| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Sullivan, B A Parker, H Szechtma. Role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat. Brain research. vol 609. issue 1-2. 1993-07-15. PMID:8508317. |
role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat. |
1993-07-15 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
substantia nigra lesions that depleted striatal dopamine blocked the suppressive effects of haloperidol. |
1993-07-14 |
2023-08-12 |
rat |
| M R Luquin, J A Obeso, J Laguna, J Guillén, J M Martínez-Lag. The AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys. European journal of pharmacology. vol 235. issue 2-3. 1993-07-13. PMID:7685291. |
in addition they indicate that there is no functional interaction between ampa and dopamine receptors in monkeys with a substantia nigra lesion. |
1993-07-13 |
2023-08-12 |
monkey |
| N W Soong, D R Hinton, G Cortopassi, N Arnhei. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature genetics. vol 2. issue 4. 1993-06-23. PMID:1303287. |
the three regions with the highest levels, caudate, putamen and substantia nigra, are characterized by a high dopamine metabolism. |
1993-06-23 |
2023-08-11 |
human |
| N Yoshimura, E Mizuta, S Kuno, M Sasa, O Yoshid. The dopamine D1 receptor agonist SKF 38393 suppresses detrusor hyperreflexia in the monkey with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8098860. |
these results indicate that, in parkinsonism, the degeneration of dopaminergic neurons in the substantia nigra leads to the detrusor hyperreflexia, probably due to a failure of activation of dopamine d1 receptors. |
1993-06-21 |
2023-08-12 |
monkey |
| O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. |
the effects of chronic treatment with the selective dopamine d1 receptor antagonist, sch 23390, on the steady-state densities and turnover rates of these receptors were investigated in the striatum and substantia nigra of the rat. |
1993-06-14 |
2023-08-12 |
rat |
| O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. |
the repeated administration of sch 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhanced the steady-state density of dopamine d1 receptors in the striatum (+30%) and substantia nigra (+24%). |
1993-06-14 |
2023-08-12 |
rat |
| O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. |
this treatment also increased the production rates of dopamine d1 receptors in the striatum (+44%) and substantia nigra (+54%). |
1993-06-14 |
2023-08-12 |
rat |
| F W Chang, S D Wang, K T Lu, E H Le. Differential interactive effects of gliotoxin and MPTP in the substantia nigra and the locus coeruleus in BALB/c mice. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:7683960. |
we have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) infusion to the substantia nigra (sn) and the locus coeruleus (lc) both produce a long-lasting neurotoxicity on dopamine (da) and norepinephrine (ne) neurons in these two areas, respectively. |
1993-06-11 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
is there a significant somatodendritic uptake of dopamine in the substantia nigra? |
1993-06-10 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
slices of the substantia nigra from normal mice and from mice with the weaver gene were used to study somatodendritic uptake of dopamine. |
1993-06-10 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
in the absence, as well as in the presence of fluoxetine and desipramine, dopamine accumulation in the substantia nigra was only slightly attenuated by the known dopamine uptake blocker gbr 12909. |
1993-06-10 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
these data argue against a significant presence of somatodendritic uptake systems for dopamine in the substantia nigra and suggest that caution be used in the interpretation of results from studies on dopamine release from nigral slices when [3h]dopamine has been used to preload the tissue. |
1993-06-10 |
2023-08-12 |
mouse |
| P A Lapchak, K D Beck, D M Araujo, I Irwin, J W Langston, F Heft. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection. Neuroscience. vol 53. issue 3. 1993-06-08. PMID:8098137. |
the medial forebrain lesions decreased the following markers of striatal dopaminergic function: [3h]opamine uptake (65%), tyrosine hydroxylase activity (79%), dopamine content (80%) and [3h]mazindol binding site density (52%), induced a pronounced loss of tyrosine hydroxylase-positive cell bodies within the substantia nigra and also reduced tyrosine hydroxylase messenger rna levels. |
1993-06-08 |
2023-08-12 |
human |
| S B Blunt, P Jenner, C D Marsde. Suppressive effect of L-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 2. 1993-05-18. PMID:8097279. |
at the end of the treatment period, the number of dopamine cells remaining in each of the lesioned and intact substantia nigra (sn) and vta were assessed, using tyrosine hydroxylase immunohistochemistry. |
1993-05-18 |
2023-08-12 |
rat |
| A Castaño, A J Herrera, J Cano, A Machad. Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:7682297. |
measurement of turnover of dopamine, noradrenaline and serotonin and their metabolites was assessed in striatum and substantia nigra of adult female rats that were fed control or vitamin e-deficient diets over 15 days. |
1993-05-12 |
2023-08-12 |
rat |
| A Castaño, A J Herrera, J Cano, A Machad. Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:7682297. |
however, the most striking result was the increase of dopamine turnover found in substantia nigra. |
1993-05-12 |
2023-08-12 |
rat |
| A Castaño, A J Herrera, J Cano, A Machad. Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:7682297. |
the present study indicates that the nigrostriatal dopamine neurons are susceptible to the deficiency of vitamin e. moreover, these data suggest that substantia nigra may be more susceptible to damage from vitamin e deficiency than striatum. |
1993-05-12 |
2023-08-12 |
rat |
| P Hantraye, M Varastet, M Peschanski, D Riche, P Cesaro, J C Willer, M Mazier. Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons. Neuroscience. vol 53. issue 1. 1993-05-12. PMID:8469305. |
neuropathological examination of caudate nucleus, putamen, substantia nigra and ventral tegmental area in brain sections stained for tyrosine hydroxylase showed a typical uneven striatal dopamine fibre loss and a neuronal depletion in the dopaminergic mesencephalic cell groups that reproduce those observed in idiopathic parkinson's disease. |
1993-05-12 |
2023-08-12 |
Not clear |
| E Magal, P Burnham, S Varon, J C Loui. Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8095711. |
convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra. |
1993-04-15 |
2023-08-12 |
rat |