All Relations between Substantia nigra and dopamine

Publication Sentence Publish Date Extraction Date Species
R F Cox, B L Waszcza. Inhibition of substantia nigra dopamine cell firing by R(-)-N-n-propylnorapomorphine: electrophysiological and autoradiographic studies after regional inactivation of dopamine receptors by microinjection of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. Brain research. vol 613. issue 1. 1993-09-15. PMID:8102308. r(-)-npa is mediated by dopamine receptors located in substantia nigra, but not striatum and confirm the predominant role of nigral d2 receptors. 1993-09-15 2023-08-12 rat
U Wüllner, E Brouillet, O Isacson, A B Young, J B Penne. Glutamate receptor binding sites in MPTP-treated mice. Experimental neurology. vol 121. issue 2. 1993-08-31. PMID:8393409. at 2 weeks striatal dopamine content in mptp-treated mice was reduced to 7% of control and n-methyl-d-aspartate (nmda)-sensitive [3h]glutamate and [3h]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa) binding sites were decreased in substantia nigra to 57 and 76% of control, respectively. 1993-08-31 2023-08-12 mouse
R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. the nr and nnr lines also differ significantly in dopamine d2 somatodendritic receptor density; within the substantia nigra zona compacta and the ventral tegmental area, the increases in the nnr line are on average 33 and 48%, respectively. 1993-08-19 2023-08-12 mouse
R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. we now report that the nnr line has a higher number of dopamine neurons in the midrostral to the midcaudal aspect of the substantia nigra zona compacta. 1993-08-19 2023-08-12 mouse
R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. although the number of dopamine neurons in the substantia nigra zona compacta was increased in the nnr line, the density of dopamine terminals in the caudate-putamen as estimated by the [3h] mazindol technique was modestly but significantly higher (8%) in the nr line. 1993-08-19 2023-08-12 mouse
P Jenne. Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 146. 1993-08-18. PMID:8333254. the mechanisms underlying dopamine cell death in substantia nigra in parkinson's disease remain unknown. 1993-08-18 2023-08-12 Not clear
M B Mattammal, H D Chung, R Strong, F F Hs. Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry. Journal of chromatography. vol 614. issue 2. 1993-07-27. PMID:8314932. gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. 1993-07-27 2023-08-12 Not clear
W S Enochs, M J Nilges, H M Swart. Purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: characterization by electron paramagnetic resonance spectroscopy. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8390568. purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: characterization by electron paramagnetic resonance spectroscopy. 1993-07-22 2023-08-12 human
R M Sullivan, B A Parker, H Szechtma. Role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat. Brain research. vol 609. issue 1-2. 1993-07-15. PMID:8508317. role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat. 1993-07-15 2023-08-12 rat
T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. substantia nigra lesions that depleted striatal dopamine blocked the suppressive effects of haloperidol. 1993-07-14 2023-08-12 rat
M R Luquin, J A Obeso, J Laguna, J Guillén, J M Martínez-Lag. The AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys. European journal of pharmacology. vol 235. issue 2-3. 1993-07-13. PMID:7685291. in addition they indicate that there is no functional interaction between ampa and dopamine receptors in monkeys with a substantia nigra lesion. 1993-07-13 2023-08-12 monkey
N W Soong, D R Hinton, G Cortopassi, N Arnhei. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature genetics. vol 2. issue 4. 1993-06-23. PMID:1303287. the three regions with the highest levels, caudate, putamen and substantia nigra, are characterized by a high dopamine metabolism. 1993-06-23 2023-08-11 human
N Yoshimura, E Mizuta, S Kuno, M Sasa, O Yoshid. The dopamine D1 receptor agonist SKF 38393 suppresses detrusor hyperreflexia in the monkey with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8098860. these results indicate that, in parkinsonism, the degeneration of dopaminergic neurons in the substantia nigra leads to the detrusor hyperreflexia, probably due to a failure of activation of dopamine d1 receptors. 1993-06-21 2023-08-12 monkey
O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. the effects of chronic treatment with the selective dopamine d1 receptor antagonist, sch 23390, on the steady-state densities and turnover rates of these receptors were investigated in the striatum and substantia nigra of the rat. 1993-06-14 2023-08-12 rat
O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. the repeated administration of sch 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhanced the steady-state density of dopamine d1 receptors in the striatum (+30%) and substantia nigra (+24%). 1993-06-14 2023-08-12 rat
O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. this treatment also increased the production rates of dopamine d1 receptors in the striatum (+44%) and substantia nigra (+54%). 1993-06-14 2023-08-12 rat
F W Chang, S D Wang, K T Lu, E H Le. Differential interactive effects of gliotoxin and MPTP in the substantia nigra and the locus coeruleus in BALB/c mice. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:7683960. we have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) infusion to the substantia nigra (sn) and the locus coeruleus (lc) both produce a long-lasting neurotoxicity on dopamine (da) and norepinephrine (ne) neurons in these two areas, respectively. 1993-06-11 2023-08-12 mouse
J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. is there a significant somatodendritic uptake of dopamine in the substantia nigra? 1993-06-10 2023-08-12 mouse
J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. slices of the substantia nigra from normal mice and from mice with the weaver gene were used to study somatodendritic uptake of dopamine. 1993-06-10 2023-08-12 mouse
J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. in the absence, as well as in the presence of fluoxetine and desipramine, dopamine accumulation in the substantia nigra was only slightly attenuated by the known dopamine uptake blocker gbr 12909. 1993-06-10 2023-08-12 mouse