| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine A Mifflin, Curtis Benson, Kevin C Thorburn, Glen B Baker, Bradley J Ker. Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice. The journal of pain. vol 17. issue 4. 2016-12-27. PMID:26748043. |
high performance liquid chromatography analysis revealed male mice had greater spinal cord increases in 5-ht and na levels compared with female mice. |
2016-12-27 |
2023-08-13 |
mouse |
| Huazheng Liang, Emma Schofield, George Paxino. Imaging Serotonergic Fibers in the Mouse Spinal Cord Using the CLARITY/CUBIC Technique. Journal of visualized experiments : JoVE. issue 108. 2016-12-13. PMID:26967767. |
spinal cord tissue was cleared in just under two weeks, and the subsequent immunofluorescent staining against serotonin was completed in less than ten days. |
2016-12-13 |
2023-08-13 |
mouse |
| Hajer El Oussini, Hanna Bayer, Jelena Scekic-Zahirovic, Pauline Vercruysse, Jérôme Sinniger, Sylvie Dirrig-Grosch, Stéphane Dieterlé, Andoni Echaniz-Laguna, Yves Larmet, Kathrin Müller, Jochen H Weishaupt, Dietmar R Thal, Wouter van Rheenen, Kristel van Eijk, Roland Lawson, Laurent Monassier, Luc Maroteaux, Anne Roumier, Philip C Wong, Leonard H van den Berg, Albert C Ludolph, Jan H Veldink, Anke Witting, Luc Dupui. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26744351. |
serotonin 2b receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. |
2016-11-08 |
2023-08-13 |
mouse |
| Hajer El Oussini, Hanna Bayer, Jelena Scekic-Zahirovic, Pauline Vercruysse, Jérôme Sinniger, Sylvie Dirrig-Grosch, Stéphane Dieterlé, Andoni Echaniz-Laguna, Yves Larmet, Kathrin Müller, Jochen H Weishaupt, Dietmar R Thal, Wouter van Rheenen, Kristel van Eijk, Roland Lawson, Laurent Monassier, Luc Maroteaux, Anne Roumier, Philip C Wong, Leonard H van den Berg, Albert C Ludolph, Jan H Veldink, Anke Witting, Luc Dupui. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26744351. |
here we observed that the serotonin 2b receptor (5-ht2b), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of als. |
2016-11-08 |
2023-08-13 |
mouse |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
moreover, it has been shown that 5-ht released in the dorsal horn of the spinal cord by stimulation of the periaqueductal gray causes activation of inhibitory interneurons, resulting in inhibition of spinal neurons. |
2016-10-05 |
2023-08-13 |
mouse |
| A Gencer, O Gunduz, A Ulugo. Involvement of Descending Serotonergic and Noradrenergic Systems and their Spinal Receptor Subtypes in the Antinociceptive Effect of Dipyrone. Drug research. vol 65. issue 12. 2016-09-12. PMID:25647230. |
the neurotoxins 5,7-dihydroxytryptamine (50 μg/mouse) and 6-hydroxydopamine (20 μg/mouse) are applied intrathecally to deplete serotonin and noradrenaline in the spinal cord. |
2016-09-12 |
2023-08-13 |
mouse |
| Antón Barreiro-Iglesias, Karolina S Mysiak, Angela L Scott, Michell M Reimer, Yujie Yang, Catherina G Becker, Thomas Becke. Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Cell reports. vol 13. issue 5. 2016-08-24. PMID:26565906. |
in adults, serotonin is supplied to the spinal cord mainly (90%) by descending axons from the brain. |
2016-08-24 |
2023-08-13 |
zebrafish |
| Bushra Azam, Jacob Wienecke, Dennis Bo Jensen, Aleena Azam, Mengliang Zhan. Spinal Cord Hemisection Facilitates Aromatic L-Amino Acid Decarboxylase Cells to Produce Serotonin in the Subchronic but Not the Chronic Phase. Neural plasticity. vol 2015. 2016-07-19. PMID:26504602. |
spinal cord hemisection facilitates aromatic l-amino acid decarboxylase cells to produce serotonin in the subchronic but not the chronic phase. |
2016-07-19 |
2023-08-13 |
rat |
| Bushra Azam, Jacob Wienecke, Dennis Bo Jensen, Aleena Azam, Mengliang Zhan. Spinal Cord Hemisection Facilitates Aromatic L-Amino Acid Decarboxylase Cells to Produce Serotonin in the Subchronic but Not the Chronic Phase. Neural plasticity. vol 2015. 2016-07-19. PMID:26504602. |
neuromodulators, such as serotonin (5-hydroxytryptamine, 5-ht) and noradrenalin, play an essential role in regulating the motor and sensory functions in the spinal cord. |
2016-07-19 |
2023-08-13 |
rat |
| Bushra Azam, Jacob Wienecke, Dennis Bo Jensen, Aleena Azam, Mengliang Zhan. Spinal Cord Hemisection Facilitates Aromatic L-Amino Acid Decarboxylase Cells to Produce Serotonin in the Subchronic but Not the Chronic Phase. Neural plasticity. vol 2015. 2016-07-19. PMID:26504602. |
we have previously shown that in the rat spinal cord the activity of aromatic l-amino acid decarboxylase (aadc) cells to produce 5-ht from its precursor (5-hydroxytryptophan, 5-htp) is dramatically increased following complete spinal cord transection. |
2016-07-19 |
2023-08-13 |
rat |
