| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Studer, E Sundström, G Jonsson, W Schult. Acute electrophysiological and neurochemical effects of administration of MPTP in mice. Neuropharmacology. vol 27. issue 9. 1988-12-16. PMID:3263584. |
levels of dopamine (da) were decreased at 3 hr after administration of mptp (50 mg/kg s.c.) by 60% and 54% in the striatum and substantia nigra, respectively. |
1988-12-16 |
2023-08-11 |
mouse |
| S Szabo, C H Ch. From cysteamine to MPTP: structure-activity studies with duodenal ulcerogens. Toxicologic pathology. vol 16. issue 2. 1988-12-15. PMID:3055230. |
both cysteamine and mptp affect endogenous dopamine; mptp is especially potent in depleting central dopamine and inducing lesions in the substantia nigra. |
1988-12-15 |
2023-08-11 |
human |
| C J Cruz, R M Beckstea. Quantitative radioimmunocytochemical evidence that haloperidol and SCH 23390 induce opposite changes in substance P levels of rat substantia nigra. Brain research. vol 457. issue 1. 1988-11-23. PMID:2458801. |
chronic blockade of the dopamine (da) d2 receptor by repeated systemic administration of the butyrophenone neuroleptic, haloperidol (hal), is known to lead to a decrease in levels of the neuroactive peptide, substance p (sp), in the rat striatum and substantia nigra (sn). |
1988-11-23 |
2023-08-11 |
rat |
| I Reisert, V Han, E Lieth, D Toran-Allerand, C Pilgrim, J Laude. Sex steroids promote neurite growth in mesencephalic tyrosine hydroxylase immunoreactive neurons in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 5. issue 2. 1988-11-21. PMID:2902739. |
based on labeling with [3h]dopamine (da) uptake and competition with specific inhibitors, these mesencephalic th-ir cells appear to represent da neurons of the a8-a10 groups (which includes the substantia nigra). |
1988-11-21 |
2023-08-11 |
rat |
| R F Cox, J L Neumeyer, B L Waszcza. Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 247. issue 1. 1988-11-18. PMID:3171980. |
prompted by conflicting reports of both agonist and antagonist properties of the s-(+)-enantiomer of the potent dopamine agonist r-(-)-n-n-propylnorapomorphine (npa), we carried out extracellular, single unit recording studies to compare the effects of both enantiomers on substantia nigra and ventral tegmental area (vta) dopamine neurons in male rats anesthetized with chloral hydrate. |
1988-11-18 |
2023-08-11 |
rat |
| R F Cox, J L Neumeyer, B L Waszcza. Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 247. issue 1. 1988-11-18. PMID:3171980. |
in addition, vta dopamine cells displayed a significantly greater sensitivity to the drug: id50 values of 149 micrograms/kg vs. 514 micrograms/kg for vta and substantia nigra neurons, respectively (p less than .01). |
1988-11-18 |
2023-08-11 |
rat |
| S B Dunnett, T D Hernandez, A Summerfield, G H Jones, G Arbuthnot. Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues. Experimental brain research. vol 71. issue 2. 1988-11-03. PMID:2901978. |
grafts of embryonic tissue taken from the substantia nigra (rich in dopamine neurons could provide a complete recovery of methamphetamine-induced rotation and a partial recovery of apomorphine-induced rotation, whereas no recovery was seen in rats with grafts of tissue rich in another monoamine (serotonin, dissected from the mesencephalic raphe) or of tissue appropriate to the target (dissected from the striatal eminence). |
1988-11-03 |
2023-08-11 |
rat |
| M G Lacey, N B Mercuri, R A Nort. On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. The Journal of physiology. vol 401. 1988-10-31. PMID:2459376. |
on the potassium conductance increase activated by gabab and dopamine d2 receptors in rat substantia nigra neurones. |
1988-10-31 |
2023-08-11 |
rat |
| N L Silva, B S Bunne. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European journal of pharmacology. vol 149. issue 3. 1988-10-05. PMID:3409955. |
intracellular recordings from dopamine (da)-sensitive neurons in rat substantia nigra tissue slices revealed that these neurons exhibit spontaneous pacemaker-like activity. |
1988-10-05 |
2023-08-11 |
rat |
| P Baruch, F Artaud, G Godeheu, L Barbeito, J Glowinski, A Chéram. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2457187. |
experiments were made in halothane-anesthetized cats implanted with one push-pull cannula in the substantia nigra and another in the ipsilateral caudate nucleus [3h]tyrosine was delivered continuously to each push-pull cannula and the release of newly synthesized [3h]dopamine measured in the superfusate. |
1988-09-22 |
2023-08-11 |
Not clear |
| P Baruch, F Artaud, G Godeheu, L Barbeito, J Glowinski, A Chéram. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2457187. |
