| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Akaoka, P Charléty, C F Saunier, M Buda, G Chouve. Inhibition of nigral dopamine neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1359456. |
peripheral administration of low doses of dopamine agonist apomorphine induces a strong and short-latency inhibition of dopamine neurons in the substantia nigra, presumably via the activation of somatodendritic autoreceptors. |
1992-12-14 |
2023-08-11 |
rat |
| H Akaoka, P Charléty, C F Saunier, M Buda, G Chouve. Inhibition of nigral dopamine neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors. Neuroscience. vol 49. issue 4. 1992-12-14. PMID:1359456. |
in contrast, the inhibition produced by systemic apomorphine was mimicked by drug application at a site 300 microns lateral and 600 microns ventral from the recording site in the zona reticulata of the substantia nigra, a region rich in dendrites of dopamine neurons. |
1992-12-14 |
2023-08-11 |
rat |
| G A Hicks, G Henderso. Lack of evidence for coupling of the dopamine D2 receptor to an adenosine triphosphate-sensitive potassium (ATP-K+) channel in dopaminergic neurones of the rat substantia nigra. Neuroscience letters. vol 141. issue 2. 1992-12-11. PMID:1436636. |
lack of evidence for coupling of the dopamine d2 receptor to an adenosine triphosphate-sensitive potassium (atp-k+) channel in dopaminergic neurones of the rat substantia nigra. |
1992-12-11 |
2023-08-11 |
rat |
| M Santiago, B H Westerin. The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: dual-probe microdialysis study in awake rats. European journal of pharmacology. vol 219. issue 2. 1992-12-07. PMID:1330605. |
a microdialysis probe implanted into the substantia nigra was used to infuse gamma-aminobutyric acid-ergic (gabaergic) compounds onto cell bodies/dendrites of dopaminergic neurons, while a second microdialysis probe was used to record the extracellular concentrations of dopamine and 3,4-dihydroxy-phenylacetic acid (dopac) in the ipsilateral striatum. |
1992-12-07 |
2023-08-11 |
rat |
| T H Lee, E H Ellinwood, G Einstei. Intracellular recording from dopamine neurons in the substantia nigra: double labelling for identification of projection site and morphological features. Journal of neuroscience methods. vol 43. issue 2-3. 1992-11-20. PMID:1405739. |
intracellular recording from dopamine neurons in the substantia nigra: double labelling for identification of projection site and morphological features. |
1992-11-20 |
2023-08-11 |
Not clear |
| C C Ouimet, A S LaMantia, P Goldman-Rakic, P Rakic, P Greengar. Immunocytochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the primate brain. The Journal of comparative neurology. vol 323. issue 2. 1992-11-03. PMID:1328330. |
this study indicates that darpp-32 is enriched in neurons in regions receiving a dense dopamine input from the substantia nigra and ventral tegmental area. |
1992-11-03 |
2023-08-11 |
monkey |
| B Giros, S el Mestikawy, N Godinot, K Zheng, H Han, T Yang-Feng, M G Caro. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Molecular pharmacology. vol 42. issue 3. 1992-10-26. PMID:1406597. |
we have screened a human substantia nigra cdna library with probes derived from the rat dopamine transporter. |
1992-10-26 |
2023-08-11 |
mouse |
| A A Grac. The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia. Journal of neural transmission. Supplementum. vol 36. 1992-10-22. PMID:1356143. |
furthermore, the clinical profile of the response to antipsychotic drugs appears to correspond to the dopamine system affected: antipsychotic drugs that exert therapeutic actions in schizophrenics inactivate dopamine neuron firing in the limbic-related ventral tegmental area, whereas drugs that precipitate extrapyramidal side effects cause depolarization block of the motor-related substantia nigra dopamine cells. |
1992-10-22 |
2023-08-11 |
rat |
| B H Westerink, M Santiago, J B De Vrie. The release of dopamine from nerve terminals and dendrites of nigrostriatal neurons induced by excitatory amino acids in the conscious rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1528270. |
varying concentrations of 3 specific eaa agonists, n-methyl-d-aspartate (nmda), kainate and amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa), were infused into the striatum or into the substantia nigra, and the extracellular dopamine (da) was recorded by the same probe. |
1992-10-22 |
2023-08-11 |
rat |
| A M Janson, K Fuxe, M Goldstei. Differential effects of acute and chronic nicotine treatment on MPTP-(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced degeneration of nigrostriatal dopamine neurons in the black mouse. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521037. |
