| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Herrera-Marschitz, L Terenius, T Sakurada, M S Reid, U Ungersted. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain research. vol 521. issue 1-2. 1990-11-09. PMID:1698511. |
when given locally into the substantia nigra, sp induces dopamine release in the ipsilateral striatum and produces contralateral rotation in a dose-dependent, but bell-shaped, manner. |
1990-11-09 |
2023-08-11 |
rat |
| G al-Tajir, M S Starr, B S Star. Proconvulsant effect of SKF 38393 mediated by nigral D1 receptors. European journal of pharmacology. vol 182. issue 2. 1990-10-17. PMID:2204536. |
this study investigated the hypothesis that the proconvulsant action of systemically applied dopamine d1 receptor stimulants is mediated by d1 receptors in the substantia nigra. |
1990-10-17 |
2023-08-11 |
rat |
| G al-Tajir, M S Starr, B S Star. Proconvulsant effect of SKF 38393 mediated by nigral D1 receptors. European journal of pharmacology. vol 182. issue 2. 1990-10-17. PMID:2204536. |
these results indicate that dopamine d1 receptors in the substantia nigra (pars reticulata) mediate a proconvulsant action of dopamine, which is opposite to the anticonvulsant effect of the amine at striatal d2 receptors. |
1990-10-17 |
2023-08-11 |
rat |
| M S Reid, W T O'Connor, M Herrera-Marschitz, U Ungersted. The effects of intranigral GABA and dynorphin A injections on striatal dopamine and GABA release: evidence that dopamine provides inhibitory regulation of striatal GABA neurons via D2 receptors. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:1975763. |
the effects of injections of gamma-aminobutyric acid (gaba) and dynorphin a into the substantia nigra, pars reticulata on the levels of extracellular dopamine (da) and gaba in the ipsilateral striatum of halothane-anaesthetized rats were studied using microdialysis. |
1990-10-16 |
2023-08-11 |
rat |
| I Date, D L Felten, S Y Felte. Long-term effect of MPTP in the mouse brain in relation to aging: neurochemical and immunocytochemical analysis. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:1975765. |
given 12 h apart) resulted in significant depletion of dopamine (da) concentration in the striatum, substantia nigra, nucleus accumbens, and olfactory tubercle 1 week after treatment in both young and aging mice. |
1990-10-16 |
2023-08-11 |
mouse |
| S Che. [Experimental research on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian animal models in the rhesus monkey and C57 black mouse]. Zhonghua yi xue za zhi. vol 70. issue 5. 1990-10-16. PMID:2168792. |
parkinson's disease (pd) is a common neurodegenerative disease of old age characterized by triad of akinesia, rigidity and tremor, reduction of dopamine (da) content in the nigrostriatum, and severe degeneration of neuron in the substantia nigra. |
1990-10-16 |
2023-08-11 |
mouse |
| C J Schmidt, C K Black, V L Taylo. Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine. European journal of pharmacology. vol 181. issue 1-2. 1990-09-27. PMID:1974858. |
similar results were achieved by selectively inhibiting dopamine synthesis with alpha-methyl-p-tyrosine or through bilateral lesions of the substantia nigra with 6-hydroxydopamine. |
1990-09-27 |
2023-08-11 |
Not clear |
| M Tanaka, A Sotomatsu, H Kanai, S Hira. [Iron-dependent cytotoxic effects of dopa on cultured neurons of the dorsal root ganglia]. Rinsho shinkeigaku = Clinical neurology. vol 30. issue 4. 1990-09-21. PMID:2117513. |
although many authors have suggested that dopamine and its metabolites producing free radicals have an harmful effect in the substantia nigra, experimental evidence has not been shown. |
1990-09-21 |
2023-08-11 |
mouse |
| N B Mercuri, P Calabresi, G Bernard. Responses of rat substantia nigra compacta neurones to L-DOPA. British journal of pharmacology. vol 100. issue 2. 1990-09-13. PMID:2165836. |
we propose that l-dopa inhibits the firing of substantia nigra zona compacta neurones by being converted to dopamine which is then released by these cells. |
1990-09-13 |
2023-08-11 |
rat |
| T Kiriu, K Ameno, C Fuke, S Ameno, I Ijir. [The distribution of toluene in the brain and its effects on the brain catecholamines in acute toluene poisoning]. Nihon hoigaku zasshi = The Japanese journal of legal medicine. vol 44. issue 1. 1990-08-13. PMID:2366393. |
