| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Fusco, B Figliomeni, A Gorio, G Vantin. Postnatal development of bulbospinal serotoninergic system. effects of GMI ganglioside following neonatal 5,7-dihydroxytryptamine treatment. Neurochemistry international. vol 13. issue 2. 2012-10-02. PMID:20501295. |
the postnatal development of serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) in the pons medulla and spinal cord segments of rats treated with 5,7-dihydroxytryptamine (5,7-ht) and/or gm1 ganglioside has been investigated. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, E F Schwab, R Maureen Murphy, M M Behbehan. Identification of a novel 5-HT(1) binding site in rat spinal cord. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504589. |
identification of a novel 5-ht(1) binding site in rat spinal cord. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, E F Schwab, R Maureen Murphy, M M Behbehan. Identification of a novel 5-HT(1) binding site in rat spinal cord. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504589. |
high affinity, specific [(3)h]5-hydroxytryptamine (5-ht) binding to spinal cord synaptosomes was examined to identify the 5-ht receptor subtypes present. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, E F Schwab, R Maureen Murphy, M M Behbehan. Identification of a novel 5-HT(1) binding site in rat spinal cord. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504589. |
therefore, three major classes of [(3)h]5-ht binding sites could be demonstrated in spinal cord synaptosomes: 5-ht(1a), 5-ht(1b) and a novel [(3)h]5-ht binding site which respectively represented 25, 26 and 49% of spinal cord synaptosomal [(3)h]5-ht binding. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, E F Schwab, R Maureen Murphy, M M Behbehan. Identification of a novel 5-HT(1) binding site in rat spinal cord. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504589. |
further studies focusing on the function of the latter binding site are needed to determine if the presently identified novel binding site is the major 5-ht(1) receptor subtype present in spinal cord. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, A Zieleniewski-Murphy, R Maureen Murphy, M M Behbehan. BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504590. |
bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, A Zieleniewski-Murphy, R Maureen Murphy, M M Behbehan. BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504590. |
the present study examined the agonist and antagonist properties of bmy 7378 at spinal cord 5-ht(1a) receptors. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, A Zieleniewski-Murphy, R Maureen Murphy, M M Behbehan. BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504590. |
in electrophysiological studies, iontophoretic administration of either the 5-ht(1a) agonist 8-oh-dpat (43.8 +/- 5.4 na) or bmy 7378 (46.3 +/- 5.2 na) significantly inhibited the firing rate of wide-dynamic-range dorsal horn units indicating that bmy 7378 demonstrates significant intrinsic activity at spinal cord 5-ht(1a) receptors. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, A Zieleniewski-Murphy, R Maureen Murphy, M M Behbehan. BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504590. |
therefore, both the electrophysiologic and reflex data indicate that bmy 7378 possesses significant intrinsic activity at spinal cord 5-ht(1a) receptors, and like 8-oh-dpat is a partial agonist at these receptors. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, A Zieleniewski-Murphy, R Maureen Murphy, M M Behbehan. BMY 7378: Partial agonist at spinal cord 5-HT(1A) receptors. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504590. |
differences in bmy 7378 intrinsic activity at spinal cord as opposed to hippocampal 5-ht(1a) receptors are discussed in terms of regional differences in g-proteins coupled to 5-ht(1a) receptors in these two cns regions. |
2012-10-02 |
2023-08-12 |
rat |
| Veronika Kuscha, Antón Barreiro-Iglesias, Catherina G Becker, Thomas Becke. Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish. The Journal of comparative neurology. vol 520. issue 5. 2012-09-28. PMID:21830219. |
here we performed a quantitative study to determine the plastic changes of tyrosine hydroxylase-positive (th1(+); mainly dopaminergic), and serotonergic (5-ht(+)) terminals and cells during successful spinal cord regeneration in adult zebrafish. |
2012-09-28 |
2023-08-12 |
zebrafish |
| Veronika Kuscha, Antón Barreiro-Iglesias, Catherina G Becker, Thomas Becke. Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish. The Journal of comparative neurology. vol 520. issue 5. 2012-09-28. PMID:21830219. |
overall, th1(+) and 5-ht(+) innervation is massively altered in the successfully regenerated spinal cord of adult zebrafish. |
