| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Silva, José Tiago Costa-Pereira, Daniel Martins, Isaura Tavare. Pain modulation from the brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla. Neurobiology of disease. vol 96. 2018-02-09. PMID:27717882. |
the rostroventromedial medulla (rvm) is a key pain control center involved in descending pain modulation at the spinal cord through local release of 5-ht and plays a peculiar role in the balance of bidirectional control (i.e. |
2018-02-09 |
2023-08-13 |
Not clear |
| Marta Silva, José Tiago Costa-Pereira, Daniel Martins, Isaura Tavare. Pain modulation from the brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla. Neurobiology of disease. vol 96. 2018-02-09. PMID:27717882. |
in early phases of the disease, facilitation of pain modulation from the rvm prevails through a triplet of mechanisms which include increase in serotonin expression at the rvm and consequent rise of serotonin levels at the spinal cord and upregulation of local facilitatory 5ht3 receptors, enhancement of spontaneous activity of facilitatory rvm neurons and up-regulation of the expression of transient receptor potential vanilloid type 1 (trpv1) receptor. |
2018-02-09 |
2023-08-13 |
Not clear |
| Li-Qun Ren, Jacob Wienecke, Hans Hultborn, Mengliang Zhan. Production of Dopamine by Aromatic l-Amino Acid Decarboxylase Cells after Spinal Cord Injury. Journal of neurotrauma. vol 33. issue 12. 2018-01-04. PMID:26830512. |
we have previously found that aadc cells in the spinal cord could increase their ability to produce serotonin (5-hydroxytryptamine) from 5-hydroxytryptophan after spinal cord injury (sci). |
2018-01-04 |
2023-08-13 |
rat |
| Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bra. Changes in innervation of lumbar motoneurons and organization of premotor network following training of transected adult rats. Experimental neurology. vol 299. issue Pt A. 2017-12-20. PMID:28917641. |
rats with complete spinal cord transection (sct) can recover hindlimb locomotor function under strategies combining exercise training and 5-ht agonist treatment. |
2017-12-20 |
2023-08-13 |
rat |
| Dragana Komnenov, Julia Z Solarewicz, Fareeza Afzal, Kwaku D Nantwi, Donald M Kuhn, Jason H Mateik. Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system. Journal of applied physiology (Bethesda, Md. : 1985). vol 121. issue 2. 2017-12-11. PMID:27402561. |
moreover, we conclude that spontaneous or treatment-induced recovery of respiratory and motor limb function is not dependent on serotonin in the central nervous system in a mouse model of spinal cord injury. |
2017-12-11 |
2023-08-13 |
mouse |
| Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Li. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson's Disease. Neural plasticity. vol 2016. 2017-10-26. PMID:27747105. |
hplc analysis showed that ne content, but not dopamine or 5-ht, significantly decreased in lumbar spinal cord in pd rats. |
2017-10-26 |
2023-08-13 |
rat |
| Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Li. Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Molecular pain. vol 13. 2017-10-19. PMID:28326933. |
attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of parkinson's disease. |
2017-10-19 |
2023-08-13 |
rat |
| Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Li. Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Molecular pain. vol 13. 2017-10-19. PMID:28326933. |
the aim of the present study was to investigate the role of serotonin (5-hydroxytryptamine) in the rostral ventromedial medulla (rvm) and spinal cord in pain sensory abnormalities in a 6-hydroxydopamine-treated rat model of parkinson's disease. |
2017-10-19 |
2023-08-13 |
rat |
| Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Li. Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Molecular pain. vol 13. 2017-10-19. PMID:28326933. |
immunofluorescence was used to examine 5-hydroxytryptamine neurons and fibers in the rostral ventromedial medulla and spinal cord. |
2017-10-19 |
2023-08-13 |
rat |
| Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Li. Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Molecular pain. vol 13. 2017-10-19. PMID:28326933. |
5-hydroxytryptamine concentrations in both the rostral ventromedial medulla and spinal cord were reduced. |
2017-10-19 |
2023-08-13 |
rat |
| Jessica M D'Amico, Annie A Butler, Martin E Héroux, Florence Cotel, Jean-François M Perrier, Jane E Butler, Simon C Gandevia, Janet L Taylo. Human motoneurone excitability is depressed by activation of serotonin 1A receptors with buspirone. The Journal of physiology. vol 595. issue 5. 2017-10-03. PMID:27859267. |
in the adult turtle spinal cord, action potential generation in motoneurones is inhibited by spillover of serotonin to extrasynaptic serotonin 1a (5-ht |
2017-10-03 |
2023-08-13 |
human |
