| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enriqueta Muñoz-Islas, Guadalupe C Vidal-Cantú, Mariana Bravo-Hernández, Claudia Cervantes-Durán, Geovanna N Quiñonez-Bastidas, Jorge B Pineda-Farias, Paulino Barragán-Iglesias, Vinicio Granados-Sot. Spinal 5-HT₅A receptors mediate 5-HT-induced antinociception in several pain models in rats. Pharmacology, biochemistry, and behavior. vol 120. 2014-12-09. PMID:24517902. |
data suggest that 5-ht and 5-ct produce antinociception by activation of spinal 5-ht5a receptors in both the spinal cord and drg. |
2014-12-09 |
2023-08-12 |
rat |
| Ignacio Vinuela-Fernandez, Liting Sun, Helen Jerina, John Curtis, Andrew Allchorne, Hayley Gooding, Roberta Rosie, Pamela Holland, Basak Tas, Rory Mitchell, Sue Fleetwood-Walke. The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity. Neuropharmacology. vol 79. 2014-12-03. PMID:24269608. |
here we report the discovery that the trpm8 ion channel, co-operating with the 5-ht(1b) receptor (5-ht(1b)r) in a subset of sensory afferents, exerts an influence at the spinal cord level to suppress central hypersensitivity in pain processing throughout the central nervous system. |
2014-12-03 |
2023-08-12 |
rat |
| Ignacio Vinuela-Fernandez, Liting Sun, Helen Jerina, John Curtis, Andrew Allchorne, Hayley Gooding, Roberta Rosie, Pamela Holland, Basak Tas, Rory Mitchell, Sue Fleetwood-Walke. The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity. Neuropharmacology. vol 79. 2014-12-03. PMID:24269608. |
the enhanced activation responses of synaptoneurosomes prepared from spinal cord and cortical regions of animals with a chronic inflammatory pain state are inhibited by trpm8 activators that were applied in vivo topically to the skin, an effect potentiated by co-administered 5-ht(1b)r agonists and attenuated by 5-ht(1b)r antagonists, while 5-ht(1b)r agents alone had no detectable effect. |
2014-12-03 |
2023-08-12 |
rat |
| Jyoti N Sengupta, Aaron Mickle, Pradeep Kannampalli, Russell Spruell, John McRorie, Reza Shaker, Adrian Mirand. Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM). Neuropharmacology. vol 79. 2014-12-03. PMID:24334068. |
results indicate that teg produces analgesia via activation of supraspinal 5-ht(4) receptors which triggers the release of opioids at supraspinal site, which activates descending noradrenergic pathways to the spinal cord to produce analgesia. |
2014-12-03 |
2023-08-12 |
rat |
| Zhang Xiang Huang, Zhi Jie Lu, Wei Qing Ma, Fei Xiang Wu, Yu Qiu Zhang, Wei-Feng Yu, Zhi Qi Zha. Involvement of RVM-expressed P2X7 receptor in bone cancer pain: mechanism of descending facilitation. Pain. vol 155. issue 4. 2014-11-17. PMID:24447511. |
given that 5-ht in the rvm is involved in modulating spinal nociception, changes in 5-ht and fos expression were addressed in the spinal cord. |
2014-11-17 |
2023-08-12 |
rat |
| Zhang Xiang Huang, Zhi Jie Lu, Wei Qing Ma, Fei Xiang Wu, Yu Qiu Zhang, Wei-Feng Yu, Zhi Qi Zha. Involvement of RVM-expressed P2X7 receptor in bone cancer pain: mechanism of descending facilitation. Pain. vol 155. issue 4. 2014-11-17. PMID:24447511. |
inhibition of p2x7r by bbg or small-interference rna targeting p2x7 in the rvm markedly reduced 5-ht level and fos expression in the spinal cord. |
2014-11-17 |
2023-08-12 |
rat |
| Lee Jae Dam, Lin Hai, Yoon Myung H. Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. Neuroscience letters. vol 566. 2014-11-11. PMID:24561091. |
the concentrations of 5-ht in the spinal cord and plasma were decreased in neuropathic pain. |
2014-11-11 |
2023-08-12 |
rat |
| Lee Jae Dam, Lin Hai, Yoon Myung H. Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. Neuroscience letters. vol 566. 2014-11-11. PMID:24561091. |
intrathecal nefopam increased the levels of 5-ht in the spinal cord and plasma. |
2014-11-11 |
2023-08-12 |
rat |
| Kunlin Wei, Joshua I Glaser, Linna Deng, Christopher K Thompson, Ian H Stevenson, Qining Wang, Thomas George Hornby, Charles J Heckman, Konrad P Kordin. Serotonin affects movement gain control in the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 38. 2014-11-11. PMID:25232107. |
serotonin affects movement gain control in the spinal cord. |
2014-11-11 |
2023-08-13 |
Not clear |
| Jacob Wienecke, Li-Qun Ren, Hans Hultborn, Meng Chen, Morten Møller, Yifan Zhang, Mengliang Zhan. Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 36. 2014-11-10. PMID:25186745. |
serotonin (5-ht), an important modulator of both sensory and motor functions in the mammalian spinal cord, originates mainly in the raphe nuclei of the brainstem. |
