| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xin. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain research. vol 1330. 2010-08-02. PMID:20230801. |
in consistent with these observations, we also found an obvious decrease in the content of 5-ht and 5-hiaa, and a marked increase in the turnover rate of 5-ht (5-hiaa/5-ht) in the ipsilateral dorsal half of the lumbar spinal cord after snl. |
2010-08-02 |
2023-08-12 |
rat |
| Feng Wei, Ronald Dubner, Shiping Zou, Ke Ren, Guang Bai, Dong Wei, Wei Gu. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 25. 2010-07-15. PMID:20573908. |
although 5-ht-containing neurons in the rostral ventromedial medulla (rvm) provide the major descending serotonergic projection to the spinal cord, it is not clear whether the neurotransmitter 5-ht itself released from rvm-spinal neurons contributes to descending pain modulation. |
2010-07-15 |
2023-08-12 |
rat |
| Anne-Emilie Allain, Louis Ségu, Pierre Meyrand, Pascal Brancherea. Serotonin controls the maturation of the GABA phenotype in the ventral spinal cord via 5-HT1b receptors. Annals of the New York Academy of Sciences. vol 1198. 2010-07-07. PMID:20536936. |
serotonin controls the maturation of the gaba phenotype in the ventral spinal cord via 5-ht1b receptors. |
2010-07-07 |
2023-08-12 |
mouse |
| Anne-Emilie Allain, Louis Ségu, Pierre Meyrand, Pascal Brancherea. Serotonin controls the maturation of the GABA phenotype in the ventral spinal cord via 5-HT1b receptors. Annals of the New York Academy of Sciences. vol 1198. 2010-07-07. PMID:20536936. |
descending bulbo-spinal 5-ht fibers, coming from the caudal medullary cell groups of the raphe nuclei, progressively invade the mouse spinal cord and arrive at lumbar segments at e15.5 when the number of ventral gaba immunoreactive (gaba-ir) interneurons reaches its maximum. |
2010-07-07 |
2023-08-12 |
mouse |
| M R E Silva, D H Sproul. An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord. The Journal of physiology. vol 185. issue 2. 2010-06-29. PMID:16992231. |
an excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord. |
2010-06-29 |
2023-08-12 |
Not clear |
| M Vog. The effect of lowering the 5-hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine. The Journal of physiology. vol 236. issue 2. 2010-06-29. PMID:16992448. |
the effect of lowering the 5-hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine. |
2010-06-29 |
2023-08-12 |
rat |
| Katherine C Murray, Aya Nakae, Marilee J Stephens, Michelle Rank, Jessica D'Amico, Philip J Harvey, Xiaole Li, R Luke W Harris, Edward W Ballou, Roberta Anelli, Charles J Heckman, Takashi Mashimo, Romana Vavrek, Leo Sanelli, Monica A Gorassini, David J Bennett, Karim Foua. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nature medicine. vol 16. issue 6. 2010-06-22. PMID:20512126. |
muscle paralysis after spinal cord injury is partly caused by a loss of brainstem-derived serotonin (5-ht), which normally maintains motoneuron excitability by regulating crucial persistent calcium currents. |
2010-06-22 |
2023-08-12 |
rat |
| Xiang-Yu Kong, Jacob Wienecke, Hans Hultborn, Mengliang Zhan. Robust upregulation of serotonin 2A receptors after chronic spinal transection of rats: an immunohistochemical study. Brain research. vol 1320. 2010-06-07. PMID:20085755. |
we also found a small number of intraspinal 5-ht neurons and clusters of 5-ht fibers and their varicosities in the spinal cord caudal to the lesion, which may provide an intrinsic source of 5-ht to act upon the upregulated 5-ht2a receptors. |
2010-06-07 |
2023-08-12 |
rat |
| Arthiese Korb, Leandro Viçosa Bonetti, Sandro Antunes da Silva, Simone Marcuzzo, Jocemar Ilha, Mariane Bertagnolli, Wania Aparecida Partata, Maria Cristina Faccioni-Heuse. Effect of treadmill exercise on serotonin immunoreactivity in medullary raphe nuclei and spinal cord following sciatic nerve transection in rats. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19774460. |
effect of treadmill exercise on serotonin immunoreactivity in medullary raphe nuclei and spinal cord following sciatic nerve transection in rats. |
2010-04-30 |
2023-08-12 |
rat |
| Ning Lü, Mei Han, Zhi-Lan Yang, Yan-Qing Wang, Gen-Cheng Wu, Yu-Qiu Zhan. Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Pain. vol 148. issue 3. 2010-04-30. PMID:20036056. |
nociceptin/orphanin fq in pag modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. |
2010-04-30 |
2023-08-12 |
rat |
| Volkan Sahiner, S Ozlem Erden Ak. [Serotonin syndrome associated with linezolid use: a case report]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 20. issue 4. 2010-04-28. PMID:20013432. |
