| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S W Tam, G F Steinfels, P J Gilligan, W K Schmidt, L Coo. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles. The Journal of pharmacology and experimental therapeutics. vol 263. issue 3. 1993-01-22. PMID:1361572. |
extracellular single-unit recording studies demonstrated that dup 734 antagonized the effect of the selective sigma ligand (+)-3-(3-hydroxyphenyl-n-(1-propyl) piperidine [(+)-3-ppp] on dopamine neuronal activity in the substantia nigra of the rat with an ed90 of 3.6 mumol/kg i.v. |
1993-01-22 |
2023-08-11 |
rat |
| J Aceves, B Floran, D Martinez-Fong, J Benitez, A Sierra, G Flore. Activation of D1 receptors stimulates accumulation of gamma-aminobutyric acid in slices of the pars reticulata of 6-hydroxydopamine-lesioned rats. Neuroscience letters. vol 145. issue 1. 1993-01-13. PMID:1461565. |
d1 dopamine receptors are present on terminals of striatal neurons to the pars reticulata of the substantia nigra in the rat. |
1993-01-13 |
2023-08-11 |
rat |
| H Wachtel, M Kunow, P A Löschman. NBQX (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and CPP (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats. Neuroscience letters. vol 142. issue 2. 1993-01-06. PMID:1280793. |
nbqx (6-nitro-sulfamoyl-benzo-quinoxaline-dione) and cpp (3-carboxy-piperazin-propyl phosphonic acid) potentiate dopamine agonist induced rotations in substantia nigra lesioned rats. |
1993-01-06 |
2023-08-11 |
rat |
| N Brouwer, H Van Dijken, M H Ruiters, J D Van Willigen, G J Ter Hors. Localization of dopamine D2 receptor mRNA with non-radioactive in situ hybridization histochemistry. Neuroscience letters. vol 142. issue 2. 1993-01-06. PMID:1454220. |
positive in situ hybridization signals were also found in dopamine cell groups of the substantia nigra and ventral tegmental area and in regions where a dopaminergic innervation is controversial, like the cerebellar cortex and the hippocampus. |
1993-01-06 |
2023-08-11 |
rat |
| J L Venero, A J Herrera, A Machado, J Can. Changes in neurotransmitter levels associated with the deficiency of some essential amino acids in the diet. The British journal of nutrition. vol 68. issue 2. 1992-12-24. PMID:1359904. |
the contents of dopamine (da) and serotonin (5-ht) and their metabolites were measured in rat substantia nigra and corpus striatum following dietary changes, including restriction of protein content (low-protein diet; lpd) and the contents of several large neutral amino acids (isoleucine, leucine, methionine, phenylalanine, tryptophan and valine) for 25 d. the lpd produced an increase in the concentration of tyrosine (tyr) in the two regions of the brain studied. |
1992-12-24 |
2023-08-11 |
rat |
| L T Weiss-Wunder, M F Chessele. Acute and repeated administration of fluphenazine-N-mustard alters levels of tyrosine hydroxylase mRNA in subsets of mesencephalic dopaminergic neurons. Neuroscience. vol 49. issue 2. 1992-12-14. PMID:1359452. |
acute treatment with fluphenazine-n-mustard induced an increase in both striatal dopamine turnover and the level of tyrosine hydroxylase mrna in the substantia nigra but not the ventral tegmental area. |
1992-12-14 |
2023-08-11 |
mouse |
| L T Weiss-Wunder, M F Chessele. Acute and repeated administration of fluphenazine-N-mustard alters levels of tyrosine hydroxylase mRNA in subsets of mesencephalic dopaminergic neurons. Neuroscience. vol 49. issue 2. 1992-12-14. PMID:1359452. |
after two days of repeated drug injections (twice daily), tyrosine hydroxylase mrna was decreased in the substantia nigra despite the persistence of an elevated dopamine turnover in the striatum. |
1992-12-14 |
2023-08-11 |
mouse |
| S Masuko, S Nakajima, Y Nakajim. Dissociated high-purity dopaminergic neuron cultures from the substantia nigra and the ventral tegmental area of the postnatal rat. Neuroscience. vol 49. issue 2. 1992-12-14. PMID:1359454. |
co-existence of dopamine and cholecystokinin was found in about 70% of dopaminergic neurons from the substantia nigra and in about 35% of dopaminergic neurons from the ventral tegmental area. |
1992-12-14 |
2023-08-11 |
rat |
| H Akaoka, P Charléty, C F Saunier, M Buda, G Chouve. Inhibition of nigral dopamine neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1359456. |
peripheral administration of low doses of dopamine agonist apomorphine induces a strong and short-latency inhibition of dopamine neurons in the substantia nigra, presumably via the activation of somatodendritic autoreceptors. |
1992-12-14 |
2023-08-11 |
rat |
| H Akaoka, P Charléty, C F Saunier, M Buda, G Chouve. Inhibition of nigral dopamine neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1359456. |
in contrast, the inhibition produced by systemic apomorphine was mimicked by drug application at a site 300 microns lateral and 600 microns ventral from the recording site in the zona reticulata of the substantia nigra, a region rich in dendrites of dopamine neurons. |
1992-12-14 |
2023-08-11 |
rat |