2014-11-10 |
2023-08-13 |
rat |
| Jacob Wienecke, Li-Qun Ren, Hans Hultborn, Meng Chen, Morten Møller, Yifan Zhang, Mengliang Zhan. Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 36. 2014-11-10. PMID:25186745. |
however, following complete transection of the spinal cord, small amounts of 5-ht remain detectable below the lesion. |
2014-11-10 |
2023-08-13 |
rat |
| Jacob Wienecke, Li-Qun Ren, Hans Hultborn, Meng Chen, Morten Møller, Yifan Zhang, Mengliang Zhan. Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 36. 2014-11-10. PMID:25186745. |
we show that, following complete transection of the rat spinal cord at s2 level, aadc cells distal to the lesion acquire the ability to produce 5-ht from its immediate precursor, 5-hydroxytryptophan. |
2014-11-10 |
2023-08-13 |
rat |
| Jacob Wienecke, Li-Qun Ren, Hans Hultborn, Meng Chen, Morten Møller, Yifan Zhang, Mengliang Zhan. Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 36. 2014-11-10. PMID:25186745. |
our results indicate that this phenotypic change in spinal aadc cells is initiated by the loss of descending 5-ht projections due to spinal cord injury (sci). |
2014-11-10 |
2023-08-13 |
rat |
| Beato Suwa, Nathalie Bock, Stefan Preusse, Aribert Rothenberger, Till Manzk. Distribution of serotonin 4(a) receptors in the juvenile rat brain and spinal cord. Journal of chemical neuroanatomy. vol 55. 2014-11-06. PMID:24412663. |
distribution of serotonin 4(a) receptors in the juvenile rat brain and spinal cord. |
2014-11-06 |
2023-08-12 |
rat |
| David L García-Ramírez, Jorge R Calvo, Shawn Hochman, Jorge N Queved. Serotonin, dopamine and noradrenaline adjust actions of myelinated afferents via modulation of presynaptic inhibition in the mouse spinal cord. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587177. |
serotonin, dopamine and noradrenaline adjust actions of myelinated afferents via modulation of presynaptic inhibition in the mouse spinal cord. |
2014-10-28 |
2023-08-12 |
mouse |
| Ryo Kitamura, Tsugunobu Andoh, Shizuka Mizoguchi, Yukako Saito, Hiroki Takahata, Yasushi Kuraish. Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice. Journal of pharmacological sciences. vol 124. issue 4. 2014-10-17. PMID:24681698. |
the antiallodynic activity of orally administered gabapentin was suppressed by noradrenaline, but not serotonin, depletion in the spinal cord. |
2014-10-17 |
2023-08-12 |
mouse |
| R Naono-Nakayama, T Ikeda, O Matsushima, H Sameshima, K Takamiya, H Funahashi, T Nishimor. An amino-terminal fragment of hemokinin-1 has an inhibitory effect on pruritic processing in rats. Neuroscience. vol 259. 2014-09-11. PMID:24247001. |
furthermore, intrathecal administration of hk-1 (1-5) and sp (1-5) markedly attenuated the induction of flinching and enhancement of c-fos expression in the spinal cord following the intradermal administration of formalin, a noxious stimulant, while pretreatment with hk-1 (1-5), but not sp (1-5), markedly attenuated the induction of scratching behavior by subcutaneous administration of pruritic agents, such as serotonin or histamine. |
2014-09-11 |
2023-08-12 |
rat |
| María Eugenia Cornide-Petronio, Blanca Fernández-López, Antón Barreiro-Iglesias, María Celina Rodici. Traumatic injury induces changes in the expression of the serotonin 1A receptor in the spinal cord of lampreys. Neuropharmacology. vol 77. 2014-08-26. PMID:24490228. |
traumatic injury induces changes in the expression of the serotonin 1a receptor in the spinal cord of lampreys. |
2014-08-26 |
2023-08-12 |
Not clear |
| María Eugenia Cornide-Petronio, Blanca Fernández-López, Antón Barreiro-Iglesias, María Celina Rodici. Traumatic injury induces changes in the expression of the serotonin 1A receptor in the spinal cord of lampreys. Neuropharmacology. vol 77. 2014-08-26. PMID:24490228. |
after spinal cord injury (sci) in mammals, the loss of serotonin coming from the brainstem reduces the excitability of motor neurons and leads to a compensatory overexpression of serotonin receptors. |
2014-08-26 |
2023-08-12 |
Not clear |
| Amy N Thompson, Julie Ehret Leal, Walter A Brzezinsk. Olanzapine and baclofen for the treatment of intractable hiccups. Pharmacotherapy. vol 34. issue 1. 2014-08-26. PMID:24551889. |
it is thought that the effect is, in part, due to serotonin augmenting phrenic motoneuronal activity on the reflex arcs involved in the generation of hiccups within the spinal cord. |
2014-08-26 |
2023-08-12 |
Not clear |