| B J Dougherty, E J Gonzalez-Rothi, K Z Lee, H H Ross, P J Reier, D D Fulle. Respiratory outcomes after mid-cervical transplantation of embryonic medullary cells in rats with cervical spinal cord injury. Experimental neurology. vol 278. 2016-07-14. PMID:26808660. |
respiratory motor output after cervical spinal cord injury (csci) is profoundly influenced by spinal serotonin. |
2016-07-14 |
2023-08-13 |
rat |
| Sabino Hazael Avila-Rojas, Isabel Velázquez-Lagunas, Ana Belen Salinas-Abarca, Paulino Barragán-Iglesias, Jorge Baruch Pineda-Farias, Vinicio Granados-Sot. Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats. Brain research. vol 1622. 2016-06-01. PMID:26168890. |
results suggest that 5-ht5a receptors reduce pain processing in the spinal cord and that 5-ht and 5-ct reduce neuropathic pain through activation of 5-ht5a and 5-ht1a/1b/1d receptors. |
2016-06-01 |
2023-08-13 |
rat |
| Abbas Norouzi-Javidan, Javad Javanbakht, Fardin Barati, Nahid Fakhraei, Fatemeh Mohammadi, Ahmad Reza Dehpou. Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na(+), K(+)-ATPase/Mg(2+)-ATPase imbalances in spinal cord-injured male rats. Diagnostic pathology. vol 10. 2016-05-27. PMID:26369408. |
the observed controversy that n-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (lp-211), a selective serotonin (5-ht7) receptor agonist, may either modify or exacerbate imbalances in serum electrolyte concentrations and renal tissue of spinal cord trauma cases has not been reported yet. |
2016-05-27 |
2023-08-13 |
rat |
| Ozgur Yesilyurt, Melik Seyrek, Serdar Tasdemir, Serdar Kahraman, Mehmet Salih Deveci, Emre Karakus, Zekai Halici, Ahmet Dogru. The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia. European journal of pharmacology. vol 762. 2016-05-24. PMID:25917322. |
the expression of 5-ht7 receptors mrna in the dorsal lumbar region of spinal cord were analyzed by rt-pcr following spinal serotonin depletion or dorsolateral funiculus lesion. |
2016-05-24 |
2023-08-13 |
mouse |
| Jean-François Perrier, Florence Cote. Serotonergic modulation of spinal motor control. Current opinion in neurobiology. vol 33. 2016-04-21. PMID:25553359. |
two approaches have been used on in vitro spinal cord preparations: either applying 5-ht in the extracellular medium or inducing its synaptic release. |
2016-04-21 |
2023-08-13 |
Not clear |
| A Rubio-Casillas, C M Rodríguez-Quintero, G Rodríguez-Manzo, A Fernández-Guast. Unraveling the modulatory actions of serotonin on male rat sexual responses. Neuroscience and biobehavioral reviews. vol 55. 2016-03-31. PMID:25979142. |
experimental evidence suggests that low 5-ht concentrations produce stimulatory actions on male ejaculatory aspects that might be mediated by the blockade of the gabaergic neurotransmission in the mpoa and spinal cord, which in turn releases a tonic inhibition that allows other neurotransmitters such as glutamate, noradrenaline, oxytocin and dopamine to initiate a sequence of molecular events resulting in the expression of ejaculation. |
2016-03-31 |
2023-08-13 |
rat |
| Jeremy W Chopek, Patricia C Sheppard, Kalan Gardiner, Phillip F Gardine. Serotonin receptor and KCC2 gene expression in lumbar flexor and extensor motoneurons posttransection with and without passive cycling. Journal of neurophysiology. vol 113. issue 5. 2015-12-01. PMID:25505109. |
the purpose of this study was to examine motoneuronal gene expression of 5-ht receptors, kcc2, and mglur1 at 3 mo following a complete thoracic spinal cord transection, with and without the inclusion of daily passive cycling. |
2015-12-01 |
2023-08-13 |
Not clear |
| Hajime Hoshino, Hideaki Obata, Shigeru Sait. Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity. Neuroscience letters. vol 602. 2015-10-28. PMID:26135544. |
noradrenaline (na) and serotonin (5-ht) increase in the spinal cord by reuptake inhibition is considered to be main mechanism of the therapeutic effect of antidepressants in neuropathic pain. |
2015-10-28 |
2023-08-13 |
rat |
| Hajime Hoshino, Hideaki Obata, Shigeru Sait. Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity. Neuroscience letters. vol 602. 2015-10-28. PMID:26135544. |
we further determined na and 5-ht contents in homogenized samples from the ipsilateral dorsal spinal cord after snl. |
2015-10-28 |
2023-08-13 |
rat |
| Raffaele Nardone, Yvonne Höller, Aljoscha Thomschewski, Peter Höller, Piergiorgio Lochner, Stefan Golaszewski, Francesco Brigo, Eugen Trink. Serotonergic transmission after spinal cord injury. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 2. 2015-09-25. PMID:24866695. |
current research suggests that serotonine (5-ht) release within the ventral horn of the spinal cord plays a critical role in motor function, and activation of 5-ht receptors mediates locomotor control. |
2015-09-25 |
2023-08-13 |
Not clear |