unlike substance p or neurokinin a, neurokinin b (10(-8) m) applied for 30 min into the pars compacta of the substantia nigra was without effect on the release of [3h]dopamine from nerve terminals or dendrites. |
1988-09-22 |
2023-08-11 |
Not clear |
| P Baruch, F Artaud, G Godeheu, L Barbeito, J Glowinski, A Chéram. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2457187. |
when superfused into the pars reticulata, substance p (10(-8) m) still stimulated [3h]dopamine release from nerve terminals but not from dendrites while neurokinin a (10(-8) m) was without effect either in the caudate nucleus or the substantia nigra. |
1988-09-22 |
2023-08-11 |
Not clear |
| T E Robinson, I Q Whisha. Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats. Brain research. vol 450. issue 1-2. 1988-09-15. PMID:3135914. |
normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-ohda lesion of the substantia nigra: a microdialysis study in freely moving rats. |
1988-09-15 |
2023-08-11 |
rat |
| H Nabatame, M Sasa, S Takaori, M Kameyam. Muscarinic receptor-mediated inhibition of dopaminergic excitatory input to caudate neurons from the substantia nigra. Japanese journal of pharmacology. vol 46. issue 4. 1988-09-09. PMID:3404769. |
iontophoretic application of carbachol inhibited the spikes elicited by substantia nigra (sn) stimulation in 21 of 24 caudate neurons in which the spikes induced by sn stimulation were inhibited by microiontophoretically applied domperidone, a dopamine d-2 receptor antagonist. |
1988-09-09 |
2023-08-11 |
rat |
| K N Westlund, R M Denney, R M Rose, C W Abel. Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem. Neuroscience. vol 25. issue 2. 1988-09-01. PMID:3399053. |
neurons in the substantia nigra and the periventricular region of the hypothalamus, areas rich in dopamine neurons, stained for monoamine oxidase a but with much less frequency and intensity. |
1988-09-01 |
2023-08-11 |
human |
| M Sasa, Y Ohno, S Takaor. Presynaptic inhibition of excitatory input from the substantia nigra to caudate nucleus neurons by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392). Life sciences. vol 43. issue 3. 1988-08-31. PMID:3398698. |
in the cn neurons of which spikes elicited by stimulation of the pars compacta of substantia nigra (sn) were suppressed by iontophoretically applied domperidone, a dopamine d-2 receptor antagonist, application of opc-4392 (100-200 na) inhibited the spike generation induced by sn stimulation. |
1988-08-31 |
2023-08-11 |
Not clear |
| G Karlsson, A L Jaton, J M Vigoure. Dopamine D1- and D2-receptor interaction in turning behaviour induced by dopamine agonists in 6-hydroxydopamine-lesioned rats. Neuroscience letters. vol 88. issue 1. 1988-08-26. PMID:2969468. |
the selective dopamine d2-antagonist sulpiride potentiated contralateral circling behaviour induced by the d1-agonist cy 208-243 in rats with unilateral lesions of substantia nigra, but reduced the effects of the selective d2-agonist bromocriptine. |
1988-08-26 |
2023-08-11 |
rat |
| S J Li, S P Sivam, J F McGinty, H K Jiang, J Douglass, L Calavetta, J S Hon. Regulation of the metabolism of striatal dynorphin by the dopaminergic system. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2899169. |
seven daily injections of a dopamine (da) agonist, apomorphine (apo, 5 mg/kg, b.i.d., s.c.), caused a significant increase of dynorphin a (1-8)-like immunoreactivity (dn-li) in the striatum (140% over control) and substantia nigra (41% over control) without changing dn-li in frontal cortex, hypothalamus and hippocampus. |
1988-08-17 |
2023-08-11 |
rat |
| J Gerlach, D E Case. Tardive dyskinesia. Acta psychiatrica Scandinavica. vol 77. issue 4. 1988-08-08. PMID:2898870. |
the traditional dopamine hypersensitivity theory is no longer viable, whereby new hypotheses have been advanced: td can be due to the blockade of a subset of striatal dopamine receptors, while parkinsonism is due to the blockade of another such subset, and/or can be due to a reduced gaba turnover in a subgroup of neurons connecting striatum with globus pallidus and substantia nigra. |
1988-08-08 |
2023-08-11 |
Not clear |
| M Hajos, S Hjorth, K Svensson, A Carlsso. In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion. Experimental brain research. vol 70. issue 3. 1988-08-08. PMID:3133239. |
the in vivo dopamine (da) receptor binding and behavioural properties of the recently characterised putative preferential da autoreceptor antagonists (+)-aj 76 and (+)-uh 232 were studied in rats with a unilateral 6-oh-da lesion of the substantia nigra. |
1988-08-08 |
2023-08-11 |
rat |