| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Pehek, R Crock, B K Yamamot. Selective subregional dopamine depletions in the rat caudate-putamen following nigrostriatal lesions. Synapse (New York, N.Y.). vol 10. issue 4. 1992-06-18. PMID:1374937. |
the present research investigated whether the heterogeneous distribution of dopamine would be altered following unilateral injections of the neurotoxin 6-hydroxydopamine into the substantia nigra of the rat. |
1992-06-18 |
2023-08-11 |
rat |
| E A Pehek, R Crock, B K Yamamot. Selective subregional dopamine depletions in the rat caudate-putamen following nigrostriatal lesions. Synapse (New York, N.Y.). vol 10. issue 4. 1992-06-18. PMID:1374937. |
four weeks following injection, the nucleus accumbens and subregions of the caudate-putamen and substantia nigra were dissected and analyzed by hplc with electrochemical detection for dopamine, 5-hydroxytryptamine, and their respective metabolites. |
1992-06-18 |
2023-08-11 |
rat |
| E A Pehek, R Crock, B K Yamamot. Selective subregional dopamine depletions in the rat caudate-putamen following nigrostriatal lesions. Synapse (New York, N.Y.). vol 10. issue 4. 1992-06-18. PMID:1374937. |
paralleling these findings, dopamine was more depleted in the lateral, as opposed to the medial, substantia nigra. |
1992-06-18 |
2023-08-11 |
rat |
| P Jenne. What process causes nigral cell death in Parkinson's disease? Neurologic clinics. vol 10. issue 2. 1992-06-17. PMID:1584181. |
the action of toxins or the altered metabolism of dopamine may lead to oxidative stress in substantia nigra, thereby inducing dopamine cell death and the onset of parkinson's disease. |
1992-06-17 |
2023-08-11 |
Not clear |
| W C Kolle. When does Parkinson's disease begin? Neurology. vol 42. issue 4 Suppl 4. 1992-06-16. PMID:1350072. |
marked degeneration of the substantia nigra and loss of striatal dopamine are necessary before clinical symptoms develop. |
1992-06-16 |
2023-08-11 |
Not clear |
| S B Blunt, P Jenner, C D Marsde. Motor function, graft survival and gliosis in rats with 6-OHDA lesions and foetal ventral mesencephalic grafts chronically treated with L-dopa and carbidopa. Experimental brain research. vol 88. issue 2. 1992-06-08. PMID:1577107. |
th-immunohistochemistry revealed greater than 96% loss of dopamine cells in the substantia nigra ipsilateral to the 6-ohda lesion in all animals, but cell loss in the ipsilateral ventral tegmental area was more variable (21-46% of the intact side). |
1992-06-08 |
2023-08-11 |
rat |
| P D Shepard, H Lehman. (+-)-1-hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor-mediated mechanism. The Journal of pharmacology and experimental therapeutics. vol 261. issue 2. 1992-06-05. PMID:1578355. |
(+-)-1-hydroxy-3-aminopyrrolidone-2 (ha-966) inhibits the activity of substantia nigra dopamine neurons through a non-n-methyl-d-aspartate receptor-mediated mechanism. |
1992-06-05 |
2023-08-11 |
rat |
| I Q Whishaw, E Castañeda, B P Gorn. Dopamine and skilled limb use in the rat: more severe bilateral impairments follow substantia nigra than sensorimotor cortex 6-hydroxydopamine injection. Behavioural brain research. vol 47. issue 1. 1992-06-04. PMID:1571104. |
dopamine and skilled limb use in the rat: more severe bilateral impairments follow substantia nigra than sensorimotor cortex 6-hydroxydopamine injection. |
1992-06-04 |
2023-08-11 |
rat |
| P B Silverma. Sensitization and conditioned rotation: apomorphine, quinpirole and SKF-38393 compared. Neuroreport. vol 2. issue 11. 1992-06-03. PMID:1810459. |
rats lesioned in one substantia nigra were treated on three consecutive days with the nonselective dopamine agonist, apomorphine (0.05 mg kg-1), the selective d2 agonist, quinpirole (0.025, 0.05, or 0.2 mg kg-1) or the selective d1 agonist, skf-38393 (2.0, 4.0 or 8.0 mg kg-1). |
1992-06-03 |
2023-08-11 |
rat |
| H A Robertso. Synergistic interactions of D1- and D2-selective dopamine agonists in animal models for Parkinson's disease: sites of action and implications for the pathogenesis of dyskinesias. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 19. issue 1 Suppl. 1992-06-02. PMID:1349263. |
recent work suggests that, in addition to d1 and d2 dopamine receptor sites in the striatum (caudate-putamen), l-dopa and d1 agonists have important effects at d1 dopamine receptors in the substantia nigra. |
1992-06-02 |
2023-08-11 |
rat |