the inhalation of toluene (1,500 ppm and 10,000 ppm) caused decreases in the noradrenaline (na) levels in the dorsal part of rat pons, rich in locus coeruleus, and in the dopamine (da) levels in the hypothalamus and ventral part of the rat midbrain, rich in substantia nigra. |
1990-08-13 |
2023-08-11 |
rat |
| M G Lacey, N B Mercuri, R A Nort. Actions of cocaine on rat dopaminergic neurones in vitro. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361170. |
it is concluded that cocaine (1-10 microm) inhibits the firing and hyperpolarizes substantia nigra zona compacta neurones in vitro by blocking the uptake of dopamine which the cells continuously release. |
1990-08-08 |
2023-08-11 |
rat |
| H Dabadie, M Geffard, J Paccali. [Simultaneous detection of tryptamine and dopamine in the substantia nigra and raphe nuclei in rats using specific antibodies]. Therapie. vol 45. issue 3. 1990-08-08. PMID:2363116. |
[simultaneous detection of tryptamine and dopamine in the substantia nigra and raphe nuclei in rats using specific antibodies]. |
1990-08-08 |
2023-08-11 |
rat |
| E K Perry, E Marshall, R H Perry, D Irving, C J Smith, G Blessed, A F Fairbair. Cholinergic and dopaminergic activities in senile dementia of Lewy body type. Alzheimer disease and associated disorders. vol 4. issue 2. 1990-08-02. PMID:2357341. |
in the caudate nucleus, dopamine levels were related to the number of neurons in the substantia nigra, there being a 40-60% loss of both in sdlt--probably accounting for mild extrapyramidal features in some of these cases--compared with an 80% loss in parkinson disease and no change in ad. |
1990-08-02 |
2023-08-11 |
Not clear |
| M E Götz, A Freyberger, P Riedere. Oxidative stress: a role in the pathogenesis of Parkinson's disease. Journal of neural transmission. Supplementum. vol 29. 1990-08-01. PMID:2193108. |
the role of melanin in the degenerative process is not clear, but autoxidative reactions such as the oxidation of dopamine (da) to melanin generating radicals and toxic metabolites seem to enhance the vulnerability of neurons in the substantia nigra (sn). |
1990-08-01 |
2023-08-11 |
Not clear |
| R Meloni, K Gal. Pharmacological evidence for feedback regulation of dopamine metabolism in solid fetal substantia nigra transplants. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:2359027. |
pharmacological evidence for feedback regulation of dopamine metabolism in solid fetal substantia nigra transplants. |
1990-07-31 |
2023-08-11 |
human |
| E Castañeda, I Q Whishaw, T E Robinso. Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 6. 1990-07-26. PMID:1693953. |
intracerebral microdialysis was used to measure the extracellular concentration of striatal dopamine (da) and its metabolites in freely moving rats depleted of da by the bilateral infusion of 6-hydroxydopamine into the substantia nigra approximately 1 month earlier. |
1990-07-26 |
2023-08-11 |
rat |
| C C Ouimet, P Greengar. Distribution of DARPP-32 in the basal ganglia: an electron microscopic study. Journal of neurocytology. vol 19. issue 1. 1990-07-16. PMID:2191086. |
darpp-32, a dopamine and cyclic amp-regulated phosphoprotein, has been studied by light and electron microscopical immunocytochemistry in the rat caudatoputamen, globus pallidus and substantia nigra. |
1990-07-16 |
2023-08-11 |
rat |
| J D Elsworth, A Y Deutch, D E Redmond, J R Sladek, R H Rot. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain research. vol 513. issue 2. 1990-07-16. PMID:2350702. |
mptp-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. |
1990-07-16 |
2023-08-11 |
monkey |
| J D Elsworth, A Y Deutch, D E Redmond, J R Sladek, R H Rot. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain research. vol 513. issue 2. 1990-07-16. PMID:2350702. |
dopamine (da) and homovanillic acid (hva) concentrations were measured in subregions of substantia nigra, ventral tegmental area and retrorubral field in vervet monkeys 1 to 2 months after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
1990-07-16 |
2023-08-11 |
monkey |
| K Fuxe, A M Janson, A Jansson, K Andersson, P Eneroth, L F Agnat. Chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:2342600. |
chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection. |
1990-06-27 |
2023-08-11 |
rat |