| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Kapoor, C Webb, S A Greenfiel. Endogenous dopamine modifies electroresponsiveness of pars compacta cells in the guinea pig substantia nigra in vitro. Experimental brain research. vol 74. issue 3. 1989-06-01. PMID:2707341. |
exogenous dopamine is known to inhibit the firing of these neurones when applied directly to the substantia nigra in micromolar concentrations: but the amounts used are probably much higher than the endogenous concentration of the transmitter. |
1989-06-01 |
2023-08-11 |
Not clear |
| R Kapoor, C Webb, S A Greenfiel. Endogenous dopamine modifies electroresponsiveness of pars compacta cells in the guinea pig substantia nigra in vitro. Experimental brain research. vol 74. issue 3. 1989-06-01. PMID:2707341. |
the electrophysiological effects of endogenous dopamine were therefore examined using intracellular recordings from the substantia nigra in vitro. |
1989-06-01 |
2023-08-11 |
Not clear |
| N B Saul'skai. [Dopamine metabolism and the GABA level in the structures of the nigrostriatal and mesolimbic systems of the rat brain in experimental pathology of higher nervous activity]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 38. issue 6. 1989-05-26. PMID:3245325. |
animals with weak adaptive processes are characterized by lowered levels of dopamine and dioxyphenilacetic acid in the striatum, of dopamine in substantia nigra, of homovanillic acid in the n. accumbens and olfactory tubercle and of gaba--in the striatum, in comparison with the animals which did not show behavioural pathology. |
1989-05-26 |
2023-08-11 |
rat |
| M G Lacey, N B Mercuri, R A Nort. Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 4. 1989-05-24. PMID:2703874. |
two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. |
1989-05-24 |
2023-08-11 |
rat |
| J R Hollerman, A A Grac. Acute haloperidol administration induces depolarization block of nigral dopamine neurons in rats after partial dopamine lesions. Neuroscience letters. vol 96. issue 1. 1989-05-11. PMID:2494609. |
the effects of the antipsychotic drug haloperidol (hal) on the electrophysiological activity of dopamine (da)-containing cells in the substantia nigra was assessed in rats 6 weeks after partial 6-hydroxydopamine (6-ohda)-induced lesions of the nigrostriatal da pathway. |
1989-05-11 |
2023-08-11 |
rat |
| M Parenti, L Rusconi, V Cappabianca, E A Parati, A Groppett. Role of dopamine in manganese neurotoxicity. Brain research. vol 473. issue 2. 1989-05-10. PMID:2852985. |
manganese chloride also caused a marked decrease of striatal dopamine concentrations when infused into rat substantia nigra. |
1989-05-10 |
2023-08-11 |
human |
| J Grenhoff, L Ugedo, T H Svensso. Firing patterns of midbrain dopamine neurons: differences between A9 and A10 cells. Acta physiologica Scandinavica. vol 134. issue 1. 1989-05-10. PMID:3239415. |
dopamine neurons of the substantia nigra (a9) and the ventral tegmental area (a10), giving rise to the nigrostriatal and mesolimbic dopamine pathways, respectively, are commonly supposed to show similar electrophysiological activity. |
1989-05-10 |
2023-08-11 |
rat |
| M Koulu, J Lappalainen, U Pesonen, J Hietala, E Syvälaht. Chronic treatment with SCH 23390, a selective dopamine D-1 receptor antagonist, decreases dopamine metabolism in rat caudate nucleus. European journal of pharmacology. vol 155. issue 3. 1989-04-27. PMID:3069483. |
chronic treatment (18 days; 0.1 and 0.5 mg/kg per day) with the selective dopamine (da) d-1 receptor antagonist, sch 23390, significantly reduced the concentration of homovanillic acid (hva) and the ratios of hva/da and dopac/da in the nucleus caudatus of the rat but did not change the metabolism of da in the prefrontal cortex, substantia nigra or the a10 area. |
1989-04-27 |
2023-08-11 |
rat |
| J K Chivers, C Reavill, P Jenner, C D Marsde. Definition of the in-vivo accumulation of [3H]spiperone in brain using haloperidol and sulpiride to determine functional dopamine receptor occupation. The Journal of pharmacy and pharmacology. vol 40. issue 9. 1989-04-26. PMID:2907027. |
the functional effect produced by haloperidol correlated with its ability to define [3h]spiperone binding in-vivo to dopamine receptors in the substantia nigra, striatum and tuberculum olfactorium. |
1989-04-26 |
2023-08-11 |
Not clear |
