| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Cerruti, M J Drian, J M Kamenka, A Priva. Localization of dopamine carriers by BTCP, a dopamine uptake inhibitor, on nigral cells cultured in vitro. Brain research. vol 555. issue 1. 1991-12-20. PMID:1681995. |
btcp, n-[1-(2-benzo(b)thiopenyl)cyclohexyl]piperidine, a derivative of phencyclidine, acted as a potent dopamine (da) uptake blocking agent on primary cultures of dopaminergic neurons obtained from substantia nigra (ic50 = 70 nm). |
1991-12-20 |
2023-08-11 |
Not clear |
| M E Hall, C Nockels, J M Stewar. Effects of substance P and SP(1-7) on dopamine release from rat substantia nigra. Annals of the New York Academy of Sciences. vol 632. 1991-12-18. PMID:1719889. |
effects of substance p and sp(1-7) on dopamine release from rat substantia nigra. |
1991-12-18 |
2023-08-11 |
rat |
| S D Chen, X D Zhou, D L Xu, G W Li, Q M Tang, X R X. Hemiparkinsonism in monkeys following unilateral common carotid artery infusion of MPTP. A study of behavior, biochemistry and histology. Chinese medical journal. vol 104. issue 9. 1991-12-17. PMID:1935358. |
the ipsilateral neurotoxicity was confirmed biochemically by 99% reduction in the caudate-putamen dopamine levels and histologically by selective cell loss in the substantia nigra of the mptp-treated side. |
1991-12-17 |
2023-08-11 |
monkey |
| S O Ogren, A Pramani. Galanin stimulates acetylcholine release in the rat striatum. Neuroscience letters. vol 128. issue 2. 1991-12-02. PMID:1719453. |
it may involve effects on gal receptors in the striatum or indirect effects via stimulation of gal receptors in the substantia nigra resulting in inhibition of striatal dopamine (da) transmission. |
1991-12-02 |
2023-08-11 |
rat |
| E Mempel, M Wieczore. Parkinson's syndrome induced in cats by the use of 6-hydroxydopamine. Observations of behavior and motor disorders. Acta neurobiologiae experimentalis. vol 50. issue 4-5. 1991-11-13. PMID:2130649. |
the possibility of inducing parkinson's syndrome in cats was investigated in three kinds of lesions: by microinjection of 6-hydroxy dopamine (6-ohda) into the pars compacta of substantia nigra (snc), bilateral injection into the snc and globus pallidus (gp) and into the snc and caput nuclei caudati (nc). |
1991-11-13 |
2023-08-11 |
Not clear |
| K Chergui, P J Charléty, H Akaoka, J L Brunet, C F Saunier, M Buda, T H Svensson, G Chouve. [Participation of NMDA receptors in spontaneous burst firing of dopaminergic mesencephalic neurons]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 313. issue 2. 1991-11-05. PMID:1833036. |
in the rat, somatodendritic application of the nmda antagonist ap-5, within the substantia nigra zona compacta and ventral tegmental area, either by micro-iontophoresis or pressure ejection, reduces burst firing of dopamine neurons. |
1991-11-05 |
2023-08-11 |
rat |
| C Le Moine, B Bloc. Rat striatal and mesencephalic neurons contain the long isoform of the D2 dopamine receptor mRNA. Brain research. Molecular brain research. vol 10. issue 4. 1991-11-04. PMID:1681404. |
the present results also demonstrate that the neurons expressing the d2 receptor gene in the substantia nigra are dopamine neurons and that d2 mrna can be present in proximal dendrites. |
1991-11-04 |
2023-08-11 |
rat |
| T M Engber, Z Susel, S Kuo, C R Gerfen, T N Chas. Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats. Brain research. vol 552. issue 1. 1991-11-04. PMID:1717109. |
the effects of striatal dopamine denervation and levodopa replacement therapy on neuronal populations in the rat striatum were assessed by measurement of glutamic acid decarboxylase (gad) and choline acetyltransferase (cat) activities in the striatum, dynorphin and substance p concentrations in the substantia nigra, and enkephalin concentration in the globus pallidus. |
1991-11-04 |
2023-08-11 |
rat |
| T Hattori, M Takada, T Moriizumi, D Van der Koo. Single dopaminergic nigrostriatal neurons form two chemically distinct synaptic types: possible transmitter segregation within neurons. The Journal of comparative neurology. vol 309. issue 3. 1991-11-04. PMID:1717519. |
thus, we suggest that single dopaminergic neurons in the substantia nigra make two types of synaptic contact with striatal cells: 1) symmetric synapses en passant, which can be stained with tyrosine hydroxylase and dopamine and which contact dendritic spine necks, and 2) asymmetric terminal boutons of unknown chemical nature which end on dendritic spine heads. |
1991-11-04 |
2023-08-11 |
rat |
| M A Nastuk, A M Graybie. Pharmacologically defined M1 and M2 muscarinic cholinergic binding sites in the cat's substantia nigra: development and maturity. Brain research. Developmental brain research. vol 61. issue 1. 1991-11-04. PMID:1914150. |
