| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Ji\\xc5\\x99\\xc3\\xad R\\xc5\\xaf\\xc5\\xbei\\xc4\\x8dka, Nataliya Romanyuk, Ale\\xc5\\xa1 Hej\\xc4\\x8dl, Miroslav Vetr\\xc3\\xadk, Martin Hrub\\xc3\\xbd, Graham Cocks, Ji\\xc5\\x99\\xc3\\xad Cihl\\xc3\\xa1r, Martin P\\xc5\\x99\\xc3\\xa1dn\\xc3\\xbd, Jack Price, Eva Sykov\\xc3\\xa1, Pavla Jendelov\\xc3\\xa. Treating spinal cord injury in rats with a combination of human fetal neural stem cells and hydrogels modified with serotonin. Acta neurobiologiae experimentalis. vol 73. issue 1. 2013-12-10. PMID:23595287.' |
treating spinal cord injury in rats with a combination of human fetal neural stem cells and hydrogels modified with serotonin. |
2013-12-10 |
2023-08-12 |
human |
| Urszula Sławińska, Krzysztof Miazga, Anna M Cabaj, Anna N Leszczyńska, Henryk Majczyński, James I Nagy, Larry M Jorda. Grafting of fetal brainstem 5-HT neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion. Experimental neurology. vol 247. 2013-11-26. PMID:23481546. |
grafting of fetal brainstem 5-ht neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion. |
2013-11-26 |
2023-08-12 |
rat |
| Urszula Sławińska, Krzysztof Miazga, Anna M Cabaj, Anna N Leszczyńska, Henryk Majczyński, James I Nagy, Larry M Jorda. Grafting of fetal brainstem 5-HT neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion. Experimental neurology. vol 247. 2013-11-26. PMID:23481546. |
in rodent models of spinal cord injury, there is increasing evidence that activation of the locomotor central pattern generator (cpg) below the site of injury with 5-hydroxytryptamine (5-ht) agonists improves locomotor recovery and restores coordination. |
2013-11-26 |
2023-08-12 |
rat |
| Urszula Sławińska, Krzysztof Miazga, Anna M Cabaj, Anna N Leszczyńska, Henryk Majczyński, James I Nagy, Larry M Jorda. Grafting of fetal brainstem 5-HT neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion. Experimental neurology. vol 247. 2013-11-26. PMID:23481546. |
a promising means of replacing 5-ht control of locomotion is to graft brainstem 5-ht neurons into the spinal cord below the level of the spinal cord injury. |
2013-11-26 |
2023-08-12 |
rat |
| Curtis A Benson, Grace Wong, Gustavo Tenorio, Glen B Baker, Bradley J Ker. The MAO inhibitor phenelzine can improve functional outcomes in mice with established clinical signs in experimental autoimmune encephalomyelitis (EAE). Behavioural brain research. vol 252. 2013-10-28. PMID:23777648. |
beginning plz treatment after the start of clinical signs did however lead to significantly better 5-ht innervation density in the ventral horn of the spinal cord and also resulted in higher levels of gaba, dopamine and norepinephrine in the brain and spinal cord. |
2013-10-28 |
2023-08-12 |
mouse |
| Jessica M D'Amico, Yaqing Li, David J Bennett, Monica A Gorassin. Reduction of spinal sensory transmission by facilitation of 5-HT1B/D receptors in noninjured and spinal cord-injured humans. Journal of neurophysiology. vol 109. issue 6. 2013-09-10. PMID:23221401. |
loss or reduction of descending sources of serotonin and norepinephrine after spinal cord injury (sci) and the subsequent reduction of 5-ht1/α2 receptor activity contributes, in part, to the emergence of excessive motoneuron activation from sensory afferent pathways and the uncontrolled triggering of persistent inward currents that depolarize motoneurons during muscle spasms. |
2013-09-10 |
2023-08-12 |
human |
| Jessica M D'Amico, Katherine C Murray, Yaqing Li, K Ming Chan, Mark G Finlay, David J Bennett, Monica A Gorassin. Constitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury. Journal of neurophysiology. vol 109. issue 6. 2013-09-10. PMID:23221402. |
in animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-ht2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents (capics) without the ligands serotonin and norepinephrine below the injury. |
2013-09-10 |
2023-08-12 |
human |
| Jessica M D'Amico, Katherine C Murray, Yaqing Li, K Ming Chan, Mark G Finlay, David J Bennett, Monica A Gorassin. Constitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury. Journal of neurophysiology. vol 109. issue 6. 2013-09-10. PMID:23221402. |
in chronically injured participants with partially preserved sensory and motor function, the serotonin reuptake inhibitor citalopram facilitated long-lasting reflex responses (spasms) previously shown to be mediated by capics, suggesting that in incomplete spinal cord injury, functional descending sources of monoamines are present to activate monoamine receptors below the lesion. |
2013-09-10 |
2023-08-12 |
human |
| L-Q Ren, J Wienecke, M Chen, M Møller, H Hultborn, M Zhan. The time course of serotonin 2C receptor expression after spinal transection of rats: an immunohistochemical study. Neuroscience. vol 236. 2013-08-26. PMID:23337537. |
in the spinal cord serotonin (5-ht) systems modulate the spinal network via various 5-ht receptors. |
2013-08-26 |
2023-08-12 |
rat |
| L-Q Ren, J Wienecke, M Chen, M Møller, H Hultborn, M Zhan. The time course of serotonin 2C receptor expression after spinal transection of rats: an immunohistochemical study. Neuroscience. vol 236. 2013-08-26. PMID:23337537. |
