| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J Augood, P C Emson, I J Mitchell, S Boyce, C E Clarke, A R Crossma. Cellular localisation of enkephalin gene expression in MPTP-treated cynomolgus monkeys. Brain research. Molecular brain research. vol 6. issue 1. 1989-10-04. PMID:2788792. |
the animals which received systemic injections of mptp were found to have an essentially total loss of nigral dopamine cells whereas the intracarotid mptp treatment was found to destroy approximately 95% of the dopamine neurons in the ipsilateral substantia nigra. |
1989-10-04 |
2023-08-11 |
human |
| E R Hitchcock, C G Clough, R C Hughes, B G Kenn. Transplantation in Parkinson's disease: stereotactic implantation of adrenal medulla and foetal mesencephalon. Acta neurochirurgica. Supplementum. vol 46. 1989-09-28. PMID:2672712. |
the two possible dopamine donor sites for transplantation are autologous adrenal medulla and human foetal substantia nigra or adrenal medulla. |
1989-09-28 |
2023-08-11 |
human |
| M Okada, K Yokotani, M Yamashita, H Ikeda, Y Osum. Central depletion of dopamine in rats by 1-methyl-4-phenylpyridine. Life sciences. vol 45. issue 5. 1989-09-25. PMID:2788790. |
contents of dopamine in the substantia nigra and ventral tegmental area were not significantly affected by mpp+. |
1989-09-25 |
2023-08-11 |
rat |
| T Kaneyuki, T Morimasa, T Shohmor. Action of peripherally administered cholecystokinin on monoaminergic and GABAergic neurons in the rat brain. Acta medica Okayama. vol 43. issue 3. 1989-09-12. PMID:2763865. |
on the contrary, dopamine metabolism in the substantia nigra and locus coeruleus decreased. |
1989-09-12 |
2023-08-11 |
rat |
| T C Napier, P E Potte. Dopamine in the rat ventral pallidum/substantia innominata: biochemical and electrophysiological studies. Neuropharmacology. vol 28. issue 7. 1989-09-11. PMID:2474767. |
these observations support the contention that dopamine regulates neuronal activity within the vp/si and that cells of origin for at least a portion of this projection lie within the substantia nigra. |
1989-09-11 |
2023-08-11 |
rat |
| P Jenne. Clues to the mechanism underlying dopamine cell death in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol Suppl. 1989-08-31. PMID:2666576. |
the primary pathological change in parkinson's disease is the destruction of dopamine containing cells in the zona compacta of substantia nigra. |
1989-08-31 |
2023-08-11 |
Not clear |
| J N Johannessen, C C Chiueh, J P Bacon, N A Garrick, R S Burns, V K Weise, I J Kopin, J E Parisi, S P Marke. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the dog: effect of pargyline pretreatment. Journal of neurochemistry. vol 53. issue 2. 1989-08-25. PMID:2568405. |
pargyline pretreatment prevented the loss of striatal dopamine and cells from the substantia nigra, but did not prevent a prolonged but reversible decrease in the concentration of dopamine metabolites. |
1989-08-25 |
2023-08-11 |
dog |
| J K Chivers, C Reavill, P Jenner, C D Marsde. Definition of the in-vivo binding of [3H]spiperone in rat brain using substituted benzamide drugs. The Journal of pharmacy and pharmacology. vol 41. issue 2. 1989-08-25. PMID:2568417. |
as judged using haloperidol, [3h]spiperone identified dopamine receptors in the substantia nigra, striatum, tuberculum olfactorium and hypothalamus, but not in frontal cortex or nucleus accumbens. |
1989-08-25 |
2023-08-11 |
rat |
| C J Cruz, R M Beckstea. Nigrostriatal dopamine neurons are required to maintain basal levels of substance P in the rat substantia nigra. Neuroscience. vol 30. issue 2. 1989-08-21. PMID:2473415. |
nigrostriatal dopamine neurons are required to maintain basal levels of substance p in the rat substantia nigra. |
1989-08-21 |
2023-08-11 |
rat |
| C J Cruz, R M Beckstea. Nigrostriatal dopamine neurons are required to maintain basal levels of substance P in the rat substantia nigra. Neuroscience. vol 30. issue 2. 1989-08-21. PMID:2473415. |
striatal dopamine was depleted in adult rats by unilateral infusion of 6-hydroxydopamine near the dopamine neurons of the pars compacta of the substantia nigra. |