| Y Sato, Y Kumamot. [Psychological stress and sexual behavior in male rats. II. Effect of psychological stress on dopamine and its metabolites in the critical brain areas mediating sexual behavior]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. vol 83. issue 2. 1992-05-07. PMID:1556840. |
in the mpoa, dopamine, dopac, and hva decreased; in the substantia nigra and amygdala, dopamine and hva decreased; and in the striatum and nucleus accumbens only hva decreased after long-term psychological stress. |
1992-05-07 |
2023-08-11 |
rat |
| Y Sato, Y Kumamot. [Psychological stress and sexual behavior in male rats. II. Effect of psychological stress on dopamine and its metabolites in the critical brain areas mediating sexual behavior]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. vol 83. issue 2. 1992-05-07. PMID:1556840. |
therefore, we suspect that exposure of male rats to psychological stress leads to a decrease in the activity of dopamine neurons, especially in the mpoa, amygdala, and substantia nigra, impairing their sexual behavior. |
1992-05-07 |
2023-08-11 |
rat |
| M Santiago, B H Westerin. The regulation of dopamine release from nigrostriatal neurons in conscious rats: the role of somatodendritic autoreceptors. European journal of pharmacology. vol 204. issue 1. 1992-05-06. PMID:1687125. |
drugs were infused into the substantia nigra of the rat brain via a microdialysis probe, and the extracellular concentration of dopamine (da) and 3,4-dihydroxyphenylacetic acid was recorded from a second dialysis probe implanted in the ipsilateral striatum. |
1992-05-06 |
2023-08-11 |
rat |
| J H Meador-Woodruff, A Mansour, D J Healy, R Kuehn, Q Y Zhou, J R Bunzow, H Akil, O Civelli, S J Watso. Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 5. issue 4. 1992-05-05. PMID:1839499. |
high levels of d2 but not d1 receptor mrna were identified in the midbrain dopamine cell groups, suggesting that the autoreceptors found in the substantia nigra and ventral tegmental area are exclusively d2. |
1992-05-05 |
2023-08-11 |
rat |
| J O Rinn. Nigral degeneration in Parkinson's disease in relation to clinical features. Acta neurologica Scandinavica. Supplementum. vol 136. 1992-04-21. PMID:1801543. |
of the parkinsonian symptoms rigidity and hypokinesia are associated with neuronal loss in the lateral substantia nigra and the resulting dopamine loss in the putamen. |
1992-04-21 |
2023-08-11 |
Not clear |
| B E Mileson, M H Lewis, R B Mailma. Dopamine receptor 'supersensitivity' occurring without receptor up-regulation. Brain research. vol 561. issue 1. 1992-04-16. PMID:1686741. |
unilateral 6-hydroxydopamine (6-ohda)-induced lesions of the substantia nigra have been widely used to study various aspects of dopamine neurobiology, and to screen for antiparkinsonian drugs. |
1992-04-16 |
2023-08-11 |
rat |
| B E Mileson, M H Lewis, R B Mailma. Dopamine receptor 'supersensitivity' occurring without receptor up-regulation. Brain research. vol 561. issue 1. 1992-04-16. PMID:1686741. |
this study examined the role of receptor alterations in the pharmacological supersensitivity seen in response to lesioning of central dopamine pathways in rats by intracisternal (ic) administration of 6-ohda (200 micrograms), as well as by bilateral (bil) or unilateral (uni) infusion of 6-ohda into the substantia nigra (8 micrograms/side). |
1992-04-16 |
2023-08-11 |
rat |
| B E Mileson, M H Lewis, R B Mailma. Dopamine receptor 'supersensitivity' occurring without receptor up-regulation. Brain research. vol 561. issue 1. 1992-04-16. PMID:1686741. |
both ic and bil lesions resulted in permanent decreases in dopamine concentration in the striatum, the major terminal projection from the substantia nigra. |
1992-04-16 |
2023-08-11 |
rat |
| G Engberg, H Wikströ. Sigma-receptors: implication for the control of neuronal activity of nigral dopamine-containing neurons. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1686758. |
using extracellular single unit recording techniques, we analyzed the significance of sigma-receptors in the neuronal control of dopamine (da) neurons in the zona compacta of the substantia nigra. |
1992-04-16 |
2023-08-11 |
Not clear |
| N B Mercuri, F Stratta, P Calabresi, G Bernard. Electrophysiological effects of amineptine on neurones of the rat substantia nigra pars compacta: evidence for an inhibition of the dopamine uptake system. British journal of pharmacology. vol 104. issue 3. 1992-04-16. PMID:1797329. |
it is concluded that amineptine acts as a dopamine uptake blocker in slices of rat substantia nigra. |
1992-04-16 |
2023-08-11 |
rat |