| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D N Abrous, A T Wareham, E M Torres, S B Dunnet. Unilateral dopamine lesions in neonatal, weanling and adult rats: comparison of rotation and reaching deficits. Behavioural brain research. vol 51. issue 1. 1993-02-17. PMID:1482547. |
tyrosine hydroxylase immunohistochemistry indicated a similar degree of dopamine cell loss from the substantia nigra in all groups. |
1993-02-17 |
2023-08-11 |
rat |
| P Miu, F Karoum, G Toffano, J W Commission. Regulatory aspects of nigrostriatal dopaminergic neurons. Experimental brain research. vol 91. issue 3. 1993-02-16. PMID:1483521. |
in the urethane-anesthetized rat, electrical stimulation (10 hz, 30 s, 250 microa) of the medial forebrain bundle (mfb), at 20-min intervals over an 8-h period, combined with intracerebral microdialysis in the striatum caused: an undiminished increase in the release of dopamine (da) with each stimulation episode; a decreased efflux of 3,4-dihydroxyphenylacetic acid (dopac) and 4-hydroxy-3-methoxyphenylacetic acid (hva) after the first stimulation only; a delayed increased efflux of dopac with no change in hva; and a poststimulation depression of firing of dopaminergic neurons in the substantia nigra (before, 3.1 +/- 0.7 hz; after, 1.9 +/- 1.0 hz; p < 0.05). |
1993-02-16 |
2023-08-11 |
rat |
| M Yoshida, M Ogawa, K Suzuki, T Nagats. Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues. Advances in neurology. vol 60. 1993-02-11. PMID:8093578. |
biochemical analysis of the brains of tiq-treated monkeys revealed significant decrease in dopamine (da) and total biopterin (bp) concentrations, and tyrosine hydroxylase (th) activity in the substantia nigra. |
1993-02-11 |
2023-08-12 |
mouse |
| M B Youdim, D Ben-Shachar, P Riedere. The possible role of iron in the etiopathology of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 1. 1993-02-11. PMID:8419792. |
however, the recently described pathology of pd supports the view for a state of oxidative stress in the substantia nigra (sn), resulting as a consequence of the selective accumulation of iron in sn zona compacta and within the melanized dopamine neurons. |
1993-02-11 |
2023-08-12 |
rat |
| M Naoi, P Dostert, M Yoshida, T Nagats. N-methylated tetrahydroisoquinolines as dopaminergic neurotoxins. Advances in neurology. vol 60. 1993-02-11. PMID:8420137. |
these results indicate that these isoquinolines produced in or around dopamine neurons are n-methylated especially in substantia nigra and may be further oxidized by monoamine oxidase to produce ions. |
1993-02-11 |
2023-08-12 |
human |
| F S Adams, H Schön, R K Schwarting, J P Husto. Behavioral and neurochemical indices of barrel cortex-basal ganglia interaction. Brain research. vol 597. issue 1. 1993-02-09. PMID:1477725. |
in substantia nigra, time-related asymmetries in dopamine concentrations were found with higher ipsilateral values on day 3 and higher contralateral values on day 6. |
1993-02-09 |
2023-08-11 |
rat |
| A F Iakimovskiĭ, I V Karpov. [The effect of chronic activation and block of the dopamin- and enkephalinergic systems of the neostriatum on conditioned-reflex behavior abd dopamine metabolism in the nigrostriatal system of rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 42. issue 5. 1993-02-05. PMID:1336279. |
were studied the effects of bilateral daily intrastriatal microinjections in the course of two weeks of amphetamine (45 mcg), haloperidol (5 mcg), naloxone (5 mcg), and enkephalin synthetic tetrapeptide analogue (15 mcg) on behaviour and the level of dopamine and its metabolites in the striatum and substantia nigra of rats. |
1993-02-05 |
2023-08-11 |
rat |
| D J Calcagnetti, M D Schechte. Increases in the locomotor activity of rats after intracerebral administration of cathinone. Brain research bulletin. vol 29. issue 6. 1993-02-03. PMID:1473016. |
experiment 3 examined the effects of cath injection into the dopamine cell body region of the substantia nigra, and activity was measured. |
1993-02-03 |
2023-08-11 |
rat |
| H Nissbrandt, S Hjort. Dopaminergic neurotransmission in somatodendritic and terminal areas of the rat brain: susceptibility to modulation by D1 and D2 receptors and to axotomy. Journal of neural transmission. General section. vol 90. issue 1. 1993-01-27. PMID:1361343. |
we have investigated the influence of d1 and d2 dopamine receptor active drugs on dopamine (da) release in substantia nigra (sn), striatum and limbic forebrain in intact and in hemisected rats in vivo. |
1993-01-27 |
2023-08-11 |
rat |
| M T Lin, M T Ho, M S Youn. Stimulation of the nigrostriatal dopamine system inhibits both heat production and heat loss mechanisms in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 5. 1993-01-27. PMID:1470222. |
the effects of stimulating the pars compacta of the substantia nigra (snc) on thermoregulation were assessed in normal rats, in rats with chemical lesion of the snc dopamine (da) pathways and in rats with striatal da receptor blockade. |
1993-01-27 |
2023-08-11 |
rat |
