| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Brenchat, D Zamanillo, M Hamon, L Romero, J M Vel. Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions. European journal of pain (London, England). vol 16. issue 1. 2012-06-04. PMID:21843960. |
these studies provide evidence that, under sensitizing neurogenic/neuropathic conditions, activation of 5-ht(7) receptors exerts antinociceptive effects at the level of the spinal cord and pronociceptive effects at the periphery. |
2012-06-04 |
2023-08-12 |
rat |
| Ahmet Dogrul, Melik Seyrek, Emin Ozgur Akgul, Tuncer Cayci, Serdar Kahraman, Hayrunnisa Bola. Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT₇ receptors. European journal of pharmacology. vol 677. issue 1-3. 2012-05-17. PMID:22206817. |
pretreatment with 5,7-dht (50 μg) sharply reduced 5-ht levels in the spinal cord. |
2012-05-17 |
2023-08-12 |
mouse |
| Jana Sawynok, Allison R Rei. Caffeine inhibits antinociception by acetaminophen in the formalin test by inhibiting spinal adenosine A₁ receptors. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22085758. |
we propose that spinal adenosine a(1) receptors contribute to the action of acetaminophen secondarily to involvement of descending serotonin pathways and release of adenosine within the spinal cord. |
2012-05-03 |
2023-08-12 |
mouse |
| Scott Navarrett, Lauren Collier, Christopher Cardozo, Stella Drachev. Alterations of serotonin 2C and 2A receptors in response to T10 spinal cord transection in rats. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22056918. |
alterations of serotonin 2c and 2a receptors in response to t10 spinal cord transection in rats. |
2012-04-24 |
2023-08-12 |
rat |
| Scott Navarrett, Lauren Collier, Christopher Cardozo, Stella Drachev. Alterations of serotonin 2C and 2A receptors in response to T10 spinal cord transection in rats. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22056918. |
recent studies reported that a recovery of motoneurons after spinal cord transection at the sacrocaudal level may depend on adaptive alterations of the serotonin 2c (5-ht(2c)r) and 2a (5-ht(2c)r) receptor function via changes in mrna editing or protein expression, respectively. |
2012-04-24 |
2023-08-12 |
rat |
| Scott Navarrett, Lauren Collier, Christopher Cardozo, Stella Drachev. Alterations of serotonin 2C and 2A receptors in response to T10 spinal cord transection in rats. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22056918. |
while 5-ht(2a)r mrna expression was upregulated below the site of spinal cord injury (sci), no changes in 5-ht(2c)r mrna editing or expression were detected. |
2012-04-24 |
2023-08-12 |
rat |
| Li-Na Qiao, Yong-Sheng Yang, Jun-Ying Wang, Yong-Hui Gao, Yan-Jing Han, Shu-Ping Chen, Chang-Fu Ji, Jun-Ling Li. [Effects of electroacupuncture at "Futu" (LI 18), etc. on expression of spinal 5-HT 1 AR mRNA, 5-HT 2 AR mRNA and protein in rats with neck incision pain]. Zhen ci yan jiu = Acupuncture research. vol 36. issue 6. 2012-04-24. PMID:22379782. |
on the expression of 5-ht 1 a receptor (r) mrna, 5-ht2 ar mrna and protein in the spinal cord of rats with neck incision pain, so as to explore its underlying mechanism in relieving incision pain. |
2012-04-24 |
2023-08-12 |
rat |
| F E Perrin, Y N Gerber, M Teigell, N Lonjon, G Boniface, L Bauchet, J J Rodriguez, J P Hugnot, A M Priva. Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord. Cell death & disease. vol 2. 2012-04-10. PMID:21993394. |
anatomical study of serotonergic innervation and 5-ht(1a) receptor in the human spinal cord. |
2012-04-10 |
2023-08-12 |
human |
| F E Perrin, Y N Gerber, M Teigell, N Lonjon, G Boniface, L Bauchet, J J Rodriguez, J P Hugnot, A M Priva. Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord. Cell death & disease. vol 2. 2012-04-10. PMID:21993394. |
in rats, functional consequences of spinal cord injury at thoracic level can be improved by a substitutive transplantation of serotonin (5-ht) neurons or regeneration under the trophic influence of grafted stem cells. |
2012-04-10 |
2023-08-12 |
human |
| F E Perrin, Y N Gerber, M Teigell, N Lonjon, G Boniface, L Bauchet, J J Rodriguez, J P Hugnot, A M Priva. Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord. Cell death & disease. vol 2. 2012-04-10. PMID:21993394. |
translation to either pharmacological and/or cellular therapies in humans requires the mapping of the spinal cord 5-ht innervation and its receptors to determine their involvement in specific functions. |
2012-04-10 |
2023-08-12 |
human |
