| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Reid, M Herrera-Marschitz, L Terenius, U Ungersted. Intranigral substance P modulation of striatal dopamine: interaction with N-terminal and C-terminal substance P fragments. Brain research. vol 526. issue 2. 1991-01-31. PMID:1701682. |
the effects of unilateral injections of two substance p fragments, the n-terminal substance p (1-7) (sp1-7) and the c-terminal substance p (6-11) (sp6-11) into the substantia nigra, pars reticulata on dopamine (da) release in the ipsilateral striatum of halothane-anaesthetized rats were studied using microdialysis. |
1991-01-31 |
2023-08-11 |
rat |
| T Yamada, P L McGeer, K G Baimbridge, E G McGee. Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K. Brain research. vol 526. issue 2. 1991-01-31. PMID:2257487. |
relative sparing in parkinson's disease of substantia nigra dopamine neurons containing calbindin-d28k. |
1991-01-31 |
2023-08-11 |
Not clear |
| J S Kroin, L C Kao, T J Zhang, R D Penn, H L Klawans, P M Carve. Dopamine distribution and behavioral alterations resulting from dopamine infusion into the brain of the lesioned rat. Journal of neurosurgery. vol 74. issue 1. 1991-01-28. PMID:1984488. |
in an effort to verify the "dopamine secretion hypothesis" as the mechanism responsible for the antiparkinsonian efficacy of adrenal medullary transplants into the brain, the effects of dopamine infusion into the brains of rats with unilateral substantia nigra lesions were examined. |
1991-01-28 |
2023-08-11 |
rat |
| F Javoy-Agid, E C Hirsch, S Dumas, C Duyckaerts, J Mallet, Y Agi. Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in Parkinson's disease: an in situ hybridization study. Neuroscience. vol 38. issue 1. 1991-01-24. PMID:1979431. |
decreased tyrosine hydroxylase messenger rna in the surviving dopamine neurons of the substantia nigra in parkinson's disease: an in situ hybridization study. |
1991-01-24 |
2023-08-11 |
Not clear |
| R F Seegal, B Bush, W Shai. Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture. Toxicology and applied pharmacology. vol 106. issue 1. 1991-01-17. PMID:2123577. |
exposure of the nonhuman primate, macaca nemestrina, to aroclor 1016, a commercial mixture of 26 lightly chlorinated pcb congeners, decreased dopamine concentrations in the caudate, putamen, substantia nigra, and hypothalamus. |
1991-01-17 |
2023-08-11 |
monkey |
| O Giorgi, M L Porceddu, S Pepitoni, G P Serra, G Toffano, G Biggi. Differential effect of aging on 3H-SCH 23390 binding sites in the retina and in distinct areas of the rat brain. Journal of neural transmission. General section. vol 82. issue 3. 1991-01-15. PMID:2248731. |
the effects of age on the binding parameters of the selective d-1 dopamine (da) receptor antagonist 3h-sch 23390 were studied in membrane preparations from rat striatum, substantia nigra, olfactory tubercle, prefrontal cortex and retina. |
1991-01-15 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnett, A J Northrop, B J Morri. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--III. Reversal by embryonic nigral dopamine grafts. Neuroscience. vol 37. issue 3. 1991-01-08. PMID:2247221. |
in all the animals of the lesioned and grafted groups there was a complete loss of dopamine neurons in the ipsilateral substantia nigra as demonstrated by tyrosine hydroxylase-immunohistochemistry and in-situ hybridization histochemistry. |
1991-01-08 |
2023-08-11 |
rat |
| T L Perry, J M Wright, K Berry, S Hansen, T L Perr. Dominantly inherited apathy, central hypoventilation, and Parkinson's syndrome: clinical, biochemical, and neuropathologic studies of 2 new cases. Neurology. vol 40. issue 12. 1991-01-07. PMID:2247238. |
neurochemical studies showed a marked depletion of dopamine in substantia nigra, putamen, and caudate nucleus, as well as reduction in serotonin content in the substantia nigra. |
1991-01-07 |
2023-08-11 |
Not clear |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Neurotensin-dopamine interactions in the substantia nigra of the rat brain. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2147039. |
single or multiple doses of the potent dopamine releaser, methamphetamine (meth), increases the content of neurotensin (nt)-like immunoreactivity (ntli) in the substantia nigra of the rat brain by 2- to 3-fold. |
1990-12-31 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Neurotensin-dopamine interactions in the substantia nigra of the rat brain. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2147039. |
these results suggest that activation of d-1 receptors by endogenous dopamine results in an increase in the level of ntli in the substantia nigra. |