1989-08-21 |
2023-08-11 |
rat |
| G F Steinfels, S W Ta. Selective sigma receptor agonist and antagonist affect dopamine neuronal activity. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2568265. |
extracellular recording techniques were used to study the effects of the selective sigma receptor agonist (+)-[3h]3-(3-hydroxyphenyl)-n-(1-propyl)piperidine ((+)-3-ppp) and selective sigma receptor antagonist bmy 14802 on dopamine (da) neurons of the substantia nigra. |
1989-08-21 |
2023-08-11 |
Not clear |
| S M Sorensen, T M Humphreys, M G Palfreyma. Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2744086. |
haloperidol, but not mdl 73,147ef, given acutely increased the number of active dopamine neurons in the substantia nigra (a9). |
1989-08-21 |
2023-08-11 |
rabbit |
| E Korfali, W D Knowles, S Uysal, I H Ulus, T Ozme. Fetal substantia nigra grafts. Effect on dopamine receptors in the rat corpus striatium. Cleveland Clinic journal of medicine. vol 56. issue 3. 1989-08-17. PMID:2568188. |
effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. |
1989-08-17 |
2023-08-11 |
rat |
| J Korf, L D Loopuij. Synaptic and non-synaptic striatal dopamine D2 receptors: possible implications in normal and pathological behaviour. Acta morphologica Neerlando-Scandinavica. vol 26. issue 2-3. 1989-08-16. PMID:2908162. |
the prelimbic cortex and dopamine neurones of the ventral part of the substantia nigra; here the density of d2 receptors are lower. |
1989-08-16 |
2023-08-11 |
Not clear |
| J M Palacios, M Savasta, G Mengo. Does cholecystokinin colocalize with dopamine in the human substantia nigra? Brain research. vol 488. issue 1-2. 1989-08-14. PMID:2743135. |
does cholecystokinin colocalize with dopamine in the human substantia nigra? |
1989-08-14 |
2023-08-11 |
human |
| Y Masuo, I Kanazaw. Effects of the unilateral striatal lesion on neurotransmitter markers in the contralateral striatum and both substantia nigrae of the rat. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:2908058. |
the latter interpretation was supported by the finding that the changes observed were abolished by an additional callosal transection; (2) the second series of changes were transient (only found at 3-7 post-operative days) effects represented by an increase in gaba content, a decrease of tyrosine hydroxylase activity, and a decrease of dopamine content, which mostly appeared in the contralateral substantia nigra. |
1989-08-01 |
2023-08-11 |
rat |
| Y Masuo, I Kanazaw. Effects of the unilateral striatal lesion on neurotransmitter markers in the contralateral striatum and both substantia nigrae of the rat. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:2908058. |
the decrease of dopamine markers may be a subsequent secondary effect of the increase of gaba in the substantia nigra. |
1989-08-01 |
2023-08-11 |
rat |
| M Morelli, T Mennini, G Di Chiar. Nigral dopamine autoreceptors are exclusively of the D2 type: quantitative autoradiography of [125I]iodosulpride and [125I]SCH 23982 in adjacent brain sections. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:2978051. |
the results indicate that dopamine autoreceptors are present in the substantia nigra and in the ventral tegmental area and that they are exclusively of the d2 type. |
1989-08-01 |
2023-08-11 |
rat |
| R M Beckstea. Association of dopamine D1 and D2 receptors with specific cellular elements in the basal ganglia of the cat: the uneven topography of dopamine receptors in the striatum is determined by intrinsic striatal cells, not nigrostriatal axons. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:3150855. |
nearly all d2 receptors in the substantia nigra are associated with dopamine neurons (autoreceptors). |
1989-08-01 |
2023-08-11 |
cat |
| L Ugedo, J Grenhoff, T H Svensso. Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition. Psychopharmacology. vol 98. issue 1. 1989-07-07. PMID:2524859. |
dopamine cells of the zona compacta, substantia nigra (zc-sn) and the ventral tegmental area (vta) were identified by established criteria. |
1989-07-07 |
2023-08-11 |
rat |