| H Nissbrandt, E Sundström, G Jonsson, S Hjorth, A Carlsso. Synthesis and release of dopamine in rat brain: comparison between substantia nigra pars compacts, pars reticulata, and striatum. Journal of neurochemistry. vol 52. issue 4. 1989-04-21. PMID:2564423. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic neuronal pathway, but also from the dendrites in the substantia nigra. |
1989-04-21 |
2023-08-11 |
rat |
| R Cortés, B Gueye, A Pazos, A Probst, J M Palacio. Dopamine receptors in human brain: autoradiographic distribution of D1 sites. Neuroscience. vol 28. issue 2. 1989-04-18. PMID:2522166. |
the highest densities of dopamine d1 sites were seen in the nucleus caudatus, putamen, globus pallidus pars medialis and substantia nigra. |
1989-04-18 |
2023-08-11 |
human |
| C M Sinton, S L Fallo. Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor. European journal of pharmacology. vol 157. issue 2-3. 1989-04-06. PMID:2906291. |
serotonin (5-ht) neurons in the dorsal (drn) and median (mrn) raphe nuclei, and dopamine (da) neurons in the substantia nigra (sn) were recorded extracellularly in the anesthetized rat. |
1989-04-06 |
2023-08-11 |
rat |
| J F Reinhard, D B Miller, J P O'Callagha. The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: evidence for glial response to injury. Neuroscience letters. vol 95. issue 1-3. 1989-03-29. PMID:3265770. |
mptp produced a smaller elevation in gfap levels within a midbrain section of tissue containing the substantia nigra, without significantly decreasing the dopamine content of this structure, suggesting neurotoxic involvement at the level of dopamine perikarya. |
1989-03-29 |
2023-08-11 |
mouse |
| E C Wolters, D B Caln. Parkinson's disease. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. vol 140. issue 5. 1989-03-28. PMID:2563667. |
in parkinson's disease there is degeneration of neurons in the substantia nigra, with consequent depletion of the neurotransmitter dopamine. |
1989-03-28 |
2023-08-11 |
Not clear |
| R Araneda, G Busto. Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra. Journal of neurochemistry. vol 52. issue 3. 1989-03-24. PMID:2563759. |
modulation of dendritic release of dopamine by n-methyl-d-aspartate receptors in rat substantia nigra. |
1989-03-24 |
2023-08-11 |
rat |
| R Araneda, G Busto. Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra. Journal of neurochemistry. vol 52. issue 3. 1989-03-24. PMID:2563759. |
a superfusion system was used to study the effects of excitatory amino acids (eaa) on release of [3h]dopamine ([3h]da) previously taken up by rat substantia nigra (sn) slices. |
1989-03-24 |
2023-08-11 |
rat |
| H Pakkenberg, B Pakkenberg, R Fog, E Eldru. The effect of MPTP on uridine uptake in murine nerve cells. Brain research. vol 460. issue 1. 1989-03-23. PMID:2464401. |
the amount of dopamine in striatum and substantia nigra following mptp did not change significantly during the 9 weeks. |
1989-03-23 |
2023-08-11 |
mouse |
| G Von Euler, K Fuxe, T Hansson, P Eneroth, J A Gustafsso. Persistent effects of neonatal toluene exposure on regional brain catecholamine levels and turnover in the adult male rat. Toxicology. vol 54. issue 1. 1989-03-23. PMID:2916239. |
neonatal toluene exposure produced a reduction of dopamine levels and utilization selectively in the olfactory tubercle and substantia nigra of the adult rat. |
1989-03-23 |
2023-08-11 |
rat |
| G Von Euler, K Fuxe, T Hansson, P Eneroth, J A Gustafsso. Persistent effects of neonatal toluene exposure on regional brain catecholamine levels and turnover in the adult male rat. Toxicology. vol 54. issue 1. 1989-03-23. PMID:2916239. |
in some of the dopamine nerve terminal systems of the forebrain and in the dopamine cell body containing area of the substantia nigra neonatal toluene exposure appears to have made the dopamine neurons insensitive to adult subacute toluene exposure. |
1989-03-23 |
2023-08-11 |
rat |
| G Von Euler, K Fuxe, T Hansson, P Eneroth, J A Gustafsso. Persistent effects of neonatal toluene exposure on regional brain catecholamine levels and turnover in the adult male rat. Toxicology. vol 54. issue 1. 1989-03-23. PMID:2916239. |
the present results indicate that neonatal toluene exposure in doses at the threshold limit value produces persistent changes in dopamine and noradrenaline neurons of the forebrain, hypothalamus and substantia nigra in the presence of a relatively intact neuroendocrine system. |
1989-03-23 |
2023-08-11 |
rat |