the present and previous studies indicate that nicotine treatment can markedly alter the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity in the black mouse based on biochemical determinations of dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) levels in neostriatum and substantia nigra 2 weeks after mptp injection. |
1992-10-15 |
2023-08-11 |
mouse |
| M N Friedemann, G A Gerhard. Regional effects of aging on dopaminergic function in the Fischer-344 rat. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1522947. |
when potassium was used to elicit the presynaptic overflow of dopamine (da) in striatal areas predominantly innervated by the substantia nigra, the amplitude of da overflow was significantly lower in 24- and 30-month-old rats (p less than 0.05 and p less than 0.01 vs. 6 months, respectively). |
1992-10-13 |
2023-08-11 |
rat |
| I Pérez-Otaño, M T Herrero, M R Luquin, J A Obeso, J Del Rí. Chronic MPTP treatment reduces substance P and met-enkephalin content in the basal ganglia of the marmoset. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1380867. |
in addition to a strong decrease of dopamine in the striatum, there were significant reductions in substance p and met-enkephalin content in the substantia nigra, caudate nucleus and putamen. |
1992-09-29 |
2023-08-11 |
monkey |
| G M Farfel, M S Kleven, W L Woolverton, L S Seiden, B D Perr. Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites and behavior in rhesus monkey. Brain research. vol 578. issue 1-2. 1992-09-25. PMID:1380862. |
there were no differences in d2 receptor binding site densities in the caudate, nor were there differences in binding sites between groups in the other brain regions examined: prefrontal cortex (d1, d2, dopamine transporter, beta), nucleus accumbens (d1, d2, dopamine transporter) and substantia nigra (d2). |
1992-09-25 |
2023-08-11 |
monkey |
| D Ben-Shachar, G Eshel, P Riederer, M B Youdi. Role of iron and iron chelation in dopaminergic-induced neurodegeneration: implication for Parkinson's disease. Annals of neurology. vol 32 Suppl. 1992-09-18. PMID:1510367. |
recent studies in parkinson's disease suggest that the degeneration of the nigrostriatal melanin-containing dopaminergic neurons results from toxic effects of free radicals, which are generated during dopamine metabolism in the substantia nigra (sn). |
1992-09-18 |
2023-08-11 |
rat |
| E K O'Malley, B A Sieber, I B Black, C F Dreyfu. Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture. Brain research. vol 582. issue 1. 1992-09-14. PMID:1379874. |
we previously demonstrated that substantia nigra (sn) support cells selectively increase sn dopamine (da) neuron survival in dissociated primary culture. |
1992-09-14 |
2023-08-11 |
rat |
| Y Xia, D J Goebel, G Kapatos, M J Banno. Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal. Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494906. |
dopamine transporter mrna levels in the rat substantia nigra were quantified using a sensitive nuclease protection assay with a highly homologous human dopamine transporter cdna clone. |
1992-09-09 |
2023-08-11 |
human |
| Y Xia, D J Goebel, G Kapatos, M J Banno. Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal. Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494906. |
the same probe was also used to visualize dopamine transporter mrna in the substantia nigra by in situ hybridization. |
1992-09-09 |
2023-08-11 |
human |
| M J Bannon, M S Poosch, Y Xia, D J Goebel, B Cassin, G Kapato. Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 15. 1992-09-04. PMID:1353885. |
dopamine transporter mrna content in human substantia nigra decreases precipitously with age. |
1992-09-04 |
2023-08-11 |
human |
| M J Bannon, M S Poosch, Y Xia, D J Goebel, B Cassin, G Kapato. Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 15. 1992-09-04. PMID:1353885. |
the postmortem content of dopamine transporter mrna in the substantia nigrae of 18- to 57-yr-old subjects was relatively constant, while in subjects greater than 57 yr old, a precipitous (greater than 95%) decline in substantia nigra dopamine transporter mrna was evident. |
1992-09-04 |
2023-08-11 |
human |
| S J Kish, Y Robitaille, M el-Awar, B Clark, L Schut, M J Ball, L T Young, R Currier, K Shanna. Striatal monoamine neurotransmitters and metabolites in dominantly inherited olivopontocerebellar atrophy. Neurology. vol 42. issue 8. 1992-09-03. PMID:1353622. |
seven patients had marked putamen dopamine loss (-62% to -81%) but without evidence of correspondingly severe substantia nigra cell damage; this suggests the possibility of a "dying-back" phenomenon in which nerve terminal loss precedes cell body degeneration. |
1992-09-03 |
2023-08-11 |
Not clear |