| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaqing Li, Lisa Li, Marilee J Stephens, Dwight Zenner, Katherine C Murray, Ian R Winship, Romana Vavrek, Glen B Baker, Karim Fouad, David J Bennet. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. Journal of neurophysiology. vol 111. issue 1. 2014-08-11. PMID:24068759. |
synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-htp after spinal cord injury in rats. |
2014-08-11 |
2023-08-12 |
rat |
| Yaqing Li, Lisa Li, Marilee J Stephens, Dwight Zenner, Katherine C Murray, Ian R Winship, Romana Vavrek, Glen B Baker, Karim Fouad, David J Bennet. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. Journal of neurophysiology. vol 111. issue 1. 2014-08-11. PMID:24068759. |
spinal cord transection leads to elimination of brain stem-derived monoamine fibers that normally synthesize most of the monoamines in the spinal cord, including serotonin (5-hydroxytryptamine, 5-ht) synthesized from tryptophan by enzymes tryptophan hydroxylase (tph, synthesizing 5-hydroxytryptophan, 5-htp) and aromatic l-amino acid decarboxylase (aadc, synthesizing 5-ht from 5-htp). |
2014-08-11 |
2023-08-12 |
rat |
| Yaqing Li, Lisa Li, Marilee J Stephens, Dwight Zenner, Katherine C Murray, Ian R Winship, Romana Vavrek, Glen B Baker, Karim Fouad, David J Bennet. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. Journal of neurophysiology. vol 111. issue 1. 2014-08-11. PMID:24068759. |
here we examine whether spinal cord caudal to transection remains able to manufacture and metabolize 5-ht. |
2014-08-11 |
2023-08-12 |
rat |
| Yaqing Li, Lisa Li, Marilee J Stephens, Dwight Zenner, Katherine C Murray, Ian R Winship, Romana Vavrek, Glen B Baker, Karim Fouad, David J Bennet. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. Journal of neurophysiology. vol 111. issue 1. 2014-08-11. PMID:24068759. |
however, immunolabeling for 5-ht reveals that there is no detectable endogenous 5-ht synthesis in any structure in the spinal cord caudal to a chronic transection, including in aadc-containing vessels and neurons, consistent with a lack of tph. |
2014-08-11 |
2023-08-12 |
rat |
| Yaqing Li, Lisa Li, Marilee J Stephens, Dwight Zenner, Katherine C Murray, Ian R Winship, Romana Vavrek, Glen B Baker, Karim Fouad, David J Bennet. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. Journal of neurophysiology. vol 111. issue 1. 2014-08-11. PMID:24068759. |
in summary, after spinal cord injury aadc is upregulated in vessels, pericytes, and neurons but does not endogenously produce 5-ht, whereas when exogenous 5-htp is provided aadc does produce functional amounts of 5-ht, some of which is able to escape metabolism by mao, diffuse out of these aadc-containing cells, and ultimately act on 5-ht receptors on motoneurons. |
2014-08-11 |
2023-08-12 |
rat |
| F Hashemi, R Laufer, P Szegi, V Csomor, H Kalász, Kornélia Teke. HPLC determination of brain biogenic amines following treatment with bispyridinium aldoxime K203. Acta physiologica Hungarica. vol 101. issue 1. 2014-08-11. PMID:24631794. |
effect of a new acetylcholine-esterase reactivator, k203 as a new potential antidote in organophosphate intoxications was studied on dopamine (da), homovanillic acid (hva), serotonin (5-ht) and 5-hydroxyindolacetic acid (5-hiaa) levels in seven brain regions (cerebellum, spinal cord, hippocampus, hypothalamus, striatum, medulla oblongata and frontal cortex) of rats by an optimized and validated hplc method. |
2014-08-11 |
2023-08-12 |
rat |
| Ingvild Wendelbo, Tarek Mazzawi, Magdy El-Salh. Increased serotonin transporter immunoreactivity intensity in the ileum of patients with irritable bowel disease. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24213511. |
serotonin acts upon sensory neurons in the submucosal and myenteric ganglia, as well as in the spinal cord, which is in agreement with this hypothesis. |
2014-07-29 |
2023-08-12 |
human |
| Naotaka Horiguchi, Yukio Ago, Shigeru Hasebe, Kosuke Higashino, Kazuki Asada, Yuki Kita, Kazuhiro Takuma, Toshio Matsud. Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain. Pharmacology, biochemistry, and behavior. vol 113. 2014-06-23. PMID:24161684. |
fca increased 5-ht turnover and decreased 5-ht1a receptor expression in the spinal cord of group-reared mice, while it did not have these effects in isolation-reared mice. |
2014-06-23 |
2023-08-12 |
mouse |
| R J Hernandez, D M Fong, G Chagoya, M P Fillion, G Fillio. Existence of [(3)H]serotonin binding sites in the rat spinal cord: A developmental study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 2. issue 1. 2014-06-02. PMID:24873850. |
existence of [(3)h]serotonin binding sites in the rat spinal cord: a developmental study. |
2014-06-02 |
2023-08-13 |
rat |
| R J Hernandez, D M Fong, G Chagoya, M P Fillion, G Fillio. Existence of [(3)H]serotonin binding sites in the rat spinal cord: A developmental study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 2. issue 1. 2014-06-02. PMID:24873850. |
