology. vol 26. issue 4. 1987-07-08. PMID:3295579. |
sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metoclopramide and sch 23390. |
1987-07-08 |
2023-08-11 |
Not clear |
| M E Trulson, A Hossein. Dopamine neuron transplants: electrophysiological unit activity of intrastriatal nigral grafts in freely moving cats. Life sciences. vol 40. issue 21. 1987-07-06. PMID:3586853. |
fetal transplants of substantia nigra dopamine (da)-containing neurons into the caudate nucleus in cats produced functional synaptic connections, as measured by behavioral analysis. |
1987-07-06 |
2023-08-11 |
Not clear |
| R J D'Amato, G M Alexander, R J Schwartzman, C A Kitt, D L Price, S H Snyde. Evidence for neuromelanin involvement in MPTP-induced neurotoxicity. Nature. vol 327. issue 6120. 1987-07-02. PMID:2884568. |
in the present study, chloroquine, administered to monkeys in conventional anti-malarial doses before mptp, protects them from mptp-induced parkinsonian motor abnormalities, dopamine depletion in the striatum, and neuropathological changes in the substantia nigra. |
1987-07-02 |
2023-08-11 |
monkey |
| R M Beckstea. Striatal substance P cell clusters coincide with the high density terminal zones of the discontinuous nigrostriatal dopaminergic projection system in the cat: a study by combined immunohistochemistry and autoradiographic axon-tracing. Neuroscience. vol 20. issue 2. 1987-06-26. PMID:2438592. |
thus, whereas dopamine axons are distributed densely throughout the striatum, those originating from cells in the caudal pars compacta et dorsalis of the substantia nigra and ending in the head of the caudate nucleus appear to terminate preferentially within the substance p cell clusters. |
1987-06-26 |
2023-08-11 |
cat |
| R M Beckstea. Striatal substance P cell clusters coincide with the high density terminal zones of the discontinuous nigrostriatal dopaminergic projection system in the cat: a study by combined immunohistochemistry and autoradiographic axon-tracing. Neuroscience. vol 20. issue 2. 1987-06-26. PMID:2438592. |
these data suggest that the striatal substance p cells, which send their axons selectively to the entopeduncular nucleus and substantia nigra, but much less so the globus pallidus, are a major target of nigrostriatal dopamine transmission. |
1987-06-26 |
2023-08-11 |
cat |
| Y Ohno, M Sasa, S Takaor. Coexistence of inhibitory dopamine D-1 and excitatory D-2 receptors on the same caudate nucleus neurons. Life sciences. vol 40. issue 19. 1987-06-18. PMID:3553819. |
microiontophoretic studies using cats anesthetized with alpha-chloralose were performed to determine whether or not dopamine d-1 and d-2 receptors co-exist in the same caudate nucleus (cn) neurons that receive inputs from the substantia nigra (sn), and in which spikes elicited by sn stimulation were blocked by domperidone, a selective d-2 antagonist. |
1987-06-18 |
2023-08-11 |
Not clear |
| E P Lapin, H S Maker, H Sershen, Y Hurd, A Lajth. Dopamine-like action of nicotine: lack of tolerance and reverse tolerance. Brain research. vol 407. issue 2. 1987-06-17. PMID:3567650. |
however, 10 min after the acute injection of 0.8 mg/kg nicotine no change was found in the ratios of dopamine to its metabolites dopac and homovanillic acid in the substantia nigra, caudate-putamen, nucleus accumbens, olfactory tubercle, frontal cortex, or ventral tegmental area. |
1987-06-17 |
2023-08-11 |
rat |
| A A Letter, K Merchant, J W Gibb, G R Hanso. Effect of methamphetamine on neurotensin concentrations in rat brain regions. The Journal of pharmacology and experimental therapeutics. vol 241. issue 2. 1987-06-12. PMID:3572804. |
these meth-induced increases in ntli concentrations were attenuated by coadministration of haloperidol in the substantia nigra, hypothalamus and hippocampus, indicating a possible involvement of dopamine receptors in these tissues. |
1987-06-12 |
2023-08-11 |
rat |
| E Kelly, P Jenner, C D Marsde. Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats. The Journal of pharmacy and pharmacology. vol 39. issue 3. 1987-06-10. PMID:2883284. |
however, the changes in motor activity are not necessarily related to altered nigrostriatal activity, suggesting the involvement of dopamine receptors located at non-dopaminergic sites within the substantia nigra. |
1987-06-10 |
2023-08-11 |
rat |
| J Chivers, P Jenner, C D Marsde. Pharmacological characterization of binding sites identified in rat brain following in vivo administration of [3H]-spiperone. British journal of pharmacology. vol 90. issue 3. 1987-05-28. PMID:2882801. |
[3h]-spiperone in vivo mainly labels dopamine receptors in striatum, tuberculum olfactorium, hypothalamus, substantia nigra and olfactory lobes. |
1987-05-28 |
2023-08-11 |
rat |
| A Y Deutch, S Y Tam, A S Freeman, M B Bowers, R H Rot. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:3569414. |
since the firing rate of both a10 (ventral tegmental area) and a9 (substantia nigra) dopamine neurons has previously been shown to be increased by phencyclidine, these data suggest that phencyclidine results in a differential regulation of presynaptic release of dopamine in mesolimbic/cortical as opposed to nigrostriatal dopaminergic regions. |
1987-05-28 |
2023-08-11 |
rat |
| J M Walker, L A Thompson, J Frascella, M W Friederic. Opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat. European journal of pharmacology. vol 134. issue 1. 1987-05-18. PMID:3030781. |
opposite effects of mu and kappa opiates on the firing-rate of dopamine cells in the substantia nigra of the rat. |
1987-05-18 |
2023-08-11 |
rat |