serotonin 2a receptor and serotonin 2c receptor (5-ht2a and 2c receptors) are likely the most important 5-ht receptors for enhancing the motoneuron excitability by facilitating the persistent inward current (pic), and thus play an important role for the pathogenesis of spasticity after spinal cord injury. |
2013-08-26 |
2023-08-12 |
rat |
| María Eugenia Cornide-Petronio, Ramón Anadón, María Celina Rodicio, Antón Barreiro-Iglesia. The sea lamprey tryptophan hydroxylase: new insight into the evolution of the serotonergic system of vertebrates. Brain structure & function. vol 218. issue 2. 2013-08-16. PMID:22527120. |
in the sea lamprey brain, the tph transcript was expressed in perikarya of the pineal organ, the retina, the diencephalic and rhombencephalic nuclei reported previously with serotonin immunohistochemistry and in small cells of the spinal cord, with a pattern similar to that observed with anti-serotonin antibodies. |
2013-08-16 |
2023-08-12 |
zebrafish |
| Jean Liu, Allison R Reid, Jana Sawyno. Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. Neuroscience letters. vol 536. 2013-06-28. PMID:23313594. |
in the present study, we determined whether these two actions are linked by delivering a selective 5-ht(7)r antagonist to the spinal cord of mice and examining nociception using the formalin 2% model. |
2013-06-28 |
2023-08-12 |
mouse |
| Jean Liu, Allison R Reid, Jana Sawyno. Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. Neuroscience letters. vol 536. 2013-06-28. PMID:23313594. |
in summary, we demonstrate a link between spinal 5-ht(7)rs and a(1)rs in the spinal cord relevant to antinociception by systemic acetaminophen. |
2013-06-28 |
2023-08-12 |
mouse |
| Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Ko Hosokawa, Takashi Mashim. Serotonin 2C receptor alternative splicing in a spinal cord injury model. Neuroscience letters. vol 532. 2013-05-30. PMID:23123772. |
serotonin 2c receptor alternative splicing in a spinal cord injury model. |
2013-05-30 |
2023-08-12 |
rat |
| Francesco Dose, Giuliano Taccol. Coapplication of noisy patterned electrical stimuli and NMDA plus serotonin facilitates fictive locomotion in the rat spinal cord. Journal of neurophysiology. vol 108. issue 11. 2013-05-20. PMID:22956799. |
coapplication of noisy patterned electrical stimuli and nmda plus serotonin facilitates fictive locomotion in the rat spinal cord. |
2013-05-20 |
2023-08-12 |
human |
| Kathleen Scullion, Jeffery A Boychuk, Glenn R Yamakawa, Justin T G Rodych, Stan T Nakanishi, Angela Seto, Victoria M Smith, Ryan W McCarthy, Patrick J Whelan, Michael C Antle, Quentin J Pittman, G Campbell Teske. Serotonin 1A receptors alter expression of movement representations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486969. |
serotonin has a myriad of central functions involving mood, appetite, sleep, and memory and while its release within the spinal cord is particularly important for generating movement, the corresponding role on cortical movement representations (motor maps) is unknown. |
2013-05-06 |
2023-08-12 |
mouse |
| Kathleen Scullion, Jeffery A Boychuk, Glenn R Yamakawa, Justin T G Rodych, Stan T Nakanishi, Angela Seto, Victoria M Smith, Ryan W McCarthy, Patrick J Whelan, Michael C Antle, Quentin J Pittman, G Campbell Teske. Serotonin 1A receptors alter expression of movement representations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486969. |
we ruled out the possibility that reduced spinal cord excitability could account for the serotonin depletion-induced changes as we observed an enhanced hoffman reflex (h-reflex), indicating a hyperexcitable spinal cord. |
2013-05-06 |
2023-08-12 |
mouse |
| Amanda L Zimmerman, Michael Sawchuk, Shawn Hochma. Monoaminergic modulation of spinal viscero-sympathetic function in the neonatal mouse thoracic spinal cord. PloS one. vol 7. issue 11. 2013-04-22. PMID:23144807. |
whole-cell recordings from sympathetic preganglionic neurons (spns) in spinal cord slice demonstrated that serotonin, noradrenaline, and dopamine modulated spn excitability. |
2013-04-22 |
2023-08-12 |
mouse |
| Christel Dentel, Lavinia Palamiuc, Alexandre Henriques, Béatrice Lannes, Odile Spreux-Varoquaux, Lise Gutknecht, Frédérique René, Andoni Echaniz-Laguna, Jose-Luis Gonzalez de Aguilar, Klaus Peter Lesch, Vincent Meininger, Jean-Philippe Loeffler, Luc Dupui. Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity. Brain : a journal of neurology. vol 136. issue Pt 2. 2013-04-10. PMID:23114367. |
in sod1 (g86r) mice, a transgenic model of amyotrophic lateral sclerosis, serotonin levels were decreased in brainstem and spinal cord before onset of motor symptoms. |
2013-04-10 |
2023-08-12 |
mouse |
| Mark A Masino, Matthew D Abbinanti, John Eian, Ronald M Harris-Warric. TTX-resistant NMDA receptor-mediated membrane potential oscillations in neonatal mouse Hb9 interneurons. PloS one. vol 7. issue 10. 2013-04-01. PMID:23094101. |
a genetically identified population of ventromedial interneurons, called hb9, in the mouse spinal cord has been shown to generate ttx-resistant membrane potential oscillations in the presence of nmda, serotonin and dopamine, but these oscillatory properties are not well characterized. |
2013-04-01 |
2023-08-12 |
mouse |