| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E K Richfiel. Quantitative autoradiography of the dopamine uptake complex in rat brain using [3H]GBR 12935: binding characteristics. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:1829013. |
lesioning of the dopaminergic median forebrain bundle resulted in a dramatic loss of the dopamine uptake complex in the striatum, nucleus accumbens, olfactory tubercle, and substantia nigra. |
1991-07-31 |
2023-08-11 |
rat |
| T M Dawson, V L Dawson, F H Gage, L J Fisher, M A Hunt, J K Wamsle. Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:1905173. |
the autoradiographic distribution and density of muscarinic receptors was studied in the neostriatum of rats with long-term unilateral 6-hydroxydopamine (6-ohda) lesions of the nigrostriatal dopaminergic pathway and in lesioned rats who had additionally received embryonic substantia nigra grafts in the dopamine denervated striatum. |
1991-07-31 |
2023-08-11 |
rat |
| T M Dawson, V L Dawson, F H Gage, L J Fisher, M A Hunt, J K Wamsle. Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:1905173. |
the findings of downregulation of muscarinic receptors following long-term dopamine denervation and the subsequent normalization of muscarinic receptor density after fetal mesencephalic transplantation suggests that transplanted substantia nigra cells are able to restore inhibitory control on striatal cholinergic interneurons. |
1991-07-31 |
2023-08-11 |
rat |
| M Herkenham, M D Little, K Bankiewicz, S C Yang, S P Markey, J N Johannesse. Selective retention of MPP+ within the monoaminergic systems of the primate brain following MPTP administration: an in vivo autoradiographic study. Neuroscience. vol 40. issue 1. 1991-07-22. PMID:2052148. |
the apparent degeneration of the dopamine axon terminals in the caudate-putamen and the development of parkinson-like behavioral signs seen at 10 days survival were observed to precede the loss of cell bodies in the substantia nigra, which appeared normal by the criteria of nissl staining and neuromelanin content at all time points in the acute conditions. |
1991-07-22 |
2023-08-11 |
monkey |
| M Yoshida, T Niwa, T Nagats. Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: the behavioral and biochemical changes. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:1982957. |
biochemical analysis of the brains of tiq-treated monkeys revealed significant decrease in dopamine (da) and total biopterin (bp) concentrations, and tyrosine hydroxylase (th) activity in the substantia nigra, and these biochemical changes were not reversed by 7 days following the termination of chronic administration of tiq. |
1991-07-19 |
2023-08-11 |
monkey |
| R Rivest, F B Jolicoeur, C A Marsde. Neurotensin causes a greater increase in the metabolism of dopamine in the accumbens than in the striatum in vivo. Neuropharmacology. vol 30. issue 1. 1991-07-17. PMID:2046877. |
neurotensin (0.1, 1.0 and 3.0 micrograms/0.5 microliter), injected into the ventral tegmental area, induced a potent and long-lasting elevation of the peak height for dopac in the nucleus accumbens, while the same doses in the substantia nigra produced effects on the metabolism of dopamine in the striatum of smaller amplitude and shorter duration. |
1991-07-17 |
2023-08-11 |
rat |
| J N Crawle. Cholecystokinin-dopamine interactions. Trends in pharmacological sciences. vol 12. issue 6. 1991-07-17. PMID:2048219. |
cholecystokinin (cck) coexists with dopamine in a large proportion of the ventral tegmental and substantia nigra neurons in rodents and primates. |
1991-07-17 |
2023-08-11 |
Not clear |
| P M Carvey, A McRae, T F Lint, L R Ptak, E S Lo, C G Goetz, H L Klawan. The potential use of a dopamine neuron antibody and a striatal-derived neurotrophic factor as diagnostic markers in Parkinson's disease. Neurology. vol 41. issue 5 Suppl 2. 1991-07-10. PMID:2041594. |
the cerebral spinal fluid (csf) of patients with parkinson's disease (pd) contains an antibody that immunocytochemically reacts with dopamine (da) neurons in the substantia nigra (sn). |
1991-07-10 |
2023-08-11 |
Not clear |
| I Strömberg, C van Horne, M Bygdeman, N Weiner, G A Gerhard. Function of intraventricular human mesencephalic xenografts in immunosuppressed rats: an electrophysiological and neurochemical analysis. Experimental neurology. vol 112. issue 2. 1991-07-02. PMID:1674693. |
much greater levels of dopamine and serotonin were detected in the grafts, compared to in normal rat substantia nigra, as measured with hplc coupled to a 16-channel electrochemical array detector. |
1991-07-02 |
2023-08-11 |
human |
| G S Zubenko, J Moossy, A J Martinez, G Rao, D Claassen, J Rosen, U Kop. Neuropathologic and neurochemical correlates of psychosis in primary dementia. Archives of neurology. vol 48. issue 6. 1991-06-28. PMID:1710105. |
the concentrations of norepinephrine, dopamine, and serotonin, the metabolites of these biogenic amines, and the specific activity of choline acetyltransferase were also determined in these four cortical regions as well as in the substantia nigra, thalamus, amygdala, and caudate nucleus. |
