| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Tsou, J A Girault, P Greengar. Dopamine D1 agonist SKF 38393 increases the state of phosphorylation of ARPP-21 in substantia nigra. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8436957. |
dopamine d1 agonist skf 38393 increases the state of phosphorylation of arpp-21 in substantia nigra. |
1993-03-24 |
2023-08-12 |
Not clear |
| K Takada, T Murai, T Kanayama, N Koshikaw. Effects of midazolam and flunitrazepam on the release of dopamine from rat striatum measured by in vivo microdialysis. British journal of anaesthesia. vol 70. issue 2. 1993-03-23. PMID:8435263. |
flunitrazepam 10 mumol litre-1 also decreased striatal dopamine release when infused through a dialysis probe placed into the striatum, but it failed to affect striatal dopamine release when infused into the ipsilateral substantia nigra. |
1993-03-23 |
2023-08-12 |
rat |
| P B Silverma. Sensitization, response fluctuation and long-term effect of SKF-82958 and bromocriptine in the hemi-parkinsonian rat. European journal of pharmacology. vol 229. issue 2-3. 1993-03-02. PMID:1362705. |
rats with a unilateral 6-hydroxydopamine lesion of substantia nigra were treated with the dopamine agonists skf-82958 (d1 receptor selective) or bromocriptine (d2 receptor-selective) and their circling response recorded. |
1993-03-02 |
2023-08-11 |
rat |
| P W Kalivas, P Duff. Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 1. 1993-02-24. PMID:8380850. |
using microdialysis in the ventral tegmental area and medial substantia nigra, the effect of repeated cocaine was examined on the extracellular levels of dopamine. |
1993-02-24 |
2023-08-12 |
rat |
| P W Kalivas, P Duff. Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 1. 1993-02-24. PMID:8380850. |
in separate animals, the basal concentration of dopamine in the ventral tegmental area/medial substantia nigra was measured by determining the concentration of dopamine at which no net flux occurred across the dialysis membrane in vivo. |
1993-02-24 |
2023-08-12 |
rat |
| K Rasmussen, J F Czachura, M E Stockton, J J Howber. Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8423546. |
the diphenylpyrazolidinone cholecystokinin (cck)-b antagonist ly262691 has recently been demonstrated to decrease the number of spontaneously active dopamine (da) cells in the ventral tegmental area (a10) and substantia nigra (a9) of the anesthetized rat. |
1993-02-23 |
2023-08-12 |
rat |
| G Tunniclif. Significance of gamma-hydroxybutyric acid in the brain. General pharmacology. vol 23. issue 6. 1993-02-19. PMID:1487112. |
ghb might play a role as a neurotransmitter, particularly being involved in influencing dopamine release in the substantia nigra. |
1993-02-19 |
2023-08-11 |
Not clear |
| B H Westerink, M Santiago, J B De Vrie. In vivo evidence for a concordant response of terminal and dendritic dopamine release during intranigral infusion of drugs. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 6. 1993-02-18. PMID:1362452. |
in the present study we have administered prototypical drugs of 5 different receptors (d-2, gaba-a, gaba-b, nmda, kainate) to the substantia nigra by infusion via a microdialysis probe, whereas the release of dopamine and 3,4-dihydroxyphenylacetic acid (dopac) were recorded both in the substantia nigra and (by a second microdialysis probe) in the ipsilateral striatum. |
1993-02-18 |
2023-08-11 |
Not clear |
| D N Abrous, A T Wareham, E M Torres, S B Dunnet. Unilateral dopamine lesions in neonatal, weanling and adult rats: comparison of rotation and reaching deficits. Behavioural brain research. vol 51. issue 1. 1993-02-17. PMID:1482547. |
tyrosine hydroxylase immunohistochemistry indicated a similar degree of dopamine cell loss from the substantia nigra in all groups. |
1993-02-17 |
2023-08-11 |
rat |
| P Miu, F Karoum, G Toffano, J W Commission. Regulatory aspects of nigrostriatal dopaminergic neurons. Experimental brain research. vol 91. issue 3. 1993-02-16. PMID:1483521. |
in the urethane-anesthetized rat, electrical stimulation (10 hz, 30 s, 250 microa) of the medial forebrain bundle (mfb), at 20-min intervals over an 8-h period, combined with intracerebral microdialysis in the striatum caused: an undiminished increase in the release of dopamine (da) with each stimulation episode; a decreased efflux of 3,4-dihydroxyphenylacetic acid (dopac) and 4-hydroxy-3-methoxyphenylacetic acid (hva) after the first stimulation only; a delayed increased efflux of dopac with no change in hva; and a poststimulation depression of firing of dopaminergic neurons in the substantia nigra (before, 3.1 +/- 0.7 hz; after, 1.9 +/- 1.0 hz; p < 0.05). |
1993-02-16 |
2023-08-11 |
rat |
