| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N L Silva, B S Bunne. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European journal of pharmacology. vol 149. issue 3. 1988-10-05. PMID:3409955. |
intracellular recordings from dopamine (da)-sensitive neurons in rat substantia nigra tissue slices revealed that these neurons exhibit spontaneous pacemaker-like activity. |
1988-10-05 |
2023-08-11 |
rat |
| P Baruch, F Artaud, G Godeheu, L Barbeito, J Glowinski, A Chéram. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2457187. |
experiments were made in halothane-anesthetized cats implanted with one push-pull cannula in the substantia nigra and another in the ipsilateral caudate nucleus [3h]tyrosine was delivered continuously to each push-pull cannula and the release of newly synthesized [3h]dopamine measured in the superfusate. |
1988-09-22 |
2023-08-11 |
Not clear |
| P Baruch, F Artaud, G Godeheu, L Barbeito, J Glowinski, A Chéram. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2457187. |
unlike substance p or neurokinin a, neurokinin b (10(-8) m) applied for 30 min into the pars compacta of the substantia nigra was without effect on the release of [3h]dopamine from nerve terminals or dendrites. |
1988-09-22 |
2023-08-11 |
Not clear |
| P Baruch, F Artaud, G Godeheu, L Barbeito, J Glowinski, A Chéram. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2457187. |
when superfused into the pars reticulata, substance p (10(-8) m) still stimulated [3h]dopamine release from nerve terminals but not from dendrites while neurokinin a (10(-8) m) was without effect either in the caudate nucleus or the substantia nigra. |
1988-09-22 |
2023-08-11 |
Not clear |
| T E Robinson, I Q Whisha. Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats. Brain research. vol 450. issue 1-2. 1988-09-15. PMID:3135914. |
normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-ohda lesion of the substantia nigra: a microdialysis study in freely moving rats. |
1988-09-15 |
2023-08-11 |
rat |
| H Nabatame, M Sasa, S Takaori, M Kameyam. Muscarinic receptor-mediated inhibition of dopaminergic excitatory input to caudate neurons from the substantia nigra. Japanese journal of pharmacology. vol 46. issue 4. 1988-09-09. PMID:3404769. |
iontophoretic application of carbachol inhibited the spikes elicited by substantia nigra (sn) stimulation in 21 of 24 caudate neurons in which the spikes induced by sn stimulation were inhibited by microiontophoretically applied domperidone, a dopamine d-2 receptor antagonist. |
1988-09-09 |
2023-08-11 |
rat |
| K N Westlund, R M Denney, R M Rose, C W Abel. Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem. Neuroscience. vol 25. issue 2. 1988-09-01. PMID:3399053. |
neurons in the substantia nigra and the periventricular region of the hypothalamus, areas rich in dopamine neurons, stained for monoamine oxidase a but with much less frequency and intensity. |
1988-09-01 |
2023-08-11 |
human |
| M Sasa, Y Ohno, S Takaor. Presynaptic inhibition of excitatory input from the substantia nigra to caudate nucleus neurons by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392). Life sciences. vol 43. issue 3. 1988-08-31. PMID:3398698. |
in the cn neurons of which spikes elicited by stimulation of the pars compacta of substantia nigra (sn) were suppressed by iontophoretically applied domperidone, a dopamine d-2 receptor antagonist, application of opc-4392 (100-200 na) inhibited the spike generation induced by sn stimulation. |
1988-08-31 |
2023-08-11 |
Not clear |
| G Karlsson, A L Jaton, J M Vigoure. Dopamine D1- and D2-receptor interaction in turning behaviour induced by dopamine agonists in 6-hydroxydopamine-lesioned rats. Neuroscience letters. vol 88. issue 1. 1988-08-26. PMID:2969468. |
the selective dopamine d2-antagonist sulpiride potentiated contralateral circling behaviour induced by the d1-agonist cy 208-243 in rats with unilateral lesions of substantia nigra, but reduced the effects of the selective d2-agonist bromocriptine. |
1988-08-26 |
2023-08-11 |
rat |
| S J Li, S P Sivam, J F McGinty, H K Jiang, J Douglass, L Calavetta, J S Hon. Regulation of the metabolism of striatal dynorphin by the dopaminergic system. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2899169. |
seven daily injections of a dopamine (da) agonist, apomorphine (apo, 5 mg/kg, b.i.d., s.c.), caused a significant increase of dynorphin a (1-8)-like immunoreactivity (dn-li) in the striatum (140% over control) and substantia nigra (41% over control) without changing dn-li in frontal cortex, hypothalamus and hippocampus. |