[(3)h]5-ht specific binding sites have been characterized in the rat spinal cord. |
2014-06-02 |
2023-08-13 |
rat |
| Florent Viguier, Benoît Michot, Michel Hamon, Sylvie Bourgoi. Multiple roles of serotonin in pain control mechanisms--implications of 5-HT₇ and other 5-HT receptor types. European journal of pharmacology. vol 716. issue 1-3. 2014-04-24. PMID:23500207. |
among monoamine neurotransmitters, serotonin (5-ht) is known to play complex modulatory roles in pain signaling mechanisms since the first reports, about forty years ago, on its essentially pro-nociceptive effects at the periphery and anti-nociceptive effects when injected directly at the spinal cord level. |
2014-04-24 |
2023-08-12 |
rat |
| Yoshikazu Ugaw. [Sensory input and basal ganglia]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 11. 2014-04-21. PMID:23196445. |
descending pain modulation system: several brainstem nuclei send descending pain modulation fibers to the spinal cord mediated by serotonin or noradrenalin. |
2014-04-21 |
2023-08-12 |
Not clear |
| Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Toshihiro Sekizawa, Shuichiro Kakimoto, Mina Tsukamoto, Tomoya Oe, Ryugo Enomoto, Nozomu Hamakawa, Nobuya Matsuok. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. The Journal of pharmacology and experimental therapeutics. vol 348. issue 3. 2014-04-02. PMID:24338505. |
in addition, as1069562 increased the ratio of the contents of both 5-ht and ne to their metabolites in rat spinal cord, whereas duloxetine slightly increased only the ratio of the content of 5-ht to its metabolite. |
2014-04-02 |
2023-08-12 |
rat |
| Ruixin Zhang, Lixing Lao, Ke Ren, Brian M Berma. Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology. vol 120. issue 2. 2014-03-11. PMID:24322588. |
these include opioids, which desensitize peripheral nociceptors and reduce proinflammatory cytokines peripherally and in the spinal cord, and serotonin and norepinephrine, which decrease spinal n-methyl-d-aspartate receptor subunit glun1 phosphorylation. |
2014-03-11 |
2023-08-12 |
Not clear |
| Takeyuki Iwasaki, Ken-ichi Otsuguro, Takeshi Kobayashi, Toshio Ohta, Shigeo It. Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors. European journal of pharmacology. vol 702. issue 1-3. 2014-02-04. PMID:23399761. |
endogenously released 5-ht inhibits a and c fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of gaba/glycine and 5-ht release via 5-ht(2a) and 5-ht(3) receptors. |
2014-02-04 |
2023-08-12 |
rat |
| Takeyuki Iwasaki, Ken-ichi Otsuguro, Takeshi Kobayashi, Toshio Ohta, Shigeo It. Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors. European journal of pharmacology. vol 702. issue 1-3. 2014-02-04. PMID:23399761. |
in the neonatal spinal cord, dl-p-chloroamphetamine (pca), a 5-ht releaser, inhibited both a fiber-evoked monosynaptic reflex potential (msr) and c fiber-evoked slow ventral root potential (svrp). |
2014-02-04 |
2023-08-12 |
rat |
| Laura Mòdol, Renzo Mancuso, Albert Alé, Isaac Francos-Quijorna, Xavier Navarr. Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons. Frontiers in cellular neuroscience. vol 8. 2014-01-30. PMID:24478630. |
moreover, 5-ht fibers were increased in the ventral horn of the lumbar spinal cord at late stage of disease progression in sod1(g93a) mice. |
2014-01-30 |
2023-08-12 |
mouse |
| Edouard Pearlstei. Role of descending aminergic pathways in the development of locomotion. Current pharmaceutical design. vol 19. issue 24. 2014-01-27. PMID:23360267. |
numerous studies have shown that aminergic (serotonin, noradrenaline, dopamine) projections to the spinal cord could contribute to the maturation of locomotor networks. |
2014-01-27 |
2023-08-12 |
Not clear |
| Jean-François Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen, Anders Victor Peterse. Modulation of the intrinsic properties of motoneurons by serotonin. Current pharmaceutical design. vol 19. issue 24. 2014-01-27. PMID:23360270. |
under pathological conditions, such as after a spinal cord injury, the promotion of persistent inward currents by serotonin and/or the overexpression of autoactive serotonergic receptors may contribute to motoneuronal excitability, muscle spasms and spasticity and hence, impairment of stereotyped motor behaviors such as locomotion, ejaculation and micturition. |
2014-01-27 |
2023-08-12 |
Not clear |
| Shinichi Ogino, Yukinori Nagakura, Mina Tsukamoto, Tomonari Watabiki, Tohru Ozawa, Tomoya Oe, Yasuaki Shimizu, Hiroyuki It. Systemic administration of 5-HT(2C) receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model. Pharmacology, biochemistry, and behavior. vol 108. 2014-01-02. PMID:23603031. |
microdialysis experiments showed that the concentration of serotonin (5-ht) in the spinal cord of rim rats was significantly lower than that of controls. |
2014-01-02 |
2023-08-12 |
rat |