the serotonin syndrome is a toxic state largely attributable to changes in sensitivity of serotonin receptor system in the brainstem and spinal cord resulting from increased serotonergic activity in central neurologic system, due to use of serotonergic agents either in overdose or in combination. |
2010-04-28 |
2023-08-12 |
Not clear |
| Christopher J Madden, Shaun F Morriso. Endogenous activation of spinal 5-hydroxytryptamine (5-HT) receptors contributes to the thermoregulatory activation of brown adipose tissue. American journal of physiology. Regulatory, integrative and comparative physiology. vol 298. issue 3. 2010-03-30. PMID:20071609. |
these results are consistent with our earlier demonstration of a potentiating effect of 5-ht within the iml on bat sna and indicate that activation of 5-ht(1a) and 5-ht(7) receptors in the spinal cord contributes to increases in bat sna and thermogenesis. |
2010-03-30 |
2023-08-12 |
rat |
| J J Cragg, A L Scott, M S Rame. Depletion of spinal 5-HT accelerates mechanosensory recovery in the deafferented rat spinal cord. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079735. |
depletion of spinal 5-ht accelerates mechanosensory recovery in the deafferented rat spinal cord. |
2010-03-26 |
2023-08-12 |
rat |
| Mary J Dunbar, Michelle A Tran, Patrick J Whela. Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse. The Journal of physiology. vol 588. issue Pt 1. 2010-03-25. PMID:19884315. |
many of these findings have been obtained by applying serotonin exogenously to the isolated spinal cord of in vitro preparations, which has the drawback of indiscriminately activating extrasynaptic receptors and neurons. |
2010-03-25 |
2023-08-12 |
mouse |
| Chi-Sang Poo. Optimal interaction of respiratory and thermal regulation at rest and during exercise: role of a serotonin-gated spinoparabrachial thermoafferent pathway. Respiratory physiology & neurobiology. vol 169. issue 3. 2010-02-24. PMID:19770073. |
this optimization model of respiratory-thermoregulatory interaction is supported by a host of recent studies which demonstrate that animals with serotonin (5-ht) dysfunction at the spinal dorsal horn--due to 5-ht antagonism, genetic 5-ht defects or spinal cord injury--all display similar respiratory abnormalities that are consistent with hyperactivity of the spinoparabrachial thermoafferent (and pain) pathway. |
2010-02-24 |
2023-08-12 |
human |
| Zhiyang Song, Camilla Ultenius, Björn A Meyerson, Bengt Linderot. Pain relief by spinal cord stimulation involves serotonergic mechanisms: an experimental study in a rat model of mononeuropathy. Pain. vol 147. issue 1-3. 2010-02-23. PMID:19836134. |
when scs was applied immediately prior to sacrifice, the 5-ht content in the dorsal quadrant of the spinal cord ipsilateral to the nerve injury was increased in scs responding rats. |
2010-02-23 |
2023-08-12 |
rat |
| Yue Dai, Kevin P Carlin, Zongming Li, Douglas G McMahon, Robert M Brownstone, Larry M Jorda. Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice. Journal of neurophysiology. vol 102. issue 6. 2010-02-22. PMID:19793882. |
using neonatal transgenic mice that express enhanced green fluorescent protein (egfp) driven by the c-fos promoter, we visualized egfp-positive neurons in spinal cord slices from animals that were subjected to a locomotor task or drug cocktail [n-methyl-d-aspartate, serotonin (5-ht), dopamine, and acetylcholine (ach)]. |
2010-02-22 |
2023-08-12 |
mouse |
| Y Hayashi, S Jacob-Vadakot, E A Dugan, S McBride, R Olexa, K Simansky, M Murray, J S Shumsk. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19840787. |
5-ht precursor loading, but not 5-ht receptor agonists, increases motor function after spinal cord contusion in adult rats. |
2010-02-16 |
2023-08-12 |
rat |
| Y Hayashi, S Jacob-Vadakot, E A Dugan, S McBride, R Olexa, K Simansky, M Murray, J S Shumsk. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19840787. |
serotonergic (5-ht) receptors are upregulated following spinal cord transection. |
2010-02-16 |
2023-08-12 |
rat |
| Y Hayashi, S Jacob-Vadakot, E A Dugan, S McBride, R Olexa, K Simansky, M Murray, J S Shumsk. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19840787. |
distribution of 5-ht and its transporter and expression of 5-ht(2c) receptors were evaluated in lumbar spinal cord and motor response to 5-ht receptor activation was assessed using open field locomotion (bbb) score, percent weight supported treadmill stepping (%ws) and evaluation of hindlimb muscle activation (tremor and serotonin syndrome). |
2010-02-16 |
2023-08-12 |
rat |