| F E Perrin, Y N Gerber, M Teigell, N Lonjon, G Boniface, L Bauchet, J J Rodriguez, J P Hugnot, A M Priva. Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord. Cell death & disease. vol 2. 2012-04-10. PMID:21993394. |
here, we have performed a preliminary mapping of serotonergic processes and serotonin-la (5-ht(1a)) receptors in thoracic and lumbar segments of the human spinal cord. |
2012-04-10 |
2023-08-12 |
human |
| F E Perrin, Y N Gerber, M Teigell, N Lonjon, G Boniface, L Bauchet, J J Rodriguez, J P Hugnot, A M Priva. Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord. Cell death & disease. vol 2. 2012-04-10. PMID:21993394. |
as in rodents and non-human primates, 5-ht profiles in human spinal cord are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at lumbar level. |
2012-04-10 |
2023-08-12 |
human |
| Carla Morgado, Liliana Silva, Patrícia Pereira-Terra, Isaura Tavare. Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: the preventive action of IGF1. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515376. |
since the pag uses relay stations at serotoninergic and noradrenergic brainstem areas, we determined the serotonin and noradrenaline levels at the spinal cord of streptozotocin-diabetic rats and at those brainstem areas (serotoninergic rostroventromedial medulla and noradrenergic a(5) and a(7) cell groups). |
2012-04-09 |
2023-08-12 |
rat |
| Carla Morgado, Liliana Silva, Patrícia Pereira-Terra, Isaura Tavare. Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: the preventive action of IGF1. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515376. |
serotonin and noradrenaline levels were quantified by elisa at the spinal cord, whereas at the brainstem, the quantification was performed by immunohistochemistry against, respectively, tryptophan hydroxylase (tph) or tyrosine hydroxylase (th). |
2012-04-09 |
2023-08-12 |
rat |
| Katherine C Murray, Marilee J Stephens, Michelle Rank, Jessica D'Amico, Monica A Gorassini, David J Bennet. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. Journal of neurophysiology. vol 106. issue 2. 2012-03-26. PMID:21653728. |
spinal cord injury (sci) that eliminates this 5-ht innervation leads to a disinhibition of sensory transmission and a consequent emergence of unusually long polysynaptic excitatory postsynaptic potentials (epsps) in motoneurons. |
2012-03-26 |
2023-08-12 |
rat |
| Y M Qiu, Y T Liu, S T L. Tramadol requirements may need to be increased for the perioperative management of pain in smokers. Medical hypotheses. vol 77. issue 6. 2012-03-06. PMID:22001127. |
the serotonergic system plays an important part in modulating anti-nociception, and decreasing the concentration of serotonin in vesicles in neurons of the brain and spinal cord is an effective method. |
2012-03-06 |
2023-08-12 |
Not clear |
| Shu-Yan Yu, Gui-Min Wang, Hui Wang, Hui Zhang, Qin L. Raphe pallidus modulates Bötzinger complex-induced inhibition of the phrenic nerve activity in rats. The European journal of neuroscience. vol 34. issue 7. 2012-02-10. PMID:21895801. |
moreover, as the relevant 5-ht receptors for rpa's modulatory effects are located in the cervical spinal cord, 5-ht may, in part, function as a modulator to suppress the bötc neuronal activity via direct rpa-pmn and bötc-pmn convergent projection pathways to phrenic motoneurons. |
2012-02-10 |
2023-08-12 |
rat |
| Travis Musgrave, Curtis Benson, Grace Wong, Ikennah Browne, Gustavo Tenorio, Gail Rauw, Glen B Baker, Bradley J Ker. The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE). Brain, behavior, and immunity. vol 25. issue 8. 2012-02-01. PMID:21723939. |
however, eae mice treated with plz showed a normalization of 5-ht levels in the ventral horn of the spinal cord that might account for the improvements in behavioral outcomes. |
2012-02-01 |
2023-08-12 |
mouse |
| Evelyn Amaya-Castellanos, Jorge B Pineda-Farias, Gabriela Castañeda-Corral, Guadalupe C Vidal-Cantú, Janet Murbartián, Héctor I Rocha-González, Vinicio Granados-Sot. Blockade of 5-HT7 receptors reduces tactile allodynia in the rat. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21693130. |
in addition, the 5-ht(7) receptors level in dorsal root ganglion and spinal cord was also determined. |
2011-12-09 |
2023-08-12 |
rat |
| Evelyn Amaya-Castellanos, Jorge B Pineda-Farias, Gabriela Castañeda-Corral, Guadalupe C Vidal-Cantú, Janet Murbartián, Héctor I Rocha-González, Vinicio Granados-Sot. Blockade of 5-HT7 receptors reduces tactile allodynia in the rat. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21693130. |
moreover, 5-ht(7) receptor levels were lower in the ipsilateral dorsal spinal cord of neuropathic rats compared to naïve and sham rats. |
2011-12-09 |
2023-08-12 |
rat |