| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R F Cox, B L Waszcza. Differences in dopamine receptor reserve for N-n-propylnorapomorphine enantiomers: single unit recording studies after partial inactivation of receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. Molecular pharmacology. vol 35. issue 1. 1989-03-01. PMID:2563304. |
for example, (s)-(+)npa had weak dopaminergic agonist potency, in that it could slow and ultimately stop firing of substantia nigra and ventral tegmental area dopamine neurons. |
1989-03-01 |
2023-08-11 |
rat |
| R F Cox, B L Waszcza. Differences in dopamine receptor reserve for N-n-propylnorapomorphine enantiomers: single unit recording studies after partial inactivation of receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. Molecular pharmacology. vol 35. issue 1. 1989-03-01. PMID:2563304. |
to test this hypothesis, we conducted dose-response studies for the inhibition of rat substantia nigra dopamine cell firing by (r)-(-)- and (s)-(+)-npa 1 day after partial irreversible dopamine receptor inactivation with 6 mg/kg n-ethoxycarbonyl-2-ethoxy-1-2-dihydroquinoline (eedq) in an ethanol vehicle. |
1989-03-01 |
2023-08-11 |
rat |
| R J Kasser, K J Renner, J X Feng, M P Brazell, R N Adam. Spreading depression induced by 100 mM KCl in caudate is blocked by local anesthesia of the substantia nigra. Brain research. vol 475. issue 2. 1989-02-28. PMID:3145783. |
unilateral 6-hydroxydopamine lesions of the substantia nigra (sn) demonstrated that over 90% of the voltammetric signal generated was dopamine. |
1989-02-28 |
2023-08-11 |
rat |
| J H Carlson, D A Bergstrom, B G Weick, J R Walter. Neurophysiological investigation of effects of the D-1 agonist SKF 38393 on tonic activity of substantia nigra dopamine neurons. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2975067. |
neurophysiological investigation of effects of the d-1 agonist skf 38393 on tonic activity of substantia nigra dopamine neurons. |
1989-02-23 |
2023-08-11 |
rat |
| E B De Souza, B L Kuyat. Autoradiographic localization of 3H-paroxetine-labeled serotonin uptake sites in rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2975068. |
high concentrations of 3h-paroxetine binding sites were found in brainstem areas containing dopamine (substantia nigra and ventral tegmental area) and norepinephrine (locus coeruleus) cell bodies. |
1989-02-23 |
2023-08-11 |
rat |
| b' G Bagetta, G De Sarro, E Priolo, G Nistic\\xc3\\xb. Ventral tegmental area: site through which dopamine D2-receptor agonists evoke behavioural and electrocortical sleep in rats. British journal of pharmacology. vol 95. issue 3. 1989-02-16. PMID:2974741.' |
in particular, dopamine agonists were microinfused in the ventral tegmental area (vta) and substantia nigra (sn) or into the caudate nucleus, n. accumbens and prefrontal cortex. |
1989-02-16 |
2023-08-11 |
rat |
| S Nedergaard, C Webb, S A Greenfiel. A possible ionic basis for dendritic release of dopamine in the guinea-pig substantia nigra. Acta physiologica Scandinavica. vol 135. issue 1. 1989-02-14. PMID:2911951. |
a possible ionic basis for dendritic release of dopamine in the guinea-pig substantia nigra. |
1989-02-14 |
2023-08-11 |
Not clear |
| L C Triarhou, J Norton, B Ghett. Synaptic connectivity of tyrosine hydroxylase immunoreactive nerve terminals in the striatum of normal, heterozygous and homozygous weaver mutant mice. Journal of neurocytology. vol 17. issue 2. 1989-02-06. PMID:2904978. |
a single micrograph of each of 1543 dopamine axon terminals was examined in total in the three genotypes; quantitative analyses of the relations of tyrosine hydroxylase immunoreactive nerve terminals were carried out in the dorsolateral striatum, which receives the dopamine projection from the substantia nigra proper. |
1989-02-06 |
2023-08-11 |
mouse |
| D J Sirinathsinghji, R P Heavens, S J Richards, I J Beresford, M D Hal. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--I. Behavioural, neurochemical and histological characterization of the lesion. Neuroscience. vol 27. issue 1. 1989-01-26. PMID:3264391. |
the present results provide evidence that direct infusion of mpp+ into the medial forebrain bundle of the rat can lead to a complete loss of dopamine neurons in the pars compacta of the substantia nigra with ensuing behavioural, neurochemical and biochemical changes characteristic of the lesion. |
1989-01-26 |
2023-08-11 |
rat |
| I J Beresford, A P Davenport, D J Sirinathsinghji, M D Hall, R G Hill, J Hughe. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--II. Differential localization of dopamine and cholecystokinin receptors. Neuroscience. vol 27. issue 1. 1989-01-26. PMID:3264392. |
treatment with 1-methyl-4-phenyl pyridinium ion produced a marked depletion of dopamine cell bodies in the substantia nigra together with greater than 95% loss of tyrosine hydroxylase immunoreactivity in the striatum. |
1989-01-26 |
2023-08-11 |
rat |
