| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yvette S Nout, Esther Culp, Markus H Schmidt, C Amy Tovar, Christoph Pröschel, Margot Mayer-Pröschel, Mark D Noble, Michael S Beattie, Jacqueline C Bresnaha. Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:21040723. |
serotonergic input to the lumbosacral spinal cord was not affected by treatment, but the amount of serotonin immediately caudal to the lesion was reduced in the camp groups. |
2011-02-04 |
2023-08-12 |
rat |
| Christine G Gerin, Angela Hill, Seritta Hill, Kristin Smith, Alain Priva. Serotonin release variations during recovery of motor function after a spinal cord injury in rats. Synapse (New York, N.Y.). vol 64. issue 11. 2011-01-13. PMID:20842719. |
serotonin release variations during recovery of motor function after a spinal cord injury in rats. |
2011-01-13 |
2023-08-12 |
rat |
| Christine G Gerin, Angela Hill, Seritta Hill, Kristin Smith, Alain Priva. Serotonin release variations during recovery of motor function after a spinal cord injury in rats. Synapse (New York, N.Y.). vol 64. issue 11. 2011-01-13. PMID:20842719. |
current literature suggests that serotonin (5-ht) release within the ventral horn of the spinal cord plays a role in motor function. |
2011-01-13 |
2023-08-12 |
rat |
| Christine G Gerin, Angela Hill, Seritta Hill, Kristin Smith, Alain Priva. Serotonin release variations during recovery of motor function after a spinal cord injury in rats. Synapse (New York, N.Y.). vol 64. issue 11. 2011-01-13. PMID:20842719. |
we hypothesized that endogenous 5-ht release is involved in the recovery of motor function after spinal cord injury. |
2011-01-13 |
2023-08-12 |
rat |
| Junichi Hachisuka, Hidemasa Furue, Masutaka Furue, Megumu Yoshimur. Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo. Journal of neurophysiology. vol 104. issue 1. 2011-01-07. PMID:20484528. |
these observations suggest that the long-lasting-firing c neurons in rat drg sensitive to 5-ht are responsible for conveying pruritic information to the spinal cord. |
2011-01-07 |
2023-08-12 |
rat |
| Christopher M Peters, Ken-ichiro Hayashida, Eric E Ewan, Kunie Nakajima, Hideaki Obata, Qinghao Xu, Tony L Yaksh, James C Eisenac. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain research. vol 1352. 2010-12-22. PMID:20637741. |
we also determined the density of serotonergic nerve fibers, serotonin content and the levels of 5-ht3 receptors within the spinal cord at this time point. |
2010-12-22 |
2023-08-12 |
rat |
| Amar N Maurya, Shripad B Deshpand. Involvement of 5-hydroxytryptaminergic transmission for the Mesobuthus tamulus venom-induced depression of spinal reflexes in neonatal rat in vitro. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20603188. |
5-hydroxytryptamine (5-ht) is another excitatory transmitter in the spinal cord therefore, the present study was undertaken to examine the involvement of 5-ht in the venom-induced depression of reflexes. |
2010-12-13 |
2023-08-12 |
rat |
| Alex Brenchat, Xavier Nadal, Luz Romero, Sergio Ovalle, Asunción Muro, Ricard Sánchez-Arroyos, Enrique Portillo-Salido, Marta Pujol, Ana Montero, Xavier Codony, Javier Burgueño, Daniel Zamanillo, Michel Hamon, Rafael Maldonado, José Miguel Vel. Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain. vol 149. issue 3. 2010-11-29. PMID:20399562. |
the 5-ht(7) receptor co-localized with gabaergic cells in the dorsal horn of the spinal cord, suggesting that the activation of spinal inhibitory gabaergic interneurons could contribute to the analgesic effects of 5-ht(7) receptor agonists. |
2010-11-29 |
2023-08-12 |
mouse |
| Alex Brenchat, Xavier Nadal, Luz Romero, Sergio Ovalle, Asunción Muro, Ricard Sánchez-Arroyos, Enrique Portillo-Salido, Marta Pujol, Ana Montero, Xavier Codony, Javier Burgueño, Daniel Zamanillo, Michel Hamon, Rafael Maldonado, José Miguel Vel. Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain. vol 149. issue 3. 2010-11-29. PMID:20399562. |
in addition, a significant increase of 5-ht(7) receptors was found by immunohistochemistry in the ipsilateral dorsal horn of the spinal cord after nerve injury, suggesting a "pain"-triggered regulation of receptor expression. |
2010-11-29 |
2023-08-12 |
mouse |
| Xavier Pichon, Anne S Wattiez, Carine Becamel, Ingrid Ehrlich, Joel Bockaert, Alain Eschalier, Philippe Marin, Christine Courtei. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 8. 2010-11-23. PMID:20531396. |
