| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A H Rajput, W R Gibb, X H Zhong, K S Shannak, S Kish, L G Chang, O Hornykiewic. Dopa-responsive dystonia: pathological and biochemical observations in a case. Annals of neurology. vol 35. issue 4. 1994-05-10. PMID:7908789. |
biochemical studies revealed reduced dopamine in the substantia nigra and striatum (8% in the putamen and 18% of control in the caudate) with a similar but not identical subregional distribution as in idiopathic parkinson's disease. |
1994-05-10 |
2023-08-12 |
Not clear |
| G R Uhl, D Walther, D Mash, B Faucheux, F Javoy-Agi. Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. Annals of neurology. vol 35. issue 4. 1994-05-10. PMID:8154880. |
dopamine transporter messenger rna in parkinson's disease and control substantia nigra neurons. |
1994-05-10 |
2023-08-12 |
Not clear |
| S A Richardson, Y Tizab. Hyperactivity in the offspring of nicotine-treated rats: role of the mesolimbic and nigrostriatal dopaminergic pathways. Pharmacology, biochemistry, and behavior. vol 47. issue 2. 1994-05-02. PMID:8146225. |
discrete brain areas (the nucleus accumbens [nacc], striatum [str], frontal cortex [fc], ventral tegmental area [vta], and substantia nigra [sn]) were microdissected for the evaluation of dopamine (da) concentration and/or the d2 receptor subtype. |
1994-05-02 |
2023-08-12 |
rat |
| N Todo, T Momiyama, T Amano, Y Kohno, M Sas. Excitation by talipexole, a dopamine D2 agonist, of caudate nucleus neurons activated by nigral stimulation. Life sciences. vol 54. issue 14. 1994-04-26. PMID:7908115. |
an electrophysiological study using cats anesthetized with alpha-chloralose was performed to elucidate whether or not talipexole (b-ht 920 cl2: 6-allyl-2-amino -5, 6, 7, 8-tetrahydro-4h-thiazolo [4, 5 -d] -azepine-dihydrochroride), a dopamine d2 agonist, acts on postsynaptic dopamine receptors in the caudate nucleus (cn) neurons receiving excitatory input from the pars compacta of substantia nigra (sn). |
1994-04-26 |
2023-08-12 |
Not clear |
| O Stork, T Hashimoto, K Obat. Haloperidol activates tyrosine hydroxylase gene-expression in the rat substantia nigra, pars reticulata. Brain research. vol 633. issue 1-2. 1994-04-25. PMID:7907932. |
number and density of both th immunoreactive and th crna labeled cells were increased in the pars reticulata of the substantia nigra (snr) 8 h after single administration of a dopamine antagonist haloperidol. |
1994-04-25 |
2023-08-12 |
rat |
| W H Church, V L War. Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. Brain research bulletin. vol 33. issue 4. 1994-04-13. PMID:8124580. |
uric acid is reduced in the substantia nigra in parkinson's disease: effect on dopamine oxidation. |
1994-04-13 |
2023-08-12 |
human |
| W H Church, V L War. Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. Brain research bulletin. vol 33. issue 4. 1994-04-13. PMID:8124580. |
postmortem caudate and substantia nigra tissue samples from human parkinsonian patients (pd) and age-matched controls (nc) were analyzed for uric acid (ua), dopamine (da), and ascorbic acid (aa) by hplc/uv/ed. |
1994-04-13 |
2023-08-12 |
human |
| E K Perry, E Marshall, P Thompson, I G McKeith, D Collerton, A F Fairbairn, I N Ferrier, D Irving, R H Perr. Monoaminergic activities in Lewy body dementia: relation to hallucinosis and extrapyramidal features. Journal of neural transmission. Parkinson's disease and dementia section. vol 6. issue 3. 1994-04-12. PMID:8123190. |
in the neostriatum (caudate nucleus), loss of dopamine and increased hva:dopamine ratio correlated with the reduction in substantia nigra neurons in lbd but not pd, despite the greater loss of neurones and dopamine and the higher dopamine turnover ratio in pd. |
1994-04-12 |
2023-08-12 |
Not clear |
| M T Martin-Iverson, K G Todd, C A Alta. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:8074747. |
both trophic factors decreased dopamine turnover in the infused substantia nigra relative to the contralateral hemisphere and increased 5-ht turnover in the striatum of both sides. |
1994-04-07 |
2023-08-12 |
rat |
| M T Martin-Iverson, K G Todd, C A Alta. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:8074747. |
contraversive rotations were positively correlated with dopamine content decreases and 5-ht turnover increases in the striatum ipsilateral to the infused substantia nigra. |
1994-04-07 |
2023-08-12 |
rat |
| M A Meyer, M M Goodma. Intravenously administered dopamine transporter site radioligand is not significantly retained in mouse substantia nigra or other sites outside of basal ganglia. Annals of neurology. vol 35. issue 3. 1994-04-05. PMID:8122897. |
intravenously administered dopamine transporter site radioligand is not significantly retained in mouse substantia nigra or other sites outside of basal ganglia. |
1994-04-05 |
2023-08-12 |