2012-09-28 |
2023-08-12 |
zebrafish |
| Mary J Eaton, Yerko Berrocal, Stacey Q Wolf. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines. Pain research and treatment. vol 2012. 2012-08-23. PMID:22619713. |
cell lines derived from the human neuronal nt2 cell line parentage, the hnt2.17 and hnt2.19 lines, which synthesize and release the neurotransmitters gamma-aminobutyric acid (gaba) and serotonin (5ht), respectively, have been used to evaluate the potential of cell-based release of antinociceptive agents near the lumbar dorsal (horn) spinal sensory cell centers to relieve neuropathic pain after pns (partial nerve and diabetes-related injury) and cns (spinal cord injury) damage in rat models. |
2012-08-23 |
2023-08-12 |
human |
| Dongmei Wang, Tingjun Chen, Yun Gao, Rémi Quirion, Yanguo Hon. Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats. Pharmacology, biochemistry, and behavior. vol 101. issue 3. 2012-08-02. PMID:22342663. |
inhibition of snl-induced upregulation of cgrp and npy in the spinal cord and dorsal root ganglia by the 5-ht(2a) receptor antagonist ketanserin in rats. |
2012-08-02 |
2023-08-12 |
rat |
| Dongmei Wang, Tingjun Chen, Yun Gao, Rémi Quirion, Yanguo Hon. Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats. Pharmacology, biochemistry, and behavior. vol 101. issue 3. 2012-08-02. PMID:22342663. |
the present study demonstrated that: (1) the expression of cgrp was enhanced in the spinal dorsal horn and npy was expressed in the drg containing injured neurons, but not in the adjacent drg containing intact neurons, following l5 snl; (2) the maladaptive changes in cgrp and npy expression in the spinal cord and drg mediated the bioactivity of 5-ht/5-ht(2a) receptors in neuropathic pain and (3) the blockade of 5-ht(2a) receptors by ketanserin reversed the evoked upregulation of both cgrp and npy in the spinal cord and drg contributing to the inhibition of neuropathic pain. |
2012-08-02 |
2023-08-12 |
rat |
| R S Fais, G M Reis, J W S Silveira, Q M Dias, A C Rossaneis, W A Prad. Amitriptyline prolongs the antihyperalgesic effect of 2- or 100-Hz electro-acupuncture in a rat model of post-incision pain. European journal of pain (London, England). vol 16. issue 5. 2012-08-01. PMID:22337080. |
the mechanisms through which electro-acupuncture (ea) and tricyclic antidepressants produce analgesia seem to be complementary: ea inhibits the transmission of noxious messages by activating supraspinal serotonergic and noradrenergic neurons that project to the spinal cord, whereas tricyclic antidepressants affect pain transmission by inhibiting the reuptake of norepinephrine and serotonin at the spinal level. |
2012-08-01 |
2023-08-12 |
rat |
| Baojun Gu, Gang Wu, Jieming Si, Yuemin Xu, Karl-Erik Andersso. Improving voiding efficiency in the diabetic rat by a 5-HT1A serotonin receptor agonist. Neurourology and urodynamics. vol 31. issue 1. 2012-07-02. PMID:21780177. |
serotonin affects micturition in the normal rat through actions not only on ascending and descending spinal pathways and supraspinal centers but also on the lumbosacral spinal cord level. |
2012-07-02 |
2023-08-12 |
rat |
| V F Lyalka, L-J Hsu, A Karayannidou, P V Zelenin, G N Orlovsky, T G Deliagin. Facilitation of postural limb reflexes in spinal rabbits by serotonergic agonist administration, epidural electrical stimulation, and postural training. Journal of neurophysiology. vol 106. issue 3. 2012-06-26. PMID:21653706. |
the goal of this study was to improve postural functions in chronic spinal rabbits by regular application of different factors: intrathecal injection of the 5-ht(2) agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (doi), epidural electrical spinal cord stimulation (ees), and specific postural training (spt). |
2012-06-26 |
2023-08-12 |
Not clear |
| Nicole M Geremia, Feng Bao, Trina E Rosenzweig, Todd Hryciw, Lynne Weaver, Gregory A Dekaban, Arthur Brow. CD11d Antibody Treatment Improves Recovery in Spinal Cord-Injured Mice. Journal of neurotrauma. vol 29. issue 3. 2012-06-15. PMID:22044160. |
these improvements in the injured spinal cord microenvironment were accompanied by increased serotonin (5-ht) immunoreactivity below the level of the lesion and improved locomotor recovery. |
2012-06-15 |
2023-08-12 |
mouse |
| Timothy M Marshall, David S Herman, Tally M Largent-Milnes, Hamid Badghisi, Konstantina Zuber, Shannon C Holt, Josephine Lai, Frank Porreca, Todd W Vandera. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord. Pain. vol 153. issue 1. 2012-06-05. PMID:22030324. |
the present studies suggest that chronic nerve injury can result in activation of descending facilitatory mechanisms that may promote hyperalgesia via ultimate release of pge₂ and 5-ht in the spinal cord. |
2012-06-05 |
2023-08-12 |
rat |