| C Pifl, G Schingnitz, O Hornykiewic. The neurotoxin MPTP does not reproduce in the rhesus monkey the interregional pattern of striatal dopamine loss typical of human idiopathic Parkinson's disease. Neuroscience letters. vol 92. issue 2. 1988-12-21. PMID:3263594. |
using high-pressure liquid chromatography with electrochemical detection, we measured dopamine (da) and homovanillic acid (hva) in caudate nucleus, putamen and substantia nigra in 4 untreated rhesus monkeys and 4 monkeys with permanent parkinsonism produced by repeated injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; total dose: 2.1-6.45 mg/kg, i.m.). |
1988-12-21 |
2023-08-11 |
human |
| L T Meltzer, C L Christofferse. Effects of intraperitoneal administration of apomorphine and the isomers of 3-(1-propyl-3-piperidinyl)phenol on the firing activity of substantia nigra dopamine neurons: comparison of agonist efficacies and development of acute tolerance. Neuropharmacology. vol 27. issue 9. 1988-12-16. PMID:3185867. |
effects of intraperitoneal administration of apomorphine and the isomers of 3-(1-propyl-3-piperidinyl)phenol on the firing activity of substantia nigra dopamine neurons: comparison of agonist efficacies and development of acute tolerance. |
1988-12-16 |
2023-08-11 |
rat |
| A Studer, E Sundström, G Jonsson, W Schult. Acute electrophysiological and neurochemical effects of administration of MPTP in mice. Neuropharmacology. vol 27. issue 9. 1988-12-16. PMID:3263584. |
levels of dopamine (da) were decreased at 3 hr after administration of mptp (50 mg/kg s.c.) by 60% and 54% in the striatum and substantia nigra, respectively. |
1988-12-16 |
2023-08-11 |
mouse |
| S Szabo, C H Ch. From cysteamine to MPTP: structure-activity studies with duodenal ulcerogens. Toxicologic pathology. vol 16. issue 2. 1988-12-15. PMID:3055230. |
both cysteamine and mptp affect endogenous dopamine; mptp is especially potent in depleting central dopamine and inducing lesions in the substantia nigra. |
1988-12-15 |
2023-08-11 |
human |
| C J Cruz, R M Beckstea. Quantitative radioimmunocytochemical evidence that haloperidol and SCH 23390 induce opposite changes in substance P levels of rat substantia nigra. Brain research. vol 457. issue 1. 1988-11-23. PMID:2458801. |
chronic blockade of the dopamine (da) d2 receptor by repeated systemic administration of the butyrophenone neuroleptic, haloperidol (hal), is known to lead to a decrease in levels of the neuroactive peptide, substance p (sp), in the rat striatum and substantia nigra (sn). |
1988-11-23 |
2023-08-11 |
rat |
| I Reisert, V Han, E Lieth, D Toran-Allerand, C Pilgrim, J Laude. Sex steroids promote neurite growth in mesencephalic tyrosine hydroxylase immunoreactive neurons in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 5. issue 2. 1988-11-21. PMID:2902739. |
based on labeling with [3h]dopamine (da) uptake and competition with specific inhibitors, these mesencephalic th-ir cells appear to represent da neurons of the a8-a10 groups (which includes the substantia nigra). |
1988-11-21 |
2023-08-11 |
rat |
| R F Cox, J L Neumeyer, B L Waszcza. Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 247. issue 1. 1988-11-18. PMID:3171980. |
prompted by conflicting reports of both agonist and antagonist properties of the s-(+)-enantiomer of the potent dopamine agonist r-(-)-n-n-propylnorapomorphine (npa), we carried out extracellular, single unit recording studies to compare the effects of both enantiomers on substantia nigra and ventral tegmental area (vta) dopamine neurons in male rats anesthetized with chloral hydrate. |
1988-11-18 |
2023-08-11 |
rat |
| R F Cox, J L Neumeyer, B L Waszcza. Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 247. issue 1. 1988-11-18. PMID:3171980. |
in addition, vta dopamine cells displayed a significantly greater sensitivity to the drug: id50 values of 149 micrograms/kg vs. 514 micrograms/kg for vta and substantia nigra neurons, respectively (p less than .01). |
1988-11-18 |
2023-08-11 |
rat |
| S B Dunnett, T D Hernandez, A Summerfield, G H Jones, G Arbuthnot. Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues. Experimental brain research. vol 71. issue 2. 1988-11-03. PMID:2901978. |
grafts of embryonic tissue taken from the substantia nigra (rich in dopamine neurons could provide a complete recovery of methamphetamine-induced rotation and a partial recovery of apomorphine-induced rotation, whereas no recovery was seen in rats with grafts of tissue rich in another monoamine (serotonin, dissected from the mesencephalic raphe) or of tissue appropriate to the target (dissected from the striatal eminence). |
1988-11-03 |
2023-08-11 |
rat |
| M G Lacey, N B Mercuri, R A Nort. On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. The Journal of physiology. vol 401. 1988-10-31. PMID:2459376. |
on the potassium conductance increase activated by gabab and dopamine d2 receptors in rat substantia nigra neurones. |
1988-10-31 |
2023-08-11 |
rat |