5-ht(2a) receptor density was not changed in the spinal cord of diabetic rats, whereas postsynaptic density protein-95 (psd-95), one of the psd-95/disc large suppressor/zonula occludens-1 (pdz) domain containing proteins interacting with these receptors, was upregulated. |
2010-11-23 |
2023-08-12 |
rat |
| K-Y Ho, W Tay, M-C Yeo, H Liu, S-J Yeo, S-L Chia, N-N L. Duloxetine reduces morphine requirements after knee replacement surgery. British journal of anaesthesia. vol 105. issue 3. 2010-10-05. PMID:20573635. |
serotonin and norepinephrine are involved in the modulation of endogenous analgesic mechanisms via descending inhibitory pain pathways in the brain and spinal cord. |
2010-10-05 |
2023-08-12 |
Not clear |
| Hideaki Obata, Masafumi Kimura, Kunie Nakajima, Masaru Tobe, Koichi Nishikawa, Shigeru Sait. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. The Journal of pharmacology and experimental therapeutics. vol 334. issue 3. 2010-09-23. PMID:20558774. |
the neurotransmitters serotonin (5-ht) and noradrenaline (na) have important roles in suppressing nociceptive transmission in the spinal cord. |
2010-09-23 |
2023-08-12 |
rat |
| Hideaki Obata, Masafumi Kimura, Kunie Nakajima, Masaru Tobe, Koichi Nishikawa, Shigeru Sait. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. The Journal of pharmacology and experimental therapeutics. vol 334. issue 3. 2010-09-23. PMID:20558774. |
in the present study, we determined the efficacy and nature of the antihypersensitivity effects of milnacipran, a 5-ht and na reuptake inhibitor (snri), in the spinal cord in a rat model of postoperative pain. |
2010-09-23 |
2023-08-12 |
rat |
| Hideaki Obata, Masafumi Kimura, Kunie Nakajima, Masaru Tobe, Koichi Nishikawa, Shigeru Sait. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. The Journal of pharmacology and experimental therapeutics. vol 334. issue 3. 2010-09-23. PMID:20558774. |
microdialysis studies of the dorsal horn of the lumbar spinal cord were also performed to measure 5-ht and na levels after systemic injection of milnacipran. |
2010-09-23 |
2023-08-12 |
rat |
| Jae K Lee, Renee Chow, Fang Xie, Sharon Y Chow, Kristine E Tolentino, Binhai Zhen. Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 32. 2010-09-03. PMID:20702718. |
after a complete transection spinal cord injury, there was no significant enhancement of 5-ht axon regeneration beyond the injury site in either nogo/mag/ngr1 triple mutants or ngr1 single mutants. |
2010-09-03 |
2023-08-12 |
mouse |
| Jae K Lee, Renee Chow, Fang Xie, Sharon Y Chow, Kristine E Tolentino, Binhai Zhen. Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 32. 2010-09-03. PMID:20702718. |
in contrast with previous reports, these data demonstrate that attenuating myelin or semaphorin-mediated inhibition of axon growth is insufficient to promote 5-ht axon regeneration and further indicate that even attenuating both classes of inhibitory influences is insufficient to promote regeneration of injured axons through a complete transection spinal cord injury. |
2010-09-03 |
2023-08-12 |
mouse |
| Katie Kingwel. Spinal cord injury: the two faces of spontaneous serotonin signalling. Nature reviews. Drug discovery. vol 9. issue 8. 2010-08-25. PMID:20671763. |
spinal cord injury: the two faces of spontaneous serotonin signalling. |
2010-08-25 |
2023-08-12 |
Not clear |
| Katie Kingwel. Spinal cord injury: The two faces of spontaneous serotonin signalling. Nature reviews. Neuroscience. vol 11. issue 8. 2010-08-13. PMID:20672426. |
spinal cord injury: the two faces of spontaneous serotonin signalling. |
2010-08-13 |
2023-08-12 |
Not clear |
| Kunihiro Nakai, Aya Nakae, Sosuke Oba, Takashi Mashimo, Koichi Ued. P2X4 receptor expression in a rat model of trigeminal neuropathic pain. Neuroreport. vol 21. issue 8. 2010-08-09. PMID:20407394. |
we investigated the p2x4 receptor (p2x4r) expression in the cervical spinal cord, trigeminal ganglion, and infraorbital nerve (ion), after a chronic constriction injury of unilateral ion and a treatment with selective serotonin reuptake inhibitor (ssri). |
2010-08-09 |
2023-08-12 |
rat |
| Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xin. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain research. vol 1330. 2010-08-02. PMID:20230801. |
in the present study, we observed that the inhibitory effects of 5-ht and its receptor agonists including 1a, 1b, 3, 4, and probably 2c receptor agonists, on the c-fiber responses of dorsal horn wide dynamic range (wdr) neurons in the spinal cord decreased significantly following spinal nerve ligation (snl). |
2010-08-02 |
2023-08-12 |
rat |