| Fiona M Bright, Roger W Byard, Robert Vink, David S Paterso. Medullary Serotonin Neuron Abnormalities in an Australian Cohort of Sudden Infant Death Syndrome. Journal of neuropathology and experimental neurology. vol 76. issue 10. 2017-10-02. PMID:28922849. |
serotonin (5-hydroxytryptamine [5-ht]) neurons in the medulla oblongata project extensively to key autonomic and respiratory nuclei in the brainstem and spinal cord regulating critical homeostatic functions. |
2017-10-02 |
2023-08-13 |
Not clear |
| Anna M Cabaj, Henryk Majczyński, Erika Couto, Phillip F Gardiner, Katinka Stecina, Urszula Sławińska, Larry M Jorda. Serotonin controls initiation of locomotion and afferent modulation of coordination via 5-HT The Journal of physiology. vol 595. issue 1. 2017-09-25. PMID:27393215. |
serotonin controls initiation of locomotion and afferent modulation of coordination via 5-ht experiments on neonatal rodent spinal cord showed that serotonin (5-ht), acting via 5-ht |
2017-09-25 |
2023-08-13 |
Not clear |
| Theeradej Thaweerattanasinp, Charles J Heckman, Vicki M Tysselin. Firing characteristics of deep dorsal horn neurons after acute spinal transection during administration of agonists for 5-HT1B/1D and NMDA receptors. Journal of neurophysiology. vol 116. issue 4. 2017-09-05. PMID:27486104. |
spinal cord injury (sci) results in a loss of serotonin (5-ht) to the spinal cord and a loss of inhibition to deep dorsal horn (ddh) neurons, which produces an exaggerated excitatory drive to motoneurons. |
2017-09-05 |
2023-08-13 |
Not clear |
| Yaqing Li, Ana M Lucas-Osma, Sophie Black, Mischa V Bandet, Marilee J Stephens, Romana Vavrek, Leo Sanelli, Keith K Fenrich, Antonio F Di Narzo, Stella Dracheva, Ian R Winship, Karim Fouad, David J Bennet. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nature medicine. vol 23. issue 6. 2017-08-29. PMID:28459438. |
we find that, months after the imposition of sci, the spinal cord below the site of injury is in a chronic state of hypoxia owing to paradoxical excess activity of monoamine receptors (5-ht |
2017-08-29 |
2023-08-13 |
rat |
| Anne Gautier, Hanady El Ouaraki, Natacha Bazin, Soha Salam, Guilan Vodjdani, Sylvie Bourgoin, Sophie Pezet, Jean-François Bernard, Michel Hamo. Lentiviral vector-driven inhibition of 5-HT synthesis in B3 bulbo-spinal serotonergic projections - Consequences on nociception, inflammatory and neuropathic pain in rats. Experimental neurology. vol 288. 2017-05-12. PMID:27983993. |
together with the long term disappearance of this enzyme in the whole rostro-caudal extent of b3 group, 5-ht was markedly depleted selectively in the dorsal horn at all levels of the spinal cord. |
2017-05-12 |
2023-08-13 |
rat |
| Mohammad Ahmad, Abdulrahim Zakaria, Khalid M Almutair. Effectiveness of minocycline and FK506 alone and in combination on enhanced behavioral and biochemical recovery from spinal cord injury in rats. Pharmacology, biochemistry, and behavior. vol 145. 2017-04-20. PMID:27106204. |
thereafter, the animals were sacrificed and the segment of the spinal cord centered at the injury site was removed for the histopathological studies as well as for biochemical analysis of monoamines such as 5-hydroxytryptamine (5-ht) and 5-hydroxy-indolacetic acid (5-hiaa) and some oxidative stress indices, such as thiobarbituric acid-reactive substances (tbars), total glutathione (gsh) and myeloperoxidase (mpo). |
2017-04-20 |
2023-08-13 |
rat |
| Kenichiro Yahata, Haruo Kanno, Hiroshi Ozawa, Seiji Yamaya, Satoshi Tateda, Kenta Ito, Hiroaki Shimokawa, Eiji Ito. Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury. Journal of neurosurgery. Spine. vol 25. issue 6. 2017-02-22. PMID:27367940. |
immunohistochemical staining for cd31, α-sma, and 5-ht was performed on spinal cord sections taken 42 days after sci. |
2017-02-22 |
2023-08-13 |
human |
| Jacob E Montgomery, Timothy D Wiggin, Luis M Rivera-Perez, Christina Lillesaar, Mark A Masin. Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish. Developmental neurobiology. vol 76. issue 6. 2017-01-06. PMID:26437856. |
although antibodies to serotonin (5-ht) have detected isns in the ventral spinal cord of embryos, larvae, and adults, the only tryptophan hydroxylase (tph) transcript that has been described in the spinal cord is tph1a. |
2017-01-06 |
2023-08-13 |
zebrafish |
| Katherine A Mifflin, Curtis Benson, Kevin C Thorburn, Glen B Baker, Bradley J Ker. Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice. The journal of pain. vol 17. issue 4. 2016-12-27. PMID:26748043. |
changes in serotonin (5-hydroxytryptamine; 5-ht), noradrenaline (na), and γ-aminobutyric acid (gaba) levels in the spinal cord are known to occur in response to nociceptive stimuli, yet little research has examined possible underlying sex differences in these changes and how they might affect nociception. |
2016-12-27 |
2023-08-13 |
mouse |