| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
these data argue against a significant presence of somatodendritic uptake systems for dopamine in the substantia nigra and suggest that caution be used in the interpretation of results from studies on dopamine release from nigral slices when [3h]dopamine has been used to preload the tissue. |
1993-06-10 |
2023-08-12 |
mouse |
| P A Lapchak, K D Beck, D M Araujo, I Irwin, J W Langston, F Heft. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:8098137. |
the medial forebrain lesions decreased the following markers of striatal dopaminergic function: [3h]opamine uptake (65%), tyrosine hydroxylase activity (79%), dopamine content (80%) and [3h]mazindol binding site density (52%), induced a pronounced loss of tyrosine hydroxylase-positive cell bodies within the substantia nigra and also reduced tyrosine hydroxylase messenger rna levels. |
1993-06-08 |
2023-08-12 |
human |
| S B Blunt, P Jenner, C D Marsde. Suppressive effect of L-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 2. 1993-05-18. PMID:8097279. |
at the end of the treatment period, the number of dopamine cells remaining in each of the lesioned and intact substantia nigra (sn) and vta were assessed, using tyrosine hydroxylase immunohistochemistry. |
1993-05-18 |
2023-08-12 |
rat |
| A Castaño, A J Herrera, J Cano, A Machad. Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:7682297. |
measurement of turnover of dopamine, noradrenaline and serotonin and their metabolites was assessed in striatum and substantia nigra of adult female rats that were fed control or vitamin e-deficient diets over 15 days. |
1993-05-12 |
2023-08-12 |
rat |
| A Castaño, A J Herrera, J Cano, A Machad. Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:7682297. |
however, the most striking result was the increase of dopamine turnover found in substantia nigra. |
1993-05-12 |
2023-08-12 |
rat |
| A Castaño, A J Herrera, J Cano, A Machad. Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:7682297. |
the present study indicates that the nigrostriatal dopamine neurons are susceptible to the deficiency of vitamin e. moreover, these data suggest that substantia nigra may be more susceptible to damage from vitamin e deficiency than striatum. |
1993-05-12 |
2023-08-12 |
rat |
| P Hantraye, M Varastet, M Peschanski, D Riche, P Cesaro, J C Willer, M Mazier. Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:8469305. |
neuropathological examination of caudate nucleus, putamen, substantia nigra and ventral tegmental area in brain sections stained for tyrosine hydroxylase showed a typical uneven striatal dopamine fibre loss and a neuronal depletion in the dopaminergic mesencephalic cell groups that reproduce those observed in idiopathic parkinson's disease. |
1993-05-12 |
2023-08-12 |
Not clear |
| E Magal, P Burnham, S Varon, J C Loui. Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8095711. |
convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra. |
1993-04-15 |
2023-08-12 |
rat |
| E Magal, P Burnham, S Varon, J C Loui. Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8095711. |
ciliary neurotrophic factor and dopamine were found to enhance the expression of tyrosine hydroxylase immunoreactivity in cultured neurons from the substantia nigra of 16-day-old rat fetuses. |
1993-04-15 |
2023-08-12 |
rat |
| V M Pickel, J Chan, S R Sesac. Cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra. Brain research. vol 602. issue 2. 1993-04-13. PMID:8095430. |
cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra. |
1993-04-13 |
2023-08-12 |
mouse |
| V M Pickel, J Chan, S R Sesac. Cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra. Brain research. vol 602. issue 2. 1993-04-13. PMID:8095430. |
dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (vta) and substantia nigra (sn), respectively. |
1993-04-13 |
2023-08-12 |
mouse |
| J P Heaton, S J Varri. Effects of streptozotocin-induced diabetes on dopaminergic functioning in the rat: analysis of yawning behavior. Pharmacology, biochemistry, and behavior. vol 44. issue 3. 1993-04-12. PMID:8451264. |