mouse |
| G Engberg, H Nissbrand. gamma-Hydroxybutyric acid (GHBA) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating GABAB-receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 5. 1994-03-28. PMID:8114948. |
gamma-hydroxybutyric acid (ghba) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating gabab-receptors. |
1994-03-28 |
2023-08-12 |
rat |
| F Radja, M el Mansari, J J Soghomonian, K M Dewar, A Ferron, T A Reader, L Descarrie. Changes of D1 and D2 receptors in adult rat neostriatum after neonatal dopamine denervation: quantitative data from ligand binding, in situ hybridization and iontophoresis. Neuroscience. vol 57. issue 3. 1994-03-17. PMID:7906013. |
the specific binding of [3h]sch23390 to d1 and of [3h]raclopride to d2 dopamine receptors was measured by autoradiography in the rostral and caudal halves of neostriatum and in the substantia nigra of adult rats subjected to near total destruction of nigrostriatal dopamine neurons by intraventricular 6-hydroxydopamine soon after birth. |
1994-03-17 |
2023-08-12 |
rat |
| H Allaoua, I Chaudieu, R Alonso, R Quirion, P Boks. Muscarinic potentiation of excitatory amino acid-evoked dopamine release in mesencephalic cells: specificity for the NMDA response and role of intracellular messengers. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310424. |
of the five cloned muscarinic receptor subtypes, dopamine (da) neurons in the substantia nigra and ventral tegmental areas have been shown to be selectively enriched with the mrna for the m5 subtype, suggesting that muscarinic modulation of da neurons may have a distinct pharmacology. |
1994-03-17 |
2023-08-12 |
rat |
| C W Olano. A rationale for monoamine oxidase inhibition as neuroprotective therapy for Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 8 Suppl 1. 1994-03-09. PMID:8302302. |
neurons in the substantia nigra may be vulnerable to oxidant stress because (a) the metabolism of dopamine generates peroxides, which, in the presence of iron, can lead to the formation of the highly reactive hydroxyl free radical; and (b) neuromelanin within nigral neurons can bind metals such as iron and aluminum and thereby promote the site-specific formation of free radicals. |
1994-03-09 |
2023-08-12 |
Not clear |
| C W Olano. A rationale for monoamine oxidase inhibition as neuroprotective therapy for Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 8 Suppl 1. 1994-03-09. PMID:8302302. |
these findings suggest that the substantia nigra in the patient with pd is in a state of oxidant stress and that antioxidant therapy might protect residual dopamine neurons and slow the natural progression of pd. |
1994-03-09 |
2023-08-12 |
Not clear |
| C Solà, G Mengod, W C Low, J Norton, B Ghetti, J M Palacios, L C Triarho. Regional distribution of amyloid beta-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 messenger RNAs in the nigrostriatal system of normal and Weaver mutant mice and effects of ventral mesencephalic grafts. The European journal of neuroscience. vol 5. issue 11. 1994-02-22. PMID:8287193. |
transcripts encoding gap-43, map2 and isoforms beta app695, beta app714 and beta app751 were present in normal substantia nigra and progressively reduced in weaver substantia nigra; such a reduction was correlated with dopamine neuron loss. |
1994-02-22 |
2023-08-12 |
mouse |
| C Solà, G Mengod, W C Low, J Norton, B Ghetti, J M Palacios, L C Triarho. Regional distribution of amyloid beta-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 messenger RNAs in the nigrostriatal system of normal and Weaver mutant mice and effects of ventral mesencephalic grafts. The European journal of neuroscience. vol 5. issue 11. 1994-02-22. PMID:8287193. |
these results suggest that the transplanted mesencephalic cells mature very similarly to those in the normal substantia nigra, expressing different mrnas that are normally present in the ventral midbrain and which are reduced in the weaver mutant as a consequence of dopamine neuron loss. |
1994-02-22 |
2023-08-12 |
mouse |
| D G Schaar, B A Sieber, C F Dreyfus, I B Blac. Regional and cell-specific expression of GDNF in rat brain. Experimental neurology. vol 124. issue 2. 1994-02-18. PMID:8287932. |
the survival of ventral mesencephalic substantia nigra (sn) dopamine neurons, which degenerate in parkinson's disease, is enhanced by glial cells in vitro. |
1994-02-18 |
2023-08-12 |
rat |
| S R Sesack, C Aoki, V M Picke. Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 1. 1994-02-16. PMID:7904306. |
although the light microscopic distribution of immunolabeling for the d2 peptide was diffuse, it was selectively localized to regions containing dopamine cells (substantia nigra and ventral tegmental area) or their forebrain projections (dorsal and ventral striatum, nucleus accumbens, and olfactory tubercles). |
1994-02-16 |
2023-08-12 |
rat |