1990-12-31 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Neurotensin-dopamine interactions in the substantia nigra of the rat brain. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2147039. |
in addition to the effects of direct or indirect stimulation of dopamine activity on nigral nt levels, basally released dopamine also appeared to regulate the level of ntli in the substantia nigra. |
1990-12-31 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Neurotensin-dopamine interactions in the substantia nigra of the rat brain. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2147039. |
thus, interruption of tonic dopamine activity by reserpine-induced depletion of dopamine significantly reduced the level of ntli in the substantia nigra. |
1990-12-31 |
2023-08-11 |
rat |
| R P Dilts, P W Kaliva. Autoradiographic localization of delta opioid receptors within the mesocorticolimbic dopamine system using radioiodinated [2-D-penicillamine, 5-D-penicillamine]enkephalin (125I-DPDPE). Synapse (New York, N.Y.). vol 6. issue 2. 1990-12-20. PMID:1978419. |
unilateral lesions of dopamine perikarya (a9 and a10) within the ventral tegmental area and substantia nigra produced by mesencephalic injection of 6-hydroxydopamine resulted in significant (20-30%) increases in 125i-dpdpe binding contralateral to the lesion within the striatum and nucleus accumbens. |
1990-12-20 |
2023-08-11 |
Not clear |
| M S Reid, M Herrera-Marschitz, T Hökfelt, M Ohlin, K L Valentino, U Ungersted. Effects of intranigral substance P and neurokinin A on striatal dopamine release--I. Interactions with substance P antagonists. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:1700329. |
unilateral injections of substance p (0.00007-7.0 nmol injected in 0.2 microliter) as well as neurokinin a (0.009-9.0 nmol) into the substantia nigra, pars reticulata of halothane anaesthetized rats produced long-lasting increases in ipsilateral striatal dopamine and dihydroxyphenylacetic acid levels. |
1990-12-06 |
2023-08-11 |
rat |
| M S Reid, M Herrera-Marschitz, U Ungersted. Effects of intranigral substance P and neurokinin A on striatal dopamine release--II. Interactions with bicuculline and naloxone. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:1700330. |
unilateral injections of substance p (0.07 nmol) or neurokinin a (0.09 nmol) into the substantia nigra, pars reticulata of halothane anaesthetized rats produced long-lasting increases in ipsilateral striatal dopamine and dihydroxyphenylacetic acid levels. |
1990-12-06 |
2023-08-11 |
rat |
| C W Olano. Oxidation reactions in Parkinson's disease. Neurology. vol 40. issue 10 Suppl 3. 1990-11-21. PMID:2215972. |
further, the end products of lipid peroxidation are increased in the substantia nigra of patients with pd, supporting the notions that free radicals are being generated and may contribute to dopamine neuronal death. |
1990-11-21 |
2023-08-11 |
Not clear |
| J L Cadet, S Przedborski, V Kostic, V Jackson-Lewis, E Carlson, C J Epstei. Quantitative autoradiographic distribution of [3H]mazindol-labeled dopamine uptake sites in the brains of superoxide dismutase transgenic mice. Brain research bulletin. vol 25. issue 1. 1990-11-14. PMID:2119856. |
desmethylimipramine (dmi)-insensitive [3h]mazindol binding sites which correspond to dopamine uptake sites were located in the striatum, the nucleus accumbens, the olfactory tubercle and in the substantia nigra. |
1990-11-14 |
2023-08-11 |
mouse |
| K Sasaki, H Suda, H Watanabe, H Yag. Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats. Brain research bulletin. vol 25. issue 1. 1990-11-14. PMID:2207698. |
involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats. |
1990-11-14 |
2023-08-11 |
rat |
| K Sasaki, H Suda, H Watanabe, H Yag. Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats. Brain research bulletin. vol 25. issue 1. 1990-11-14. PMID:2207698. |
in the present study, effects of electrolytic lesions of the habenula, transections of the stria medullaris, and kainic acid-induced lesions of the entopeduncular nucleus on methamphetamine-induced inhibition of substantia nigra dopamine neurons were investigated in rats. |
1990-11-14 |
2023-08-11 |
rat |
| K Sasaki, H Suda, H Watanabe, H Yag. Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats. Brain research bulletin. vol 25. issue 1. 1990-11-14. PMID:2207698. |
these results, along with other findings, indicate possibly that the pathways running through the entopeduncular nucleus, the stria medullaris, the habenula, probably the lateral habenula, and the fasciculus retroflexus are involved in a feedback loop from the striatum to the substantia nigra and regulate the activity of dopamine neurons. |
1990-11-14 |
2023-08-11 |
rat |