| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai Xu, Peng Huang, Yixuan Wu, Teng Liu, Ningyi Shao, Lulu Zhao, Xiaoyan Hu, Junlei Chang, Yongbo Peng, Shaogang Q. Engineered Selenium/Human Serum Albumin Nanoparticles for Efficient Targeted Treatment of Parkinson's Disease via Oral Gavage. ACS nano. 2023-10-09. PMID:37807265. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of dopamine (da) neurons in the midbrain substantia nigra pars compacta (snpc). |
2023-10-09 |
2023-10-15 |
human |
| Shweta Jain, Andrew G Yee, James Maas, Sarah Gierok, Hongfei Xu, Jasmine Stansil, Jacob Eriksen, Alexandra B Nelson, Katlin Silm, Christopher P Ford, Robert H Edward. Adaptor protein-3 produces synaptic vesicles that release phasic dopamine. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 42. 2023-10-09. PMID:37812725. |
the burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. |
2023-10-09 |
2023-10-15 |
Not clear |
| Kelsey Barcomb, Christopher P For. Alterations in neurotransmitter co-release in Parkinson's disease. Experimental neurology. 2023-10-06. PMID:37802381. |
parkinson's disease is a neurological disorder characterized by degeneration of midbrain dopamine neurons, which results in numerous adaptations in basal ganglia circuits. |
2023-10-06 |
2023-10-15 |
Not clear |
| Kelsey Barcomb, Christopher P For. Alterations in neurotransmitter co-release in Parkinson's disease. Experimental neurology. 2023-10-06. PMID:37802381. |
research over the past twenty-five years has identified that midbrain dopamine neurons of the substantia nigra pars compacta (snc) and ventral tegmental area (vta) co-release multiple other transmitters including glutamate and gaba, in addition to their canonical transmitter, dopamine. |
2023-10-06 |
2023-10-15 |
Not clear |
| Aastha Singh, Anne Panhelainen, Merja H Voutilaine. Feasibility of combining alpha-synuclein aggregation and 6-OHDA in embryonic midbrain culture for modeling dopamine neuron degeneration. Neuroscience letters. 2023-10-06. PMID:37802418. |
feasibility of combining alpha-synuclein aggregation and 6-ohda in embryonic midbrain culture for modeling dopamine neuron degeneration. |
2023-10-06 |
2023-10-15 |
mouse |
| Jie Zhang, Jia Li, Cheng-Xi Liu, Huan Gui, Cheng-Dong Yuan, Yi Zhan. The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786416. |
dopamine (da), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (sn) pars compacta of the midbrain. |
2023-10-03 |
2023-10-07 |
Not clear |
| Yuji K Takahashi, Zhewei Zhang, Marlian Montesinos-Cartegena, Thorsten Kahnt, Angela J Langdon, Geoffrey Schoenbau. Expectancy-related changes in firing of dopamine neurons depend on hippocampus. bioRxiv : the preprint server for biology. 2023-10-02. PMID:37781610. |
we recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which errors in the prediction of reward were induced by manipulating the number or timing of the expected rewards across blocks of trials. |
2023-10-02 |
2023-10-07 |
rat |
| Gavin C Jones, Christina A Small, Dallin Z Otteson, Caylor W Hafen, Jacob T Breinholt, Paul D Flora, Matthew D Burris, David W Sant, Tysum R Ruchti, Jordan T Yorgason, Scott C Steffensen, Kyle B Bill. Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762450. |
peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (da) system originating in the ventral tegmental area (vta) of the midbrain and projecting to the nucleus accumbens (nac) of the striatum. |
2023-09-28 |
2023-10-07 |
rat |
| Wen-Xiang Duan, Fen Wang, Jun-Yi Liu, Chun-Feng Li. Relationship Between Short-chain Fatty Acids and Parkinson's Disease: A Review from Pathology to Clinic. Neuroscience bulletin. 2023-09-27. PMID:37755674. |
parkinson's disease (pd) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in lewy bodies and neurites, and massive loss of midbrain dopamine neurons. |
2023-09-27 |
2023-10-07 |
Not clear |
| Long Din. Contributions of the Basal Ganglia to Visual Perceptual Decisions. Annual review of vision science. vol 9. 2023-09-15. PMID:37713277. |
from theoretical and experimental perspectives, the review focuses on four key stations in the bg network, namely, the striatum, pallidum, subthalamic nucleus, and midbrain dopamine neurons, which can have different roles and together support the decision process. |
2023-09-15 |
2023-10-07 |
Not clear |
| Nadine J Ortner, Anupam Sah, Enrica Paradiso, Josef Shin, Strahinja Stojanovic, Niklas Hammer, Maria Haritonova, Nadja T Hofer, Andrea Marcantoni, Laura Guarina, Petronel Tuluc, Tamara Theiner, Florian Pitterl, Karl Ebner, Herbert Oberacher, Emilio Carbone, Nadia Stefanova, Francesco Ferraguti, Nicolas Singewald, Jochen Roeper, Joerg Striessni. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI insight. 2023-09-12. PMID:37698939. |