1991-06-28 |
2023-08-11 |
Not clear |
| N L Ostrowski, A R Caggiul. Correlation between locomotor stimulation and the electrophysiological effects of low doses of morphine on substantia nigra dopamine neurons. I. Acute drug administration. The Journal of pharmacology and experimental therapeutics. vol 257. issue 1. 1991-05-24. PMID:2020010. |
correlation between locomotor stimulation and the electrophysiological effects of low doses of morphine on substantia nigra dopamine neurons. |
1991-05-24 |
2023-08-11 |
rat |
| M Santiago, H Rollema, J B de Vries, B H Westerin. Acute effects of intranigral application of MPP+ on nigral and bilateral striatal release of dopamine simultaneously recorded by microdialysis. Brain research. vol 538. issue 2. 1991-05-16. PMID:1707325. |
intracerebral microdialysis in freely moving rats was used to investigate the effects of perfusions with the 1-methyl-4-phenylpyridinium ion (mpp+) in the substantia nigra (sn) on the extracellular levels of dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva) and 5-hydroxyindoleacetic acid (5-hiaa) in the perfused sn and in the ipsi- and contralateral striata. |
1991-05-16 |
2023-08-11 |
rat |
| R F Seegal, B Bush, K O Brosc. Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function. Toxicology. vol 66. issue 2. 1991-05-13. PMID:2014516. |
aroclor 1016 significantly decreased concentrations of dopamine and its metabolites in the caudate, putamen, substantia nigra and hypothalamus but did not alter neurotransmitter or metabolite concentrations in the globus pallidus and hippocampus. |
1991-05-13 |
2023-08-11 |
monkey |
| R F Seegal, B Bush, K O Brosc. Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function. Toxicology. vol 66. issue 2. 1991-05-13. PMID:2014516. |
aroclor 1260 reduced dopamine concentrations in the caudate, putamen and hypothalamus but produced no effects in the substantia nigra, globus pallidus or hippocampus. |
1991-05-13 |
2023-08-11 |
monkey |
| M S Reid, M Herrera-Marschitz, J Kehr, U Ungersted. Striatal dopamine and glutamate release: effects of intranigral injections of substance P. Acta physiologica Scandinavica. vol 140. issue 4. 1991-05-07. PMID:1707211. |
unilateral injections of substance p (0.07 nmol) into the substantia nigra, pars reticulata enhanced the levels of dopamine and glutamate in the ipsilateral striatum. |
1991-05-07 |
2023-08-11 |
rat |
| R F Cox, B L Waszcza. Irreversible receptor inactivation reveals differences in dopamine receptor reserve between A9 and A10 dopamine systems: an electrophysiological analysis. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:1981482. |
partial receptor inactivation was used as a tool to examine whether differences in receptor reserve exist between the dopamine receptor populations which mediate responses of substantia nigra (a9) and ventral tegmental area (a10) dopamine neurons to dopamine agonist drugs. |
1991-04-18 |
2023-08-11 |
rat |
| J De Keyser, J P De Backer, G Vauquelin, G Ebinge. D1 and D2 dopamine receptors in human substantia nigra: localization and the effect of aging. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:1825842. |
d1 and d2 dopamine receptors in human substantia nigra: localization and the effect of aging. |
1991-04-15 |
2023-08-11 |
human |
| J De Keyser, J P De Backer, G Vauquelin, G Ebinge. D1 and D2 dopamine receptors in human substantia nigra: localization and the effect of aging. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:1825842. |
since nigrostriatal dopaminergic neurons degenerate with aging, these results suggest either that the nigral d2 receptors are up-regulated in response to a progressive depletion of dopamine in the substantia nigra or that, in contrast to the rat, they are not located on dopaminergic neurons. |
1991-04-15 |
2023-08-11 |
human |
| M Santiago, B H Westerink, H Rollem. Responsiveness of striatal dopamine release in awake animals after chronic 1-methyl-4-phenylpyridinium ion-induced lesions of the substantia nigra. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:2002346. |
responsiveness of striatal dopamine release in awake animals after chronic 1-methyl-4-phenylpyridinium ion-induced lesions of the substantia nigra. |
1991-04-15 |
2023-08-11 |
rat |
| M Santiago, B H Westerink, H Rollem. Responsiveness of striatal dopamine release in awake animals after chronic 1-methyl-4-phenylpyridinium ion-induced lesions of the substantia nigra. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:2002346. |
extracellular concentrations of dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), and homovanillic acid were measured by microdialysis in rat striatum 1 month after a unilateral infusion via a dialysis probe of a high concentration (10 mm) of 1-methyl-4-phenylpyridinium ion (mpp+) into the substantia nigra. |
1991-04-15 |
2023-08-11 |
rat |