1988-08-17 |
2023-08-11 |
rat |
| J Gerlach, D E Case. Tardive dyskinesia. Acta psychiatrica Scandinavica. vol 77. issue 4. 1988-08-08. PMID:2898870. |
the traditional dopamine hypersensitivity theory is no longer viable, whereby new hypotheses have been advanced: td can be due to the blockade of a subset of striatal dopamine receptors, while parkinsonism is due to the blockade of another such subset, and/or can be due to a reduced gaba turnover in a subgroup of neurons connecting striatum with globus pallidus and substantia nigra. |
1988-08-08 |
2023-08-11 |
Not clear |
| M Hajos, S Hjorth, K Svensson, A Carlsso. In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion. Experimental brain research. vol 70. issue 3. 1988-08-08. PMID:3133239. |
the in vivo dopamine (da) receptor binding and behavioural properties of the recently characterised putative preferential da autoreceptor antagonists (+)-aj 76 and (+)-uh 232 were studied in rats with a unilateral 6-oh-da lesion of the substantia nigra. |
1988-08-08 |
2023-08-11 |
rat |
| J S Schneider, F J Denar. Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain. Journal of neuropathology and experimental neurology. vol 47. issue 4. 1988-08-04. PMID:2898510. |
tyrosine hydroxylase immunocytochemistry revealed a loss of dopamine in the mouse striatum but no loss of substantia nigra neurons. |
1988-08-04 |
2023-08-11 |
mouse |
| H Mitsushio, M Takashima, N Mataga, M Tor. Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455042. |
carbamazepine also dose-dependently increased gamma-aminobutyric acid levels in the substantia nigra without altering the striatal dopamine turnover rate. |
1988-07-29 |
2023-08-11 |
rat |
| R Hashimoto, F Kimur. Long-term depressor effects of noradrenaline and dopamine neurons transplanted into the third ventricle of the brain of salt-loaded hypertensive rats. Experientia. vol 44. issue 6. 1988-07-25. PMID:3378589. |
neural tissues including a 6 group noradrenaline neurons in the locus ceruleus or a 10 group dopamine neurons in the substantia nigra were transplanted into the third ventricle at the preoptic-anterior hypothalamic level of rats made hypertensive by salt loading. |
1988-07-25 |
2023-08-11 |
rat |
| b' F Artigas, E Mart\\xc3\\xadnez, L Cam\\xc3\\xb3n, E Rodr\\xc3\\xadguez Farr\\xc3\\xa. Synthesis and utilization of neurotransmitters: actions of subconvulsant doses of hexachlorocyclohexane isomers on brain monoamines. Toxicology. vol 49. issue 1. 1988-06-30. PMID:2453940.' |
these results are in agreement with the proposed role of lindane as a "picrotoxinin-like" substance acting as an antagonist at the gaba-a receptor complex and thus impairing the inhibitory tone exerted by gaba on a variety of neurons (serotonin in raphe nuclei and dopamine in substantia nigra). |
1988-06-30 |
2023-08-11 |
Not clear |
| J Grenhoff, T H Svensso. Clonidine regularizes substantia nigra dopamine cell firing. Life sciences. vol 42. issue 20. 1988-06-20. PMID:3367694. |
clonidine regularizes substantia nigra dopamine cell firing. |
1988-06-20 |
2023-08-11 |
rat |
| J Grenhoff, T H Svensso. Clonidine regularizes substantia nigra dopamine cell firing. Life sciences. vol 42. issue 20. 1988-06-20. PMID:3367694. |
the effects of clonidine on the activity of single substantia nigra dopamine neurons were studied in the chloral hydrate anesthetized rat. |
1988-06-20 |
2023-08-11 |
rat |
| M Ziegler, H Szechtma. Differences in the behavioral profile of circling under amphetamine and apomorphine in rats with unilateral lesions of the substantia nigra. Behavioral neuroscience. vol 102. issue 2. 1988-06-16. PMID:3130074. |
in rats with severe depletion of striatal dopamine, produced by a unilateral injection of 6-hydroxydopamine into the substantia nigra, amphetamine (2 mg/kg) induces circling towards the side of the lesion and apomorphine (0.25 mg/kg) induces circling in the opposite direction. |
1988-06-16 |
2023-08-11 |
rat |
| H F Kung, J J Billings, Y Z Guo, M Blau, R Ackerhal. Preparation and biodistribution of [125I]IBZP: a potential CNS D-1 dopamine receptor imaging agent. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 15. issue 2. 1988-06-14. PMID:2966781. |
the regional distribution in rat brain, as measured by in vivo autoradiography, displayed a high uptake in the caudate putamen, accumbens nucleus and substantia nigra, regions known to have a high concentration d-1 dopamine receptors. |
1988-06-14 |
2023-08-11 |
rat |