| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J Neafsey, G Drucker, K Raikoff, M A Collin. Striatal dopaminergic toxicity following intranigral injection in rats of 2-methyl-norharman, a beta-carbolinium analog of N-methyl-4-phenylpyridinium ion (MPP+). Neuroscience letters. vol 105. issue 3. 1990-01-25. PMID:2594220. |
several laboratories have demonstrated that mpp+ administration into the substantia nigra or median forebrain bundle of rats results in extensive depletion of striatal dopamine and its metabolites. |
1990-01-25 |
2023-08-11 |
rat |
| L C Triarhou, B Ghett. The dendritic dopamine projection of the substantia nigra: phenotypic denominator of weaver gene action in hetero- and homozygosity. Brain research. vol 501. issue 2. 1990-01-08. PMID:2573407. |
the dendritic dopamine projection of the substantia nigra: phenotypic denominator of weaver gene action in hetero- and homozygosity. |
1990-01-08 |
2023-08-11 |
mouse |
| M Koulu, B Sjöholm, J Lappalainen, R Virtane. Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons. European journal of pharmacology. vol 169. issue 2-3. 1989-12-20. PMID:2530097. |
the acute administration of gr38032f, a selective 5-ht3 receptor antagonist, did not change the concentrations of dopamine (da) or 5-hydroxytryptamine (5-ht) or their deaminated metabolites in nucleus caudatus, nucleus accumbens or substantia nigra. |
1989-12-20 |
2023-08-11 |
Not clear |
| N Lindefors, S Brene, M Herrera-Marschitz, H Persso. Region specific regulation of glutamic acid decarboxylase mRNA expression by dopamine neurons in rat brain. Experimental brain research. vol 77. issue 3. 1989-12-20. PMID:2572447. |
hence, midbrain dopamine neurons appear to control neuronal expression of gad mrna by a tonic down-regulation in a fraction of gad mrna positive neurons in caudate-putamen, and a tonic up-regulation in a fraction of gad mrna positive neurons in fronto-parietal cortex and substantia nigra. |
1989-12-20 |
2023-08-11 |
rat |
| A Zuddas, G U Corsini, S Schinelli, J L Barker, I J Kopin, U di Porzi. Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the striatum. Brain research. vol 501. issue 1. 1989-12-20. PMID:2804689. |
we have previously shown that ethanol and acetaldehyde (ace) potentiate mptp toxicity in mice, selectively enhancing dopamine (da) depletion in the striatum and markedly increasing loss of da neurons in the substantia nigra. |
1989-12-20 |
2023-08-11 |
mouse |
| G Orozco, R Estrada, T L Perry, J Araña, R Fernandez, A Gonzalez-Quevedo, J Galarraga, S Hanse. Dominantly inherited olivopontocerebellar atrophy from eastern Cuba. Clinical, neuropathological, and biochemical findings. Journal of the neurological sciences. vol 93. issue 1. 1989-12-01. PMID:2809629. |
mean concentrations of dopamine metabolites were significantly low in the csf of the opca patients, corresponding to neuronal depletion observed in the substantia nigra of autopsied cases. |
1989-12-01 |
2023-08-11 |
Not clear |
| W R Martin, M R Palmer, C S Patlak, D B Caln. Nigrostriatal function in humans studied with positron emission tomography. Annals of neurology. vol 26. issue 4. 1989-11-30. PMID:2510586. |
the dopamine depletion that is characteristic of parkinson's disease has been hypothesized to result from the combination of environmentally induced subclinical damage to the substantia nigra and the age-related loss of additional nigral neurons. |
1989-11-30 |
2023-08-11 |
human |
| J D Adams, P W Kalivas, C A Mille. The acute histopathology of MPTP in the mouse CNS. Brain research bulletin. vol 23. issue 1-2. 1989-11-30. PMID:2804701. |
biochemically, dopamine was depleted in the substantia nigra and the striatum within a few hours following mptp administration. |
1989-11-30 |
2023-08-11 |
mouse |
| J D Adams, P W Kalivas, C A Mille. The acute histopathology of MPTP in the mouse CNS. Brain research bulletin. vol 23. issue 1-2. 1989-11-30. PMID:2804701. |
however, in the substantia nigra, homovanillic acid (hva), one of the metabolites of dopamine, showed relatively less depletion than did dopamine by mptp. |
1989-11-30 |
2023-08-11 |
mouse |
| J De Keyser, J P De Backer, G Ebinger, G Vauqueli. [3H]GBR 12935 binding to dopamine uptake sites in the human brain. Journal of neurochemistry. vol 53. issue 5. 1989-11-15. PMID:2795007. |
binding of [3h]gbr 12935 to the dopamine uptake sites, i.e., that displaced by dopamine uptake blockers, corresponded to part of the binding having low affinity for flupenthixol and was only detected in putamen, nucleus caudatus, nucleus accumbens, and substantia nigra. |
1989-11-15 |
2023-08-11 |
human |