| M Yoshida, M Ogawa, K Suzuki, T Nagats. Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues. Advances in neurology. vol 60. 1993-02-11. PMID:8093578. |
biochemical analysis of the brains of tiq-treated monkeys revealed significant decrease in dopamine (da) and total biopterin (bp) concentrations, and tyrosine hydroxylase (th) activity in the substantia nigra. |
1993-02-11 |
2023-08-12 |
mouse |
| M B Youdim, D Ben-Shachar, P Riedere. The possible role of iron in the etiopathology of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 1. 1993-02-11. PMID:8419792. |
however, the recently described pathology of pd supports the view for a state of oxidative stress in the substantia nigra (sn), resulting as a consequence of the selective accumulation of iron in sn zona compacta and within the melanized dopamine neurons. |
1993-02-11 |
2023-08-12 |
rat |
| M Naoi, P Dostert, M Yoshida, T Nagats. N-methylated tetrahydroisoquinolines as dopaminergic neurotoxins. Advances in neurology. vol 60. 1993-02-11. PMID:8420137. |
these results indicate that these isoquinolines produced in or around dopamine neurons are n-methylated especially in substantia nigra and may be further oxidized by monoamine oxidase to produce ions. |
1993-02-11 |
2023-08-12 |
human |
| F S Adams, H Schön, R K Schwarting, J P Husto. Behavioral and neurochemical indices of barrel cortex-basal ganglia interaction. Brain research. vol 597. issue 1. 1993-02-09. PMID:1477725. |
in substantia nigra, time-related asymmetries in dopamine concentrations were found with higher ipsilateral values on day 3 and higher contralateral values on day 6. |
1993-02-09 |
2023-08-11 |
rat |
| A F Iakimovskiĭ, I V Karpov. [The effect of chronic activation and block of the dopamin- and enkephalinergic systems of the neostriatum on conditioned-reflex behavior abd dopamine metabolism in the nigrostriatal system of rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 42. issue 5. 1993-02-05. PMID:1336279. |
were studied the effects of bilateral daily intrastriatal microinjections in the course of two weeks of amphetamine (45 mcg), haloperidol (5 mcg), naloxone (5 mcg), and enkephalin synthetic tetrapeptide analogue (15 mcg) on behaviour and the level of dopamine and its metabolites in the striatum and substantia nigra of rats. |
1993-02-05 |
2023-08-11 |
rat |
| D J Calcagnetti, M D Schechte. Increases in the locomotor activity of rats after intracerebral administration of cathinone. Brain research bulletin. vol 29. issue 6. 1993-02-03. PMID:1473016. |
experiment 3 examined the effects of cath injection into the dopamine cell body region of the substantia nigra, and activity was measured. |
1993-02-03 |
2023-08-11 |
rat |
| H Nissbrandt, S Hjort. Dopaminergic neurotransmission in somatodendritic and terminal areas of the rat brain: susceptibility to modulation by D1 and D2 receptors and to axotomy. Journal of neural transmission. General section. vol 90. issue 1. 1993-01-27. PMID:1361343. |
we have investigated the influence of d1 and d2 dopamine receptor active drugs on dopamine (da) release in substantia nigra (sn), striatum and limbic forebrain in intact and in hemisected rats in vivo. |
1993-01-27 |
2023-08-11 |
rat |
| M T Lin, M T Ho, M S Youn. Stimulation of the nigrostriatal dopamine system inhibits both heat production and heat loss mechanisms in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 5. 1993-01-27. PMID:1470222. |
the effects of stimulating the pars compacta of the substantia nigra (snc) on thermoregulation were assessed in normal rats, in rats with chemical lesion of the snc dopamine (da) pathways and in rats with striatal da receptor blockade. |
1993-01-27 |
2023-08-11 |
rat |
| S Fahn, G Cohe. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Annals of neurology. vol 32. issue 6. 1993-01-25. PMID:1471873. |
because the substantia nigra is rich in dopamine, which can undergo both enzymatic oxidation via monoamine oxidase and nonenzymatic autoxidation, hydrogen peroxide and oxyradicals (superoxide anion radical and hydroxyl radical) are generated in this midbrain nucleus. |
1993-01-25 |
2023-08-11 |
Not clear |
| N B Saul'skai. [The effect of 6-hydroxydopamine injections into the nucleus accumbens and substantia nigra on rat behavior]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 78. issue 4. 1993-01-22. PMID:1334857. |
bilateral infusion of 6-hydroxydophamine (15 mg/ml) into the n. accumbens and substantia nigra accelerated the avoidance conditioning and increased the dopamine and 3,4-dihydroxiphenylacetic acid levels in the striatum as compared with the rats which had only been injected the same agent in the substantia nigra alone. |
1993-01-22 |
2023-08-11 |
rat |