cav1.3ag mice confirm the pathogenicity of the a749g variant and point towards a pathogenetic role of altered signaling in the dopamine midbrain system. |
2023-09-12 |
2023-10-07 |
mouse |
| Jia-Xin Shi, Ke-Zhong Zhan. Advancements in autologous stem cell transplantation for Parkinson's Disease. Current stem cell research & therapy. 2023-09-11. PMID:37691194. |
parkinson's disease (pd) is a progressive neurodegenerative disease marked by comparatively focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the striatum, which causes motor and non-motor symptoms. |
2023-09-11 |
2023-10-07 |
Not clear |
| Kailin Yang, Liuting Zeng, Jinsong Zeng, Ying Deng, Shanshan Wang, Hao Xu, Qi He, Mengxia Yuan, Yanfang Luo, Anqi Ge, Jinwen G. Research Progress in the Molecular Mechanism of Ferroptosis in Parkinson's Disease and Regulation by Natural Plant Products. Ageing research reviews. 2023-09-06. PMID:37673132. |
the current understanding of pd focuses mainly on the loss of dopamine neurons in the substantia nigra region of the midbrain, which is attributed to factors such as oxidative stress, alpha-synuclein aggregation, neuroinflammation, and mitochondrial dysfunction. |
2023-09-06 |
2023-10-07 |
Not clear |
| Megan Caldwell, Vanessa Ayo-Jibunoh, Josue Criollo Mendoza, Katherine R Brimblecombe, Lauren M Reynolds, Xin Yan Zhu Jiang, Colin Alarcon, Elizabeth Fiore, Jacquelyn N Tomaio, Greg R Phillips, Susana Mingote, Cecilia Flores, Patrizia Casaccia, Jia Liu, Stephanie J Cragg, Dan P McCloskey, Leora Yetnikof. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain structure & function. 2023-09-05. PMID:37668732. |
axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. |
2023-09-05 |
2023-09-07 |
mouse |
| Megan Caldwell, Vanessa Ayo-Jibunoh, Josue Criollo Mendoza, Katherine R Brimblecombe, Lauren M Reynolds, Xin Yan Zhu Jiang, Colin Alarcon, Elizabeth Fiore, Jacquelyn N Tomaio, Greg R Phillips, Susana Mingote, Cecilia Flores, Patrizia Casaccia, Jia Liu, Stephanie J Cragg, Dan P McCloskey, Leora Yetnikof. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain structure & function. 2023-09-05. PMID:37668732. |
here, we provide evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice. |
2023-09-05 |
2023-09-07 |
mouse |
| Megan Caldwell, Vanessa Ayo-Jibunoh, Josue Criollo Mendoza, Katherine R Brimblecombe, Lauren M Reynolds, Xin Yan Zhu Jiang, Colin Alarcon, Elizabeth Fiore, Jacquelyn N Tomaio, Greg R Phillips, Susana Mingote, Cecilia Flores, Patrizia Casaccia, Jia Liu, Stephanie J Cragg, Dan P McCloskey, Leora Yetnikof. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain structure & function. 2023-09-05. PMID:37668732. |
these results suggest that oligodendrocyte lineage cells may respond to dopamine released from midbrain dopamine axons, which could affect myelination. |
2023-09-05 |
2023-09-07 |
mouse |
| Megan Caldwell, Vanessa Ayo-Jibunoh, Josue Criollo Mendoza, Katherine R Brimblecombe, Lauren M Reynolds, Xin Yan Zhu Jiang, Colin Alarcon, Elizabeth Fiore, Jacquelyn N Tomaio, Greg R Phillips, Susana Mingote, Cecilia Flores, Patrizia Casaccia, Jia Liu, Stephanie J Cragg, Dan P McCloskey, Leora Yetnikof. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain structure & function. 2023-09-05. PMID:37668732. |
together, this work broadens our understanding of neuron-glia interactions with important implications for myelin plasticity by identifying midbrain dopamine axons as a potential regulator of corpus callosal oligodendrocyte lineage cells. |
2023-09-05 |
2023-09-07 |
mouse |
| Kenta Abe, Yuki Kambe, Kei Majima, Zijing Hu, Makoto Ohtake, Ali Momennezhad, Hideki Izumi, Takuma Tanaka, Ashley Matunis, Emma Stacy, Takahide Itokazu, Takashi R Sato, Tatsuo K Sat. Enhanced Aversive Signals During Classical Conditioning in Dopamine Axons in Medial Prefrontal Cortex. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662305. |
midbrain dopamine neurons impact neural processing in the prefrontal cortex (pfc) through mesocortical projections. |
2023-09-04 |
2023-09-07 |
mouse |
| Min Jung Kim, Daniel J Gibson, Dan Hu, Ara Mahar, Cynthia J Schofield, Patlapa Sompolpong, Tomoko Yoshida, Kathy T Tran, Ann M Graybie. Dopamine Release Plateau and Outcome Signals in Dorsal Striatum Contrast with Classic Reinforcement Learning Formulations. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645888. |
in most sites, we found no evidence for a transition from outcome to cue signaling, a hallmark of temporal difference reinforcement learning as applied to midbrain dopamine activity. |
2023-08-30 |
2023-09-07 |
mouse |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |