| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G F Steinfels, S W Tam, L Coo. Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 2. issue 3. 1989-11-13. PMID:2571340. |
these data, in conjunction with anatomic data suggesting sigma receptor localization on dopamine neurons in the substantia nigra (gundlach et al: j neurosci 6:1757-1770, 1986; graybiel et al: soc neurosci abstr 13:28, 1987) demonstrate a relationship of the sigma receptor with the dopamine system and further suggest a model system to study agonist-antagonist interactions of sigma ligands. |
1989-11-13 |
2023-08-11 |
Not clear |
| L J Ryan, M Diana, S J Young, P M Grove. Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. Experimental brain research. vol 77. issue 1. 1989-11-08. PMID:2529134. |
local infusion of the direct acting, specific dopamine d1 agonist, r-skf 38393, into the substantia nigra terminal field of antidromically identified neostriatal projection neurons decreased the electrical excitability of these axons. |
1989-11-08 |
2023-08-11 |
Not clear |
| L J Ryan, M Diana, S J Young, P M Grove. Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. Experimental brain research. vol 77. issue 1. 1989-11-08. PMID:2529134. |
systemic administration of the indirect acting agonist, amphetamine (1.0 and 5.0 mg/kg, iv) also failed to change terminal excitability suggesting that, even when unnaturally high levels of dopamine are released in the substantia nigra, endogenous dopamine does not affect neostriatal axons terminating in the substantia nigra. |
1989-11-08 |
2023-08-11 |
Not clear |
| L J Ryan, M Diana, S J Young, P M Grove. Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. Experimental brain research. vol 77. issue 1. 1989-11-08. PMID:2529134. |
thus it is unlikely that endogeneous dopamine modulates neostriatal control of the substantia nigra through these presynaptic terminal d1 heteroreceptors. |
1989-11-08 |
2023-08-11 |
Not clear |
| b' E F Sperber, J N Wurpel, N S Sharpless, S L Mosh\\xc3\\xa. Intranigral GABAergic drug effects on striatal dopamine activity. Pharmacology, biochemistry, and behavior. vol 32. issue 4. 1989-11-07. PMID:2477863.' |
concentrations of striatal dopamine (da), serotonin (5-ht) and their metabolites were measured following infusions of the gabaa receptor agonist, muscimol, or gabaa receptor antagonist, bicuculline, into the substantia nigra (sn) or areas dorsal to the sn in adult rats and 16-day-old rat pups. |
1989-11-07 |
2023-08-11 |
rat |
| G S Robertson, H A Robertso. Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 9. 1989-11-07. PMID:2795165. |
this is accompanied by a loss of dopamine in brain regions, such as the corpus striatum, which receives input from dopaminergic neurons in the substantia nigra (sn). |
1989-11-07 |
2023-08-11 |
rat |
| J M Trugman, W S Arnold, N Touchet, G F Woote. D1 dopamine agonist effects assessed in vivo with [14C]-2-deoxyglucose autoradiography. The Journal of pharmacology and experimental therapeutics. vol 250. issue 3. 1989-10-17. PMID:2674418. |
in rats with unilateral 6-hydroxydopamine (6-ohda) lesions of the substantia nigra, the 2-deoxyglucose (2-dg) autoradiographic method of measuring regional cerebral glucose utilization (rcgu) was used to assess the effects of three systemically administered dopamine agonists: bromocriptine, pergolide and (+)-4-propyl-9-hydroxynaphoxazine (phno). |
1989-10-17 |
2023-08-11 |
rat |
| J Billings, M P Kung, S Chumpradit, S Pan, H F Kun. [125I](+/-)FISCH: a new CNS D-1 dopamine receptor imaging ligand. Life sciences. vol 45. issue 8. 1989-10-17. PMID:2779358. |
the regional distribution in rat brain, as measured by ex vivo autoradiography, displayed highest uptake in the regions of the striatal complex and the substantia nigra, regions known to have a high concentration of d-1 dopamine receptors. |
1989-10-17 |
2023-08-11 |
rat |
| S J Augood, P C Emson, I J Mitchell, S Boyce, C E Clarke, A R Crossma. Cellular localisation of enkephalin gene expression in MPTP-treated cynomolgus monkeys. Brain research. Molecular brain research. vol 6. issue 1. 1989-10-04. PMID:2788792. |
the animals which received systemic injections of mptp were found to have an essentially total loss of nigral dopamine cells whereas the intracarotid mptp treatment was found to destroy approximately 95% of the dopamine neurons in the ipsilateral substantia nigra. |