dopamine turnover in the substantia nigra of diabetic rats has been shown to be decreased following administration of amphetamine or apomorphine (17,21). |
1993-04-12 |
2023-08-12 |
rat |
| A Elverfors, J Jonason, G Jonason, G Leonsson, H Nissbrand. Determination of release of endogenous dopamine from superfused substantia nigra slices. Journal of neuroscience methods. vol 45. issue 3. 1993-04-09. PMID:1363484. |
determination of release of endogenous dopamine from superfused substantia nigra slices. |
1993-04-09 |
2023-08-11 |
Not clear |
| A Elverfors, J Jonason, G Jonason, G Leonsson, H Nissbrand. Determination of release of endogenous dopamine from superfused substantia nigra slices. Journal of neuroscience methods. vol 45. issue 3. 1993-04-09. PMID:1363484. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic neuronal pathway but also from cell bodies and dendrites in the substantia nigra (sn). |
1993-04-09 |
2023-08-11 |
Not clear |
| J Fornaguera, R K Schwarting, F Boix, J P Husto. Behavioral indices of moderate nigro-striatal 6-hydroxydopamine lesion: a preclinical Parkinson's model. Synapse (New York, N.Y.). vol 13. issue 2. 1993-04-02. PMID:7680495. |
asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. |
1993-04-02 |
2023-08-12 |
rat |
| L T Meltzer, C L Christoffersen, K A Serpa, A Razmpou. Comparison of the effects of the cholecystokinin-B receptor antagonist, PD 134308, and the cholecystokinin-A receptor antagonist, L-364,718, on dopamine neuronal activity in the substantia nigra and ventral tegmental area. Synapse (New York, N.Y.). vol 13. issue 2. 1993-04-02. PMID:8446920. |
comparison of the effects of the cholecystokinin-b receptor antagonist, pd 134308, and the cholecystokinin-a receptor antagonist, l-364,718, on dopamine neuronal activity in the substantia nigra and ventral tegmental area. |
1993-04-02 |
2023-08-12 |
rat |
| E Ronken, F L Van Muiswinkel, A H Mulder, A N Schoffelmee. Opioid receptor-mediated inhibition of evoked catecholamine release from cultured neurons of rat ventral mesencephalon and locus coeruleus. European journal of pharmacology. vol 230. issue 3. 1993-04-01. PMID:8095023. |
the effects of selective opioid agonists on the evoked release of [3h]dopamine and [3h]noradrenaline were studied in cultured dopaminergic neurons of the ventral mesencephalon (containing the substantia nigra and ventral tegmental area) and in cultured neurons of the noradrenergic locus coeruleus, respectively. |
1993-04-01 |
2023-08-12 |
human |
| S N Schiffmann, J J Vanderhaeghe. Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 3. 1993-03-30. PMID:7680065. |
the a2a receptor is mainly expressed by neurons projecting to the globus pallidus and expressing also the dopamine d2 receptor and enkephalin, but very sparsely by neurons projecting to the substantia nigra that express the dopamine d1 receptor and substance p. we have further examined the regulatory effect of the a2 receptors on striatal gene expression using in situ hybridization histochemistry and quantitative autoradiography. |
1993-03-30 |
2023-08-12 |
rat |
| C D Blaha, P Win. Modulation of dopamine efflux in the striatum following cholinergic stimulation of the substantia nigra in intact and pedunculopontine tegmental nucleus-lesioned rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 3. 1993-03-30. PMID:8441002. |
modulation of dopamine efflux in the striatum following cholinergic stimulation of the substantia nigra in intact and pedunculopontine tegmental nucleus-lesioned rats. |
1993-03-30 |
2023-08-12 |
rat |
| E Molina-Holgado, K M Dewar, L Grondin, N M van Gelder, T A Reade. Amino acid levels and gamma-aminobutyric acidA receptors in rat neostriatum, cortex, and thalamus after neonatal 6-hydroxydopamine lesion. Journal of neurochemistry. vol 60. issue 3. 1993-03-24. PMID:8382266. |
dopamine fibers arising from the substantia nigra represent a major input to the neostriatum where, besides their classic neurotransmitter role, they are seemingly involved in the regulation of amino acid neurotransmitter release. |
1993-03-24 |
2023-08-12 |
rat |