| S Fahn, G Cohe. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Annals of neurology. vol 32. issue 6. 1993-01-25. PMID:1471873. |
because the substantia nigra is rich in dopamine, which can undergo both enzymatic oxidation via monoamine oxidase and nonenzymatic autoxidation, hydrogen peroxide and oxyradicals (superoxide anion radical and hydroxyl radical) are generated in this midbrain nucleus. |
1993-01-25 |
2023-08-11 |
Not clear |
| N B Saul'skai. [The effect of 6-hydroxydopamine injections into the nucleus accumbens and substantia nigra on rat behavior]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 78. issue 4. 1993-01-22. PMID:1334857. |
bilateral infusion of 6-hydroxydophamine (15 mg/ml) into the n. accumbens and substantia nigra accelerated the avoidance conditioning and increased the dopamine and 3,4-dihydroxiphenylacetic acid levels in the striatum as compared with the rats which had only been injected the same agent in the substantia nigra alone. |
1993-01-22 |
2023-08-11 |
rat |
| S W Tam, G F Steinfels, P J Gilligan, W K Schmidt, L Coo. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles. The Journal of pharmacology and experimental therapeutics. vol 263. issue 3. 1993-01-22. PMID:1361572. |
extracellular single-unit recording studies demonstrated that dup 734 antagonized the effect of the selective sigma ligand (+)-3-(3-hydroxyphenyl-n-(1-propyl) piperidine [(+)-3-ppp] on dopamine neuronal activity in the substantia nigra of the rat with an ed90 of 3.6 mumol/kg i.v. |
1993-01-22 |
2023-08-11 |
rat |
| J Aceves, B Floran, D Martinez-Fong, J Benitez, A Sierra, G Flore. Activation of D1 receptors stimulates accumulation of gamma-aminobutyric acid in slices of the pars reticulata of 6-hydroxydopamine-lesioned rats. Neuroscience letters. vol 145. issue 1. 1993-01-13. PMID:1461565. |
d1 dopamine receptors are present on terminals of striatal neurons to the pars reticulata of the substantia nigra in the rat. |
1993-01-13 |
2023-08-11 |
rat |
| H Wachtel, M Kunow, P A Löschman. NBQX (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and CPP (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats. Neuroscience letters. vol 142. issue 2. 1993-01-06. PMID:1280793. |
nbqx (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and cpp (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats. |
1993-01-06 |
2023-08-11 |
rat |
| N Brouwer, H Van Dijken, M H Ruiters, J D Van Willigen, G J Ter Hors. Localization of dopamine D2 receptor mRNA with non-radioactive in situ hybridization histochemistry. Neuroscience letters. vol 142. issue 2. 1993-01-06. PMID:1454220. |
positive in situ hybridization signals were also found in dopamine cell groups of the substantia nigra and ventral tegmental area and in regions where a dopaminergic innervation is controversial, like the cerebellar cortex and the hippocampus. |
1993-01-06 |
2023-08-11 |
rat |
| J L Venero, A J Herrera, A Machado, J Can. Changes in neurotransmitter levels associated with the deficiency of some essential amino acids in the diet. The British journal of nutrition. vol 68. issue 2. 1992-12-24. PMID:1359904. |
the contents of dopamine (da) and serotonin (5-ht) and their metabolites were measured in rat substantia nigra and corpus striatum following dietary changes, including restriction of protein content (low-protein diet; lpd) and the contents of several large neutral amino acids (isoleucine, leucine, methionine, phenylalanine, tryptophan and valine) for 25 d. the lpd produced an increase in the concentration of tyrosine (tyr) in the two regions of the brain studied. |
1992-12-24 |
2023-08-11 |
rat |
| L T Weiss-Wunder, M F Chessele. Acute and repeated administration of fluphenazine-N-mustard alters levels of tyrosine hydroxylase mRNA in subsets of mesencephalic dopaminergic neurons. Neuroscience. vol 49. issue 2. 1992-12-14. PMID:1359452. |
acute treatment with fluphenazine-n-mustard induced an increase in both striatal dopamine turnover and the level of tyrosine hydroxylase mrna in the substantia nigra but not the ventral tegmental area. |
1992-12-14 |
2023-08-11 |
mouse |
| L T Weiss-Wunder, M F Chessele. Acute and repeated administration of fluphenazine-N-mustard alters levels of tyrosine hydroxylase mRNA in subsets of mesencephalic dopaminergic neurons. Neuroscience. vol 49. issue 2. 1992-12-14. PMID:1359452. |
after two days of repeated drug injections (twice daily), tyrosine hydroxylase mrna was decreased in the substantia nigra despite the persistence of an elevated dopamine turnover in the striatum. |
1992-12-14 |
2023-08-11 |
mouse |
| S Masuko, S Nakajima, Y Nakajim. Dissociated high-purity dopaminergic neuron cultures from the substantia nigra and the ventral tegmental area of the postnatal rat. Neuroscience. vol 49. issue 2. 1992-12-14. PMID:1359454. |
co-existence of dopamine and cholecystokinin was found in about 70% of dopaminergic neurons from the substantia nigra and in about 35% of dopaminergic neurons from the ventral tegmental area. |
1992-12-14 |
2023-08-11 |
rat |