| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R F Cox, B L Waszcza. Inhibition of substantia nigra dopamine cell firing by R(-)-N-n-propylnorapomorphine: electrophysiological and autoradiographic studies after regional inactivation of dopamine receptors by microinjection of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. Brain research. vol 613. issue 1. 1993-09-15. PMID:8102308. |
r(-)-npa is mediated by dopamine receptors located in substantia nigra, but not striatum and confirm the predominant role of nigral d2 receptors. |
1993-09-15 |
2023-08-12 |
rat |
| U Wüllner, E Brouillet, O Isacson, A B Young, J B Penne. Glutamate receptor binding sites in MPTP-treated mice. Experimental neurology. vol 121. issue 2. 1993-08-31. PMID:8393409. |
at 2 weeks striatal dopamine content in mptp-treated mice was reduced to 7% of control and n-methyl-d-aspartate (nmda)-sensitive [3h]glutamate and [3h]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa) binding sites were decreased in substantia nigra to 57 and 76% of control, respectively. |
1993-08-31 |
2023-08-12 |
mouse |
| R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. |
the nr and nnr lines also differ significantly in dopamine d2 somatodendritic receptor density; within the substantia nigra zona compacta and the ventral tegmental area, the increases in the nnr line are on average 33 and 48%, respectively. |
1993-08-19 |
2023-08-12 |
mouse |
| R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. |
we now report that the nnr line has a higher number of dopamine neurons in the midrostral to the midcaudal aspect of the substantia nigra zona compacta. |
1993-08-19 |
2023-08-12 |
mouse |
| R Hitzemann, Y Qian, B Hitzeman. Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice. The Journal of pharmacology and experimental therapeutics. vol 266. issue 1. 1993-08-19. PMID:8101223. |
although the number of dopamine neurons in the substantia nigra zona compacta was increased in the nnr line, the density of dopamine terminals in the caudate-putamen as estimated by the [3h] mazindol technique was modestly but significantly higher (8%) in the nr line. |
1993-08-19 |
2023-08-12 |
mouse |
| P Jenne. Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 146. 1993-08-18. PMID:8333254. |
the mechanisms underlying dopamine cell death in substantia nigra in parkinson's disease remain unknown. |
1993-08-18 |
2023-08-12 |
Not clear |
| M B Mattammal, H D Chung, R Strong, F F Hs. Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry. Journal of chromatography. vol 614. issue 2. 1993-07-27. PMID:8314932. |
gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. |
1993-07-27 |
2023-08-12 |
Not clear |
| W S Enochs, M J Nilges, H M Swart. Purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: characterization by electron paramagnetic resonance spectroscopy. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8390568. |
purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: characterization by electron paramagnetic resonance spectroscopy. |
1993-07-22 |
2023-08-12 |
human |
| R M Sullivan, B A Parker, H Szechtma. Role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat. Brain research. vol 609. issue 1-2. 1993-07-15. PMID:8508317. |
role of the corpus callosum in expression of behavioral asymmetries induced by a unilateral dopamine lesion of the substantia nigra in the rat. |
1993-07-15 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
substantia nigra lesions that depleted striatal dopamine blocked the suppressive effects of haloperidol. |
1993-07-14 |
2023-08-12 |
rat |
| M R Luquin, J A Obeso, J Laguna, J Guillén, J M Martínez-Lag. The AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys. European journal of pharmacology. vol 235. issue 2-3. 1993-07-13. PMID:7685291. |
in addition they indicate that there is no functional interaction between ampa and dopamine receptors in monkeys with a substantia nigra lesion. |
1993-07-13 |
2023-08-12 |
monkey |
| N W Soong, D R Hinton, G Cortopassi, N Arnhei. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature genetics. vol 2. issue 4. 1993-06-23. PMID:1303287. |
the three regions with the highest levels, caudate, putamen and substantia nigra, are characterized by a high dopamine metabolism. |
1993-06-23 |
2023-08-11 |
human |
| N Yoshimura, E Mizuta, S Kuno, M Sasa, O Yoshid. The dopamine D1 receptor agonist SKF 38393 suppresses detrusor hyperreflexia in the monkey with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8098860. |
these results indicate that, in parkinsonism, the degeneration of dopaminergic neurons in the substantia nigra leads to the detrusor hyperreflexia, probably due to a failure of activation of dopamine d1 receptors. |
1993-06-21 |
2023-08-12 |
monkey |
| O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. |
the effects of chronic treatment with the selective dopamine d1 receptor antagonist, sch 23390, on the steady-state densities and turnover rates of these receptors were investigated in the striatum and substantia nigra of the rat. |
1993-06-14 |
2023-08-12 |
rat |
| O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. |
the repeated administration of sch 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhanced the steady-state density of dopamine d1 receptors in the striatum (+30%) and substantia nigra (+24%). |
1993-06-14 |
2023-08-12 |
rat |
| O Giorgi, M G Pibiri, R Loi, M G Cord. Chronic treatment with SCH 23390 increases the production rate of dopamine D1 receptors in the nigro-striatal system of the rat. European journal of pharmacology. vol 245. issue 2. 1993-06-14. PMID:8098282. |
this treatment also increased the production rates of dopamine d1 receptors in the striatum (+44%) and substantia nigra (+54%). |
1993-06-14 |
2023-08-12 |
rat |
| F W Chang, S D Wang, K T Lu, E H Le. Differential interactive effects of gliotoxin and MPTP in the substantia nigra and the locus coeruleus in BALB/c mice. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:7683960. |
we have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) infusion to the substantia nigra (sn) and the locus coeruleus (lc) both produce a long-lasting neurotoxicity on dopamine (da) and norepinephrine (ne) neurons in these two areas, respectively. |
1993-06-11 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
is there a significant somatodendritic uptake of dopamine in the substantia nigra? |
1993-06-10 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
slices of the substantia nigra from normal mice and from mice with the weaver gene were used to study somatodendritic uptake of dopamine. |
1993-06-10 |
2023-08-12 |
mouse |
| J R Simon, B Ghett. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485453. |
in the absence, as well as in the presence of fluoxetine and desipramine, dopamine accumulation in the substantia nigra was only slightly attenuated by the known dopamine uptake blocker gbr 12909. |
1993-06-10 |
2023-08-12 |
mouse |