these findings provide further evidence that the substantia nigra is a site of cholinergic transmission and suggest that the functional balance between acetylcholine and dopamine in the basal ganglia acts here as well as in the striatum. |
1991-11-04 |
2023-08-11 |
cat |
| W J Florijn, T De Boer, J A Tonnaer, J W Van Nispen, D H Verstee. ACTH/MSH-like peptides inhibit the binding of dopaminergic ligands to the dopamine D2 receptor in vitro. European journal of pharmacology. vol 207. issue 1. 1991-11-01. PMID:1680721. |
acth-(1-24) also inhibited the binding of [3h]spiperone to dopamine d2 receptors in membranes of the pituitary gland, the septum and the substantia nigra. |
1991-11-01 |
2023-08-11 |
rat |
| G L Bernardini, X Gu, E Viscardi, D C Germa. Amphetamine-induced and spontaneous release of dopamine from A9 and A10 cell dendrites: an in vitro electrophysiological study in the mouse. Journal of neural transmission. General section. vol 84. issue 3. 1991-10-04. PMID:1679335. |
d-amphetamine (d-amp) is a potent releaser of dopamine (da), and its central nervous system stimulant action is mediated primarily through its effect on the substantia nigra and ventral tegmental area dopaminergic neurons (nuclei a9 and a10, respectively). |
1991-10-04 |
2023-08-11 |
mouse |
| P J Charlety, J Grenhoff, K Chergui, B De la Chapelle, M Buda, T H Svensson, G Chouve. Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate. Acta physiologica Scandinavica. vol 142. issue 1. 1991-09-23. PMID:1877358. |
midbrain dopamine neurons of the zona compacta substantia nigra (sn) and ventral tegmental area (vta), giving rise to the nigrostriatal and mesolimbocortical midbrain dopamine pathways, respectively, typically display a spontaneous activity consisting of single spikes and bursts. |
1991-09-23 |
2023-08-11 |
rat |
| P J Charlety, J Grenhoff, K Chergui, B De la Chapelle, M Buda, T H Svensson, G Chouve. Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate. Acta physiologica Scandinavica. vol 142. issue 1. 1991-09-23. PMID:1877358. |
in the present experiments, zona compacta substantia nigra and ventral tegmental area midbrain dopamine neurons were recorded in the chloral hydrate anaesthetized male rat. |
1991-09-23 |
2023-08-11 |
rat |
| P J Charlety, J Grenhoff, K Chergui, B De la Chapelle, M Buda, T H Svensson, G Chouve. Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate. Acta physiologica Scandinavica. vol 142. issue 1. 1991-09-23. PMID:1877358. |
both forms of local kynurenate application produced an immediate inhibition of burst firing and a slightly increased regularity of firing in both zona compacta substantia nigra and ventral tegmental area midbrain dopamine neurons. |
1991-09-23 |
2023-08-11 |
rat |
| M S Lawrence, D E Redmon. MPTP lesions and dopaminergic drugs alter eye blink rate in African green monkeys. Pharmacology, biochemistry, and behavior. vol 38. issue 4. 1991-09-16. PMID:1678527. |
eye blink rates were studied in african green monkeys following relatively specific destruction of substantia nigra and its dopamine projections with the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
1991-09-16 |
2023-08-11 |
monkey |
| M Mavridis, A D Degryse, A J Lategan, M R Marien, F C Colpaer. Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: a possible role for the locus coeruleus in the progression of Parkinson's disease. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1870701. |
effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: a possible role for the locus coeruleus in the progression of parkinson's disease. |
1991-09-13 |
2023-08-11 |
monkey |
| N B Mercuri, P Calabresi, G Bernard. Dopamine uptake inhibition potentiates the effects of L-DOPA on rat substantia nigra zona compacta neurons. Neuroscience letters. vol 126. issue 1. 1991-09-10. PMID:1830942. |
dopamine uptake inhibition potentiates the effects of l-dopa on rat substantia nigra zona compacta neurons. |
1991-09-10 |
2023-08-11 |
rat |
| N B Mercuri, P Calabresi, G Bernard. Dopamine uptake inhibition potentiates the effects of L-DOPA on rat substantia nigra zona compacta neurons. Neuroscience letters. vol 126. issue 1. 1991-09-10. PMID:1830942. |
intracellular electrophysiological recordings (current and voltage-clamp mode) were used to assess whether the actions of l-dopa on rat substantia nigra zona compacta neurons maintained in vitro are potentiated by drugs that block the dopamine uptake system (cocaine and nomifensine). |
1991-09-10 |
2023-08-11 |
rat |
| N B Mercuri, P Calabresi, G Bernard. Dopamine uptake inhibition potentiates the effects of L-DOPA on rat substantia nigra zona compacta neurons. Neuroscience letters. vol 126. issue 1. 1991-09-10. PMID:1830942. |
it is concluded that the dopamine uptake system have an important role in regulating the cellular responses (membrane hyperpolarization or outward current) to l-dopa application in the substantia nigra zona compacta. |
1991-09-10 |
2023-08-11 |
rat |