1989-10-04 |
2023-08-11 |
human |
| E R Hitchcock, C G Clough, R C Hughes, B G Kenn. Transplantation in Parkinson's disease: stereotactic implantation of adrenal medulla and foetal mesencephalon. Acta neurochirurgica. Supplementum. vol 46. 1989-09-28. PMID:2672712. |
the two possible dopamine donor sites for transplantation are autologous adrenal medulla and human foetal substantia nigra or adrenal medulla. |
1989-09-28 |
2023-08-11 |
human |
| M Okada, K Yokotani, M Yamashita, H Ikeda, Y Osum. Central depletion of dopamine in rats by 1-methyl-4-phenylpyridine. Life sciences. vol 45. issue 5. 1989-09-25. PMID:2788790. |
contents of dopamine in the substantia nigra and ventral tegmental area were not significantly affected by mpp+. |
1989-09-25 |
2023-08-11 |
rat |
| T Kaneyuki, T Morimasa, T Shohmor. Action of peripherally administered cholecystokinin on monoaminergic and GABAergic neurons in the rat brain. Acta medica Okayama. vol 43. issue 3. 1989-09-12. PMID:2763865. |
on the contrary, dopamine metabolism in the substantia nigra and locus coeruleus decreased. |
1989-09-12 |
2023-08-11 |
rat |
| T C Napier, P E Potte. Dopamine in the rat ventral pallidum/substantia innominata: biochemical and electrophysiological studies. Neuropharmacology. vol 28. issue 7. 1989-09-11. PMID:2474767. |
these observations support the contention that dopamine regulates neuronal activity within the vp/si and that cells of origin for at least a portion of this projection lie within the substantia nigra. |
1989-09-11 |
2023-08-11 |
rat |
| P Jenne. Clues to the mechanism underlying dopamine cell death in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol Suppl. 1989-08-31. PMID:2666576. |
the primary pathological change in parkinson's disease is the destruction of dopamine containing cells in the zona compacta of substantia nigra. |
1989-08-31 |
2023-08-11 |
Not clear |
| J N Johannessen, C C Chiueh, J P Bacon, N A Garrick, R S Burns, V K Weise, I J Kopin, J E Parisi, S P Marke. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog: effect of pargyline pretreatment. Journal of neurochemistry. vol 53. issue 2. 1989-08-25. PMID:2568405. |
pargyline pretreatment prevented the loss of striatal dopamine and cells from the substantia nigra, but did not prevent a prolonged but reversible decrease in the concentration of dopamine metabolites. |
1989-08-25 |
2023-08-11 |
dog |
| J K Chivers, C Reavill, P Jenner, C D Marsde. Definition of the in-vivo binding of [3H]spiperone in rat brain using substituted benzamide drugs. The Journal of pharmacy and pharmacology. vol 41. issue 2. 1989-08-25. PMID:2568417. |
as judged using haloperidol, [3h]spiperone identified dopamine receptors in the substantia nigra, striatum, tuberculum olfactorium and hypothalamus, but not in frontal cortex or nucleus accumbens. |
1989-08-25 |
2023-08-11 |
rat |
| C J Cruz, R M Beckstea. Nigrostriatal dopamine neurons are required to maintain basal levels of substance P in the rat substantia nigra. Neuroscience. vol 30. issue 2. 1989-08-21. PMID:2473415. |
nigrostriatal dopamine neurons are required to maintain basal levels of substance p in the rat substantia nigra. |
1989-08-21 |
2023-08-11 |
rat |
| C J Cruz, R M Beckstea. Nigrostriatal dopamine neurons are required to maintain basal levels of substance P in the rat substantia nigra. Neuroscience. vol 30. issue 2. 1989-08-21. PMID:2473415. |
striatal dopamine was depleted in adult rats by unilateral infusion of 6-hydroxydopamine near the dopamine neurons of the pars compacta of the substantia nigra. |
1989-08-21 |
2023-08-11 |
rat |
| G F Steinfels, S W Ta. Selective sigma receptor agonist and antagonist affect dopamine neuronal activity. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2568265. |
extracellular recording techniques were used to study the effects of the selective sigma receptor agonist (+)-[3h]3-(3-hydroxyphenyl)-n-(1-propyl)piperidine ((+)-3-ppp) and selective sigma receptor antagonist bmy 14802 on dopamine (da) neurons of the substantia nigra. |
1989-08-21 |
2023-08-11 |
Not clear |
| S M Sorensen, T M Humphreys, M G Palfreyma. Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2744086. |
haloperidol, but not mdl 73,147ef, given acutely increased the number of active dopamine neurons in the substantia nigra (a9). |
1989-08-21 |
2023-08-11 |
rabbit |