| J De Keyser, J P De Backer, G Ebinger, G Vauqueli. [3H]GBR 12935 binding to dopamine uptake sites in the human brain. Journal of neurochemistry. vol 53. issue 5. 1989-11-15. PMID:2795007. |
gross unilateral lesions of the striato- and pallidonigral pathways did not affect the number of dopamine uptake sites in the ipsilateral substantia nigra, suggesting that they may reside on the soma or dendrites of nigral neurons. |
1989-11-15 |
2023-08-11 |
human |
| G F Steinfels, S W Tam, L Coo. Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 2. issue 3. 1989-11-13. PMID:2571340. |
extracellular single unit recording techniques were used to study the effects of selective sigma-receptor agonist [(+)-3-ppp, (+)-pentazocine, and dtg] and selective sigma-receptor antagonists (bmy 14802 and rimcazole) on dopamine neurons of the substantia nigra. |
1989-11-13 |
2023-08-11 |
Not clear |
| G F Steinfels, S W Tam, L Coo. Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 2. issue 3. 1989-11-13. PMID:2571340. |
these data, in conjunction with anatomic data suggesting sigma receptor localization on dopamine neurons in the substantia nigra (gundlach et al: j neurosci 6:1757-1770, 1986; graybiel et al: soc neurosci abstr 13:28, 1987) demonstrate a relationship of the sigma receptor with the dopamine system and further suggest a model system to study agonist-antagonist interactions of sigma ligands. |
1989-11-13 |
2023-08-11 |
Not clear |
| L J Ryan, M Diana, S J Young, P M Grove. Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. Experimental brain research. vol 77. issue 1. 1989-11-08. PMID:2529134. |
local infusion of the direct acting, specific dopamine d1 agonist, r-skf 38393, into the substantia nigra terminal field of antidromically identified neostriatal projection neurons decreased the electrical excitability of these axons. |
1989-11-08 |
2023-08-11 |
Not clear |
| L J Ryan, M Diana, S J Young, P M Grove. Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. Experimental brain research. vol 77. issue 1. 1989-11-08. PMID:2529134. |
systemic administration of the indirect acting agonist, amphetamine (1.0 and 5.0 mg/kg, iv) also failed to change terminal excitability suggesting that, even when unnaturally high levels of dopamine are released in the substantia nigra, endogenous dopamine does not affect neostriatal axons terminating in the substantia nigra. |
1989-11-08 |
2023-08-11 |
Not clear |
| L J Ryan, M Diana, S J Young, P M Grove. Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. Experimental brain research. vol 77. issue 1. 1989-11-08. PMID:2529134. |
thus it is unlikely that endogeneous dopamine modulates neostriatal control of the substantia nigra through these presynaptic terminal d1 heteroreceptors. |
1989-11-08 |
2023-08-11 |
Not clear |
| b' E F Sperber, J N Wurpel, N S Sharpless, S L Mosh\\xc3\\xa. Intranigral GABAergic drug effects on striatal dopamine activity. Pharmacology, biochemistry, and behavior. vol 32. issue 4. 1989-11-07. PMID:2477863.' |
concentrations of striatal dopamine (da), serotonin (5-ht) and their metabolites were measured following infusions of the gabaa receptor agonist, muscimol, or gabaa receptor antagonist, bicuculline, into the substantia nigra (sn) or areas dorsal to the sn in adult rats and 16-day-old rat pups. |
1989-11-07 |
2023-08-11 |
rat |
| G S Robertson, H A Robertso. Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 9. 1989-11-07. PMID:2795165. |
this is accompanied by a loss of dopamine in brain regions, such as the corpus striatum, which receives input from dopaminergic neurons in the substantia nigra (sn). |
1989-11-07 |
2023-08-11 |
rat |
| J M Trugman, W S Arnold, N Touchet, G F Woote. D1 dopamine agonist effects assessed in vivo with [14C]-2-deoxyglucose autoradiography. The Journal of pharmacology and experimental therapeutics. vol 250. issue 3. 1989-10-17. PMID:2674418. |
in rats with unilateral 6-hydroxydopamine (6-ohda) lesions of the substantia nigra, the 2-deoxyglucose (2-dg) autoradiographic method of measuring regional cerebral glucose utilization (rcgu) was used to assess the effects of three systemically administered dopamine agonists: bromocriptine, pergolide and (+)-4-propyl-9-hydroxynaphoxazine (phno). |
1989-10-17 |
2023-08-11 |
rat |
| J Billings, M P Kung, S Chumpradit, S Pan, H F Kun. [125I](+/-)FISCH: a new CNS D-1 dopamine receptor imaging ligand. Life sciences. vol 45. issue 8. 1989-10-17. PMID:2779358. |
the regional distribution in rat brain, as measured by ex vivo autoradiography, displayed highest uptake in the regions of the striatal complex and the substantia nigra, regions known to have a high concentration of d-1 dopamine receptors. |
1989-10-17 |
2023-08-11 |
rat |