| G A Hicks, G Henderso. Lack of evidence for coupling of the dopamine D2 receptor to an adenosine triphosphate-sensitive potassium (ATP-K+) channel in dopaminergic neurones of the rat substantia nigra. Neuroscience letters. vol 141. issue 2. 1992-12-11. PMID:1436636. |
lack of evidence for coupling of the dopamine d2 receptor to an adenosine triphosphate-sensitive potassium (atp-k+) channel in dopaminergic neurones of the rat substantia nigra. |
1992-12-11 |
2023-08-11 |
rat |
| M Santiago, B H Westerin. The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: dual-probe microdialysis study in awake rats. European journal of pharmacology. vol 219. issue 2. 1992-12-07. PMID:1330605. |
a microdialysis probe implanted into the substantia nigra was used to infuse gamma-aminobutyric acid-ergic (gabaergic) compounds onto cell bodies/dendrites of dopaminergic neurons, while a second microdialysis probe was used to record the extracellular concentrations of dopamine and 3,4-dihydroxy-phenylacetic acid (dopac) in the ipsilateral striatum. |
1992-12-07 |
2023-08-11 |
rat |
| T H Lee, E H Ellinwood, G Einstei. Intracellular recording from dopamine neurons in the substantia nigra: double labelling for identification of projection site and morphological features. Journal of neuroscience methods. vol 43. issue 2-3. 1992-11-20. PMID:1405739. |
intracellular recording from dopamine neurons in the substantia nigra: double labelling for identification of projection site and morphological features. |
1992-11-20 |
2023-08-11 |
Not clear |
| C C Ouimet, A S LaMantia, P Goldman-Rakic, P Rakic, P Greengar. Immunocytochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the primate brain. The Journal of comparative neurology. vol 323. issue 2. 1992-11-03. PMID:1328330. |
this study indicates that darpp-32 is enriched in neurons in regions receiving a dense dopamine input from the substantia nigra and ventral tegmental area. |
1992-11-03 |
2023-08-11 |
monkey |
| B Giros, S el Mestikawy, N Godinot, K Zheng, H Han, T Yang-Feng, M G Caro. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Molecular pharmacology. vol 42. issue 3. 1992-10-26. PMID:1406597. |
we have screened a human substantia nigra cdna library with probes derived from the rat dopamine transporter. |
1992-10-26 |
2023-08-11 |
mouse |
| A A Grac. The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia. Journal of neural transmission. Supplementum. vol 36. 1992-10-22. PMID:1356143. |
furthermore, the clinical profile of the response to antipsychotic drugs appears to correspond to the dopamine system affected: antipsychotic drugs that exert therapeutic actions in schizophrenics inactivate dopamine neuron firing in the limbic-related ventral tegmental area, whereas drugs that precipitate extrapyramidal side effects cause depolarization block of the motor-related substantia nigra dopamine cells. |
1992-10-22 |
2023-08-11 |
rat |
| B H Westerink, M Santiago, J B De Vrie. The release of dopamine from nerve terminals and dendrites of nigrostriatal neurons induced by excitatory amino acids in the conscious rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1528270. |
varying concentrations of 3 specific eaa agonists, n-methyl-d-aspartate (nmda), kainate and amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa), were infused into the striatum or into the substantia nigra, and the extracellular dopamine (da) was recorded by the same probe. |
1992-10-22 |
2023-08-11 |
rat |
| A M Janson, K Fuxe, M Goldstei. Differential effects of acute and chronic nicotine treatment on MPTP-(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced degeneration of nigrostriatal dopamine neurons in the black mouse. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521037. |
the present and previous studies indicate that nicotine treatment can markedly alter the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity in the black mouse based on biochemical determinations of dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) levels in neostriatum and substantia nigra 2 weeks after mptp injection. |
1992-10-15 |
2023-08-11 |
mouse |
| M N Friedemann, G A Gerhard. Regional effects of aging on dopaminergic function in the Fischer-344 rat. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1522947. |
when potassium was used to elicit the presynaptic overflow of dopamine (da) in striatal areas predominantly innervated by the substantia nigra, the amplitude of da overflow was significantly lower in 24- and 30-month-old rats (p less than 0.05 and p less than 0.01 vs. 6 months, respectively). |
1992-10-13 |
2023-08-11 |
rat |
| I Pérez-Otaño, M T Herrero, M R Luquin, J A Obeso, J Del Rí. Chronic MPTP treatment reduces substance P and met-enkephalin content in the basal ganglia of the marmoset. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1380867. |
in addition to a strong decrease of dopamine in the striatum, there were significant reductions in substance p and met-enkephalin content in the substantia nigra, caudate nucleus and putamen. |
1992-09-29 |
2023-08-11 |
monkey |